ライフサイエンスコーパス: inaccessible

1 and selectivity levels that were previously inaccessible.

2 ion of pancreatic beta-cells remains largely inaccessible.

3 nlock oil and gas reserves previously deemed inaccessible.

4 instead cover the RSS, thereby rendering it inaccessible.

5 cH10-binding site of the catalytic module is inaccessible.

6 th biomolecular function and were previously inaccessible.

7 mense opportunity remains untapped or simply inaccessible.

8 to a substantial amount of information being inaccessible.

9 n hormone withdrawal their chromatin becomes inaccessible.

10 ypothesized, but ice stream beds are largely inaccessible.

11 ed by MTSEA, suggesting that this residue is inaccessible.

12 lacements of oxygen atoms that are otherwise inaccessible.

13 s that thus far have remained experimentally inaccessible.

14 of individual cells is often experimentally inaccessible.

15 wide variety of new 2D materials previously inaccessible.

16 ing the corresponding reaction intermediates inaccessible.

17 potential mechanisms that are experimentally inaccessible.

18 chromatin function that have been heretofore inaccessible.

19 ethod validation and optimization previously inaccessible.

20 mes of cellular regions that were previously inaccessible.

21 se of a metamaterial is initially completely inaccessible.

22 molecular-based refrigeration-have remained inaccessible.

23 on and analysis of fitness landscapes mostly inaccessible.

24 chnology, STR variation has remained largely inaccessible across many individuals compared to single

25 One in 5 OHCAs occurred near an inaccessible AED at the time of the OHCA.

26 f electronic/photonic devices with currently inaccessible and likely unimaginable functionalities.

27 access to molecules that would otherwise be inaccessible and the development of more efficient synth

28 y observable macroscale granular dynamics to inaccessible and/or indirectly measured molecular hydrod

29 ces, thus opening a wide range of previously inaccessible applications for voltage-sensitive dyes.

30 telemedicine in areas where intensivists are inaccessible are potential strategies that may improve q

31 We also imaged previously inaccessible areas of cells such as the side surfaces of

32 the parent chlorides, which were previously inaccessible as coupling partners.

33 rs the unique opportunity to study otherwise inaccessible aspects of human beta cell development and

34 noid development, and illuminates previously inaccessible aspects of human liver development.

35 By allowing us to predict experimentally inaccessible aspects of microcompartment function, such

36 tes in high-energy states that are otherwise inaccessible at ambient temperature.

37 DFT) analysis, it might be thermodynamically inaccessible at our experimental conditions.

38 s demonstrate that the high-affinity site is inaccessible because of either a conformational change o

39 features of Ov population biology previously inaccessible because of the limited availability of para

40 ion within the amorphous matrix has remained inaccessible, because experimentally decomposing the mec

41 cts of the decision-making process that were inaccessible before.

42 tings will enable a wide range of previously inaccessible biomedical applications.The fabrication of

43 on can be applied to synthesize a previously inaccessible BN isostere of ethylbenzene, a compound of

44 tric tissue examinations in various directly-inaccessible body cavities are envisioned.

45 ium between KaiA-accessible exposed and KaiA-inaccessible buried positions.

46 This was quantified by calculating the lipid-inaccessible buried surface area of the proteins in the

47 ort novel drug-to-target binding predictions inaccessible by 2D fingerprints and confirm three of the

48 ologic regions of the lung, especially those inaccessible by bronchoscopy, to increase in situ effica

49 stigate these phenomena at a level currently inaccessible by direct observation, we developed a compu

50 opportunities to study biological structures inaccessible by existing methods in a minimally invasive

51 oduces coherent radiation in spectral ranges inaccessible by lasers and constitutes the key to ultima

52 ng of fermionic many-body systems in regimes inaccessible by modern theoretical methods.

53 by the interpretation of 'force', which are inaccessible by most of the other analytic techniques.

54 chain dynamics to be probed in a time range inaccessible by NMR.

