ライフサイエンスコーパス: inactivation

1 as a potential surrogate marker for BRCA1/2 inactivation.

2 less efficacy in opening the pore, producing inactivation.

3 ted in phenotypic changes identical to SCCRO inactivation.

4 cient for Xist spreading during X-chromosome inactivation.

5 hat may be critical contact points for toxin inactivation.

6 MPK activation but contributed to subsequent inactivation.

7 ng Ca(2+) currents with considerably reduced inactivation.

8 in human cells by CRISPR/Cas9-mediated gene inactivation.

9 expression of hypoxic genes upon complex II inactivation.

10 of Xist, the noncoding RNA responsible for X inactivation.

11 icular pools of active R-ras, leading to its inactivation.

12 xidation data for percentage of X-chromosome inactivation.

13 rats exhibited ACD renewal regardless of PL inactivation.

14 ding that protects LPMOs from oxidative self-inactivation.

15 intense processing conditions led to enzyme inactivation.

16 ugh extracellular signal-related kinase/MAPK inactivation.

17 dentified 21 small molecules that induce HSC inactivation.

18 nt-free Na(+) one, and fast Ca(2+)-dependent inactivation.

19 TOR inactivation abolishes ROP2 regulation of translation re

20 tenascin C-associated rigidity, with p-Mypt1 inactivation/actinomyosin-mediated contractility to faci

21 However, we report that PL inactivation after training attenuates responding in the

22 STAT3 inactivation also results in abnormal morphology of repa

23 the delicate conformational coupling of the inactivation and activation gates.

24 efore provide important links between Crebbp inactivation and Bcl2 dependence and show a role for Cre

25 5% of the total IHC Ca(2+) current with slow inactivation and confer high sensitivity to nifedipine a

26 and redox inactivation of Sirt3 lead to SOD2 inactivation and contributes to the pathogenesis of hype

27 idal activities were retained following heat inactivation and drying of the yeast into tabular formul

28 explanation for the cooperation between p16 inactivation and Kras activation in PDAC development and

29 HFM provides a promising method of pathogen inactivation and may lead to new developments in sanitat

30 als3 relevant for human disease of TSC1/TSC2 inactivation and mTORC1 hyperactivity.

31 Following gene inactivation and replacement in human cells, we demonstr

32 total Ca(2+) current in IHCs displaying fast inactivation and resistance to 20 mum nifedipine, a l-ty

33 ase important for initiation of X-chromosome inactivation and XIST transcription in ES cells, also pl

34 t a transcriptional profile similar to TORC1 inactivation, and deletion of pab1 overcomes the repress

35 by altering OSK targeting, somatic-enhancer inactivation, and pluripotency enhancer selection.

36 elope glycoproteins, leading to irreversible inactivation; and (iii) exposure of cryptic epitopes to

37 erior colliculus is suppressed by reversible inactivation, animals should still show changes in perce

38 Antibiotic inactivation, antibiotic target alteration and antibioti

39 Using acute inactivation approaches and live-cell imaging in Drosoph

40 NF2 mutations and/or Merlin inactivation are also seen in other cancers including so

41 KII)-dependent alterations in NaV1.5 channel inactivation are emerging as a critical determinant of a

42 Kras activation and p16 inactivation are required to develop pancreatic ductal a

43 ta signaling and cancer cell-intrinsic RUNX3 inactivation as aggravating factors for genomic instabil

44 c, and pH stability by using Thermofluor and inactivation assays in order to evaluate potential SAT2

45 In light of the observed CBP21 inactivation at higher H2O2 levels, we conclude that con

46 explain why it does not trigger X chromosome inactivation at this stage.

47 sage compensation requires two mechanisms: X inactivation balances X gene output between males (XY) a

48 Our findings suggest a mode of Hsp70 inactivation by AMPylation and point toward a role for p

49 In particular, BiP inactivation by AMPylation of its SBD does not disturb H

50 s with cell culture medium showed that virus inactivation by detergents is annulled at physiological

51 Instead, these proteins prevented PTP1B inactivation by H2O2 Intriguingly, we discovered that Tr

52 However, inactivation by O2 remains an obstacle that prevents the

53 GSK-3 inactivation by PKB abrogates phosphorylation of Cbl-b a

54 However, apo-hemopexin is vulnerable to inactivation by reactive nitrogen (RNS) and oxygen speci

55 rendered the protein completely resistant to inactivation by S-glutathionylation, and a mutant expres

56 presence of purified CobB protects TopA from inactivation by such non-enzymatic acetylation.

