1 In this report, we examine the
in vivo function of a major Tic component, Tic110.
2 time that DsbC has been shown to affect the
in vivo function of a native E. coli protein, and the re
3 Here, we analyze the
in vivo function of a ubiquitous actin-interacting prote
4 report the first genetic study to determine
in vivo functions of a Ca(2+) pump in plants.
5 rk provides the first systematic analysis of
in vivo functions of a eukaryotic CSAS gene and sheds li
6 ess of transgenic technology in studying the
in vivo functions of a gene.
7 hysiological importance of PTMs in directing
in vivo functions of a master coregulator.
8 To explore the
in vivo functions of a new member of the family, tensin3
9 x to high-density lipoprotein (HDL), but the
in vivo functions of Abcg4 are poorly understood.
10 Recent studies have identified key
in vivo functions of ADAR enzymes, informing our underst
11 ion and the influence of HSC transfer on the
in vivo function of adoptively transferred CD8(+) T cell
12 Thus, this study not only demonstrates the
in vivo functions of AH2, but also reveals a common feat
13 of fidget mice and provide new leads on the
in vivo function of AKAP95.
14 osynthesis of 2,3-DP from l-Lys is the major
in vivo function of ALD1.
15 on of their chaperone activity in vitro, the
in vivo functions of alphaB-crystallin in the maintenanc
16 ploiting the Cre/Lox technology to study the
in vivo functions of alphav integrins during epithelial
17 To elucidate the
in vivo function of Als3, we heterologously expressed C.
18 and used these peptides to characterize the
in vivo function of antiviral CD4 T cells.
19 This has provided a definitive test of the
in vivo function of AP-1 signalling and shown that EGF s
20 bility of the apoA-I mutants on in vitro and
in vivo functions of apoA-I and lipid homeostasis are di
21 stimulated GAP activity and was required for
in vivo function of ARAP1 as a regulator of endocytic tr
22 The
in vivo functions of ARF-like members of the Ras superfa
23 the ciliary localization is crucial for the
in vivo function of Arl13b.
24 We have examined in vitro and
in vivo functions of ASAP3 and compared it to the relate
25 To determine the
in vivo function of ATF4, the ATF4 gene in murine embryo
26 The
in vivo function of Atrophin-1 is unknown.
27 To study
in vivo functions of B7-DC, we evaluated immune response
28 The
in vivo function of BBS3 is largely unknown.
29 Our data suggest that the essential
in vivo function of beta-actin is provided by the gene s
30 Our findings uncover a new
in vivo function of beta-arrestins and present a new mec
31 o remove functional redundancy obscuring the
in vivo functions of BMP-1-related proteases in mammals,
32 de important tools for future studies of the
in vivo functions of both genes.
33 To study the
in vivo functions of both ZPBP proteins, we disrupted Zp
34 ve generated Btg2-null mice to elucidate the
in vivo function of Btg2.
35 g criteria for use of STO-609 to inhibit the
in vivo functions of CaMKK2 and demonstrate its utility
36 atic conditions or during infection, and the
in vivo function of CCR10 in the intestinal IgA response
37 r Cdk6 have resulted in viable mice, but the
in vivo functions of Cdk1 have not been fully explored i
38 lve problems regarding cell lineages and the
in vivo function of certain groups of cells.
39 lium multicellular development, establish an
in vivo function of CHD Type III chromatin remodeling pr
40 osphatase ability was not as critical to the
in vivo function of CheC as the ability to bind both Che
41 Till now, the
in vivo function of chondrocyte-produced OPG in osteocla
42 ic mouse models developed to investigate the
in vivo functions of chromatin-modifying enzymes clearly
43 However, the
in vivo functions of CIB1 are not well understood.
44 Our understanding of the
in vivo function of collybistin has been hampered by lac
45 nding are also shown to be important for the
in vivo function of Cox19.
46 ded RNA binding motifs, is essential for the
in vivo function of CPL1 and includes a C-terminal 23-aa
47 Together, our results suggest that the
in vivo functions of Cpr7 include modulating Hsp90 confo
48 tion and provide important insights into the
in vivo functions of CRAC channels for T cell-mediated i
49 nd selective tool to further investigate the
in vivo function of CRTH2.
