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1 occurs via a noncanonical two-step mechanism in which 1) the cyclin-dependent kinase activating kinas
2 We conducted a single-arm, open-label study in which 15 virologically suppressed HIV-1-infected indi
3 nts' persistence, we conducted an experiment in which 15-month-olds were assigned to one of three con
4 ronary Intervention) trial, a clinical trial in which 2,604 patients with chronic angina and incomple
5 e also present a variation of Structure-seq2 in which a biotinylated nucleotide is incorporated durin
6 used Posner's classic endogenous cuing task, in which a centrally presented, spatially informative cu
7 It differs from classical Bayesian methods in which a classification model is assumed and prior dis
8 Based on these results, we propose a model in which a conformational change in BTN3A1 is a key even
10 genetically engineered mouse model was used in which a fluorophore is expressed under the TRPV1 prom
11 ur scheme is based on a two-step calculation in which a linear-response TDDFT calculation is used to
12 that leptospiral PerR assembles into a dimer in which a metal-induced conformational switch can occur
13 -beta42 (Abeta42) to an alternative sequence in which a nitroxide spin label attached to cysteine has
14 ld not feel comfortable handling a situation in which a pediatric patient's family requested care be
15 ntially pathogenic gene variants in families in which a person had multiple congenital malformations.
16 d in the assessment of acute abdominal pain, in which a physician's palpation determines if a patient
17 st this hypothesis, we created a mouse model in which a portion of the sciatic nerve from one hind li
18 nced groups, and that concomitant predation, in which a predator consumes a prey and its parasites, b
20 y pattern completion in early visual cortex, in which a stimulus sequence is recreated after only a s
21 e introduce uses precast gelatin-based molds in which a whole mouse brain is embedded, flash frozen,
22 ders and in the aftermath of chronic stress, in which aberrant choices and high-risk behaviors occur.
23 al carcinoma (ACC), a rare lethal malignancy in which aberrant Wnt/beta-catenin signaling is frequent
24 ultrasonic micro-elastography imaging system in which acoustic radiation force impulse imaging (ARFI)
25 itching limbs, and the developmental context in which activation occurs, could provide a roadmap for
28 Here we report a genome editing approach in which adeno-associated virus (AAV)-mediated CRISPR/Ca
29 s was a cross-sectional, observational study in which adult patients with adult-onset of asthma (defi
30 sing a time-restricted feeding (TRF) regimen in which all caloric intakes occur consistently within <
31 y-to-eat baby porridge was the only category in which all measured vitamin D concentrations were belo
32 igabits per second electro-optical modulator in which all the elements-the vertical grating couplers,
33 d ultimately to the design of a new protocol in which an achiral hydrogen bond donor thiourea catalys
35 iated nucleation and growth of superlattice, in which an evaporation-induced local gradient of NC con
36 We propose a sigma-bond metathesis mechanism in which an Fe-H intermediate is postulated to be a key
37 vel protein-coding gene evolution-D6Ertd527e-in which an MT LTR provided a promoter and the 5' exon w
38 g a rapid characterization of honeys via PLS in which an uncomplicated, cost-effective sample prepara
39 a simple habituation-dishabituation paradigm in which animals must discriminate between two urine sti
40 ival of early telencephalic precursor cells, in which any one of three FGFRs (FGFR1, FGFR2, or FGFR3)
41 9% all experimentally captured interactions, in which approximately 30% additional to the imposed con
42 ary outcome was the proportion of households in which at least one child had an HIV test within 4 wee
43 rts a 'conveyor belt' model of translocation in which ATP binding allows a Vps4 subunit to join the g
44 r increased prosocial behavior in situations in which attractive individuals are simply bystanders.
