ライフサイエンスコーパス: inability of @1 to

1 The inability of TuMV to access multiple copies of eIF(iso)4

2 Insulin resistance arises from the inability of insulin to act normally in regulating nutri

3 The inability of IRL to act as a donor results largely from

4 This was due to the selective inability of -/- DCs to activate I-kappaB kinase alphabe

5 We attribute the inability of acetylcholine to activate ELIC primarily to

6 lecule expression does not fully explain the inability of ECs to activate resting naive CD4+ T cells.

7 hat these two FHF residues contribute to the inability of FHFs to activate FGFRs.

8 activate JNK provide an explanation for the inability of H2O2 to activate IKK and for the selective

9 rom RXRalpha/RARalpha is responsible for the inability of LG268 to activate RXRalpha/RARalpha heterod

10 es during prometaphase, correlating with the inability of Mad1 to activate Mad2, which is required fo

11 The inability of NT3 to activate Rac1-GTP-cofilin signaling

12 The inability of PKA to activate PLB following covalent modi

13 The inability of Sp1 to activate initiator-mediated transcri

14 as found to be responsible for the selective inability of Sp1 to activate initiator-mediated transcri

15 First we determined the basis for the inability of TC21 to activate Raf-1.

16 The inability of thiocholine to activate from alphaY93C, whi

17 The inability of EtOH to acutely produce NAN in the adult CN

18 action between ANT and cyclophilin D and the inability of ANT to adopt the cytosolic conformational s

19 ne and showed that resistance was due to the inability of HA22 to ADP-ribosylate and inactivate EF2.

20 ates, which instead may simply be set by the inability of selection to advance very weakly advantageo

21 atient); 4) education shortfalls; and 5) the inability of hospitals to align disaster medical require

22 onents or patterns, therefore, relies on the inability of bacteria to alter these essential or critic

23 ncy of Twist1 results in polydactyly via the inability of Twist1 to antagonistically regulate the rel

24 classical opioid receptors together with the inability of naloxone to antagonize its effect suggest t

25 However, the inability of ZIKV to antagonize the mouse IFN response r

26 The apparent inability of AOX to assemble in the cytoplasm contrasts

27 responses is believed to be secondary to the inability of polysaccharides to associate with MHC class

28 responses in Btk-/- cells correlated with an inability of SCF to augment phospholipase Cgamma1 activa

29 Together with the observed inability of shredders to avoid neonicotinoid-contaminat

30 became committed to die, as measured by the inability of cells to be rescued by NGF readdition, at t

31 sensitivity to Ca2+ and Mg2+ inhibition and inability of MHRyR1s to be fully inactivated at [Ca2+]i

32 viral activity in cell culture, owing to the inability of rP to be converted to rPMP by cellular nucl

33 ctivation of Hog1p occurs in vivo due to the inability of Ssk1p to be phosphorylated at least in the

34 eta-hairpin (residues 97-112) results in the inability of UvrB to be loaded onto damaged DNA, defecti

35 In these cells, the inability of KLF4 to become activated in response to DNA

36 The total inability of 5 to bind to Li(+), Na(+), and K(+) denotes

37 onsistent with this mechanism and suggest an inability of ATP to bind to p38 in the absence of protei

38 The inability of gD to bind HveA(76t) suggests that addition

39 Both of these mutations result in the inability of Grauzone to bind DNA effectively.

40 ructural differences that contributed to the inability of HCPD to bind the DHBV pre-S domain.

41 erm genes in E, a result we attribute to the inability of hTCF4 to bind to C. elegans beta-catenin.

42 This explains both the inability of Juno to bind vitamin B9/folic acid [1], and

43 Pull-down experiments demonstrated the inability of Nck to bind to the CD3epsilon PRS in thymoc

44 that mediates this defect in NB cells is the inability of p21 to bind to, or inhibit the activity of

45 bstrate and co-substrate specificity and the inability of PvdA to bind FAD tightly.