50 tions in both Ctbp1 and Ctbp2 to address the
in vivo function of CtBPs during vertebrate development.
51 To validate the
in vivo function of CTOMT1, gene expression was either d
52 To target the
in vivo function of CXCR4 in bone and explore the underl
53 We aimed to assess the
in vivo function of CYP2A13 and CYP2F1 in NA bioactivati
54 To investigate the
in vivo functions of cytochrome P450 Cyp2c genes and to
55 nactin is a protein complex required for the
in vivo function of cytoplasmic dynein, a microtubule (M
56 To identify
in vivo functions of Dab2, targeted mutations were made
57 We addressed the
in vivo function of DAF in a knockout mouse model and de
58 e enzymatic properties are important for the
in vivo functions of DEAD-box proteins remains unclear.
59 he implications of this new evidence for the
in vivo function of dendritic cells.
60 Analysis of DGK1 alleles showed that the
in vivo functions of Dgk1p were specifically due to its
61 a multicellular host system for studying the
in vivo function of diverse toxins and virulence factors
62 urprisingly, this only slightly impaired the
in vivo function of DnaJ, and its ability to function as
63 ls, leading us to investigate the overlap of
in vivo functions of Dnmt1 and Suv39h1.
64 To investigate the
in vivo function of Drosophila melanogaster IAP2, we hav
65 To understand the
in vivo function of Drp1, complete and tissue-specific m
66 The
in vivo functions of DUSP14 remain unclear.
67 Thus, it is essential to understand the
in vivo function of dynactin.
68 Previous
in vivo functions of E. coli NDP kinase in the regulatio
69 (Brk1)/HSPC300, and Scar/WAVE : Defining the
in vivo function of each subunit is an important step to
70 r by more fundamental issues relating to the
in-vivo function of EGFR.
71 ceptor pharmacology, expression pattern, and
in vivo function of ELA peptides in the adult cardiovasc
72 To elucidate
in vivo functions of elongin A, we have characterized it
73 To evaluate the
in vivo function of EndoG, we have investigated the effe
74 However, the
in vivo function of endothelial heparan sulfate in lymph
75 These findings identify two distinct
in vivo functions of epidermal prostasin: a function in
76 To investigate the
in vivo function of Eset, we have generated an allele th
77 genetic-proteomic', can be used to study the
in vivo function of essentially any protein.
78 To investigate the
in vivo functions of expansins, we generated transgenic
79 The
in vivo function of FbpA is to transport unchelated Fe(3
80 In this work, we examined the
in vivo function of FD2, which we proposed to be respons
81 We have investigated the
in vivo functions of FGF22 in mice.
82 To investigate the
in vivo function of Fgfr2 signaling by myelinating glial
83 To investigate the
in vivo function of Fife, we generated a deletion of the
84 tribution of the phosphatase activity to the
in vivo function of Fig4, we introduced the mutation p.C
85 mouse MCM4/6/7 subcomplex do not affect the
in vivo function of fission yeast MCM complex.
86 The
in vivo functions of four RING-like domains within Vps-C
87 s provide a foundation for understanding the
in vivo function of Fpr3.
88 The goal of this review is to summarize the
in vivo functions of FXII, with special focus to its fun
89 Although well studied in vitro, the
in vivo functions of G-quadruplexes (G4-DNA and G4-RNA)
90 However, the
in vivo function of GABA(A) signaling on neural stem cel
91 The
in vivo function of GAS2L3 in mammals remains unknown.
92 ury models can be useful for determining the
in vivo function of genes.
93 To define the direct
in vivo function of glucocorticoid signaling in adult ut
94 To determine the
in vivo function of glucocorticoid signaling in the hear
95 To elucidate the
in vivo function of gp150, a recombinant MHV-68 deficien
96 himeric peptide is a potential tool to study
in vivo function of GPCR135.
97 early stages of initiation is thus the main
in vivo function of GreA.
98 To elucidate the
in vivo function of H3K9me, we generated mice lacking G9
99 e represents a unique model for studying the
in vivo function of hepatic HO and microsomal CYP-depend
100 a and confers glucocorticoid resistance, the
in vivo function of hGRbeta is poorly understood.
