ライフサイエンスコーパス: in vivo

1 on of the ERK pathway in vitro and in hearts in vivo.

2 from excessive inflammation and acute shock in vivo.

3 r tracking miRNA expression and localization in vivo.

4 lls (hMSCs) is poorly organized and unstable in vivo.

5 was critical to obtain the desired activity in vivo.

6 also evident in human ESCs and mouse embryos in vivo.

7 terial-tissue interactions both in vitro and in vivo.

8 oimmune inflammation was markedly attenuated in vivo.

9 the underlying mechanism of clonal expansion in vivo.

10 ced EMT and promoted metastasis in vitro and in vivo.

11 ikely binds to ssDNA with high cooperativity in vivo.

12 can act as a therapeutic agent in vitro and in vivo.

13 for 56-177 days, depending on bNAb half-life in vivo.

14 o understanding the behaviour of these cells in vivo.

15 rties and Pab1 phase separation in vitro and in vivo.

16 ibited parasite transmission and development in vivo.

17 tor, Elongin A (EloA), is methylated by PRC2 in vivo.

18 horylation and c-Myc expression in vitro and in vivo.

19 against cardiac hypertrophy and dysfunction in vivo.

20 portant mechanism during antibody maturation in vivo.

21 nt phenotypes of SCC cells both in vitro and in vivo.

22 confirmed that such timing separation occurs in vivo.

23 e of more than five-fold in imaging contrast in vivo.

24 allow modeling and therapy of human diseases in vivo.

25 ation, which takes place in palatine tonsils in vivo.

26 ting, we elucidated endonuclease specificity in vivo.

27 GF)-beta1 to -beta3 translation in vitro and in vivo.

28 f Huntington's disease, and induce autophagy in vivo.

29 agments that function to repress translation in vivo.

30 igh dopaminergic yield after transplantation in vivo.

31 nsulin levels while increasing blood glucose in vivo.

32 ufficient to impair epithelial wound healing in vivo.

33 NAs in vitro; but neither miRNAs nor miRNA*s in vivo.

34 and LPS in retinal axons during arborization in vivo.

35 particles that were infectious in vitro and in vivo.

36 sh directional transport on the cytoskeleton in vivo.

37 equired for Th9 differentiation in vitro and in vivo.

38 acterized biochemical functions in vitro and in vivo.

39 steps of transcription on a single-copy gene in vivo.

40 derlying progressive CD4(+) T cell depletion in vivo.

41 revealed a functional Caspase-8 inflammasome in vivo.

42 ices of mouse and monkey, and in mouse brain in vivo.

43 1A1-positive cancer cells, both in vitro and in vivo.

44 e reliable and valuable tools correlative to in vivo.

45 increased mast cell activation in vitro and in vivo.

46 n profoundly impacts nervous system function in vivo.

47 r a high glucose condition both in vitro and in vivo.

48 n, increase cell death, and induce tolerance in vivo.

49 med from hMSCs remained stable and organized in vivo.

50 MDA-MB-231 breast cancer cells in vitro and in vivo.

51 strong inhibitor of angiogenesis ex vivo and in vivo.

52 t and patient-derived xenograft mouse models in vivo.

53 tion and cargo transport functions of dynein in vivo.

54 d silencing of RanBP6 promoted glioma growth in vivo.

55 d protection against divergent virus strains in vivo.

56 iver GEN transdermally at therapeutic levels in vivo.

57 energy-integrating detector (EID) technology in vivo.

58 anti-estrogen chemosensitivity in vitro and in vivo.

59 cells and to generate pathogenic TH17 cells in vivo.

60 paralogs that perform non-overlapping roles in vivo.

61 functional development of individual neurons in vivo.

62 been extensively investigated and validated in vivo.

63 osynthesis and thus function can be achieved in vivo.

64 nhanced clearance of PD-L1+ tumor xenografts in vivo.

65 ibited Wnt/beta-catenin pathway in vitro and in vivo.

66 + cardiomyoblasts mature into cardiomyocytes in vivo.

67 hogens to their preferred sites of infection in vivo.

68 nts over hours and days both in phantoms and in vivo.