46 The inability of Sir3p to bind methylated H3 Lys-4 tails sug

47 Fidelity was thought to arise from the inability of SRP to bind strongly to incorrect cargos.

48 Thus, the inability of TC21 to bind to RBS1 may prevent it from pr

49 We conclude that the increasing inability of TRF2 to bind telomeres as they shorten is a

50 The correlation between the ability or inability of XRCC4 to bind DNA ligase IV and its ability

51 These data were substantiated by the inability of cyanovirin to block gp120-Fc binding to DC-

52 These data show that the inability of EBOV to block apoptotic pathways may open u

53 anization and growth inhibition, despite the inability of FTI to block prenylation of either K-Ras or

54 energetics of this process and the apparent inability of AXS to catalyze the conversion of UDP-D-xyl

55 The inability of RT to catalyze removal of a chain terminato

56 These features rely on the inability of RseP to cleave intact RseA.

57 endently of Tpp1, which was explained by the inability of Tpp1 to cleave 3' alpha,beta-unsaturated al

58 obo inactivation in mouse lung results in an inability of PNECs to cluster into sensory organoids and

59 Moreover, the inability of alpha1 to compensate for alpha4 suggests th

60 ultiple capsular polysaccharides rescues the inability of mutants to compete for commensalism.

61 y functional in vivo, as demonstrated by the inability of each to complement scp160/eap1 synthetic le

62 The inability of imidazole to complement function in the axi

63 osyltransferase, probably accounting for the inability of lpcC to complement S. meliloti lpsB mutants

64 The inability of Z3206 to complement the loss of the gne gen

65 elucidated chromosomal abnormalities and the inability of chromosomes to complete congression to the

66 cations but are selected against through the inability of hPolbeta to complete thumb domain closure.

67 The biases may be related to the inability of models to constrain turbulent mixing realis

68 Gr1(+) inflammatory monocytes resulted in an inability of mice to control replication of the parasite

69 strand passage activity, due primarily to an inability of ATP to convert the enzyme to a protein clam

70 significant decline in beat frequency and an inability of cilia to coordinate their oscillations and

71 Constructional apraxia refers to the inability of patients to copy accurately drawings or thr

72 eating these infections is attributed to the inability of investigators to cultivate the parasite, wh

73 The inability of SP to cut at guanine residues and the favor

74 hlamydiae synthesize a cell wall despite the inability of efforts to date to detect peptidoglycan in

75 , apparently because egg destruction and the inability of females to defend their eggs from cobreeder

76 The inability of angiography to depict the true extent of at

77 oaches for cancer are in part limited by the inability of drugs to destroy neoplastic cells within po

78 lved computational problem partly due to the inability of algorithms to detect them.

79 first coined by James Moulder, describes the inability of researchers to detect or purify peptidoglyc

80 Discrepancies were mostly in the inability of TEE to detect superficial ulcerations.

81 To determine whether an inability of TLR9 to detect endogenous DNA could explain

82 onal block from pro-B to pre-B cells and the inability of thymocytes to develop beyond the CD4(-)CD8(

83 omenon may result, at least in part, from an inability of guardians to differentiate between kin and

84 r reliabilities for process measures: (1) an inability of reviewers to differentiate among cases with

85 ether this attenuated binding was due to the inability of VEK30 to dimerize, we defined the minimal l

86 oop in certain maspin functions, despite the inability of maspin to directly inhibit tPA or uPA catal

87 We hypothesized that the inability of tumstatin to directly suppress tumor cell g

88 ol), is mainly entropic, consistent with the inability of THZ to displace water from the "attacking g

89 This difference is responsible for the inability of LT2 to display a sustained log-phase acid t

90 This limitation highlights the inability of SPIOs to distinguish stem cell viability.

91 ing cardiomyocytes, which contrasts with the inability of mammals to do so after the immediate postna

92 ar the peptide-lipid-water interface and the inability of nonimmobilizer to do the same may represent

93 he Trp(8) binding pocket for SRIF-14 and the inability of pyrazine to do so was explained through dif

94 This correlated with a progressive inability of NRG to down-regulate a group of proliferati

95 ased in lyn-/- B cells, correlating with the inability of CD22 to downregulate the BCR-induced calciu

96 s is impaired without STAT3, in spite of the inability of Ras to drive STAT3 tyrosine phosphorylation

97 by the low correction efficiency in vivo and inability of AMOs to efficiently cross the blood brain b