45 gs indicate that, in contrast to tumor cells in which autophagy promotes caspase-independent cell dea
46 ated legumes that form indeterminate nodules in which bacterial symbionts undergo terminal differenti
48 es of taxed beverages among the chain stores in which Berkeley implemented the tax in 2015; (2) sales
49 n vivo have focused on knockout (KO) studies in which both the receptor and its signaling are deleted
53 efits resembling non-optimal decision-making in which choices of high-cost/high-reward options are sh
55 tem away from half-filling, towards a regime in which complex many-body states are expected, and find
56 arious regulations and standards, the manner in which compliance is maintained and the degree of addi
58 Our results suggest an evolutionary model in which contemporary subgroups of the superfamily have
59 nditional-by-inversion (Notch2(COIN) ) model in which Cre recombination generates a Notch2(DeltaPEST)
60 ed mice that were crossed with DAT-Cre mice, in which Cre- recombinase expression is under dopamine t
61 (MDC1A) is a dramatic neuromuscular disease in which crippling muscle weakness is evident from birth
63 udies have recovered an alternative topology in which ctenophores are the sister group to all other a
64 lyzed by copper via an out-of-cage mechanism in which [Cu(I)(carb)2](-) and [Cu(II)(carb)3](-) (carb
65 alized nutrition might be in the current era in which data-intensive biomedical characterization of i
66 were the most commonly reported environment in which de-escalation occurs, and nursing the disciplin
67 erentiation is important from other diseases in which demyelination is a feature (eg, neuromyelitis o
69 s represent different genetic architectures, in which disease-associated variants have different effe
70 e existence of magnetically gated accretion, in which disk material builds up around the magnetospher
72 ey performed a modified Eriksen flanker task in which distractors and targets flickered within (10 Hz
73 expression in the shoot, leading to a model in which dorsoventral genes coordinate to regulate plant
77 MT1 and KIT form a positive regulatory loop, in which ectopic DNMT1 expression increases, whereas tar
79 d "smorgasbord" models of enhancer function, in which elements cooperate to bind components of the av
81 these MA currents were not detected in cells in which endogenous Piezo1 was CRISPR/Cas9 inactivated.
82 que size was unchanged in atheroprone areas, in which endothelial autophagy flux is already blocked.
87 nments are dramatically different from those in which full-term infants mature and thus likely impact
88 latforms for the prominent genus Bacteroides in which gene expression is controlled by a synthetic in
90 bnormalities in disorders like schizophrenia in which gluatamatergic signalling is implicated may be
91 lar complex studied, we could exclude models in which GreB is selectively recruited to backtracked co
93 -man's land, the temperature-pressure window in which homogeneous nucleation prevents the investigati
94 viral infections cause host shutoff, a state in which host protein synthesis is globally inhibited.
95 ; yet data suggest that the clinical context in which hyperkalemia develops is at least as important
96 magnetic resonance (MR) imaging examination in which images were acquired before and dynamically aft
97 Here we introduce a single-molecule assay in which individual SOS molecules are captured from raw
98 athies refer to a diverse group of disorders in which inflammation of the heart (or myocarditis) is t
99 developed a new mouse model, PMN(DTR) mice, in which injection of diphtheria toxin induces selective
100 etlands have been identified as environments in which inorganic divalent mercury (Hg(II)) is transfor
102 endotoxemia, we present examples of the way in which intravital FLIM can be applied to study kidney
103 r-suppressor role of SPOP in prostate cancer in which it acts as a negative regulator of BET protein
104 ional, periodic, decaying orbit - a spiral - in which it behaved as a true attractor, converging to t
108 CaM adopts a highly compact conformation in which its open Ca(2+)-activated C-lobe and closed N-l
111 P- and E-selectin suggest a two-state model in which ligand binding to the lectin domain closes loop
112 ys (at least) a 2-timescale processing mode, in which lower and higher perceptual sampling scales are
113 ocal blood vessels to a multidimensional one in which mediators released from multiple cells engage d
114 conclusion, our results suggest a mechanism in which MEF2 transcriptional activity is differentially
115 tity using a multistage clustering algorithm in which metabolic pathway associations are used along w
116 sing conditioned place preference and a task in which mice learn associations between cues and food r
118 Effort Expenditure for Rewards Task (EEfRT), in which motivation for high-effort/high-reward trials v
121 we have analyzed the structures of compounds in which multiple benzothiadiazole units are attached to
122 rointestinal tract is a highly complex organ in which multiple dynamic physiological processes are ti
123 tibility and are well documented in families in which multiple members have had pancreatic cancer.