55 vides the means to generate therapeutic ADCs inaccessible by other methods that are efficient in thei

56 ng the opportunity of stabilizing new states inaccessible by quasi-adiabatic pathways.

57 utes a member of an analogue class presently inaccessible by semisynthetic derivatization of the natu

58 mations not known in biology, and reactivity inaccessible by small-molecule catalysts.

59 and used to generate a protein bioconjugate inaccessible by solution-phase batch sortagging.

60 access to a unique set of microbes that are inaccessible by standard cultivation.

61 , also known as viologens, that proved to be inaccessible by the classical two-step route.

62 f a cyclohex-3-enecarbaldehyde motif that is inaccessible by the Diels-Alder cycloaddition.

63 e used to form several solid-state compounds inaccessible by traditional synthetic routes, but there

64 production of complex heterocycles that are inaccessible by typical synthetic methods.

65 a large number of novel RNA regulatory sites inaccessible by uniquely mapped reads.

66 e anions were found to template an otherwise inaccessible capsular structure in a manner usually asso

67 lecular deactivation and stabilizes solution-inaccessible catalysts for broad-scope organic transform

68 e and transferase domains creating a solvent inaccessible cavity.

69 observe the behavior of specific and usually inaccessible cells, such as human motor neurons.

70 e chemical nature of complex, experimentally inaccessible cellular microenvironments, such as the hum

71 the obstacles of drug delivery to the highly inaccessible chondrocytes.

72 tivation of enhancer elements located within inaccessible chromatin may contribute to the ability of

73 quired for myoblast proliferation, was in an inaccessible chromatin state in the SE-Brg1 mutant, sugg

74 e associated with an underlying inactive and inaccessible chromatin state, indicative of their select

75 exists in a heterochromatic state defined by inaccessible chromatin that is marked by H3K9me2 and H3K

76 recognise and bind their target sequences in inaccessible chromatin to establish new transcriptional

77 s (NDRs), a fraction of promoter copies with inaccessible chromatin was detected and enriched upon se

78 In some instances, GATA3 binds previously inaccessible chromatin, characterized by stable, positio

79 ions and, remarkably, fall within regions of inaccessible chromatin, suggesting that TP53 has intrins

80 ound enhancers are located within regions of inaccessible chromatin.

81 We report routes to previously inaccessible classes of 3D constructs in advanced materi

82 extend single-molecule studies to previously inaccessible classes of receptors.

83 al for enhancer activity that are located in inaccessible, closed chromatin regions.

84 cal DNA methylation patterns from previously inaccessible cohorts, and reveal novel survival differen

85 The previously inaccessible combinations of high stiffness, damping and

86 heterogeneous, protease-resistant, antibody-inaccessible compartments.

87 chanism will facilitate access to previously inaccessible complex crystalline systems from racemic an

88 n used to explore additional, experimentally inaccessible conditions to predict when increased local

89 the IL-2 promoter to retain the locus in an inaccessible configuration.

90 problematic bacterial colonization within UV-inaccessible confines where chemical techniques have fou

91 d characterize the dynamics of what had been inaccessible conformations of the DNA-protein complex.

92 rest occur in optically opaque or physically inaccessible contexts, necessitating approaches other th

93 ic and magnetic torques, enabling previously inaccessible control of light.

94 Mutations at solvent-inaccessible core positions in proteins can impact funct

95 It, therefore, makes available previously inaccessible data, offering new insights and providing a

96 be useful for the assembly of many otherwise inaccessible DNA nanostructures and help to increase the

97 y of individual neurons has remained largely inaccessible due to the large TMS-induced electromagneti

98 n studies in plants remain underutilized and inaccessible due to the use of disparate transcriptome r

99 We hypothesized that these cryptic 3'SS are inaccessible during normal splicing catalysis and that t

100 s-molecular events that have previously been inaccessible experimental analysis.

101 neural probes, which may support previously inaccessible experimental and clinical research.

102 ate the correlated plasma regime, previously inaccessible experimentally in two-dimensional electron

103 c control of proteins has revealed otherwise inaccessible facets of signaling dynamics.