69 lective pressures encountered by S. enterica in vivo.

70 cells behave as intestinal stem cells (ISCs) in vivo.

71 ortant roles in multiple signalling pathways in vivo.

72 sitivity to LPS-induced TNF-alpha production in vivo.

73 latelet activation and in thrombus formation in vivo.

74 lar chaperone accelerates prion pathogenesis in vivo.

75 crease in hDBR1 expression both in vitro and in vivo.

76 In vivo, AAV9 (adeno-associated virus serotype 9)-mediat

77 levance of 5-HT2 receptor heterodimerization in vivo Accordingly, exogenous expression of an inactive

78 olished by reducing the neutrophil load with in vivo administration of an anti-Ly6G antibody.

79 ells from Spi2A knockout mice (P < .005) and in vivo after ovalbumin challenge (P < .05), higher leve

80 mannii and enhanced the activity of colistin in vivo against colistin-resistant P. aeruginosa.

81 In vivo alphaCD20-IL-21 therapy resulted in a significan

82 hroughout disease development by integrating in vivo analysis of gene expression dynamics with a reve

83 ecifically localized to endothelial caveolae in vivo and compared its effects to non-caveolar target

84 ay survival, invasive arterial pressure, and in vivo and ex vivo arterial response to phenylephrine a

85 the ERK pathway in primary cancer specimens in vivo and in cancer cell lines in vitro.

86 site both in male and female transgenic mice in vivo and in cell lines and primary neuronal culture d

87 e maintenance of numerous patterning systems in vivo and in explant culture.

88 Taken together, by combining in vivo and in vitro analysis using TC10-deficient mice,

89 nd miR-148 antagonism modified PTH secretion in vivo and in vitro, implying roles for these specific

90 nto/osteogenic differentiation of DPSCs both in vivo and in vitro.

91 atase expression is also spatially regulated in vivo and in vitro.

92 clocks are oscillating with distinct phases in vivo and in vitro.

93 aces constraints on how S-nitrosation occurs in vivo and on its mechanisms of cardioprotection and mo

94 tient information (M36IEP); another based on in vivo and patient information only (M36IP); and a thir

95 o defects in the function of neural circuits in vivo and provide an approach for exploring the geneti

96 h FLT3-ITD to promote myeloid cell expansion in vivo and that this involves a multitarget mechanism t

97 udy infection with the pathogen in vitro and in vivo and the immune response to these bacteria.

98 By combining in vivo and tissue culture models, we show here that VEG

99 ted by parathyroid hormone both in vitro and in vivo, and protects osteocytes from oxidative stress.

100 dicated that TCTP forms complexes with Rad51 in vivo, and the stability maintenance of Rad51 requires

101 mitochondrial oxidative stress and mitophagy in vivo, and were preceded by increased phosphorylation

102 otherapy and diagnostics with an emphasis on in vivo applications.

103 that control extracellular serotonin levels in vivo are not well-defined.

104 ologies that allow imaging of corneal nerves in vivo are spawning questions regarding the relationshi

105 degrees C and that Tfu-FNO is likely to act in vivo as an F420 reductase at the expense of NADPH, si

106 ts and selectively binds to TrkB/C receptors in vivo, as evidenced by entrectinib blocking studies.

107 reduce amyloid deposition both in vitro and in vivo Because N-terminally truncated pyroglutamate (pE

108 e observed impairments proved to be decisive in vivo because silencing of the INSR attenuated clinica

109 n local frustration also affect partitioning in vivo between spontaneous and chaperonin-mediated fold

110 e potential to be used for both in vitro and in vivo biomedical applications.

111 (+) MKs, leading to increased platelet yield in vivo, but not in vitro.

112 ong peptide-specific CD8(+) T cell responses in vivo by incorporating an NKT cell-activating glycolip

113 a broad anti-leukemic activity in vitro and in vivo by inhibiting leukemia cell proliferation/viabil

114 IL-18 activity is modulated in vivo by its naturally occurring antagonist, IL-18 Bin

115 blation of JNK1 or JNK2 decreased ATZ levels in vivo by reducing c-Jun-mediated SERPINA1 gene express

116 orylation and the tumor growth were verified in vivo by xenograft tumor studies.