57 te XI by protecting one X in both sexes from inactivation by XIST, the noncoding RNA that silences th

58 ng that the tumor-promoting effect of E2F7/8 inactivation can be partially compensated via E2F1-depen

59 oversial, but, based on the finding that Rac inactivation can rescue cytokinesis failure when the GTP

60 naling pathway, revealing that BMP signaling inactivation causes exhaustion of lipid reserves in soma

61 In females, erasure follows loss of X inactivation, causing X dosage excess.

62 s of most genes that escape XCI and at the X-inactivation center, validating this epigenetic mark as

63 ed distinct transcriptional and X chromosome inactivation changes associated with the early and late

64 Pten inactivation created an abnormal perivascular proliferat

65 o higher pH values and a slight shift of the inactivation curve to lower pH values.

66 r an additional hyperpolarizing shift of the inactivation curve.

67 tivation kinetic models was fit to the viral inactivation data.

68 switched from Context A to Context B, but PL inactivation decreased responding only in Context A.

69 Here, we show that temporary FEF inactivation decreases all aspects of functionally relat

70 Instead, FEF inactivation delayed the onset of saccade-related accumu

71 mPFC inactivation did not impair spatial learning or retrieva

72 Contrary to predictions, inactivation disrupted model-based behavior without affe

73 a role in determining the rate at which the inactivation domain dissociates.

74 cterized serines within the Kv3.4 N-terminal inactivation domain eliminated the effects of CaN inhibi

75 n is a rate limiting step for release of the inactivation domain, and highlights the functional speci

76 he propensity of some human proteins towards inactivation due to disease-associated mutations and pol

77 h loop of RF1, which enables its conditional inactivation during cell lysis.

78 ent phosphorylation status of Spc110, or its inactivation during the induction of a DNA lesion, gener

79 Despite markedly different inactivation dynamics, there was no difference in AP par

80 Conditional inactivation experiments previously demonstrated that ex

81 reprogramming and immediately initiate their inactivation genome-wide by inducing the redistribution

82 Furthermore, skewed X chromosome inactivation has been found in the thyroid condition, Gr

83 tical output with lesions or pharmacological inactivation has identified movements that require motor

84 The enzyme inactivation higher than 99% was obtained at 100% amplit

85 shown to have diverse roles in X-chromosome inactivation, imprinting and double-strand break repair,

86 germline NF1 mutations and found somatic NF1 inactivation in 74% of the PN.

87 However, its systemic inactivation in adult mice induces T-cell acute lymphobl

88 for genomic instability.Significance: RUNX3 inactivation in cancer removes an antioxidant barrier ag

89 stability, which are also compromised by p53 inactivation in cancer.

90 Similarly, Gi-DREADD-mediated inactivation in conjunction with response-outcome condit

91 al et al. (2015) to perform conditional gene inactivation in Drosophila.

92 t (Xist) RNA during the earliest stages of X inactivation in embryonic stem cells and is dependent on

93 Effects of conditional Lis1 inactivation in excitatory pyramidal neurons, starting i

94 Cic inactivation in mice induces T-ALL by a mechanism involv

95 ineage cells, with evidence that its genetic inactivation in mice is sufficient to drive acute myeloi

96 ineage cells, with evidence that its genetic inactivation in mice is sufficient to drive acute myeloi

97 two-photon calcium imaging, and optogenetic inactivation in mice.

98 er persistent sodium current and depolarized inactivation in neurons from F1.Q54 animals.

99 We also showed that NF-kappaB inactivation in oligodendrocytes aggravated IFN-gamma-in

100 Here the authors show that Ccdc88b inactivation in T cells prevents colitis in a transfer m

101 this process by examining the effects of its inactivation in the differentiating spermatogonia, sperm

102 d Bcl2 dependence and show a role for Crebbp inactivation in the induction of Myc expression.

