ライフサイエンスコーパス: inaccessibility

1 osomes have been hampered by the organelle's inaccessibility.

2 lencing and reversing Xist-induced chromatin inaccessibility.

3 icipate in catalysis, despite their presumed inaccessibility.

4 resumably due to substrate unavailability or inaccessibility.

5 viding a rationale for its current synthetic inaccessibility.

6 g plants has been hampered by their size and inaccessibility.

7 operties have been hindered due to synthetic inaccessibility.

8 mputational science has added a new layer of inaccessibility.

9 community is limited by their computational inaccessibility.

10 rchitecture mainly attributable to synthetic inaccessibility.

11 y because of their small size and anatomical inaccessibility.

12 t detected in preformed chromatin due to its inaccessibility.

13 t with technical difficulty due to issues of inaccessibility and instability of the requisite heteroc

14 is poorly understood, chiefly because of the inaccessibility and poor optical qualities inherent in m

15 otion in vivo are severely restricted by its inaccessibility and sensitivity to surgical trauma, so,

16 r half remain unexchanged because of solvent inaccessibility and/or hydrogen-bonded structure.

17 of high meteorological variability, physical inaccessibility, and the complex interplay between clima

18 ent repressive characteristics and chromatin inaccessibility are established.

19 ethylation associates with the silencing and inaccessibility at promoters.

20 shaped configuration is assumed based on its inaccessibility by extracellular matrix probes, caveolin

21 Apart from insecurity and inaccessibility challenges, the substantial shift of uni

22 Chromatin inaccessibility decreases dCas9 binding to other sites w

23 ta indicate that this might be due to target inaccessibility determined by sequences flanking target

24 ce sites that sorb organic species and cause inaccessibility due to physical isolation and chemical s

25 psulating guest molecules into MOFs, such as inaccessibility for larger guest molecules due to limita

26 t D segment accessibility and that J segment inaccessibility in the enhancerless minilocus resulted i

27 investigation of CSMN is severely limited by inaccessibility in the heterogeneous cortex.

28 24 in the transition state, coupled with its inaccessibility in the native state, promotes fast unfol

29 recent years, their high costs and relative inaccessibility make their use limited.

30 end of the spore, indicating the absence or inaccessibility of Alr in this region.

31 use models remains hampered by the technical inaccessibility of an accurate input function (IF).

32 ves may be explained in part by the relative inaccessibility of antibody to PsaA on the surface of en

33 fixation, the paucity of antibodies and the inaccessibility of antigens.

34 al T cells can mediate autoimmunity, but the inaccessibility of autoimmune tissues and the rarity of

35 been difficult primarily due to the relative inaccessibility of BCs to standard AAV vectors.

36 signaling have been severely hindered by the inaccessibility of bioactive proteins.

37 beta allelic exclusion does not result from inaccessibility of D beta gene segments.

38 arrier to research on Parkinson's disease is inaccessibility of diseased tissue for study.

39 nt has been limited, at least in part due to inaccessibility of early stages of human development to

40 lopment is poor, at least in part due to the inaccessibility of early stages to genetic and developme

41 ructures were found to be complicated by the inaccessibility of electrolyte counterions due to the co

42 Double mutant analysis suggests a possible inaccessibility of eye-specific protein kinase C to NORP

43 l coupling strength is determined due to the inaccessibility of gap junctions on the dendritic tree.

44 ell development are limited in large part by inaccessibility of germ cells during development.

45 -cell formation and differentiation owing to inaccessibility of germ cells during fetal development.

46 orly understood, at least in part due to the inaccessibility of germ cells to study especially during

47 flowcell of a biosensor chip, confirming the inaccessibility of Gly 1 and Lys 27 when IGF-1 is bound

48 hromosome V, RE increases HML usage, but the inaccessibility of HML without RE apparently depends on

49 ributes to neurodevelopmental disorders, the inaccessibility of human fetal brain tissue during devel

50 disease are not fully understood due to the inaccessibility of human tissues for detailed analysis a

51 the tongue (TOT) state refers to a temporary inaccessibility of information that one is sure exists i

52 necessity by the complexity, fragility, and inaccessibility of intact nervous systems, such that inv

53 The relative inaccessibility of intracellular calcium stores in the n

54 rol that PT domains exert is hindered by the inaccessibility of intrinsically unstable poly-beta-keto

55 tracellular calcium concentration due to the inaccessibility of its C1A domain, whereas PKCgamma rapi

56 reesC results, at least in part, from steric inaccessibility of its N-terminal arginine.

57 rmation of the beta 4-beta 5 loop results in inaccessibility of Met-100, thought to catalyze chromoph

58 A major barrier, however, is inaccessibility of metastatic tissue.

59 The molecular complexity of tissues and the inaccessibility of most cells within a tissue limit the

60 ding sites are unoccupied, demonstrating the inaccessibility of most of the nuclear DNA.

61 mmon source of self-knowledge failure is the inaccessibility of much of the mind to consciousness, in

62 cult to obtain because of the small size and inaccessibility of nerve terminals in the central nervou

63 play a role in synaptic plasticity, but the inaccessibility of nerve terminals to electrical recordi

64 nogenic diabetes is not yet clear due to the inaccessibility of patient samples.

