ライフサイエンスコーパス: inability

1 lthcare from the clinic to the home, but the inability for clinicians to conduct remote palpation, or

2 This inability is due to residues in the bacterial cyt c N te

3 hromosomal instability (CIN), the persistent inability of a cell to faithfully segregate its genome,

4 The inability of A2 mice to undergo immunoglobulin class swi

5 The inability of acute MNoV to shed and persist is rescued i

6 Infantile amnesia, the inability of adults to recollect early episodic memories

7 h a homozygous ANKZF1 R585Q mutation, and an inability of ANKZF1 R585Q and E152K to rescue the phenot

8 R11, and G15 are largely responsible for the inability of B virus to utilize HVEM for entry.

9 e often irreversible in mammals owing to the inability of cells in the inner ear to proliferate and r

10 Loss of Nol12 results in the inability of cells to recover from DNA stress and a rapi

11 lysis of these simulations indicate that the inability of Chl reductions to increase photosynthesis a

12 However, the inability of common spectroscopic identifiers to registe

13 ess in the clinic has been attributed to the inability of conventional gene vectors to achieve gene t

14 The inability of current global models to accurately calcula

15 te of relapse may in part be a result of the inability of current treatment to effectively overcome t

16 tif during chiral proofreading underlies the inability of D-aminoacyl-tRNA deacylase (DTD) to discrim

17 The inability of elite controller Nef to fully remove CD4 fr

18 Inability of ethylene to suppress sHSP genes in rin/rin

19 The major reason is the inability of existing treatments to eradicate the multip

20 nched hemicelluloses and pectin, despite the inability of F. succinogenes to utilize non-cellulosic (

21 uated/absent effects were underpinned by the inability of FGF21 to increase the expression of key the

22 usality will continue to be frustrated by an inability of footprinting to identify the causative vari

23 In the octameric Hda-beta clamp complex, the inability of Hda to interact with DnaA is a novel mechan

24 valence of C. difficile colonization and the inability of hospitals to limit testing to patients with

25 cations but are selected against through the inability of hPolbeta to complete thumb domain closure.

26 Consistent with this, the inability of IFN-alphabetagammaR(-/-) immune cells to co

27 mportance of miR-155 was demonstrated by the inability of IL-10 to enhance anaphylaxis in miR-155-def

28 In contrast, the inability of inactivated vaccines to replicate enhances

29 skin of Krt16-/- mice and correlates with an inability of keratinocytes to sustain nuclear factor ery

30 nsformation by VB12 appears to be due to the inability of L-perfluoroalkyl sulfonates to complex with

31 eral fundamental aspects of FHL, namely, the inability of many pathogenic antigens to induce hyperinf

32 tion, reduced neuronal excitability, and the inability of medium spiny neurons to regulate activity-i

33 This minimal effect correlates with the inability of Mn(2+) and pro-TGF-beta1 to stabilize the o

34 -stimulated ATP-hydrolysis, resulting in the inability of modified BiP to attain high affinity for it

35 We confirm the inability of MojV-G to interact with known paramyxoviral

36 es to measure extracellular vesicles and the inability of most techniques to capture the entire size

37 sub-domain (myo2-E1-Sup1) that reverses the inability of myo2-E1 to form colonies at the restrictive

38 not from defects in mitosis, but rather the inability of neural progenitors to ever reach this stage

39 ns with lipids are unknown or limited due to inability of obtaining stable purified protein in suffic

40 posterior-anterior shift may not reflect the inability of older adults to engage in sensory processin

41 ine lactone quorum signals, resulting in the inability of P. aeruginosa to produce virulence factors

42 obo inactivation in mouse lung results in an inability of PNECs to cluster into sensory organoids and

43 Finally, an approach to circumvent the inability of post-mitotic cells to support homologous re

44 age-gated potassium channels accompanies the inability of Purkinje neurons early in disease to mainta

45 response in infected macrophages due to the inability of RESTV GP to stimulate TLR4.

