ライフサイエンスコーパス: inability to

1 DRS presents with inability to abduct one or both eyes.

2 , progress in such systems is impeded by the inability to access more than a fraction of the total mi

3 Thus, an inability to accommodate changes in viewpoint does not a

4 e sampling, short follow-up periods, and the inability to account for combat-related trauma.

5 An inability to accurately classify HRGPs leads to inconsis

6 ue, preclinical models may be limited by the inability to accurately replicate pathophysiologic inter

7 ique has multiple limitations because of its inability to accurately visualize and target prostate le

8 ent limitation with SSO methodologies is the inability to achieve conditional control of their functi

9 for brain cancers, potentially due to their inability to achieve sufficient drug levels in the CNS.

10 mats, however, a remaining limitation is the inability to achieve temporal control over their sensing

11 We demonstrate that this inability to activate mast cells is based on a biophysic

12 s its binding with LEPR, consistent with its inability to activate STAT3-binding element in the lucif

13 gatively affected by ageing leading to their inability to adapt to higher levels of oxidative stress

14 ation may be required due to poor vision and inability to adequately monitor for tumor recurrence.

15 It is unclear whether this is due to the inability to adequately propagate these bacteria or to c

16 Limitations of the study include an inability to adjust for comorbid conditions or demograph

17 physician, lacking easy access to medicine, inability to afford needed care, overall health status,

18 xpansion states had a decrease in reports of inability to afford needed follow-up care (difference-in

19 atio, 1.34; 95% CI, 1.03-1.73; P = .04), and inability to ambulate (hazard ratio, 1.81; 95% CI, 1.25-

20 ations of this application of MR include the inability to analyse non-linear associations, to underta

21 mass cytometry has some shortcomings such as inability to analyze potential transformation or dissolu

22 functions of brain lipids is limited by the inability to analyze these molecules at cellular resolut

23 luating emotional salience may contribute to inabilities to appreciate the risks inherent in this dis

24 me bottom: +93%; abnormal behaviours: +138%; inability to ascend: +280%) over a longer period (60 min

25 portant methodological components of FMT and inability to assess the actual conduct of studies and wh

26 an G269S, as observed by its aggregation and inability to associate with the HexA beta chain.

27 d ability to non-covalently dimerize and its inability to bind and recruit TbetaRI, enabled it to bin

28 the addition of Hh ligand independent of its inability to bind other factors such as Smurf2.

29 transcriptional function as a consequence of inability to bind to p300.

30 the RBDs of RAF kinases, resulting in their inability to bind to RAS, disruption of RAF activation,

31 tion approaches currently are limited by our inability to bioengineer full-sized, living replacement

32 nge is the slow clinical progression and the inability to biopsy the affected tissue, the brain, maki

33 of representativeness of trial participants, inability to blind participants and health professionals

34 ing from personal preferences and beliefs to inability to book a timely appointment with their local

35 n in school (OR 1.22, 95% CI 1.13-1.31), and inability to borrow funds from family or the community (

36 ls engineering but have been hindered by the inability to bubble Xe through the desired media as a re

37 Patients with inability to capture at 10 V or a final capture threshol

38 the running costs of extended access and an inability to capture health outcomes and other health se

39 Si elimination was also observed despite its inability to catalyze C-H silylation; the reductive elim

40 ical RS enzyme, consistent with its reported inability to catalyze formation of a 5'-deoxyadenosyl 5'

41 the most refractory hyperglycemia due to an inability to change lifestyle to reverse positive energy

42 ) due to rapid changes in cellularity and an inability to characterize both ECM microstructure and fu

43 le sizes for non-European ancestries and the inability to classify approximately one-third of the var

44 e main limitations of this study include the inability to classify fractures by severity, challenges

45 ZMs led to defective F-actin polymerization, inability to clear ACs, and, eventually, MZM dissipation

46 idence of B cell tumors, confirming that the inability to clear NKG2D ligand-expressing cells was imp

47 f packed red blood cells (median >10 units), inability to close the abdominal wall without tension, d

48 12) compared to increasing species due to an inability to colonize new sites beyond their range perip

49 ing of C. muridarum mutants was due to their inability to colonize the gastrointestinal tract since i

50 ol in the ileS(T233P) strain resulted in the inability to compete with a wild-type strain under selec

51 hat cause macrozoospermia and result from an inability to complete meiosis I (MI).