117 By coupling in vivo Ca(2+) imaging of dentate granule neurons with a

118 radigm of repetitive whisker stimulation and in vivo calcium imaging to assess tactile defensiveness

119 thermore, positive modulation of BK channels in vivo can enhance short-term habituation.

120 contributions of Wnt versus RSPO ligands to in vivo canonical Wnt signalling and ISC biology remain

121 However, the in vivo cardiac function of IF1 and the potential therap

122 estigate the effects of increased CD39 in an in vivo cerebral ischemia model, we developed a transgen

123 In vivo, CL photoactivation could be shown by using the

124 ogenicity and malignant growth of SCLC cells in vivo Collectively, our studies validate the utility o

125 n coding genes were differentially expressed in vivo compared with in vitro (false discovery rate, </

126 the extracted biological data using in vitro-in vivo correlations.

127 The noninvasive imaging of MMP activity in vivo could have a high impact in basic research as we

128 Despite often minute concentrations in vivo, d-amino acid containing peptides (DAACPs) are c

129 flow-limited assumption and largely rely on in vivo data for parametrization.

130 promote viral clearance, but increased IL-22 in vivo decreased T cell numbers and functions in the li

131 Here, using human in vivo deuterium labeling, we demonstrate that classica

132 sults suggest that repeated cocaine exposure in vivo disrupts the balance between excitation and inhi

133 This study assessed the in vivo distribution of (11)C-nicotine and the absorbed

134 thways should generate biomarkers useful for in vivo dose responses of beta-lapachone treatment in hu

135 In-vivo Drosophila studies showed a genetic interaction

136 s or Escherichia coli cells both ex vivo and in vivo During systemic candidiasis, the absence of alph

137 Here, we report in vitro and in vivo effects of inhibiting PI3Kdelta in APDS.

138 lity and to identify suitable candidates for in vivo efficacy evaluation.

139 hether systemic drug exposure is crucial for in vivo efficacy.

140 In addition, in vivo electrophysiological recordings from GPe showed

141 transcriptional latency may not be possible in vivo, especially in the presence of combination antir

142 In vivo, EspL cysteine protease activity contributes to

143 the terminal complement complex and provide in vivo evidence for contributions of complement-depende

144 nation system, our results provide the first in vivo evidence that BMP signaling activity is required

145 These findings provide further in vivo evidence that distribution of the [18F]AV-1451 s

146 uration: one model based on a combination of in vivo, ex vivo, and clinical patient information (M36I

147 Our previous preclinical in vivo experiments demonstrated that only certain HCV-N

148 In vitro-in vivo extrapolation (IVIVE) analyses translating high-

149 nction, whereas the IgG4 isotype can undergo in vivo Fab arm exchange leading to bispecific antibody

150 Additionally, in vivo findings support our data, providing evidence th

151 Correlative studies included analysis of in vivo FLT3 inhibition by plasma inhibitory activity as

152 ssion throughout orthotopic rat brain tumors in vivo following administration by convection enhanced

153 g perlecan domain I and VEGF189 and analyzed in vivo for their ability to promote dermal wound healin

154 g that these activities are critical for the in vivo function of STN1.

155 Here, we use in vivo functional imaging to identify a class of cutane

156 Recent studies have identified key in vivo functions of ADAR enzymes, informing our underst

157 Relatively little is known about the in vivo functions of newly emerging genes, especially in

158 However, the in vivo functions of specific microRNAs in controlling m

159 xon projection of DRG toward the spinal cord in vivo Furthermore, live-cell imaging of end-binding pr

160 Specifically, we used IL-23 in vivo gene transfer to induce arthritis in mice and sh

161 l delivery of Cre recombinase to hepatocytes in vivo, GsD is expressed and allows CNO-dependent cAMP

162 ascular and fibrotic diseases, but its short in vivo half-life is an obstacle to long-term administra

163 Ultradian rhythms in mouse hepatocytes in vivo have been published, and we validated our approa

164 t investigations into the function of CLEC-2 in vivo have focused on knockout (KO) studies in which b

165 dioligand binding to neuroreceptors in brain in vivo, here applied to noradrenaline receptors in rat

166 rafish by generating intronic insertions via in vivo homologous recombination.