46 tion assay in lung sections demonstrated the inability of S32T Prdx6 to bind to the chaperone protein

47 Together with the observed inability of shredders to avoid neonicotinoid-contaminat

48 ice to deliver fewer pups due in part due to inability of some embryos to implant in the uterus, indi

49 sruption of the membrane skeleton due to the inability of spectrin filaments to spontaneously form th

50 The inability of the adult mammalian heart to regenerate fol

51 fails to enter this pathway and leads to the inability of the apical exosomal cargo protein GPRC5B to

52 exity in multistep chemical synthesis or the inability of the biosynthetic alpha1,6-fucosyltransferas

53 Strenuous exercise can result in an inability of the central nervous system to drive skeleta

54 rapeutic consequences but is hampered by the inability of the current tumor-node-metastasis-blood (TN

55 icant bacterial expansion associated with an inability of the decidua to mount appropriate innate cel

56 "Fundamental immunodeficiency" is the inability of the encoded immune system to protect an oth

57 s of infected hepatocytes, as well as to the inability of the immune system to efficiently counteract

58 Inability of the late Na(+) current to inactivate leads

59 ng the first days in high CO2 was due to the inability of the mutant cells to adjust photosynthesis t

60 conditional LD lethality likely results from inability of the mutant to activate reductant-requiring

61 ed to control IRF3 phosphorylation due to an inability of the mutant to sustain expression of ICP0.

62 of Il1b expression may have been due to the inability of the Twist2-IKKbetaca transgene to induce in

63 hin the neointima may be associated with the inability of the vessel to dilate and may predispose to

64 ion is due in part to impaired expansion and inability of their HSCs to induce and expand Tregs in th

65 the instability of their oxidized forms, the inability of their oxidized forms to activate a water ox

66 ssion was restricted to B cells revealed the inability of these cells to prime TH2 responses but high

67 These results indicate that the inability of TRalpha1PV to recruit NCOR1DeltaID to form

68 we find that this deficit is centered on the inability of transitional type 1 B cells to survive and

69 sclerosing cholangitis (AISC) either through inability of Tregs to restrain proliferation and effecto

70 lar bacterial survival, as determined by the inability of vapA deletion mutants to replicate in host

71 However, the inability of ZIKV to antagonize the mouse IFN response r

72 nventional CRT or remain untreated due to an inability or impediment to coronary sinus (CS) lead impl

73 DRS presents with inability to abduct one or both eyes.

74 , progress in such systems is impeded by the inability to access more than a fraction of the total mi

75 Thus, an inability to accommodate changes in viewpoint does not a

76 e sampling, short follow-up periods, and the inability to account for combat-related trauma.

77 An inability to accurately classify HRGPs leads to inconsis

78 ue, preclinical models may be limited by the inability to accurately replicate pathophysiologic inter

79 ique has multiple limitations because of its inability to accurately visualize and target prostate le

80 for brain cancers, potentially due to their inability to achieve sufficient drug levels in the CNS.

81 mats, however, a remaining limitation is the inability to achieve temporal control over their sensing

82 We demonstrate that this inability to activate mast cells is based on a biophysic

83 s its binding with LEPR, consistent with its inability to activate STAT3-binding element in the lucif

84 ation may be required due to poor vision and inability to adequately monitor for tumor recurrence.

85 Limitations of the study include an inability to adjust for comorbid conditions or demograph

86 xpansion states had a decrease in reports of inability to afford needed follow-up care (difference-in

87 ations of this application of MR include the inability to analyse non-linear associations, to underta

88 mass cytometry has some shortcomings such as inability to analyze potential transformation or dissolu

89 functions of brain lipids is limited by the inability to analyze these molecules at cellular resolut

90 me bottom: +93%; abnormal behaviours: +138%; inability to ascend: +280%) over a longer period (60 min

91 portant methodological components of FMT and inability to assess the actual conduct of studies and wh

92 an G269S, as observed by its aggregation and inability to associate with the HexA beta chain.

93 d ability to non-covalently dimerize and its inability to bind and recruit TbetaRI, enabled it to bin

94 the addition of Hh ligand independent of its inability to bind other factors such as Smurf2.

95 transcriptional function as a consequence of inability to bind to p300.