124 al design of complex new molecular materials in which multiple optoelectronically active components a
125 jectories of the human dopamine transporter, in which multiple spontaneous Na(+) release events were
126 Muscle differentiation is a complex process in which muscle progenitor cells undergo determination a
127 hominins, such as Neanderthals, and the ways in which natural selection, in its various guises, has s
128 oward an alternative computational framework in which neural activity in each brain area depends on a
132 ph networks were then converted to circuits, in which node voltages of the circuit reflecting the ves
134 ategories by a transitive inference paradigm in which novel exemplars of five categories were present
135 ment could be improved by preschool pedagogy in which numerate adults engage children's spontaneous,
136 RI and a sustained selective listening task, in which one out of two competing speech streams had to
137 role in other autosomal-recessive disorders, in which only one heterozygous pathogenic variant is ide
141 multicenter study of sporadic retinoblastoma in which parents of 99 unilateral and 56 bilateral age-m
142 st between these alternatives we used a task in which participants were required to reach to either a
143 d pooled individual patient data from trials in which patients with respiratory infections were rando
145 ked kinase (ILK) form a multiprotein complex in which PDLIM5 provides a bridge between ILK and AE1C.
146 myocardium, and observed a fourth mechanism in which PECs migrate along the surface of the inflow tr
147 ired according to a double baseline protocol in which PET examinations were repeated within 2 d of ea
148 Here we consider a more dynamic scenario in which phage infections give rise to abrupt and severe
149 r investigations are consistent with a model in which PhoPQ-dependent Mg(2+) homeostasis protects Sal
150 vironments and provides a new interpretation in which place and grid cells mutually interact to form
152 pplication of purified proteins at pH ranges in which PMEI inhibition differed between AtPMEI4 and At
153 er export rates can be accessed in scenarios in which polymers are allowed to diffuse back into the m
154 rize our long-term institutional experience, in which postshunt benefits in patients with initial dia
156 a complex reward-guided decision-making task in which predicted reward value was independently manipu
157 thelial dynamics and characterize situations in which processes involved in cell turnover become unco
159 es after transfer from the dark to the light in which protein import into plastids is required to rap
160 Scholar databases were searched for studies in which rates of immediate adverse events to GBCAs were
161 two-step mechanism of cellular reprogramming in which repression of pre-existing ES cell-associated g
162 Intranuclear rod myopathy is a subtype of NM in which rod-like bodies are seen in the nucleus, and it
163 e generated Sco1hrt/hrt and Sco1stm/stm mice in which Sco1 was specifically deleted in heart and stri
166 stinction: Unlike most animal communication, in which signals are either true or false, art and ficti
168 attributed to Pleistocene climatic changes, in which sky-islands acted as long-term refuges and crad
169 re also implicated in neurological disorders in which sleep abnormalities are common; for example, va
170 e of such small effects, we present examples in which small effects persist and have been replicated
171 ng male and female Dmp1Cre.Socs3 (f/f) mice, in which SOCS3 has been ablated in osteocytes, have high
172 vent using an in situ microextraction device in which solvent moves through the probe, drawing in the
174 e assembly of singly modified RNA constructs in which specific G residues are replaced with (th) G, a
175 tudies have supported the classical scenario in which sponges (Porifera) are the sister group to all
176 the BRCA2-dependent fork protection pathway, in which stable RAD51 filament formation prevents MRE11-
177 Synesthesia, an anomalous blending of senses in which stimulation of one sensory modality produces se
178 e tested this model using cued recall tasks, in which subjects had to memorize object arrays composed
179 th the morpheein model of enzyme hysteresis, in which substrate binding induces conformational change
180 roma following anterior stromal keratectomy, in which surgical removal of the epithelium, basement me
181 is tightly controlled by neuronal activity, in which synapse to nucleus signalling, mediated via NMD
182 sed a structural model for the TatA oligomer in which TatA monomers self-assemble using electrostatic
183 y identifies a potential "two-hit" mechanism in which tau acetylation disengages tau from MTs and als
184 eptor expression in known JH target tissues, in which temporal expression corresponds with periods of
188 ions in this gene cause childhood blindness, in which the a- and b-wave responses of electroretinogra
189 o allow users to identify areas of the image in which the activation density was too high and correct
190 study is on single layer epithelial tissues in which the adherence junctions of cells form a 2D mani
191 f two different goals; a No Effort condition in which the adult achieved the goals effortlessly; or a
192 IL-1beta is highly expressed in cancer cells in which the androgen receptor (AR) is not detected (AR-
193 ration for the transition to the adult form, in which the AP axis converges on a molecular architectu
194 he greater stability of the transition state in which the Ar and NO2 groups are anti to each other.