104 variety of nut species, including otherwise inaccessible foods.

105 hose of interlayers and are therefore rather inaccessible for anions.

106 bodies, but in many viruses, parts of V3 are inaccessible for antibody recognition.

107 owever, human hypothalamic cells are largely inaccessible for direct study.

108 50% of the cortical surface was effectively inaccessible for long-range diffusion tracking because o

109 to specialised clinical centres and remains inaccessible for most patients.

110 found that sequestration of Y551 renders it inaccessible for phosphorylation.

111 in keratinocytes, presumably by rendering DP inaccessible for protein kinase C (PKC) phosphorylation.

112 This inaccessible fraction amounts to 66% in nanodiscs and 82

113 ived, structurally more complex vinblastines inaccessible from the natural product itself that are a

114 o adopt what are otherwise thermodynamically inaccessible functional conformations.

115 t predicts accessible and, more importantly, inaccessible gene-regulatory chromatin regions solely re

116 limited to the prediction of accessible and inaccessible gene-regulatory chromatin regions, but cons

117 ables the functional discovery of previously inaccessible genes or domains with phenotypes masked by

118 l analogues can be used to shed new light on inaccessible gravitational objects.

119 of new insights gained from these previously inaccessible groups is providing a deeper understanding

120 DNase accessible H3K27Ac-rich chromatin and inaccessible H3K27Ac-depleted MaLR-enriched chromatin.

121 map the physical 3D structure of previously inaccessible habitats and demonstrates the complexity an

122 ctively-have been used to realize previously inaccessible heterostructures with interesting physical

123 hich do not exist in isolated chains and are inaccessible in bulk films where they are present but ma

124 a conducting polar monoclinic oxide that is inaccessible in compositionally identical films grown on

125 ticolor tuning in a single crystal, which is inaccessible in conventional upconversion nanoparticles.

126 thogenesis is scarce because brain tissue is inaccessible in life.

127 al testing, which is complex, expensive, and inaccessible in many settings.

128 insically favor nucleosome formation and are inaccessible in other cell types without p63 to prevent

129 re prophylaxis, but this is costly and often inaccessible in rural Africa.

130 wide array of C-H transformations previously inaccessible in synthesis.

131 to achieve tailored functionalities that are inaccessible in the bulk form.

132 ouse mouse, thereby unmasking gene functions inaccessible in the domesticated mutant model.

133 ode resonances with characteristics that are inaccessible in their 'ideal' counterparts.

134 rials with physical and transport properties inaccessible in their constituents or poorly prepared mi

135 sponse to the tidal stress carries otherwise inaccessible information about fault strength and rheolo

136 imaging techniques provide complementary and inaccessible information compared to conventional X-ray

137 Our approach provides previously inaccessible insight into the topology of eukaryotic chr

138 The previously inaccessible intermediates, trapped by ethyl propiolate,

139 e here the population genetics of previously inaccessible intestinal microbes, providing a comprehens

140 ovel antibiotics by targeting the previously inaccessible intracellular reservoir in KCs.

141 t attainable in the isolated, but chemically inaccessible, [IrO6](8-) species (the simplest molecular

142 be extended to the preparation of previously inaccessible key analogues that contain deep-seated stru

143 al growth transitions that is independent of inaccessible kinetic parameters.

144 ation that can resolve processes on hitherto inaccessible length and time scales.

145 novel engineered disulfide bond at a solvent inaccessible location in the CH2 domain.

146 Both inaccessible meso-/micropore size distributions decrease

147 CMP-based biomaterials and enable previously inaccessible molecular designs.

148 plicable to a tremendous range of previously inaccessible molecular targets.

149 , but also provide a pathway to a previously inaccessible morphology.

150 such description ultimately relies on often inaccessible multi-particle information.

151 res will enable future studies of previously inaccessible nanoscale magnetism in condensed-matter sys

152 Given the sheer scale and inaccessible nature of contaminated areas, phytoremediat

153 n and is applicable to classes of previously inaccessible neuronal and non-neuronal cells in vivoSIGN

154 odynamic reach" for inspiration of otherwise inaccessible odors.