101 To evaluate the
in vivo function of HNF-6, we examined the hepatic expre
102 unction in yeast Sco1, are also critical for
in vivo function of human Sco1 and Sco2.
103 ets the stage for systematic analysis of the
in vivo functions of human DCs.
104 However, the
in vivo functions of HuR are not well understood.
105 RNA interference (RNAi), to investigate the
in vivo functions of HvNAC6 in basal resistance response
106 In vivo function of IDO during infections, however, is n
107 The
in vivo function of IGFBP-3, however, is unclear.
108 the current understanding of the specialized
in vivo functions of ILCs.
109 To better understand the
in vivo functions of InhBP/p120, we characterized the In
110 In order to assess the
in vivo function of integrins containing the beta8 subun
111 To determine the
in vivo function of IP-10, we constructed an IP-10-defic
112 ated Ras activation is well established, the
in vivo function of its Dbl Rac GEF domain is less clear
113 To investigate the
in vivo function of JARID1B, we developed Jarid1b(-/-) m
114 To investigate the
in vivo function of Kbtbd5, we used gene disruption tech
115 the best experimental paradigm to mimic the
in vivo function of KL(4).
116 This study reveals a novel
in vivo function of KSRP in controlling adipose lipolysi
117 This study reveals the
in vivo function of KSRP in controlling brown-like trans
118 To investigate the
in vivo function of Kvbeta2, Kvbeta2-null and point muta
119 To study the
in vivo function of LAB, LAB-deficient mice were generat
120 To study the
in vivo function of LAIR-1, we generated LAIR-1(-/-) mic
121 To investigate the
in vivo function of lamin B1, the major B-type lamin, we
122 To further investigate the
in vivo function of liCTLA-4, specifically whether liCTL
123 To gain insight into the
in vivo functions of LIS1, we characterized a male-steri
124 with the current techniques for studying the
in vivo function of lncRNAs in the light of different mo
125 rse and this interaction is critical for the
in vivo function of Lrrc6/Seahorse in zebrafish.
126 In this study, we explore the
in vivo function of LTBP-2 by generating Ltbp2(-/-) mice
127 MFP-dependent transporters from E. coli, the
in vivo function of MacAB requires the outer membrane ch
128 Nevertheless, direct demonstration of
in vivo function of mammalian IQGAP1 is limited.
129 However, the
in vivo functions of mammalian CST remain unclear.
130 However, the
in vivo functions of mammalian Hem1 are not known.
131 In summary, our results reveal the first
in vivo functions of mammalian Twf2a and demonstrate tha
132 survival of neutrophils and macrophages, the
in vivo function of Mcl-1 in these 2 cell lineages remai
133 ch as these, several aspects regarding basic
in vivo functions of MDM2 remain unknown.
134 To elucidate the
in vivo function of MEKK2, we generated mice carrying a
135 To examine the
in vivo function of menin in bone, we conditionally inac
136 r DDD(610) or DDE(610) significantly reduced
in vivo functions of Metnase in NHEJ repair and accelera
137 provide mechanistic details of the two known
in vivo functions of Mgm1, membrane fusion and cristae m
138 The
in vivo function of microRNAs (miRs) in diabetic retinop
139 and cost effectively modulate and assess the
in vivo function of microRNAs and mRNAs in TEMCs.
140 To address the
in vivo functions of miR-142, we utilized a novel report
141 To gain insights into the
in vivo function of miRNAs in the context of periodontit
142 n implicated in many human diseases, but the
in vivo functions of most RBPs and the splicing outcome
143 In the present study, we have assessed the
in vivo function of mouse tankyrase 2 by germ line gene
144 Our findings reveal a novel
in vivo function of MPYS that is distinct from its role
145 Our study revealed previously unrecognized
in vivo functions of MPYS and advanced our understanding
146 The
in vivo function of murine gimap5 is largely unknown.
147 To examine the
in vivo function of Mycl1 in mice, we generated an inact
148 alyze the contribution of each domain to the
in vivo function of Nab2p.
149 To test the
in vivo function of NADH-GOGAT, we conducted molecular a
150 These results strongly support
in vivo function of NEIL1 in preferential repair of oxid
151 hway for FPR1 in cell lines, but its role in
in vivo functioning of neutrophils is unclear.