196 e studies by generating Atp7a(LysMcre) mice, in which the Atp7a gene was specifically deleted in cell
197 omophores based on a novel coumarin scaffold in which the carbonyl of the lactone function of the ori
198 espiratory abnormalities present in diseases in which the carotid bodies are hyperactive at rest, e.g
199 bivalency model posited in mammalian cells, in which the coexistence of H3K4me3 and H3K27me3 at deve
201 main of subunit b or the OSCP, respectively, in which the corresponding genes, ATP5F1 and ATP5O, had
202 and its larger host represent a metaorganism in which the cross talk between microbes and host cells
203 ted in a region of the world other than that in which the death occurred, and about 22 per cent (762,
204 ients with suspected acute coronary syndrome in which the diagnosis was adjudicated according to the
205 developed a method of polymerization control in which the differential diffusion distance of unreacte
206 AMP shows an inactive form of the tetramer, in which the dimer pairs are rotated by 18 degrees relat
208 , whereas biased ones exhibit pixel locking, in which the estimated particle positions concentrate to
211 C) is an open-label, 2-cohort clinical trial in which the first cohort assessed for the safety and ef
212 best explained by a form of path integration in which the flies use idiothetic cues to search near th
213 ion of the food, we constructed an apparatus in which the food could be rapidly translated from the c
214 NA origami technology and colloidal science, in which the former allows for rapid and robust synthesi
215 while two macaques performed a reaching task in which the gain scaling between the hand and a present
217 late recurrent viremia had virologic relapse in which the HCV present at baseline persisted in the li
219 multivariate Cox proportional hazards model in which the impact of each covariate was adjusted for t
220 Herein, we report on a series of cyclophanes in which the interplanar distance between two phenyl-ext
221 sistently closed form of the activation gate in which the intracellular ends of the four S6 segments
222 enesis, we utilized a transgenic mouse model in which the keratin 14 promoter drives expression of th
223 radentate siderophore mimics was synthesized in which the length of the linker between the two iron-b
224 l approach by developing long-read ChIA-PET, in which the length of the paired-end tags is increased
225 an apoE is a polymorphic 299-residue protein in which the less common E4 isoform differs from the maj
226 identified in garlic (Allium sativum) bulbs in which the LM26 epitope is widespread throughout most
228 ete LOS along the entire length to nanobeams in which the LOS ranges from partially to entirely block
231 end, we have synthesized a platinum complex in which the metal is connected to a Lewis acidic bis(tr
233 cificity of this interaction in a background in which the native A. thaliana CENH3 is replaced with C
234 contrast, in a mouse gut colonization model in which the natural microbiota is unperturbed, the disr
235 ggest a view of differing cultural histories in which the Neolithic transition was driven by mass mig
236 on process of a uracil-azobenzene derivative in which the nucleobase is conjugated to a phenyldiazene
237 l) Arabidopsis (Arabidopsis thaliana) plants in which the oscillator gene CIRCADIAN CLOCK ASSOCIATED1
238 phosphorylated Pdc and 14-3-3 form a complex in which the Pdc-ND region 45-80, which forms a part of
239 ns to two ion channels and a binding protein in which the peptide toxins successfully reverted back t
240 This is especially crucial for the tasks, in which the performance is heavily dependent on the fea
241 abilizing role of higher-order interactions, in which the presence of a species influences the intera
242 election, a mutant strain Apmu4 was derived, in which the rate of loss of the integration plasmid was
243 stological and functional outcome in studies in which the rate of subclinical rejection in the first
244 has temperature-dependent sex determination, in which the sex of an embryo is determined by the incub
245 s analytical models of homogeneous materials in which the skyrmion compression and expansion are reve
246 specificity and the mechanism of inhibition, in which the small molecule stabilizes a mobile C-termin
247 ort a rechargeable magnesium/iodine battery, in which the soluble iodine reacts with Mg(2+) to form a
249 his study, we generated Nf123aIN/23aIN mice, in which the splicing signals surrounding Nf1 exon 23a w
250 ubstrate, 3beta-hydroperoxycholestane (3HPC) in which the sterol -OH group is replaced by the hyper n
251 observational fear (OF) paradigm in rodents, in which the subject is exposed to a distressed conspeci
252 e recently described a knock-in mouse strain in which the substitution of 2 amino acids of the endoge
255 overing distinct classes of these materials, in which the topology of electronic states leads to robu
256 novel binding mode by X-ray crystallography, in which the triazolo N1 atom coordinates in a hitherto
257 percept gives way to perceptual alternations in which the two images compete for perceptual dominance
258 t for insulin resistance in Type-2 diabetes, in which the unmet therapeutic need remains substantial.