52 ankle joint, contraindication to nailing, or inability to complete questionnaires.

53 ry rare genetic disorder characterized by an inability to conjugate bilirubin.

54 The inability to consistently develop such bioreactors affec

55 This may underlie their inability to contain VZV reactivation and prevent the de

56 Others included 5 different injury patterns, inability to control bleeding by conventional methods, a

57 However, safety concerns related to the inability to control CAR-T cells once infused into the p

58 countries die of rabies each year due to the inability to control dog populations and implement mass

59 Addiction involves an inability to control drug-seeking behavior.

60 Inability to control elevated phenylalanine levels in th

61 Key limitations of the study include the inability to control for confounding by indication in th

62 e in human populations is challenging due to inability to control genetic background and variation in

63 ne drawback to previous studies has been the inability to control intrinsic and extrinsic factors.

64 ce of normal horizontal canals results in an inability to control the network properly and brings abo

65 ce of normal horizontal canals results in an inability to control the network properly and brings abo

66 Inability to cooperate may limit use of some tests in ch

67 Moreover, the inability to correctly compute the likelihood or to corr

68 main-specific receptor expression and not an inability to couple with the signaling machinery.

69 studies were excluded from our analysis was inability to cross-tabulate histologic and serologic fin

70 t have been difficult to identify due to the inability to culture and genetically manipulate T. palli

71 d in the pre-chemotherapy era, including the inability to cure tuberculosis, high mortality, and the

72 pective multicenter U.S. study indicate that inability to decrease procalcitonin by more than 80% is

73 To prospectively validate that the inability to decrease procalcitonin levels by more than

74 A limitation of NIR-PIT is the inability to deliver NIR light to a tumor located deep i

75 ues that have previously been limited by the inability to deposit sufficient amounts of optical energ

76 a magnitude large enough to account for our inability to detect a significant advance over time.

77 The inability to detect IL-33 or TSLP, or to neutralize thei

78 (POka) VZV resulted in latent infection with inability to detect several viral mRNAs by reverse trans

79 alization might also be reduced alongside an inability to detect the adverse emotional response, leav

80 population-wide studies are limited by their inability to detect variation between individual cells w

81 Limitations of the study were the inability to determine (i) the actual amount of IgG3-H43

82 chromosomal anomaly, death within 48 hours, inability to determine AKI status or severe congenital k

83 This study is limited by the inability to determine the timing of acquisition of the

84 rotonated glycoconjugates is hindered by the inability to differentiate linkage and stereoisomers.

85 e due to subjective assessment of stridor or inability to differentiate supraglottic from subglottic

86 ciated pigments arises from their unexpected inability to dimerize via transmembrane helices 1 and 5.

87 acute HCV infection have been limited by the inability to directly identify and characterize HCV-spec

88 linked to function has been hampered by the inability to directly measure signaling activity or prot

89 s known about the ENS in part because of the inability to directly monitor its activity in live anima

90 Inability to disengage from ZO-1 correlated with increas

91 hrin-binding efficiency, suggesting that the inability to disengage from ZO-1 prevented maturation of

92 eal part of the self-energy and an intrinsic inability to disentangle various contributions to the im

93 situ analysis of virus spread shows that the inability to disrupt Aux/IAA CC nuclear localization cor

94 n of thrombi, but has some limitations, e.g. inability to distinguish between an old and fresh thromb

95 luded potential residual confounding and the inability to distinguish between dietary and metabolic i

96 Limitation: Inability to distinguish between improvement caused by t

97 o characterize this interplay suffer from an inability to distinguish between multiple cell types, of

98 ess in human neurosciences is limited by the inability to easily apply a wide range of analysis metho

99 memories is important for survival, but the inability to effectively adapt to the trauma is a charac

100 The FDA's inability to effectively manage the safety of hundreds o

101 e allyl radical, which was attributed to the inability to efficiently delocalize the spin on a phenyl

102 Despite inability to efficiently induce cell death, the Fas C194

103 ve not been well defined, largely due to the inability to efficiently isolate VLVs that are free of v

104 Mitochondrial dysfunction, the inability to efficiently utilise metabolic fuels and oxy

105 in DNA replication fork progression and the inability to eliminate DPCs.