96 the RBDs of RAF kinases, resulting in their inability to bind to RAS, disruption of RAF activation,

97 tion approaches currently are limited by our inability to bioengineer full-sized, living replacement

98 nge is the slow clinical progression and the inability to biopsy the affected tissue, the brain, maki

99 ing from personal preferences and beliefs to inability to book a timely appointment with their local

100 n in school (OR 1.22, 95% CI 1.13-1.31), and inability to borrow funds from family or the community (

101 ls engineering but have been hindered by the inability to bubble Xe through the desired media as a re

102 Si elimination was also observed despite its inability to catalyze C-H silylation; the reductive elim

103 le sizes for non-European ancestries and the inability to classify approximately one-third of the var

104 e main limitations of this study include the inability to classify fractures by severity, challenges

105 idence of B cell tumors, confirming that the inability to clear NKG2D ligand-expressing cells was imp

106 f packed red blood cells (median >10 units), inability to close the abdominal wall without tension, d

107 12) compared to increasing species due to an inability to colonize new sites beyond their range perip

108 ing of C. muridarum mutants was due to their inability to colonize the gastrointestinal tract since i

109 ol in the ileS(T233P) strain resulted in the inability to compete with a wild-type strain under selec

110 ankle joint, contraindication to nailing, or inability to complete questionnaires.

111 ry rare genetic disorder characterized by an inability to conjugate bilirubin.

112 The inability to consistently develop such bioreactors affec

113 This may underlie their inability to contain VZV reactivation and prevent the de

114 Others included 5 different injury patterns, inability to control bleeding by conventional methods, a

115 Addiction involves an inability to control drug-seeking behavior.

116 Inability to control elevated phenylalanine levels in th

117 Key limitations of the study include the inability to control for confounding by indication in th

118 ne drawback to previous studies has been the inability to control intrinsic and extrinsic factors.

119 Inability to cooperate may limit use of some tests in ch

120 main-specific receptor expression and not an inability to couple with the signaling machinery.

121 studies were excluded from our analysis was inability to cross-tabulate histologic and serologic fin

122 d in the pre-chemotherapy era, including the inability to cure tuberculosis, high mortality, and the

123 pective multicenter U.S. study indicate that inability to decrease procalcitonin by more than 80% is

124 To prospectively validate that the inability to decrease procalcitonin levels by more than

125 A limitation of NIR-PIT is the inability to deliver NIR light to a tumor located deep i

126 ues that have previously been limited by the inability to deposit sufficient amounts of optical energ

127 a magnitude large enough to account for our inability to detect a significant advance over time.

128 The inability to detect IL-33 or TSLP, or to neutralize thei

129 (POka) VZV resulted in latent infection with inability to detect several viral mRNAs by reverse trans

130 population-wide studies are limited by their inability to detect variation between individual cells w

131 Limitations of the study were the inability to determine (i) the actual amount of IgG3-H43

132 chromosomal anomaly, death within 48 hours, inability to determine AKI status or severe congenital k

133 This study is limited by the inability to determine the timing of acquisition of the

134 rotonated glycoconjugates is hindered by the inability to differentiate linkage and stereoisomers.

135 e due to subjective assessment of stridor or inability to differentiate supraglottic from subglottic

136 Inability to disengage from ZO-1 correlated with increas

137 hrin-binding efficiency, suggesting that the inability to disengage from ZO-1 prevented maturation of

138 situ analysis of virus spread shows that the inability to disrupt Aux/IAA CC nuclear localization cor

139 n of thrombi, but has some limitations, e.g. inability to distinguish between an old and fresh thromb

140 o characterize this interplay suffer from an inability to distinguish between multiple cell types, of

141 ess in human neurosciences is limited by the inability to easily apply a wide range of analysis metho

142 memories is important for survival, but the inability to effectively adapt to the trauma is a charac

143 The FDA's inability to effectively manage the safety of hundreds o

144 e allyl radical, which was attributed to the inability to efficiently delocalize the spin on a phenyl

145 ve not been well defined, largely due to the inability to efficiently isolate VLVs that are free of v

146 Mitochondrial dysfunction, the inability to efficiently utilise metabolic fuels and oxy

147 They exhibit increased quiescence, an inability to enter the cell cycle in response to hematop

148 r reason for failure of HBV treatment is the inability to eradicate or inactivate the viral covalentl

149 Limitations of the study include inability to establish causal links due to observational

150 travasation behavior is often impeded by the inability to establish complex tissue-like extracellular

151 in measurement after day 42, resulting in an inability to estimate the cumulative risk of anaemia.