155 the <1 nm pores, and all pores <0.25 nm, are inaccessible or closed to CO2, suggesting that despite t

156 nature of binding by improving on previously inaccessible or inaccurate multibody and many-electron c

157 redox potential, a previously experimentally inaccessible parameter.

158 nipulation of the packaged RNA, a previously inaccessible part of the viral architecture.

159 Inaccessible PAS-HAMP surfaces overlapped with a cluster

160 Other engineered yeasts produce previously inaccessible pathway intermediates and a novel derivativ

161 cell (iPSC) technologies enable the study of inaccessible patient cell types, cellular heterogeneity

162 key structural features and yield otherwise inaccessible phases, but the extent to which crystal str

163 The ratio of volumes of inaccessible pores (<4 mum) to bioaccessible pores (>4 m

164 ified by focusing on structures with methane-inaccessible pores blocked away from the main adsorption

165 s show that surface fractal dimension D s of inaccessible pores is greater than that for total pores

166 ntegration and utilization of the previously inaccessible pores.

167 Overall, a large value of inaccessible porosity occurs at pore diameters <10 nm, w

168 Multi-scale (five pore-diameter intervals) inaccessible porosity to N2 was determined using SANS an

169 magnetic resonance imaging (fMRI), a highly inaccessible procedure.

170 We generate light fields with previously inaccessible properties by avoiding these uncontrolled c

171 ias reaction pathways and activate otherwise inaccessible reactions.

172 have opened the door to activating otherwise inaccessible reactions.

173 hotorefractive polymer (PRP) in a previously inaccessible regime located between millisecond and micr

174 y because the stem initiates in a relatively inaccessible region of the shoot apical meristem called

175 tion as genomic first responders, binding to inaccessible regions of chromatin to promote enhancer fo

176 actor activity and binds within structurally inaccessible regions of chromatin.

177 tion enclosed in such a pattern is typically inaccessible, since the complete distribution can be vis

178 ting electronically unique and homogeneously inaccessible single-site solid catalysts for organic syn

179 erials, systematically exploring a typically inaccessible site in the molecule enlisting a powerful f

180 nucleophilic coupling handle at a previously inaccessible site of 2,1-borazaronaphthalenes.

181 ng ETS-1 and RUNX1 recruitment to previously inaccessible sites.

182 ese processes, which has been experimentally inaccessible so far, is essential for further advances.

183 uld produce protonated CO2, an energetically inaccessible species that can be avoided by transfer of

184 it can be switched to a metastable thermally inaccessible spin state via visible/near-IR light at cry

185 these elements maintain the V1V2 loop in an inaccessible state and which expose V1V2 and/or V3 epito

186 We label previously inaccessible subpopulations of noradrenergic neurons to

187 This method provides access to previously inaccessible sulfur isotope-labeled substrates for sulfu

188 adiofrequency (RF) electric-fields may reach inaccessible targets in vivo.

189 cular square complexes, including previously inaccessible targets, through the use of ball milling me

190 species and clinical research of previously inaccessible targets, which is a testament to the creati

191 patients by providing information currently inaccessible through conventional MRI techniques.

192 dness and drug resistance haplotypes that is inaccessible through conventional sequencing of infectio

193 to access a "forbidden glass" regime that is inaccessible through thermal history or pressure history

194 on oxygen-evolving catalyst film, which was inaccessible thus far due to the lack of tdelay control,

195 It calls for studies at hitherto inaccessible time and length scales, and therefore for s

196 r tissues with a limited cell population and inaccessible tissue types.

197 ference, one can impute expression levels in inaccessible tissues in non-GTEx expression studies.

198 to impute gene expression in uncollected or inaccessible tissues.

199 cell type expression dynamics in previously inaccessible tissues.

200 s), provides functional complexity otherwise inaccessible to a single gene product.