106 a confused, agitated state and a pronounced inability to encode new memories and sustain attention.

107 They exhibit increased quiescence, an inability to enter the cell cycle in response to hematop

108 in plasma HIV rebound, thus highlighting its inability to entirely rid the body of infection.

109 r reason for failure of HBV treatment is the inability to eradicate or inactivate the viral covalentl

110 ween-group comparison human studies is their inability to establish a causal relationship between coc

111 The inability to establish a persistent infection in mice, e

112 Limitations of the study include inability to establish causal links due to observational

113 travasation behavior is often impeded by the inability to establish complex tissue-like extracellular

114 intain functional alveolar lumens, due to an inability to establish normal apical/basal epithelial po

115 in measurement after day 42, resulting in an inability to estimate the cumulative risk of anaemia.

116 on in murine macrophages (associated with an inability to evade the maturing phagosome) and were sign

117 y include a small number of clusters and the inability to evaluate the incremental effectiveness of i

118 itations, such as technical difficulties and inability to evaluate the surrounding tissues.

119 al confounding and ascertainment bias and an inability to examine dosage effects.

120 d by these clusters is hampered owing to our inability to express these gene clusters in the laborato

121 The inability to extinguish these associations is a key fact

122 uamous cell carcinoma (SCC), anogenital SCC, inability to extract cSCC data from other malignancy dat

123 Complete passivity-the inability to extract work from equilibrium states-implie

124 ive care units is often delayed due to their inability to feed by mouth safely and competently.

125 xhibited significantly greater mortality, an inability to fight bacterial infection, heightened level

126 he inherent complexity of ecosystems and the inability to foresee all consequences of interventions a

127 of rfaG, waaL, wzzE, and wzyE resulted in an inability to form reservoirs in mouse bladders.

128 f basal cells, both in vivo and in vitro The inability to form structurally normal ducts and alveoli

129 into Pip, their Pip deficiency relies on the inability to form the 2,3-DP intermediate.

130 testing and treatment were available) and an inability to formally investigate the effect of crowding

131 ST data enabled management action despite an inability to fully model FIB dynamics in the coupled wat

132 rosis factor alpha and IL-10, indicating the inability to generate adequate protective and balancing

133 roles remain largely unknown because of our inability to generate and isolate pure populations.

134 al SOD isoform in Leishmania amazonensis Our inability to generate L. amazonensis SODA null mutants a

135 he deficiency in photorespiration due to the inability to generate lipoic acid from mitochondrially s

136 existing platforms suffer from low potency, inability to generate long-term immune memory and decrea

137 ic individuals is not a consequence of their inability to generate or experience negative emotions.

138 efect in positive selection would reflect an inability to generate the appropriate positively selecti

139 fluence the physiology of their hosts is our inability to genetically manipulate new bacterial specie

140 have a more severe cataract, as measured by inability to grade vitreous haze, gained an additional 4

141 of Plasmodium vivax genes is limited by our inability to grow the parasites in long-term in vitro cu

142 doned wearing the scleral lens because of an inability to handle the lenses, and 40 eyes wore the len

143 s life-giving organs and hospital resources, inability to honor the donor's memory and character, and

144 es to date have been limited by sample size, inability to identify confounding, and a focus limited t

145 g the treatment of concussion is our current inability to identify patients that will experience pers

146 is field has been greatly limited due to our inability to identify their alternate structures from th

147 ion for highly pigmented tumors, as does the inability to image the entire iris in a single field.