152 y include a small number of clusters and the inability to evaluate the incremental effectiveness of i

153 itations, such as technical difficulties and inability to evaluate the surrounding tissues.

154 The inability to extinguish these associations is a key fact

155 Complete passivity-the inability to extract work from equilibrium states-implie

156 ive care units is often delayed due to their inability to feed by mouth safely and competently.

157 xhibited significantly greater mortality, an inability to fight bacterial infection, heightened level

158 he inherent complexity of ecosystems and the inability to foresee all consequences of interventions a

159 of rfaG, waaL, wzzE, and wzyE resulted in an inability to form reservoirs in mouse bladders.

160 f basal cells, both in vivo and in vitro The inability to form structurally normal ducts and alveoli

161 into Pip, their Pip deficiency relies on the inability to form the 2,3-DP intermediate.

162 testing and treatment were available) and an inability to formally investigate the effect of crowding

163 rosis factor alpha and IL-10, indicating the inability to generate adequate protective and balancing

164 roles remain largely unknown because of our inability to generate and isolate pure populations.

165 al SOD isoform in Leishmania amazonensis Our inability to generate L. amazonensis SODA null mutants a

166 he deficiency in photorespiration due to the inability to generate lipoic acid from mitochondrially s

167 existing platforms suffer from low potency, inability to generate long-term immune memory and decrea

168 efect in positive selection would reflect an inability to generate the appropriate positively selecti

169 have a more severe cataract, as measured by inability to grade vitreous haze, gained an additional 4

170 of Plasmodium vivax genes is limited by our inability to grow the parasites in long-term in vitro cu

171 doned wearing the scleral lens because of an inability to handle the lenses, and 40 eyes wore the len

172 s life-giving organs and hospital resources, inability to honor the donor's memory and character, and

173 es to date have been limited by sample size, inability to identify confounding, and a focus limited t

174 g the treatment of concussion is our current inability to identify patients that will experience pers

175 ion for highly pigmented tumors, as does the inability to image the entire iris in a single field.

176 ight to conservation, as well as the field's inability to improve predictor performance.

177 Inability to inactivate GSK3beta through Ser(389) phosph

178 ynthesis could be attributed entirely to the inability to incorporate Sec.

179 energy production to glycolysis, despite an inability to increase glucose uptake in response to IGF-

180 oped overt endothelial dysfunction due to an inability to increase NO dependent vasodilation.

181 es of cell death in complex organisms is the inability to induce and visualize this process with spat

182 re in many patients was not solely due to an inability to induce immune reinvigoration, but rather re

183 Among other rationale, the inability to influence photochemical reactions with temp

184 Impulsiveness describes the inability to inhibit behaviour in the presence of salien

185 loss of agency ('helplessness'), or from an inability to inhibit the mental exploration of aversive

186 ies in A20-deficient cells, caused by cell's inability to inhibit TNF-induced NF-kappaB response.

187 high mortality rate is, in part, due to the inability to initiate an effective antifungal therapy ea

188 thermodynamic openness of a living cell, the inability to instantaneously match fluctuating supply an

189 in coupling these methods is hindered by the inability to interpret the complex exchange patterns in

190 ting medical records to assess outcomes, the inability to isolate the effect of each component of the

191 As a hallmark of drug addiction is the inability to limit drug use despite negative consequence

192 e attributed to infectious complications and inability to maintain adequate hydration and nutrition.

193 form beige adipocytes was accompanied by an inability to maintain body temperature and by hyperglyca

194 ch emphasize intrapsychic conflicts such as "inability to maintain body weight," "undue influence of

195 to a specific proliferative block due to the inability to maintain NAD(+)/NADH homeostasis.