167 egeneration-associated proteins in vitro and in vivo; however, the regulation of HSJ1 function is lit

168 a correlative gene-expression microarray and in vivo imaging analysis, and identified novel molecular

169 excitation, hold promise for ultrasensitive in vivo imaging because they eliminate tissue autofluore

170 acoustic microscopy allows for label-free 3D in vivo imaging by detecting the acoustic response of a

171 minescence, vascular leakage by fluorescence in vivo imaging, histopathological changes by semiquanti

172 ar cells (BCs) in the zebrafish retina using in vivo imaging.

173 icantly inhibited the growth of MGC803 cells in vivo in a xenograft mouse model without observed toxi

174 s and mo-Macs closely resembling those found in vivo in ascites, we show that IRF4 and MAFB were crit

175 ired for induction of ATF4 protein synthesis in vivo in erythroid cells during ID.

176 y, early neural development is here followed in vivo in real time at high resolution along several hu

177 We confirmed these findings in vitro and in vivo in two murine tumor models, in primary human bre

178 e progenitor cells into neonatal rat hearts, in vivo incubation and analysis.

179 594A) mutation) triggers lung adenocarcinoma in vivo, indicating that BRAF-inactivating mutations are

180 s, while decreasing the levels of Th17 cells in vivo, indicating that CCR2 regulates the immune respo

181 This study provides in vivo indication of a role for postsynaptic factors in

182 e brain endothelial cells (a target of MAV-1 in vivo) infected ex vivo with MAV-1 had no difference i

183 mechanism and relevance to other viruses or in vivo infections remained unknown.

184 formation only (M36IP); and a third based on in vivo information only (M36I).

185 a fundamentally new approach for systematic in vivo investigations of cell membrane structure.

186 CTC and CPC characterization in humans in vivo is still challenging.

187 m channel-transporter complexes in vitro and in vivo KCNQ2/3 coexpression protected SMIT1 activity fr

188 licing of P-transposable element transcripts in vivo, leading to the production of the non-transposas

189 ured organic electronic devices and circuits in vivo, leveraging the internal structure and physiolog

190 Immunodetection and in vivo localization of AtCPT7 fluorescent protein fusio

191 electrochemical characteristics and used for in vivo measurements of oxygen with high resolution in t

192 l model that incorporates the uncertainty in in vivo measurements, in addition to electrode variabili

193 PET was developed in the 1970s as an in vivo method to measure regional pathophysiologic proc

194 In vivo, mice with knockout of SREBP2 in astrocytes have

195 mpared using in vitro transporter assays and in vivo microdialysis in rat nucleus accumbens.

196 We conducted immunoblotting and in vivo microdialysis procedures in MA high/low drinking

197 We also show that a well-established in vivo mild chronic hypoxia (MCH) mouse model and a new

198 hibitor, LY3023414, on established EAC in an in vivo model.

199 NS, and to efficiently generate personalized in vivo models of genetic renal diseases bearing patient

200 nd airway inflammation was assessed by using in vivo models of IL-13-induced lung pathology and in vi

201 We then combined these analytical tools with in vivo models of osteotomy healing and implant osseoint

202 Using both in vitro and in vivo models, we go on to demonstrate that hydralazine

203 Using ex vivo and in vivo models, we identify the Hedgehog (HH) paracrine

204 aphy (PET) is a powerful analytical tool for in vivo molecular imaging of the human brain.

205 valuable tool for the detection of microRNAs in vivo, molecular beacons can also be employed to inhib

206 ecting near-infrared autofluorescence allows in vivo monitoring of intraplaque hemorrhage, establishi

207 ovitine can speed up inflammation resolution in vivo more efficiently than the free drug.

208 -positive model T126, was chosen to generate in vivo mouse models containing orthotopic breast tumors

209 Using in vitro cell culture and in vivo mouse models, we showed that COUP-TFII hinders m

210 athway in reparative dentinogenesis using an in vivo mouse tooth damage model.