259 ion (V247fs-WT and V247fs-MT), and iPSC line in which the V247fs mutation was corrected by CRISPR/Cas
260 onal substates of the complex, including one in which the VPS34 catalytic domain is dislodged from th
262 ese changes with other neurological diseases in which there is also BBB malfunction, and highlighting
264 V) chains normally produced by tumour cells, in which they affect growth by enhancing the ability of
265 morphisms, which profoundly affect the cells in which they appear and contribute to a variety of dise
266 ed an associative memory task during hr-fMRI in which they encoded and later retrieved face-name pair
269 al pathogens appearing in geographical areas in which they have not been previously recognised; and c
270 s of microcephaly and, although the contexts in which they occur vary greatly, all are of concern.
271 od, hungry flies exhibit a peculiar behavior in which they repeatedly stray from, but then return to,
272 one of three conditions: an Effort condition in which they saw an adult try repeatedly, using various
274 aken together, these results support a model in which this IDR of Med13 plays a key role in controlli
275 hool canteens represent an opportune setting in which to deliver public health nutrition strategies b
276 ponses of the pistil makes it a prime system in which to study the consequences of plant-pathogen int
277 conductive states of the selectivity filter in which to test competitive binding of Na(+) These expe
278 ammes, governments can create an environment in which tobacco use is reduced and citizens maintain go
279 m promoting rural biogas stoves in a context in which traditional stove use persists, although pollut
280 is attributed to a new modulation mechanism, in which transport of silver ions through alumina dielec
281 allows one-step mapping of all genetic loci in which transposons can insert without disrupting essen
282 s a quark-rearrangement, exothermic reaction in which two heavy baryons (Lambdac) undergo fusion to p
283 ond patient, we observed polyclonal seeding, in which two independent clones seeded the metastatic li
284 Au23(SR)16](-) (R = cyclohexyl) nanocluster, in which two neighboring surface Au atomic sites "coales
285 orylation results in a conformational change in which Ub adopts a dynamic equilibrium between the kno
286 btained using "temporal response functions," in which unique electroencephalographic (EEG) signals co
287 cardiac and mediastinal segmentation schemes in which upper and lower limits of the heart were determ
290 C beta or with a rapamycin-inducible system in which various phosphatidylinositol phosphatases were
291 e leads to an extreme form of eye dominance, in which vision through the nondominant eye is degraded.
293 S summary statistics in a Bayesian framework in which we explicitly model various functional annotati
294 e results of the MS-STAT cognitive substudy, in which we investigated the treatment effect on cogniti
295 nd validated its accuracy in the two cohorts in which we previously identified ARDS subphenotypes.
296 opean starling nestlings (Sturnus vulgaris), in which we separately manipulated nutritional shortfall
297 in P4 resistance, we generated a mouse model in which we specifically ablated Mig-6 in uterine epithe
300 pletion of a mechanical cycle in a direction in which work is done on the environment - the requisite
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