196 iability and robustness, often leading to an inability to make scientific claims with verifiable leve

197 The inability to manage type 1 diabetes effectively during t

198 Limitations of this study included the inability to mask participants or data collectors to the

199 y owing to a paucity of animal models and an inability to measure infection directly.

200 glucuronosyltransferase 1A1 (UGT1A1) and the inability to metabolize bilirubin.

201 s, including poor discrimination capability, inability to multiplex targets, high rates of false posi

202 us-macrophage interactions resulting from an inability to neutralize the phagosome.

203 eoff for modest reduction in sensitivity and inability to observe alternative splicing, and should en

204 A major bottleneck has been our inability to observe GCs and their degeneration in the l

205 Failure was defined as the inability to obtain a valid examination.

206 oil embolization technique is limited by its inability to occlude wide-neck aneurysms.

207 rstanding of SC structure in Drosophila, the inability to optically resolve the minute distances betw

208 sm of action of chemokine antagonists and an inability to optimize compounds in the absence of struct

209 level likely lead to position errors and an inability to orient neural projections at single-cell re

210 rmalities, cell-cycle delays, defective HRR, inability to overcome replication fork stalling, and rep

211 ck to replicative DNA polymerases due to its inability to participate in Watson-Crick (W-C) base pair

212 able to colonize intestinal crypts due to an inability to pass through the intestinal mucus layer to

213 ial growth, complete loss of conidiation and inability to penetrate the host surface by mycelia-forme

214 The inability to perceive IL-21 signals under competitive co

215 infectious than both parents, indicating an inability to pilot DNA.

216 eir biological counterparts because of their inability to position organic molecules in three dimensi

217 h atopic dermatitis (AD) is fraught with the inability to precisely assess the age of skin lesions, t

218 covery efforts are at present hampered by an inability to precisely control the allosteric site.

219 imitations associated with their complexity, inability to precisely control the dimensions, and limit

220 e is reluctance to use DCD hearts, due to an inability to precisely identify hearts that have suffere

221 y, low cultural consonance and an associated inability to predict adaptive outcomes may activate impu

222 is so-called "stasis paradox" highlights our inability to predict evolutionary change, which is espec

223 evidence, unclear patient preferences, or an inability to predict how treatments will fit into patien

224 However, our present inability to predict the effect of genome sequence varia

225 even for those with moderate disease and the inability to predict the transition from mild to moderat

226 However, our inability to prevent diLQTS has resulted in removal of m

227 langiopathy, and this was associated with an inability to produce an alkali bile during NESLiP.

228 creased CD57 and Ig-like transcript 2 and an inability to produce IFN-gamma (p = 0.002) compared with

229 ued by inefficiency, slow conversion, and an inability to produce mature functional cells.

230 d stability in the forward direction and the inability to produce proactive anticipatory adjustments.

231 The inability to produce recombinant hMPV F glycoprotein in

232 liferation in vitro and in vivo, despite its inability to promote one-carbon metabolism.

233 The inability to propagate molluscum contagiosum virus, whic

234 tems suffer from a lack of validation and an inability to provide accurate health risk warnings in a

235 sis has not been formally tested owing to an inability to purify or track these progenitors for detai

236 in Parkinson's disease may be related to an inability to pursue reward based on complete representat

237 afficking remain tenuous, largely due to the inability to quantify key features of the actin cytoskel

238 Addiction to nicotine and the inability to quit smoking are influenced by genetic fact

239 The inability to reach the distal target zone (n=48/100) or

240 uropsychiatric disorders for reasons such as inability to readily penetrate blood brain barriers.

241 matopoiesis, and is reflected in our current inability to recapitulate the development of HSCs from p

242 in the combining site, which explains their inability to recognize LPS.

243 Crowding, the inability to recognize objects in clutter, is known to p

244 re to form a functional Cas9-gRNA complex or inability to recognize targets in vivo.

245 on in anxiety patients may be mediated by an inability to recruit the dlPFC, which mediates the cogni

246 3, becoming Th2-like cells, explaining their inability to regulate immune responses.