103 ecapitulating phenotypes reported with Slit3 inactivation in the mouse.

104 r 11 (GDF11) and an unusual mechanism of its inactivation in TNBC.

105 erance to morphine and kappa opioid receptor inactivation in vivo.

106 approach (ie, autoclaving, boiling, chemical inactivation, incineration, or encapsulation) followed b

107 tional rearrangement required for proteinase inactivation, increase the risk of venous thrombosis.

108 ing or salt intake following salt depletion; inactivation increased saline intake after dehydration a

109 xpression of human MYCN in the context of Rb inactivation increased the expression of MYC-, E2F-, and

110 The activation enthalpy and free energy of inactivation indicated an endothermic reaction, not spon

111 We provided evidence that KIT inactivation induces global DNA hypomethylation, restore

112 Acid inactivation is a hallmark of viruses that enter via low

113 tion factor involved in myelopoiesis and its inactivation is associated with acute myeloid leukemia (

114 s a master regulator of myelopoiesis and its inactivation is associated with acute myeloid leukemia.

115 X-chromosome inactivation is established during early development.

116 Furthermore, BRCA1 inactivation is strongly associated with 10 kilobase ta

117 We also find that escape from X-inactivation is tissue-specific, with leg muscle showing

118 d (iii) that, in the total absence of C-type inactivation, KcsA's mode-shift was prevented.

119 A suite of inactivation kinetic models was fit to the viral inactiv

120 nstant for the transition state, to describe inactivation kinetics of enzymes and micro-organisms sub

121 At 70-80 degrees C, the thermal inactivation kinetics was best described by a biphasic m

122 specific DNA repair proteins and/or that NMD inactivation may lead to aberrant mRNAs leading to synth

123 ese findings provide novel insights into the inactivation mechanism of TNFalpha and the basis for str

124 ation profiles and identify their reversible inactivation mechanism(s).

125 of carbapenemase production, the carbapenem inactivation method (CIM), was recently described.

126 assay, a molecular test, and the carbapenem inactivation method (CIM).

127 nual Blue Carba, and the modified carbapenem inactivation method for the detection of any CPE.

128 romogenic assays and the modified carbapenem inactivation method.

129 The characteristic inactivation model parameters, standard activation entha

130 +) channel harboring a selenocysteine in its inactivation motif, as a non-photonic, sensitive, gateab

131 iscovered that in budding yeast, kinetochore inactivation occurs by reducing the abundance of a limit

132 NCX inactivation occurs in the absence of phosphatidylinosit

133 In these studies, we observe that inactivation of a cis-acyltransferase (AT) domain to cir

134 a refractory period (e.g. G protein), and 3) inactivation of a factor needed for Fshb induction (e.g.

135 As proof of principle, we demonstrated that inactivation of a non-essential gene not previously foun

136 Depletion or inactivation of a ROCK-dependent regulator of actin remo

137 vel appetitive odor learning is sensitive to inactivation of adult-born neurons, revealing that devel

138 Importantly, the depletion or inactivation of Akt or Skp2 abrogated Hippo signal defic

139 Inactivation of alpha2-antiplasmin was comparable to pha

140 Inactivation of AMT1;2 by direct interaction with CIPK23

141 ng and extinction paradigms, pharmacological inactivation of area 25 decreased the autonomic and beha

142 tes of negative emotion expectation, whereas inactivation of area 32 increased them via generalizatio

143 The effect was anatomically specific, as inactivation of areas outside ML did not affect face det

144 Inactivation of basophils ('basophil anergy') was observ

145 Inactivation of BLA terminals in the OFC, but not OFC te

146 ba(-/-)) and mice with neural crest-specific inactivation of Bmp4 ( Bmp4(ncko/ncko)) both exhibit bud

147 esence of an antimicrobial peptide in vitro, inactivation of both phoP and Sant_4061 is necessary to

148 curs at kinetochores and in the cytosol, and inactivation of both pools of Mps1 during metaphase is e