98 The inability of Fes to efficiently hydrolyze ferric MGE, fe

99 hemicals has been hampered mainly due to the inability of microorganisms to efficiently co-ferment pe

100 The inability of pseudovirions to efficiently bind and infec

101 ibrosis lung disease has been limited by the inability of vectors to efficiently and persistently tra

102 Here, we provide evidence that the inability of Env to elicit the production of broadly neu

103 he acrosome reaction, as demonstrated by the inability of inducers to elicit exocytosis when streptol

104 The inability of Pn14 to elicit a boosted PPS14-specific IgG

105 rug tolerance is largely responsible for the inability of antibiotics to eradicate infections and is

106 e T-cell responses and may contribute to the inability of hosts to eradicate the infection and add to

107 Failure to reach CMR results from the inability of TKIs to eradicate quiescent CML leukaemia s

108 resistance and have a negligible role in the inability of TKIs to eradicate residual disease in patie

109 changed for two protons despite the apparent inability of MdfA to exchange two protons for a single d

110 We determined that the inability of XPLN to exchange RhoC is mediated by isoleu

111 The inability of cells to execute their migratory trajectori

112 owever, this article suggests that it is the inability of stakeholders to find a common language to e

113 The inability of biofilm to firmly attach to the surface and

114 Selectivity arises due to the inability of K(+) to fit between a plane of glutamate re

115 g patients, providers, and interpreters, (b) inability of patients to follow through with treatment p

116 This correlates with the inability of BtuB to form ion channels in planar bilayer

117 removing the repressor gene accounts for the inability of D29 to form lysogens.

118 The inability of K16 to form urea-stable tetramers in vitro

119 explanation does not appear to reside in an inability of K18 to form 10-nm filaments with K5, which

120 The inability of MutSDelta800 to form tetramers may indicate

121 These studies also demonstrate an inability of tobramycin to form a stable low-energy comp

122 We propose that the inability of CaM to fully activate the PMCA after methio

123 The inability of Hsc70 to fully protect protein synthesis fr

124 ity than K5- K14, which may help explain the inability of K16 to fully rescue the skin blistering cha

125 due to potential species differences and the inability of models to fully capture the dynamics of hum

126 Thus it appears that despite the inability of morin to fully block Abeta aggregation or b

127 We show that at least a part of the inability of PpABI3A to fully complement the phenotypes

128 The inability of DC to function as APCs for exogenous HBcAg

129 ide (and DnaJ) is likely responsible for the inability of I462T to function in vivo.

130 tive in animal blastomeres and show that the inability of LvDsh to function in animal cells is not a

131 The inability of OUbx to function like Drosophila Ubx (DUbx)

132 t the lack of insulin secretion suggested an inability of granules to fuse at the plasma membrane of

133 ars, these studies have been hampered by the inability of researchers to generate simple linear gradi

134 in accumulation, and a far-red light-induced inability of seedlings to green upon subsequent transfer

135 CI) causes permanent debilitation due to the inability of axons to grow through established scars.

136 grow in media containing methionine and the inability of cells to grow in media supplemented with me

137 rophic growth conditions and resulted in the inability of cells to grow in the presence of glucose wi

138 e downstream GAL7 promoter, resulting in the inability of cells to grow on galactose.

139 the ts phenotype and can fully suppress the inability of cells to grow on glycerol and the hypersens

140 e wild type or ER+ proteins as tested by the inability of cells to grow on glycerol or ethanol.

141 amily of proteins, was found to result in an inability of gonococci to grow anaerobically.

142 nted suggesting that the previously reported inability of pgs1Delta to grow in the presence of ethidi

143 usality will continue to be frustrated by an inability of footprinting to identify the causative vari

144 Because of the inability of fluoroscopy to image intracardiac structure

145 n has been severely hampered by the reported inability of planarians to incorporate exogenous DNA pre

146 uated/absent effects were underpinned by the inability of FGF21 to increase the expression of key the

147 ppression of late flowering is caused by the inability of FRI to increase FLC mRNA levels in the abh1

148 The inability of insulin to increase skeletal muscle capilla

149 ty bNAb-expressing cells, as measured by the inability of Ags to induce rapid increases in intracellu

150 This is consistent with the inability of cGMP to induce functional conformational ch

151 In this study, we show that the inability of CXCL12 to induce Rap1 GTP loading in CLL ce

152 The inability of I643A to induce actin polymerization in cel

153 bition of IFN-induced gene expression and an inability of IFNs to induce an antiviral state.