148 this disease to rapidly metastasize and the inability to improve patient outcomes, despite efforts a

149 ight to conservation, as well as the field's inability to improve predictor performance.

150 Inability to inactivate GSK3beta through Ser(389) phosph

151 ynthesis could be attributed entirely to the inability to incorporate Sec.

152 energy production to glycolysis, despite an inability to increase glucose uptake in response to IGF-

153 oped overt endothelial dysfunction due to an inability to increase NO dependent vasodilation.

154 es of cell death in complex organisms is the inability to induce and visualize this process with spat

155 re in many patients was not solely due to an inability to induce immune reinvigoration, but rather re

156 ions are consistent with our patients' sperm inability to induce oocyte activation and initiate embry

157 The main limitations of our findings are the inability to infer causality because the taxes were impl

158 Among other rationale, the inability to influence photochemical reactions with temp

159 Impulsiveness describes the inability to inhibit behaviour in the presence of salien

160 loss of agency ('helplessness'), or from an inability to inhibit the mental exploration of aversive

161 ies in A20-deficient cells, caused by cell's inability to inhibit TNF-induced NF-kappaB response.

162 high mortality rate is, in part, due to the inability to initiate an effective antifungal therapy ea

163 thermodynamic openness of a living cell, the inability to instantaneously match fluctuating supply an

164 t the whole genome scale, largely due to the inability to integrate additional informative datasets (

165 new MAbs for the cyclic epitope and to their inability to interact with the epitope in more flexible

166 g at the plasma membrane, as a result of the inability to internalize TLR4, Siglec-E-deficient dendri

167 in coupling these methods is hindered by the inability to interpret the complex exchange patterns in

168 ting medical records to assess outcomes, the inability to isolate the effect of each component of the

169 ve/motivational processing, as opposed to an inability to judge the wrongness of an action.

170 cell-lines or experimental conditions due an inability to leverage distributed processing architectur

171 As a hallmark of drug addiction is the inability to limit drug use despite negative consequence

172 We propose that these patients have an inability to link intact semantic representations with p

173 e attributed to infectious complications and inability to maintain adequate hydration and nutrition.

174 form beige adipocytes was accompanied by an inability to maintain body temperature and by hyperglyca

175 ch emphasize intrapsychic conflicts such as "inability to maintain body weight," "undue influence of

176 to a specific proliferative block due to the inability to maintain NAD(+)/NADH homeostasis.

177 ted a senescence state causing a progressive inability to maintain tissue homeostasis and proliferate

178 relationship to disease, symptomatic of our inability to make even crude quantitative assertions abo

179 iability and robustness, often leading to an inability to make scientific claims with verifiable leve

180 The inability to manage type 1 diabetes effectively during t

181 Limitations of this study included the inability to mask participants or data collectors to the

182 y owing to a paucity of animal models and an inability to measure infection directly.

183 tation of this method, thus far, has been an inability to measure or manipulate materials outside of

184 ion, but information has been limited by our inability to measure the fields below the stellar surfac

185 glucuronosyltransferase 1A1 (UGT1A1) and the inability to metabolize bilirubin.

186 s, including poor discrimination capability, inability to multiplex targets, high rates of false posi

187 us-macrophage interactions resulting from an inability to neutralize the phagosome.

188 eoff for modest reduction in sensitivity and inability to observe alternative splicing, and should en

189 A major bottleneck has been our inability to observe GCs and their degeneration in the l

190 Failure was defined as the inability to obtain a valid examination.

191 oil embolization technique is limited by its inability to occlude wide-neck aneurysms.

192 rstanding of SC structure in Drosophila, the inability to optically resolve the minute distances betw

193 sm of action of chemokine antagonists and an inability to optimize compounds in the absence of struct

194 level likely lead to position errors and an inability to orient neural projections at single-cell re

195 rmalities, cell-cycle delays, defective HRR, inability to overcome replication fork stalling, and rep

196 ck to replicative DNA polymerases due to its inability to participate in Watson-Crick (W-C) base pair

197 able to colonize intestinal crypts due to an inability to pass through the intestinal mucus layer to

198 ial growth, complete loss of conidiation and inability to penetrate the host surface by mycelia-forme

199 The inability to perceive IL-21 signals under competitive co

200 ng SPAK or OSR1 alone, DKO mice displayed an inability to phosphorylate NCC under these conditions.