149 Biallelic inactivation of BRCA1 or BRCA2 is associated with a patt

150 ealed its ability to induce a dose-dependent inactivation of BU-1 expression in two steps: the loss o

151 tration as expected, reciprocal depletion or inactivation of CD4(+) T lymphocytes decreased vessel no

152 eity in more than 75% of patients, including inactivation of CDKN2C and TP53, and mutations affecting

153 Scavenging the peroxynitrite avoids the inactivation of cellular enzymes and modification of the

154 We also demonstrate that inactivation of CGRP(PBN) neurons prevents lethargy, anx

155 Inactivation of chitin-receptor genes in Ljlys6, Mtlyk9,

156 Inactivation of citrate synthase, but not down-stream en

157 The inactivation of Crkl in the mouse model induced developm

158 Inactivation of D-serine synthesis within the astroglial

159 Regulatory inactivation of DnaA (RIDA) is one of the major regulato

160 evidence that the decrease of GSCs upon the inactivation of E(z) in the germline could be attributed

161 ed by sonication of aluminum foil on the UVC inactivation of E. coli bacteria and demonstrate a new r

162 Genetic inactivation of ectopic EFNA3 restores a wild-type corti

163 iR-217-mediated, genetic, or pharmacological inactivation of EHMT1/2 was sufficient to promote pathol

164 in the enzymatic performances as a result of inactivation of either of the protein complexes or varia

165 These findings indicate that inactivation of Fam20C in cells expressing type I collag

166 everal approaches, including CRISPR-mediated inactivation of FGFR3-TACC3 fusion genes.

167 The efficacy of cold plasma for inactivation of food-borne pathogens in foods is establi

168 Pharmacogenetic inactivation of FosB-expressing neuron electrophysiologi

169 alian target of rapamycin and its subsequent inactivation of FoxO1.

170 p of syn-isomers may also participate in the inactivation of free radicals.

171 This allows facile inactivation of genes with coding homopolymer runs inclu

172 Heat inactivation of HIV-1 blocks nuclear localization of Lys

173 The target and mechanism(s) of low-pH inactivation of HSV are unclear.

174 crobiota colonization leads to activation or inactivation of hundreds of enhancers along with drastic

175 We report that kidney tubule-specific inactivation of Inpp5b on a global Ocrl-knockout mouse b

176 Inactivation of IRP1 RNA binding by iron primarily invol

177 ighttime signaling events revolve, including inactivation of KaiA and reciprocal regulation of the mu

178 Here we show that inactivation of KCNQ1 channels derives from the differen

179 enerated three mouse models with CD-specific inactivation of key miRNA pathway genes Dicer, Dgcr8, an

180 Clonal genetic inactivation of KRas(G12D) in mouse lung epithelial cell

181 is well exemplified by the Ca(2+)-dependent inactivation of L-type Ca(2+) channels, whose alteration

182 ruption of Ca(2+)/calmodulin (CaM)-dependent inactivation of L-type Ca(2+) channels.

183 Compared to the wild type (WT), the inactivation of misR identified 157 differentially regul

184 ction, and it was categorically specific, as inactivation of ML impaired face detection while sparing

185 combined it with fMRI-guided pharmacological inactivation of ML to test whether ML is of critical imp

186 s and of thin sections revealed that genetic inactivation of mNEET did not affect the size of mitocho

187 investigate the enhancement of the photonic inactivation of Murine Leukemia Virus (MLV) via 805 nm f

188 The results showed that maximum inactivation of myrosinase and preservation of glucosino

189 l(-) cotransporter (NCC) compensated for the inactivation of NDCBE.

190 n of TLR4/MyD88 signaling cascade as well as inactivation of NLRP3 inflammasome.

191 Germline inactivation of one allele of the SLN gene normalizes SL

192 C) biology, we generated mice with catalytic inactivation of one SHIP2 allele selectively in ECs (ECS

193 Inactivation of opioid receptors limits the therapeutic

194 Moreover, genetic inactivation of Osr2, a negative regulator of the odonto

195 DKN2A deletion in human cancer that, through inactivation of p14ARF, activates MDM2 protein, which in

196 Similarly, delayed inactivation of p16(INK4a) in mice several weeks post ex

197 topoietic ablation was completely rescued by inactivation of p53.