154 ng an HIV-1 vaccine has been hampered by the inability of immunogens to induce broadly neutralizing A

155 e NF-kappa B in neuronal cells is due to the inability of MV to induce phosphorylation and degradatio

156 This study analyses whether the inability of p53 to induce G1 arrest after the restricti

157 The inability of TSLP to induce DC maturation without produc

158 We show that the inability of Xbra to induce goosecoid is imposed by an N

159 ell may contribute, at least in part, to the inability of 87V to infect cells in vitro.

160 The inability of adenovirus to infect primitive hematopoieti

161 The inability of HCMV to infect Caco-2 cells at late stages

162 In addition, the inability of hHDV to infect PWH was not overcome using a

163 Whether the inability of HIV to infect these resting CD4+ T cells is

164 e pharmacotherapy and is characterized by an inability of addicts to inhibit relapse to drug use.

165 Despite the inability of C5a to inhibit IL-12 production by DCs, the

166 5 to alanine in DOR likewise resulted in the inability of DPDPE to inhibit [3H]cAMP production, the a

167 a single substitution, D92Y, resulted in the inability of NS to inhibit RIG-I ubiquitination.

168 The inability of OAADPr to inhibit the reaction of NUDT9 wit

169 that absence of Mig-6 in mice results in the inability of P4 to inhibit E2-induced uterine weight gai

170 ional consequence of this phenomenon was the inability of SKF38393 to inhibit Na/K-ATPase activity an

171 modulated by hypermethylation, and that the inability of sulindac to inhibit tumor formation in Apc+

172 riptional repressors, partially restores the inability of dgt to initiate lateral root primordia but

173 This inability of p53 to initiate a G(1) arrest after DDATHF

174 In the octameric Hda-beta clamp complex, the inability of Hda to interact with DnaA is a novel mechan

175 The inability of LIP5 to interact with Vps4 is the probable

176 The inability of Y122A to interact with both the polymerase

177 by the emergence of drug resistance and the inability of antibiotics to kill dormant organisms.

178 aused by enhanced neutrophil survival or the inability of neutrophils to leave the vascular compartme

179 valence of C. difficile colonization and the inability of hospitals to limit testing to patients with

180 Loss of this interaction resulted in the inability of POMGnT1 to localize to the Golgi and reduce

181 f hematopoietic stem cells is limited by the inability of cytokines to maintain primitive cells witho

182 ffects are part of "anabolic resistance"-the inability of muscle to maintain its protein mass by appr

183 cification were up-regulated, reflecting the inability of pteropods to maintain calcification rates.

184 hereas the PCP deficit was mainly due to the inability of rats to maintain reinforced choice behavior

185 The inability of neutrophils to make tumor necrosis factor o

186 failure of hair differentiation reflects an inability of keratinocytes to migrate along the outer ro

187 VLS seen in CD44 KO mice was not due to the inability of lymphocytes to migrate to these organs.

188 ockade by the Gq/G11 inhibitor FR900359, the inability of AZ1729 to mimic or regulate propionate-medi

189 The apparent inability of Leishmania to modulate the expression of ac

190 ite is not affected by the mfd mutation, the inability of Mfd to modulate CCR of acsA expression most

191 An inability of PARP1 to modulate this response results in

192 re largely unknown but may be related to the inability of piroxicam to modulate other biochemical pat

193 These data indicate that the inability of cells to more strictly control cytosolic le

194 nd the canonical nucleobases, as well as the inability of nucleosides to mutually select their pairin

195 ugh robust, seems to fail as a result of the inability of axons to navigate in the proper direction.