65 is area has been particularly limited by the inaccessibility of peptides and proteins that are phosph

66 e in the Ca2+ release channel which leads to inaccessibility of phase 1 sulfhydryls to NEM alkylation

67 y epithelial cells to NO could be due to the inaccessibility of PKR, which is bound to inhibitor p58.

68 ons in ComGG that prevent processing and the inaccessibility of pre-ComGG to externally added proteas

69 A key obstacle has been the inaccessibility of PrP27-30 epitopes.

70 The inaccessibility of PV1 to host cell nutrients may explai

71 Other reasons include inaccessibility of services and difficulties experienced

72 However, the relative inaccessibility of somatic cells in adult animals greatl

73 The inherent inaccessibility of sweat in sedentary individuals in lar

74 The relative inaccessibility of the 13A5 epitope likely reflects eith

75 nd entry data using primary isolates suggest inaccessibility of the 2F5 and 4E10 epitopes on the vira

76 methylation, but are likely due to either 1) inaccessibility of the 5'-enhancer region in HepG2 cells

77 otein at the cell surface rather than to the inaccessibility of the antigens to Kell antibodies.

78 atial resolution, because of the geometrical inaccessibility of the brain.

79 Despite the theoretical concern regarding inaccessibility of the central nervous system to systemi

80 The inaccessibility of the clamp binding motifs in the CDP-b

81 ude the instability of the gp120 trimer, the inaccessibility of the conserved sequences, highly varia

82 The rarity and inaccessibility of the earliest primordial germ cells (P

83 icult to predict and monitor, because of the inaccessibility of the endocrine pancreas, the integrate

84 Because of the relative inaccessibility of the enthesis, the inflammatory, micro

85 r staining FFPE tissue, primarily due to the inaccessibility of the epitopes.

86 brain development in mammals because of the inaccessibility of the fetal brain in the uterine enviro

87 Collisional quenching by iodide showed more inaccessibility of the fluorophore in the myristoylated

88 ing trips has been poorly studied due to the inaccessibility of the foraging site-the open ocean-to r

89 Steric inaccessibility of the grooves to large CoHex ions leads

90 However, the fundamental inaccessibility of the human brain for invasive studies

91 try have been constrained by the fundamental inaccessibility of the human brain for invasive studies.

92 The fundamental inaccessibility of the human neural types affected by di

93 E1 endonuclease domain, explained by solvent inaccessibility of the imine bond in the enzyme-inhibito

94 remains challenging because of the relative inaccessibility of the infected tissue and the difficult

95 earing loss (ASNHL) has been hindered by the inaccessibility of the inner ear to biopsy and the lack

96 Potential mechanisms for latency include inaccessibility of the integrated viral genome, absence

97 mplexed monomers, together with the relative inaccessibility of the P14 hinge residue in the oligomer

98 a replicase; this was shown to be due to the inaccessibility of the partially base-paired CCCA.

99 que stability of MIDA boronates to a kinetic inaccessibility of the potentially reactive boron p-orbi

100 P) in the CA1 region of hippocampus, but the inaccessibility of the presynaptic terminal has prevente

101 we establish a correlation between predicted inaccessibility of the pyrimidine tract and IRES activit

102 cine products could be due to the absence or inaccessibility of the relevant epitopes.

103 mutant toward peroxides was not a result of inaccessibility of the remaining thiol as demonstrated b

104 use of the high spatial variability of R(S), inaccessibility of the soil medium and the inability of

105 ormational changes on the ensemble level and inaccessibility of the structural details from experimen

106 rks is challenging due to the complexity and inaccessibility of the system.

107 studies, with limited study in humans due to inaccessibility of the target brain tissue.

108 lished crystal structure showing the solvent inaccessibility of the target lysines.

109 The reason is probably, in part, due to the inaccessibility of the targeted extracellular structures

110 und in plant genomes, diverse reactivity and inaccessibility of their substrates and products.

111 synaptic terminals have been hampered by the inaccessibility of these synapses to soluble reagents.

112 the C1'-position of nucleotides, despite the inaccessibility of this hydrogen in duplex DNA.

113 The inaccessibility of U8 in the canonical L-shaped form of

114 st that tight Cdh1 binding combined with the inaccessibility of ubiquitinatable lysines contributes t

115 The inaccessibility of uniform-diameter, single-chirality ca

116 lifespan of less than 6 months, geographical inaccessibility precluded return for follow-up visits, t

117 in a manner previously impossible because of inaccessibility to early human embryonic tissues.

118 Inaccessibility to individual data and time-to-event dat

119 omplexity of phenotypes, and until recently, inaccessibility to large numbers of genes that might und

120 site spatiotemporal resolution; however, the inaccessibility to light of widely distributed neuronal

121 ription activation concomitant with promoter inaccessibility to restriction enzyme digestion.

122 ystem has been hampered by their paucity and inaccessibility to single-cell measurements.

123 me ligands such as cyanide, indicating their inaccessibility to the heme.

124 ricular tachycardia (VT) can fail because of inaccessibility to the VT substrate.

125 Lack of adherence, inaccessibility to viral reservoirs, long-term drug toxi

126 This inaccessibility, together with the generally low mobilit

127 An assay based on biotin inaccessibility was used for alpha1 subunits.

128 Additionally, due to central nervous system inaccessibility we undertook quantification of phosphati

129 nd show that they induce both cell death and inaccessibility when transiently expressed in Mla10 and