152 Relatively little is known about the
in vivo functions of newly emerging genes, especially in
153 ses have yielded contrasting results and the
in vivo function of NKG2A remains unclear.
154 This is the first demonstration of an
in vivo function of Nm23 family genes in regulating epit
155 of unbiased genetic/RNAi screens to identify
in vivo functions of non-nucleic acid-based metabolites
156 en described, the biochemical activities and
in vivo functions of nonmuscle calponins and transgelins
157 However, the
in vivo function of Notch signaling in transplantation r
158 , this is the first study characterizing the
in vivo functions of Notch1 and Notch2 in Kras(G12D)-dri
159 the absence of nTregs, and suggested a novel
in vivo function of nTregs in T1D prevention by regulati
160 in heterologous expression systems, but the
in vivo function of OsHKT2;1 remains unknown.
161 tinal basolateral bile acid transporter, the
in vivo functions of Ostalpha-Ostbeta have not been inve
162 should be generally applicable to study the
in vivo functions of other developmental regulators with
163 1)C]N-desmethyl-loperamide (dLop) images the
in vivo function of P-glycoprotein (P-gp), a transporter
164 Yet the localization and
in vivo function of Pak1 in heart cells is poorly unders
165 To elucidate the
in vivo function of PAM14, we characterized the expressi
166 , we tested this hypothesis by assessing the
in vivo function of Pam18 variants having altered abilit
167 rum in vitro, but nothing is known about the
in vivo functions of PAT in Plasmodium life cycle stages
168 lack of suitable genetic mutants, the exact
in vivo function of Patj in regulating apical-basal pola
169 Previous analysis of the
in vivo functions of Pbx1 by targeted mutagenesis in mic
170 The
in vivo function of PC7 is unknown.
171 cytoplasmic CR domains are required for the
in vivo function of Pcdh15a in zebrafish hair cells.SIGN
172 To understand the
in vivo function of Pen-2, we used morphant technology a
173 Here, we investigated the cell-specific
in vivo function of PGE2 signaling through its E-prostan
174 Using this method, we examined the
in vivo function of phospholamban (PLB) by stably transf
175 cellular events, we have tested directly the
in vivo function of PINCH in Drosophila melanogaster.
176 used gene targeting in mice to identify the
in vivo functions of PKD1.
177 bred mice are a useful tool for studying the
in vivo functions of platelets.
178 e interaction with PCNA is essential for the
in vivo function of Poleta.
179 For further exploration of the
in vivo functions of Polycystin-2, this study examined i
180 PPARgamma-independent effects, the specific
in vivo function of PPARgamma in cartilage homeostasis a
181 The
in vivo function of PRMT1 is largely unknown.
182 vides the first demonstration that essential
in vivo functions of prostasin are executed by a non-enz
183 These studies define the
in vivo functions of protein VII in DNA binding, condens
184 i screens are powerful tools to identify the
in vivo functions of protein-encoding genes, but not of
185 Here, we report the
in vivo function of PU.1 in mediating mature macrophage
186 Despite a number of in vitro studies, the
in vivo function of R-Ras remains unclear.
187 g water content strongly correlates with the
in vivo function of R67 DHFR.
188 neural stem cells into neurons; however, the
in vivo function of RA during adult neurogenesis remains
189 hemical support for what may be an important
in vivo function of Rad52.
190 This Rad51 variant distinguishes the
in vivo functions of Rad54 and Rdh54, leading to the con
191 To understand the
in vivo functions of Rap1 in regulating T cell immune re
192 ohepatitis; 3) document abnormalities in the
in vivo function of remaining adipose tissue, including
193 To study the
in vivo function of RhoG, we generated mice homozygous f
194 Although the
in vivo function of RNase R is not known, its ability to
195 To further probe the
in vivo function of SCNM1, we constructed a floxed allel
196 ular mechanism of ligand selectivity and the
in vivo function of SCP-2 remain unclear.
197 Significance statement: Here we examine the
in vivo function of SCYL2, an evolutionarily conserved a
198 red, consistent with other evidence that the
in vivo function of septins requires filament formation.