196 n-swapping approach, we demonstrate that the inability of p73 to nuclear-export is attributable to it

197 the SPR surfaces; this is likely due to the inability of CCL7 to oligomerize because CCL2(P8A) also

198 The inability of CsA to overcome ongoing allograft rejection

199 interference with DNA binding resulted in an inability of Rep40 to package adeno-associated virus DNA

200 secretion, apparent lack of polymerization, inability of calnexin to participate in the degradation

201 rt of GAP-stimulated catalysis, and that the inability of p85 to participate in these interactions ma

202 istic patient/family expectations 2.5 (1.0), inability of patients to participate in discussions 2.7

203 are completely nonpathogenic because of the inability of appressoria to penetrate plant cell surface

204 cleavage events was also demonstrated by the inability of transposase to perform second cleavage at 2

205 The inability of zfhoxa3a to perform all of the normal roles

206 AKT activity by this compound results in the inability of AKT to phosphorylate and inactivate the pro

207 The inability of 27 to potentiate memory when given systemic

208 inhibitory interactions are reflected by the inability of CBP to potentiate the low levels of gene ac

209 ance in H-2M-deficient mice is not due to an inability of APCs to present p35-55, or an intrinsic def

210 The inability of ATVDelta57R to prevent phosphorylation of e

211 xicity when applied in vitro may explain the inability of GDNF to prevent the loss of dopamine neuron

212 The inability of SENP1 to process sentrinized RanGAP1 in viv

213 ascular growth and tissue healing, while the inability of BMDCs to produce tumor necrosis factor alph

214 sular polysaccharides (PS) combined with the inability of infants to produce anti-PS antibody may exp

215 l-like receptors, our data indicate that the inability of macrophages to produce cytokines is due to

216 commodation into tolerance, indicated by the inability of mice to produce anti-Gal antibodies despite

217 severe immune disorder characterized by the inability of phagocytes to produce bacteria-destroying R

218 These include the inability of cells to progress past G2, global chromosom

219 The inability of Cs+ to promote decay of IM1, despite having

220 We found that an inability of Tir to promote actin assembly resulted in a

221 The inability of Y257F to promote the distorted substrate st

222 ion induced by heat shock or GSSG was due to inability of Hsc70 to protect eIF-4 E from heat-induced

223 iabetic neuropathy may be due to a selective inability of NGF to protect this particular population o

224 date has not been determined because of the inability of researchers to quantify chlamydiae in semen

225 ents an additional source of stress, and the inability of dimples to rearrange during crystallization

226 The consistent inability of cells to recognize RNA transcripts possessi

227 Thus, the inability of Spp1 to recognize H3 methylated at R2 preve

228 Infantile amnesia, the inability of adults to recollect early episodic memories

229 Loss of Nol12 results in the inability of cells to recover from DNA stress and a rapi

230 budding arrests might have resulted from the inability of Gag to recruit or utilize members of the ho

231 structure, transcriptional interference, the inability of Tat to recruit positive transcription facto

232 These results indicate that the inability of TRalpha1PV to recruit NCOR1DeltaID to form

233 ancer-binding protein alpha gene, due to the inability of TRalpha1PV to recruit NCOR1DeltaID to form

234 grow, a phenotype presumed to be due to the inability of cells to reduce the essential enzyme ribonu

235 The inability of axons to regenerate after a spinal cord inj

236 by a loss of NAD is primarily driven by the inability of cells to regenerate ATP.

237 he inherent repair process is limited by the inability of podocytes to regenerate.

238 Despite the inability of AMPK to regulate ACC activity, hearts from

239 We investigated whether a potential inability of HCMV to regulate these Rb-controlled pathwa

240 ted with insulin resistance is caused by the inability of insulin to regulate FoxO1 transcriptional a

241 The inability of p53 to regulate oxygen deprivation-induced

242 largely depleted of Ca2+, as assessed by the inability of ionomycin to release additional Ca2+.

243 ion, which has been attributed to either the inability of ChR2 to reliably fire presynaptic axons or

244 ith hydroxyl termination, resulting from the inability of HF to remove the last oxygen layer at the o

245 del, and this effect was associated with the inability of centrosomes to reorient in the direction of

246 These results indicate that the inability of poliovirus to replicate in the mouse alimen

247 event in anti-Fas-induced apoptosis, and the inability of cells to repolarize via inhibition of the N

248 rare circadian rhythm disorder caused by an inability of light to reset their circadian pacemaker.