211 In vivo, MR-409 mitigated cardiac hypertrophy in mice su

212 Quantitative histological and in vivo MRI assessments of non-heme cellular iron reveal

213 A further analysis of 102 hemispheres of in vivo MRI scans (N = 51 males, mean +/- SD 24.1 +/- 3.

214 In vivo, myeloid cells and their progenitors are an impo

215 This unique in vivo nano-bio interaction in the sub-nanometre regime

216 In vivo neutralization of these proinflammatory cytokine

217 mediating metastatic phenotypes in vitro and in vivo Notably, pharmacologic targeting of SPHK1 or YAP

218 In vivo OCT imaging of LVYE-1 showed that the biomarker

219 fficient to inhibit neuroblastoma metastasis in vivo Overall, we identify gene expression signatures

220 ion and de novo design of new NM with better in vivo performance.

221 on the superior electrochemical properties, in-vivo performance and long term stability under electr

222 In vivo pharmacokinetic analysis shows that GEBR-32a is

223 In vivo, pharmacological inhibition of HDAC6 improved es

224 eless optofluidic neural probes for advanced in vivo pharmacology and optogenetics in freely moving r

225 properties and dendrite morphology, studied in vivo, play a role in selective sensory processing in

226 PLIP1 is a phospholipase A1 In vivo, PLIP1 hydrolyzes polyunsaturated acyl groups fr

227 dies (DMAbs) can be produced by muscle cells in vivo, potentially allowing prevention or treatment of

228 tical step in the assembly of elastic fibers in vivo, preceding chemical cross-linking.

229 ward allergic responses induced by naive and in vivo-primed human T helper 2 cells.

230 xpression of ACTRT1 reduced the in vitro and in vivo proliferation rates of cell lines with aberrant

231 In vivo, promoter responses to TAF mutations correlate w

232 ate the MSERg method, we aligned 45 pairs of in vivo prostate MRI and corresponding ex vivo histopath

233 e considered as promising siRNA carriers for in vivo purposes towards therapeutic applications.

234 Photoacoustic imaging for in vivo quantification of placental oxygenation in mice.

235 Our results provide the first in vivo quantitative estimates of parameters characteriz

236 aw-pressure and incapacitance tests using an in vivo RA model.

237 e there does not appear to be an alternative in vivo reconstitution path, most likely due to greater

238 new technique to dual micro-electrode array in vivo recordings from two distinct regions: olfactory

239 [(18)F]AV-1451 binds in vivo regions that are likely to contain TDP-43 and no

240 However, the precise assessment of in vivo relevance in different disease settings has been

241 vitro, their contribution to ZIKV infection in vivo remains unclear.

242 lations closely match those for unbound LacI in vivo reported in the literature.

243 elial cell angiogenic responses in vitro and in vivo require ETS1-mediated transduction of VEGF signa

244 e found that efficient stress erythropoiesis in vivo requires E2F-2, and we also identified an unappr

245 (PK) characteristics are key to generate an in vivo response, specifically whether systemic drug exp

246 However, the in vivo roles of TFEB in the mammalian intestinal epithe

247 reclinical and clinical circumstances, their in vivo safety profiles (which are being incorporated in

248 Elimination of in vivo signaling by all six of these 'lineage-specifyin

249 To characterize in vivo signatures of pathological diagnosis in a large

250 ly and most importantly, ribavirin treatment in vivo significantly enhances chemo-radiotherapy effica

251 chronic and acute mouse models of CCM3 loss in vivo, significantly reducing lesion burden and extend

252 dels containing orthotopic breast tumors for in vivo SPECT/MRI and biodistribution studies after inje

253 In vivo studies confirmed the ability of the selected le

254 In vivo studies demonstrate the essential role of RbpA,

255 In contrast to the suggestions by earlier in vivo studies of mitochondrial processing, we found th

256 In vivo studies revealed higher tumor uptake for (64)Cu-

257 In this in vitro and in vivo study we hypothesized that the hepatokine fetuin

258 ibrotic response and myofibroblast formation in vivo, suggesting a novel therapeutic approach with p3

259 volved in the VtE-induced amelioration of DN in vivo, suggesting that DGKalpha is an attractive thera

260 promote cell proliferation and tumor growth in vivo Taken together, our findings reveal a novel post

261 For compounds with in vivo target activity data (e.g. animal toxicity testi

262 In vitro reconstitution and in vivo targeting assays show that SecA is necessary and

263 ing mouse PK profile, making it suitable for in vivo testing.