198 While the inactivation of phoP, phoQ or Sant_4061 completely retar

199 e find that excitotoxicity provokes an early inactivation of PKD1 through a dephosphorylation-depende

200 The study indicates that the inactivation of POD by PL is an all-or-none process rela

201 Inactivation of POT1 telomere protective functions in mo

202 The slow spontaneous inactivation of potassium channels exhibits classic sign

203 C1 inactivation upon starvation leads to the inactivation of PP2A-B55(Pab1) through the Greatwall-End

204 Inactivation of PRC1 in male germ cells results in the g

205 growth factor signaling involves reversible inactivation of protein tyrosine phosphatases (PTPs) thr

206 a1, which encodes a key enzyme for catabolic inactivation of RA required for tight control of local R

207 ogated either by direct depletion or through inactivation of RB function; however, the basis for this

208 In Fos-lacZ transgenic rats, selective inactivation of relapse test-activated Fos neurons in DM

209 or ectopic expression of EspL leads to rapid inactivation of RIPK1, RIPK3, TRIF and ZBP1/DAI and inhi

210 displayed elevated frequency of Rad52 foci, inactivation of RNase H2 and RAD52 led to synthetic leth

211 145 via shRNA-mediated knockdown, or chronic inactivation of RNF145 by genetic deletion, potentiates

212 Following selective genetic inactivation of Robo2 in the adult VTA of mice, reduced

213 tocrine Schwann cell survival signaling, and inactivation of Schwann cell STAT3 results in a striking

214 Inactivation of Sec23b exclusively in the pancreatic aci

215 that SERINC5 promotes spontaneous functional inactivation of sensitive but not resistant Env glycopro

216 fertility due to meiotic arrest and impaired inactivation of sex chromosomes.

217 e report that hematopoietic-specific genetic inactivation of Sin3B, an essential component of the mam

218 t that diminished Sirt3 expression and redox inactivation of Sirt3 lead to SOD2 inactivation and cont

219 ng the lifespan of normal human cells due to inactivation of STAG2 could promote tumorigenesis by ext

220 The oligodendrocyte-specific inactivation of sterol regulatory element-binding protei

221 Targeted inactivation of SWI/SNF nucleosome-remodeling complex me

222 phenotypes could be phenocopied by selective inactivation of synaptic transmission from local GABAerg

223 As we previously reported, inactivation of Synpcc7942_2071 enables biofilm formatio

224 Temporary functional inactivation of the 60S ribosome assembly factor Bop1 in

225 Here we show that inactivation of the beta-arrestin-2 gene, barr2, in beta

226 SCD1 activation of nuclear YAP/TAZ requires inactivation of the beta-catenin destruction complex.

227 f DA antagonists combined with contralateral inactivation of the BLA or NAc.

228 pediatric cancer characterized by biallelic inactivation of the core BAF complex subunit SMARCB1 (BA

229 s of either the transcription factor Gln3 or inactivation of the CTP synthetase Ura7 both resulted in

230 m of Ras was found to stabilize Etv5 through inactivation of the cullin-RING ubiquitin ligase CRL4(CO

231 nthase (PKS) were investigated by systematic inactivation of the DHs in module-6, -9, -10 of MgsF (i.

232 ir per se, while Sit4 was required for rapid inactivation of the DNA damage checkpoint after DSB repa

233 memory-effector T cells such that with acute inactivation of the gene encoding FOXO1, T cells revert

234 However, genetic inactivation of the GR in kidney epithelial cells did no

235 ritis (rapidly progressive GN), this genetic inactivation of the GR in kidney epithelial cells exerte

236 the activation of FAK, nor did EDTA-mediated inactivation of the integrin.

237 Critically, at P12, inactivation of the medial septum eliminates theta in bo

238 mplete disassembly of MCC, necessary for the inactivation of the mitotic checkpoint.