201 ong immunogenicity, the target epitopes were inaccessible to Abs on intact spirochetes, suggesting a

202 Although early memories are inaccessible to adults, early-life events, such as negle

203 presence of preparation and detection noise (inaccessible to all parties) may be so strong to prevent

204 l properties of DX-based assemblies that are inaccessible to all-atom based models alone.

205 model captures junction properties that are inaccessible to all-atom studies, opening the possibilit

206 lex features identified here would have been inaccessible to analysis using previous methods.

207 plethora of chemical environments previously inaccessible to analysis, with unprecedented sensitivity

208 the HIV envelope (Env) spike are relatively inaccessible to antibodies (Abs) compared to their expos

209 light-driven water splitting using a pathway inaccessible to biology and report on a widely applicabl

210 l production remain elusive and subsequently inaccessible to biomimetic strategies.

211 on of silks remains elusive and subsequently inaccessible to biomimetic strategies.

212 Despite this, it remains essentially inaccessible to biosynthetic approaches.

213 suggesting that the presence of MA made Env inaccessible to biotinylation.

214 osolically shielded environment and remained inaccessible to both cytosolic and lumenal compartments

215 on among single cells can reveal information inaccessible to cell-population averaged measurements.

216 cessors promise fast algorithms for problems inaccessible to classical computers.

217 se of its intracellular localization, p53 is inaccessible to classical therapeutic monoclonal antibod

218 limates previously occurred, and are thereby inaccessible to climate migrants tracking isotherms: 16%

219 entirely above the Fermi level, making them inaccessible to conventional angle-resolved photoemissio

220 , a third of the genes of barley are largely inaccessible to conventional breeding programmes as cros

221 Muscles inaccessible to conventional clinical and electrophysiol

222 l RNA genes and the centromeres, are largely inaccessible to current sequencing and assembly methods

223 occur with a time constant of several hours, inaccessible to current single-molecule approaches.

224 Thus, many of these compounds are still inaccessible to date.

225 is especially so over millennial timescales inaccessible to direct observation.

226 Internal stellar magnetic fields are inaccessible to direct observations, and little is known

227 ly when the target C-H bond is geometrically inaccessible to directed metallation owing to the ring s

228 Nucleosomal DNA is thought to be generally inaccessible to DNA-binding factors, such as micrococcal

229 isk for reinitiating infection within niches inaccessible to drugs, and tuning viral control of migra

230 r of information on genome structure that is inaccessible to each approach independently.

231 xadecapoles and describe the ensuing bonding inaccessible to elastic dipoles, quadrupoles and other n

232 logy in a huge variety of systems previously inaccessible to electrode-based measurements.

233 of capsid assembly and maturation have been inaccessible to examination in living cells.

234 ied for amorphous and glassy states that are inaccessible to existing methods.

235 aces efficiently, remains a mystery thus far inaccessible to experiment.

236 orbing microporous materials suddenly become inaccessible to guest molecules below certain temperatur

237 ist by growing in places that are physically inaccessible to herbivores, or can persist where high pr

238 by experimental structure determination and inaccessible to homology modeling.

239 s for scientific exploration in environments inaccessible to humans, from distant planets to deep oce

240 and reveals functional interactions that are inaccessible to individual studies.

241 also neuromotor noise, typically regarded as inaccessible to intervention.

242 pen-source bacterial genome assembly remains inaccessible to many biologists because of its complexit

243 , palliative care expertise is conspicuously inaccessible to many patients with ILD.

244 as separations possible that were previously inaccessible to membranes.

245 ome of the small (sodalite) cages, otherwise inaccessible to most molecules.

246 particles, however, makes Cerenkov emission inaccessible to most nanoscale electronic and photonic d

247 calculation of their spectra, which has been inaccessible to most users due to the high computational

248 the ability of neutrons to probe pore spaces inaccessible to N2 and mercury.

249 to solve complex, structured tasks that are inaccessible to neural networks without external read-wr

250 cally colonized by complex consortia and are inaccessible to observation.