264 of an aggressive, orthotopic 4T1 tumor model in vivo than free DOX and GEM and the single drug HA con

265 High resolution ChIP-exo was used to analyze in vivo the association of M1BP, TRF2 and TFIID subunit,

266 highly permissive to HIV-1 both ex vivo and in vivo The expression of Ki67, a marker of proliferativ

267 Here we present the first, to our knowledge, in vivo therapeutic micromotors application for active d

268 f dynamic regulation of protein interactions in vivo, there is a need for techniques that can yield t

269 alloproteinase-7), and cyclin D1in vitro and in vivo These data indicate that Gab2 mediates the patho

270 ry cytokines, resulting in viral attenuation in vivo This might represent an adaptation of pH1N1 viru

271 pathology on the function of neural circuits in vivo This work describes early postnatal developmenta

272 Tregs potently suppress autoimmune responses in vivo through inhibition of the autophagic machinery i

273 poptotic cancer cell death both in vitro and in vivo through tumor-specific (1) O2 generation and sub

274 and AR inhibition activates the PARP pathway in vivo, thus inhibition of both AR and PARP is required

275 tromal cells (MSCs) are continuously exposed in vivo to a dynamically changing biomechanical environm

276 ntal models of immune responses in vitro and in vivo to quantify the spatial extent of cytokine commu

277 Amongst the cerebral areas identified using in vivo tractography, in addition to the cerebral motor

278 ccuracy) were employed for both in vitro and in vivo tumor phenotyping to identify the tumorigenicity

279 d computational simulations with analysis of in vivo two-photon Ca(2+) imaging data from somatosensor

280 n the capacity to differentiate in vitro and in vivo upon downregulation of OCT4 expression.

281 Cross-reactivity was addressed in vivo using 2 different mouse strains (BALB/c and C3H)

282 irst example of optical control of analgesia in vivo using a photocaged mGlu5 receptor negative allos

283 are required for adipogenesis in culture and in vivo Using conditional knockout mice and derived whit

284 papulosum cyprini [EPC] fish cell line) and in vivo (using rainbow trout fry) in a dose-dependent an

285 The expression of KCa3.1 in vivo was confirmed by immunofluorescence staining on

286 In vivo, we also found TE-specific endosiRNAs present du

287 ous effects on loss of B cell self-tolerance in vivo, we depleted neutrophils at different stages of

288 To investigate the effects of ARHGAP29 in vivo, we generated a novel murine allele by inserting

289 Furthermore, by implementing GBAi in vivo, we show that GBA-dependent signaling modulates

290 nding of the fate and transformation of IAPP in vivo, which are expected to have consequential bearin

291 ter gene into adult hematopoietic stem cells in vivo, which are predominantly quiescent, by generatin

292 ngStar, a platform for perturbation analysis in vivo, which combines live imaging, real-time image an

293 -depleted mice exhibit delayed wound closure in vivo, which could be rescued by topical IL-27 treatme

294 1-mediated profibrotic pathways in vitro and in vivo, while esculetin significantly inhibited Wnt/bet

295 Validating these associations in vivo will lead to new diagnostic tools for Alzheimer

296 ived cardiomyocytes from patients presenting in vivo with extremely low or high changes in cardiac re

297 erapeutic vectors that can be photoactivated in vivo with high spatial and temporal control.

298 n predicting extrusion hotspots and dynamics in vivo, with potential applications to tissue regenerat

299 RT-10 could effectively repressed CCA growth in vivo without inducing obvious side effects.

300 Analogous interactions in vivo would permit lncRNAs to mediate the juxtapositio