199 To begin to dissect the
in vivo functions of SGK3, we generated and characterize
200 We studied
in vivo functions of Siglec-F, the CD33rSiglec expressed
201 Our results reveal the gene dosage-dependent
in vivo functions of SIRT1 in skin tumorigenesis and may
202 alent modification of phosphorylation, while
in vivo function of some enzymes is governed by their su
203 Much remains to be learnt about the
in vivo function of specific microRNAs.
204 To understand the cellular and
in vivo functions of specific K(+) channels in glia, we
205 However, the
in vivo functions of specific microRNAs in controlling m
206 jectives of this study were to determine the
in vivo functions of SPLUNC1 following bacterial (eg, Mp
207 objective of this study was to determine the
in vivo functions of SPLUNC1 following Pseudomonas aerug
208 ngs indicate that spreading is important for
in vivo function of Spo0J.
209 , it has been a challenge to demonstrate the
in vivo function of SRCs due to the overlapping function
210 g that these activities are critical for the
in vivo function of STN1.
211 m of MeCP2 phosphorylation together with the
in vivo function of such modifications are yet to be rev
212 r our results provide strong evidence for an
in vivo function of syndapin in endocytic recycling, and
213 To analyse the
in vivo function of TAK1 in cartilage, we generated mice
214 post-gastrulation defects revealed the first
in vivo functions of Tcf3-beta-catenin interaction affec
215 a melanogaster), as they are crucial for the
in vivo functions of TFs.
216 However, the
in vivo function of TGF-beta in skeletal development is
217 To evaluate the
in vivo function of TGF-beta in the development of pancr
218 Here we investigate the
in vivo function of the Acf1 subunit of ACF/CHRAC in Dro
219 We examined the
in vivo function of the angiotensin II type 1 receptor (
220 functions to melt promoter DNA; however, the
in vivo function of the Cdk7 kinase subunit of TFIIH, wh
221 ng and oligomerization are essential for the
in vivo function of the chemokines MCP-1/CCL2, RANTES/CC
222 In this study, we report a new
in vivo function of the Drosophila beta-arrestin Kurtz (
223 r phosphatidate phosphatase activity and the
in vivo function of the enzyme.
224 To further investigate the
in vivo function of the FA pathway, mice with a targeted
225 The
in vivo function of the genomes described herein demonst
226 The
in vivo function of the GOF TRPP2 was investigated in ze
227 To understand the
in vivo function of the Kif3C gene, we used homologous r
228 factor LpoB has been found essential for the
in vivo function of the major peptidoglycan synthase PBP
229 d fused (stk36) knockout mice to address the
in vivo function of the mouse Fu (mFu) homologue.
230 avetch describes how he came to identify the
in vivo function of the once mysterious Fc receptors.
231 ed both the in vitro binding of SaeR and the
in vivo function of the P1 promoter.
232 These findings illustrate the
in vivo function of the PDK1-AKT-CREB/CBP pathway in bon
233 quitylated form of PCNA and is essential for
in vivo function of the polymerase, but only in conjunct
234 However, the specific
in vivo function of the PRLs remains elusive.
235 s between in vitro substrate specificity and
in vivo function of the S. aureus sortase isoforms.
236 To analyze the
in vivo function of the Scl +40 enhancer within the Scl/
237 embranes; however, little is known about the
in vivo function of the specific transporters involved.
238 from Swi3 and characterize the in vitro and
in vivo function of the SWIRM domains from Saccharomyces
239 The
in vivo function of the two L. lactis birA genes was jud
240 Furthermore, the
in vivo function of the two major Toc159 family members
241 al model of CMV infection to investigate the
in vivo function of the UL128 complex.
242 nd organs; however, little is know about the
in vivo function of the v-ATPase complex or its roles du
243 onse in the lymph node appears to be a major
in vivo function of the Y. pestis virulence plasmid.
244 is to investigate the ligand selectivity and
in vivo function of the yellow fever mosquito sterol car
245 The
in vivo functions of the activin A receptor type 1b (Acv
246 Relatively little is known about the
in vivo functions of the alpha subunit of the heterotrim
247 ymaw mice with gene targeting to examine the
in vivo functions of the fusion genes.