251 l control of biological processes previously inaccessible to optogenetic control has developed rapidl

252 give rise to useful characteristics that are inaccessible to ordered states.

253 t loci within regions of the genome that are inaccessible to other DNA-targeting molecules.

254 nformation in the optical near field that is inaccessible to other optical microscopy methods can be

255 and have therefore been rendered relatively inaccessible to pediatric recipients under KAS.

256 eavage site between CA and p10 appears to be inaccessible to PR.

257 XPCI to areas which were unpractical or even inaccessible to previous XPCI solutions.

258 n of the motif from a target gene renders it inaccessible to REF6 in vivo.

259 e lumen of engaged mother centrioles becomes inaccessible to SAS-6, correlating with a block for redu

260 solution access to structural variants often inaccessible to shorter reads.

261 f thousands of cells, with a level of detail inaccessible to similar methods.

262 ally populated and transiently formed, it is inaccessible to standard NMR approaches.

263 iate conformations, which makes them largely inaccessible to standard structure determination methods

264 e identified subtle but relevant differences inaccessible to subjective conceptualization.

265 biomass would quickly accumulate and become inaccessible to terrestrial food webs and the global car

266 ountries where high-tech diagnostic aids are inaccessible to the bulk of the population.

267 (13 patients) or because lobar segments were inaccessible to the endobronchial valves (3 patients).

268 ion of resources that would otherwise remain inaccessible to the host, such digestive actions alone c

269 to use, and read-level data are practically inaccessible to the non-computational immunologist.

270 This renders the gene inaccessible to the transcriptional machinery and preven

271 transient states, and asynchronous dynamics inaccessible to these standard techniques.

272 nation centres are located in urban centres, inaccessible to those in rural areas.

273 ground state (Rg = 14.7 A) and is therefore inaccessible to time-resolved protein crystallography.

274 ive because this abiotic-biotic interface is inaccessible to traditional structural methods.

275 be engaged in biological activities that are inaccessible to well folded proteins with their unique s

276 behave as structural analogues of otherwise inaccessible 'toy' spin models and also how the theoreti

277 Intriguingly, these inaccessible TP53 binding sites feature several enhancer

278 ability to measure frequencies of previously inaccessible transitions makes possible improved determi

279 ron provides access to a range of previously inaccessible triazinyl radicals with excellent benchtop

280 d aromatic amines including those previously inaccessible using CH amination methods.

281 n of transparent glass structures previously inaccessible using conventional glass fabrication proces

282 environments (including rare media typically inaccessible using established methods), unusual organic

283 rt-butylphosphinoborane), that are currently inaccessible using other routes (e.g. catalytic dehydroc

284 These observations are inaccessible using standard bulk techniques like X-ray a

285 nic functional groups that are energetically inaccessible using traditional HAT-based approaches.

286 rial surfaces in complex geometries that are inaccessible using traditional soft lithography techniqu

287 ot only the natural product but also analogs inaccessible via bioengineering.

288 allows the preparation of biaryls previously inaccessible via decarboxylative methods and holds other

289 talline materials with compositions that are inaccessible via direct synthetic routes.

290 Inaccessible via photoluminescence, these states are oft

291 ormation under physiological conditions thus inaccessible via X-ray crystallography.

292 bility of the amine binding sites, which are inaccessible when they strongly interact with the silica

293 ion about low rotational mobilities that are inaccessible with bulk fluorescence anisotropy approache

294 transiently populated intermediates that are inaccessible with existing single-molecule approaches.

295 and coronary artery disease that were simply inaccessible with other techniques.

296 to create 2D materials that were previously inaccessible with preexisting methods.

297 erates acyl zirconium(IV) complexes that are inaccessible with the Schwartz reagent, including those

298 sound pressure levels of 90.1 dB, which are inaccessible with the unprotected films.

299 s probe subsurface carrier dynamics that are inaccessible with traditional optical techniques.

300 inal exposed and the azide terminal deep and inaccessible within the cavitand.