247 sm underlying our previous observation of an inability to replenish brain ATP during times of high en

248 rcuit in Neurog2(-/-);Ascl1(-/-) mutants: an inability to repress expression of Tbr1 (a deep layer VI

249 AR antagonists are ineffective due to their inability to repress the expression of AR or its splice

250 Despite what appears to be an inability to resolve concatenation between chromosomes d

251 for glycan profiling but are limited by the inability to resolve isobaric species such as linkage an

252 An inability to resolve this issue using single-Purkinje ce

253 ersist in hostile environments because of an inability to respond to inflammatory signals.

254 applications are often limited either by the inability to respond to visible light or the need for sp

255 This, and the inability to restore wild-type behaviour in the infectio

256 nding site points to steric hindrance and an inability to retain the interactions used for tryptophan

257 y decline during regeneration, suggesting an inability to return to quiescence.

258 Finally, we show that the inability to robustly repair DSBs causes some of these l

259 raphene suffers from metal contamination and inability to scale graphene growth over large area.

260 cy, complicated fabrications, high cost, and inability to scale up.

261 proliferation is not conferred solely by the inability to sense centrosome loss.

262 from severe paroxysmal pain to a congenital inability to sense pain.

263 ematopoiesis has been challenging due to the inability to separate and study normal and leukemic SCs

264 normal and diseased human intestine and the inability to separate the different functional compartme

265 The inability to show the fistula in relation to normal anat

266 Insomnia and the inability to sleep affect people's health and well-being

267 condition that is associated with life-long inability to smell.

268 In young adults, an inability to solve a multistep task quickly, compounded

269 ro anti-cancer properties, is limited by its inability to specifically reach tumors following intrave

270 eatment of cancers are often hampered by the inability to specifically target neoplastic cells.

271 Despite its inability to spread systemically, PA14::hepP formed peri

272 Thus, the inability to stabilize proteins in controlled-release sy

273 Inefficient starch solubilization and the inability to standardize sugar colourants explained why

274 In untargeted metabolomics approaches, the inability to structurally annotate relevant features and

275 nt frontotemporal dementia revealed that the inability to subjectively differentiate the valence of p

276 The inability to successfully adapt to stress produces patho

277 lack of methods for early detection and the inability to successfully treat patients once diagnosed.

278 n impaired localization to chromatin and the inability to support loading of Cdc45.

279 ate (Glu)-microtubules (MTs; Glu-MTs) and an inability to support the localization of RNAs at protrus

280 ty of the E24A point mutant of EcMazF in its inability to support the substrate binding-competent con

281 The inability to sustain a vascular compensatory response li

282 The inability to switch between the oxidation of lipid and c

283 lammation within 6 months of completing ATT, inability to taper oral corticosteroids to less than 10

284 ion to induce death, but are undercut by the inability to target latently infected cells.

285 A shortcoming of these drugs is their inability to target the intractable infectious stage of

286 e niT cells as a direct consequence of their inability to transfer FOXO1 to T cells.

287 on that restrict PDT to superficial lesions, inability to treat hypoxic tumours, and incomplete tumou

288 infarct, a substantial comorbid disease, an inability to undergo an MRI scan, or had a history of sp

289 ic exhibit greater shell dissolution and the inability to upregulate their metabolism when exposed to

290 tead, monkeys with MDmc lesions exhibited an inability to use reward to promote choice repetition aft

291 ntamination susceptibility, water usage, and inability to utilize 5-carbon sugars and disaccharides a

292 One criticism of the approach is an inability to validate its algorithms within a biological

293 The long-standing inability to visualize connections between poxvirus memb

294 re poorly understood, largely because of the inability to visualize dynamic cell-BM interactions in v

295 on have remained largely unclear, due to our inability to visualize protein-tyrosine phosphatase oxid

296 on for ventricular arrhythmias is limited by inability to visualize tissue destruction, by reversible

297 (29 [54.7%] of 53, P < .001) IVIG treatment, inability to walk unaided (21 [35.0%] of 60 vs 6 [5.3%]

298 e prevalence; frequency of hospitalizations, inability to walk, bradykinesia, scoliosis, gastrostomy

299 and lead to physical disabilities, including inability to work, physical deformities, and amputations

300 and the need for disability benefits due to inability to work.