201 infectious than both parents, indicating an inability to pilot DNA.

202 eir biological counterparts because of their inability to position organic molecules in three dimensi

203 h atopic dermatitis (AD) is fraught with the inability to precisely assess the age of skin lesions, t

204 covery efforts are at present hampered by an inability to precisely control the allosteric site.

205 imitations associated with their complexity, inability to precisely control the dimensions, and limit

206 e is reluctance to use DCD hearts, due to an inability to precisely identify hearts that have suffere

207 y, low cultural consonance and an associated inability to predict adaptive outcomes may activate impu

208 is so-called "stasis paradox" highlights our inability to predict evolutionary change, which is espec

209 evidence, unclear patient preferences, or an inability to predict how treatments will fit into patien

210 However, our present inability to predict the effect of genome sequence varia

211 even for those with moderate disease and the inability to predict the transition from mild to moderat

212 However, our inability to prevent diLQTS has resulted in removal of m

213 Options remain extremely limited, and our inability to prevent the frequently, often relentless sy

214 formance differences are not explained by an inability to process the social stimuli and its causes,

215 langiopathy, and this was associated with an inability to produce an alkali bile during NESLiP.

216 creased CD57 and Ig-like transcript 2 and an inability to produce IFN-gamma (p = 0.002) compared with

217 ued by inefficiency, slow conversion, and an inability to produce mature functional cells.

218 d stability in the forward direction and the inability to produce proactive anticipatory adjustments.

219 The inability to produce recombinant hMPV F glycoprotein in

220 liferation in vitro and in vivo, despite its inability to promote one-carbon metabolism.

221 The inability to propagate molluscum contagiosum virus, whic

222 tems suffer from a lack of validation and an inability to provide accurate health risk warnings in a

223 sis has not been formally tested owing to an inability to purify or track these progenitors for detai

224 in Parkinson's disease may be related to an inability to pursue reward based on complete representat

225 afficking remain tenuous, largely due to the inability to quantify key features of the actin cytoskel

226 Addiction to nicotine and the inability to quit smoking are influenced by genetic fact

227 Failure was due to inability to reach or cannulate the intact papilla or bi

228 The inability to reach the distal target zone (n=48/100) or

229 uropsychiatric disorders for reasons such as inability to readily penetrate blood brain barriers.

230 matopoiesis, and is reflected in our current inability to recapitulate the development of HSCs from p

231 in the combining site, which explains their inability to recognize LPS.

232 Crowding, the inability to recognize objects in clutter, is known to p

233 re to form a functional Cas9-gRNA complex or inability to recognize targets in vivo.

234 on in anxiety patients may be mediated by an inability to recruit the dlPFC, which mediates the cogni

235 Inability to reduce ammonia by 48 hours confers poor pro

236 3, becoming Th2-like cells, explaining their inability to regulate immune responses.

237 sm underlying our previous observation of an inability to replenish brain ATP during times of high en

238 rcuit in Neurog2(-/-);Ascl1(-/-) mutants: an inability to repress expression of Tbr1 (a deep layer VI

239 AR antagonists are ineffective due to their inability to repress the expression of AR or its splice

240 Despite what appears to be an inability to resolve concatenation between chromosomes d

241 for glycan profiling but are limited by the inability to resolve isobaric species such as linkage an

242 An inability to resolve this issue using single-Purkinje ce

243 ersist in hostile environments because of an inability to respond to inflammatory signals.

244 applications are often limited either by the inability to respond to visible light or the need for sp

245 This, and the inability to restore wild-type behaviour in the infectio

246 nding site points to steric hindrance and an inability to retain the interactions used for tryptophan

247 y decline during regeneration, suggesting an inability to return to quiescence.

248 Finally, we show that the inability to robustly repair DSBs causes some of these l

249 raphene suffers from metal contamination and inability to scale graphene growth over large area.