248 e development of genetic models to study the
in vivo functions of the hepatic cytochrome P450 (P450)
249 To analyze the
in vivo functions of the IBB domain, we created a series
250 re currently is little information regarding
in vivo functions of the LxxLL motifs either in MED1 or
251 However, the
in vivo functions of the pump have not been determined t
252 However, these studies did not address the
in vivo functions of the putative elements or their chro
253 similar target DNA sequence preferences, the
in vivo functions of the two proteins are quite differen
254 on of type III-secreted toxins in vitro, the
in vivo functions of the type III-secreted exoenzymes ar
255 ns are essential for the proper assembly and
in vivo functions of their respective complexes.
256 lished safety of oncolytic adenoviruses, the
in vivo function of these agents is not well understood
257 ly members, it is critical to understand the
in vivo function of these molecules.
258 ve to DNA has important implications for the
in vivo function of these previously enigmatic enzymes.
259 physical properties of calcium channels, the
in vivo functions of these auxiliary subunits remain unc
260 Nhe2, and Nhe3 genes were used to study the
in vivo functions of these exchangers in parotid glands.
261 To elucidate
in vivo functions of these metalloproteases, meprin beta
262 s are discussed in relation to the potential
in vivo functions of these OMTs based on our current und
263 major challenges remain in establishing the
in vivo functions of these proteins and their roles in d
264 t limited information is available about the
in vivo functions of these syntaxin-1 domains.
265 es, drug resistance activities and potential
in vivo functions of these unusual pumps.
266 se of a defect in ventral morphogenesis, the
in vivo function of this factor in heart development rem
267 yonic and neonatal cortical neurons, but the
in vivo function of this GABA excitation is essentially
268 bed here have important implications for the
in vivo function of this histone variant and are consist
269 The molecular identity and
in vivo function of this PDE remained unknown.
270 However, the
in vivo function of this phosphorylation event remains e
271 erated Mmp25-deficient mice to elucidate the
in vivo function of this protease.
272 ted with Set2 to gain some insights into the
in vivo function of this protein.
273 To date, the
in vivo function of this receptor is undefined.
274 Here, we used R-Ras-null mice to explore the
in vivo function of this small GTPase.
275 (Cam) of Drosophila to gain insight into the
in vivo functions of this important calcium sensor.
276 The
in vivo functions of this intriguing E2, however, remain
277 gs provide the first characterization of the
in vivo functions of this novel and critical regulator o
278 highlight recent progress in dissecting the
in vivo functions of this pathway in immune defense as w
279 histone genotype, and we use it to test the
in vivo function of three histone residues.
280 We examined the
in vivo functions of three of these Pi SLFLs and found t
281 The
in vivo functions of Tim-4 in phagocytosis and immune re
282 However, the
in vivo functions of Tmem30a remain unknown.
283 r TLR-induced type I IFN production, but the
in vivo function of TRAF3 in myeloid cells remains unkno
284 , which allowed us to gain insights into the
in vivo functions of TRAF3 in myeloid cells.
285 ferent cell types, little is known about the
in vivo functions of TRAF3.
286 generate a tool for elucidating the complex
in vivo functions of TRIM32, we created the first murine
287 In vivo function of TRIP-1 was studied by an implantatio
288 iae in terms of genetic characterization and
in vivo function of tRNA modifications.
289 To better understand the
in vivo function of TRPML2, we generated a TRPML2-knocko
290 Here we report examination of the
in vivo function of TSG in early Xenopus development usi
291 to determine whether IL-15 could enhance the
in vivo function of tumor/self-reactive CD8(+) T cells b
292 cell biological approaches, we assessed the
in vivo function of two actin turnover proteins: actin i
293 In contrast, we report the
in vivo function of two additional downstream elements l
294 ction studies in M. truncatula confirmed the
in vivo function of UGT73F3 in saponin biosynthesis.
295 ory processes of early atherogenesis and the
in vivo function of vascular cells.
296 nt in the lung and a new scope for assessing
in vivo functions of viral genes latent in the infection
297 To determine potential
in vivo functions of Vps34, we generated mutations in th
298 We found that the
in vivo function of VSK3 depends on the presence of the
299 To understand
in vivo functions of WWOX, we used liver-specific Wwox(h
300 ow that the SANT domain is essential for the
in vivo functions of yeast Swi3p, Ada2p, and Rsc8p, subu