249 from DTI has been hindered, however, by the inability of DTI to resolve more than a single axon dire

250 anergy reflects nothing more than the normal inability of cells to respond to antigen following prece

251 For example, TNF-alpha contributes to the inability of cells to respond to insulin and to the incr

252 Moreover, the inability of HPK1 to respond to PGE(2) stimulation in PK

253 of studies dating back several decades is an inability of lymphocytes to respond appropriately to fil

254 not to the kappa 3, site contributed to the inability of macrophages to respond to a second LPS chal

255 s, providing direct in vivo evidence for the inability of Th2 to respond to P/E-selectin despite incr

256 bD creating blocks at two points: (i) in the inability of TonB to respond to the cytoplasmic membrane

257 Furthermore the inability of adults to restore immune function following

258 sclerosing cholangitis (AISC) either through inability of Tregs to restrain proliferation and effecto

259 NOS3) and NO generation, as indicated by the inability of CO to reverse chronic hypoxia-induced PAH i

260 The inability of mDCs to secrete IL-12 was maintained, even

261 The inability of CD1d2 to select NK T cells is not due to th

262 the risk of tumor formation by iPSCs and the inability of iNCs to self-renew in culture.

263 r PC2 may therefore lead to PKD owing to the inability of cells to sense mechanical cues that normall

264 e responsible for the ability of E1A and the inability of E7 to sensitize cells to killing by NK cell

265 t negative form of mu-calpain resulted in an inability of cells to spread or to form focal adhesions,

266 Combined, the inability of Phe28 to stabilize the guanine base and the

267 defect to uridylylation was a result of the inability of 3CD to stimulate this reaction.

268 Furthermore, we show that the relative inability of Elongin to stimulate elongation by early el

269 n insulin resistance, as demonstrated by the inability of insulin to stimulate mobilization of a pool

270 An inability of DCs to sufficiently activate effector cells

271 azaki strand synthesis, we conclude that the inability of aRPA to support pol alpha loading causes aR

272 dies with chimeric proteins suggest that the inability of mPER3 to support circadian clock function r

273 -induced shut-off is not due to an intrinsic inability of p100 to support capped mRNA translation, bu

274 ssociation with wild-type TMV infections: an inability of TMV to support dRNAs that can move in plant

275 icoid receptor nuclear translocation and the inability of DEX to suppress cytokine production by B ce

276 Inability of ethylene to suppress sHSP genes in rin/rin

277 of pyruvate and lactate metabolites, and an inability of insulin to suppress fatty acid oxidation.

278 Type 2 diabetes is characterized by the inability of insulin to suppress glucose production in t

279 y week 12 of the study, there was a complete inability of insulin to suppress glucose production.

280 The inability of insulin to suppress hepatic glucose output

281 The inability of insulin to suppress hepatic glucose product

282 However, there is a complete inability of insulin to suppress hepatic glucose product

283 skin of Krt16-/- mice and correlates with an inability of keratinocytes to sustain nuclear factor ery

284 increased IMCL are associated with a marked inability of mitochondria to switch from lipid to glucos

285 Unexpectedly, the additional inability of CAT40 to synthesize enterobactin resulted i

286 antigen 1-positive endosomes, reflecting the inability of cargo to traffic from the early endosome to

287 castration resistance is associated with the inability of AR to transcriptionally regulate Nrdp1, and

288 a mechanistic rationale for the paradoxical inability of asbestos to transform HM in vitro, elucidat

289 However, the inability of MHV68 to transform primary murine B cells i

290 To determine if the inability of Raf to transform RIE-1 cells is due to a fa

291 in CaN activity was not attributable to the inability of CaN to translocate to the membrane and was

292 These data suggest that the inability of cGKs to translocate to the nucleus is respo

293 These results suggest that the inability of MDR2 to transport most MDR1 drugs efficient

294 The inability of etoposide to trigger apoptosis in precondit

295 imately arrests protein transport due to the inability of membranes to uncoat.

296 cretion of protective paracrine factors, the inability of CPCeA to undergo lineage commitment hinders

297 that key defect in Hs2st null kidneys is the inability of MM to undergo induction either through a fa

298 tudies (GWAS) have been disappointing in the inability of investigators to use the results of identif

299 To explore the apparent inability of taTrxR to use NADPH or NADH as a reductant,

300 in filament nucleation was supported by the inability of Bni1FH1FH2 to utilize a mutant profilin, H1