250 cy, complicated fabrications, high cost, and inability to scale up.

251 This defect led to an inability to sense and repair DNA torsional stress, whic

252 proliferation is not conferred solely by the inability to sense centrosome loss.

253 from severe paroxysmal pain to a congenital inability to sense pain.

254 ematopoiesis has been challenging due to the inability to separate and study normal and leukemic SCs

255 normal and diseased human intestine and the inability to separate the different functional compartme

256 An inability to shift has been implicated in disorders with

257 The inability to show the fistula in relation to normal anat

258 Insomnia and the inability to sleep affect people's health and well-being

259 condition that is associated with life-long inability to smell.

260 In young adults, an inability to solve a multistep task quickly, compounded

261 ro anti-cancer properties, is limited by its inability to specifically reach tumors following intrave

262 eatment of cancers are often hampered by the inability to specifically target neoplastic cells.

263 Despite its inability to spread systemically, PA14::hepP formed peri

264 Thus, the inability to stabilize proteins in controlled-release sy

265 Inefficient starch solubilization and the inability to standardize sugar colourants explained why

266 In untargeted metabolomics approaches, the inability to structurally annotate relevant features and

267 nt frontotemporal dementia revealed that the inability to subjectively differentiate the valence of p

268 The inability to successfully adapt to stress produces patho

269 lack of methods for early detection and the inability to successfully treat patients once diagnosed.

270 n impaired localization to chromatin and the inability to support loading of Cdc45.

271 ate (Glu)-microtubules (MTs; Glu-MTs) and an inability to support the localization of RNAs at protrus

272 ty of the E24A point mutant of EcMazF in its inability to support the substrate binding-competent con

273 cognitive overload is thought to reflect an inability to suppress non-salient information, a process

274 degrees C, which likely contributed to their inability to survive in a mammalian host.

275 The inability to sustain a vascular compensatory response li

276 The inability to switch between the oxidation of lipid and c

277 The inability to synthetically attain the diversity enabled

278 lammation within 6 months of completing ATT, inability to taper oral corticosteroids to less than 10

279 ion to induce death, but are undercut by the inability to target latently infected cells.

280 A shortcoming of these drugs is their inability to target the intractable infectious stage of

281 n, described using the analogy of a persons' inability to tickle oneself, is a reduction in the perce

282 e niT cells as a direct consequence of their inability to transfer FOXO1 to T cells.

283 hogenic bacteria is compromised due to their inability to traverse eukaryotic membranes.

284 on that restrict PDT to superficial lesions, inability to treat hypoxic tumours, and incomplete tumou

285 infarct, a substantial comorbid disease, an inability to undergo an MRI scan, or had a history of sp

286 ic exhibit greater shell dissolution and the inability to upregulate their metabolism when exposed to

287 tead, monkeys with MDmc lesions exhibited an inability to use reward to promote choice repetition aft

288 ntamination susceptibility, water usage, and inability to utilize 5-carbon sugars and disaccharides a

289 One criticism of the approach is an inability to validate its algorithms within a biological

290 inly due to limited statistical power and an inability to verify hundreds of putative biomarkers.

291 The long-standing inability to visualize connections between poxvirus memb

292 re poorly understood, largely because of the inability to visualize dynamic cell-BM interactions in v

293 on have remained largely unclear, due to our inability to visualize protein-tyrosine phosphatase oxid

294 The inability to visualize the initiation and progression of

295 on for ventricular arrhythmias is limited by inability to visualize tissue destruction, by reversible

296 Measurements: MMD, defined as the inability to walk 400 m, was assessed every 6 months for

297 (29 [54.7%] of 53, P < .001) IVIG treatment, inability to walk unaided (21 [35.0%] of 60 vs 6 [5.3%]

298 e prevalence; frequency of hospitalizations, inability to walk, bradykinesia, scoliosis, gastrostomy

299 and lead to physical disabilities, including inability to work, physical deformities, and amputations

300 and the need for disability benefits due to inability to work.