239 in other contexts, we found that individual inactivation of the MLL1-4/COMPASS family members has li

240 IFN-beta promoter, and second, p38-mediated inactivation of the mRNA-destabilizing factor tristetrap

241 Inactivation of the nonessential omega-subunit of the RN

242 uction is decreased by dephosphorylation and inactivation of the NPR2 guanylyl cyclase, and cGMP hydr

243 ct in srs2Delta mutants can be suppressed by inactivation of the resection nuclease Exo1.

244 ell surface that functions efficiently after inactivation of the sec7-1 allele of Sec7, which control

245 kinetic scheme describing the activation and inactivation of the underlying calcium channels and corr

246 Inactivation of the VHL (Von Hippel Lindau) tumour suppr

247 carcinomas (ccRCCs) are initiated by somatic inactivation of the VHL tumor suppressor gene.

248 imed to study potential methylation-mediated inactivation of these genes in parathyroid adenomas.

249 Inactivation of these pathways can lead to altered vascu

250 Inactivation of TLE by UBR5-dependent ubiquitylation als

251 lted in the upregulation/activity of HuR and inactivation of tristetraprolin, two AU-rich element-bin

252 ional events fall into two broad categories: inactivation of tumor suppressor genes (hypomorph, antim

253 Here we report that neural-specific inactivation of two murine post-transcriptional regulato

254 d NRAS expression, which could be blocked by inactivation of Usp9x and therapeutic combination of Usp

255 est as a photonic approach for the selective inactivation of virus contaminations in biological sampl

256 The inactivation of vri disrupts multiple output pathways th

257 Further, mice with conditional inactivation of Xpr1 in the renal tubule exhibited gener

258 Finally, we found that reversible inactivations of the MFC in the opposite hemisphere elim

259 Experiment 2a examined the effects of PL inactivation on ABC renewal in the same rats.

260 lasminogen activation and alpha2-antiplasmin inactivation on experimental thrombus dissolution and bl

261 drial function, emphasizing the role of PDK3 inactivation on the positive effects achieved by SB trea

262 ing literature data for enzyme and microbial inactivation over a wide range of temperature and pH.

263 Kitz-Wilson analysis reveals similar inactivation parameters for the two antipodes, L-alpha-(

264 d resurgent currents and rightward shifts in inactivation parameters, leading to significant increase

265 In addition, ventral subiculum inactivation prevented OFC neurons from integrating info

266 n; (ii) that Cs(+) or Rb(+), known to halt C-inactivation, prevented mode-shift of gating; and (iii)

267 First, we used the Daun02 inactivation procedure in male FosLacZ-transgenic rats t

268 zation, immunohistochemistry, and the Daun02 inactivation procedure to demonstrate a critical role of

269 and selective inhibitory effect on the fast inactivation process of NaV1.1 and 1.3.

270 t despite continued ROCK2 activities/p-Mypt1 inactivation, progression to SCC required loss of compen

271 get of mutations, the mechanism by which its inactivation promotes tumorigenesis is unclear.

272 Inactivation protocols for HFV should be validated with

273 , but the atomic-resolution mechanism of its inactivation remains poorly understood.

274 all, our findings uncover a mechanism of SAC inactivation required for timely mitotic exit.

275 d persistent current and depolarized channel inactivation resembling the properties of F1.Q54 neurona

276 g mutated fetuses, the lack of complete gene inactivation resulted in animals with an intact pancreas

277 O-deficient cells during abscission, and its inactivation resulted in phenotypic changes identical to

278 Accordingly, Kinesin-5 inactivation results in force imbalance leading to monop

279 RhoA inactivation selectively inhibited phosphorylation of th

280 Drosophila eye, we found that partial APC/C inactivation severely inhibits retinal differentiation i

281 However, alpha2-antiplasmin inactivation showed a unique pattern of thrombus specifi

282 Gene inactivation studies have revealed a critical requiremen

283 expected based on prior studies using other inactivation techniques.

284 inds to tankyrase and prevents its oxidative inactivation, thereby preventing Axin1-dependent degrada

285 on NCLX and is required for preventing Orai1 inactivation through oxidation of a critical cysteine (C

286 Rb family protein inactivation triggers the progressive E2f-mediated trans

287 To identify putative 'escape from X-inactivation tumor-suppressor' (EXITS) genes, we examine

288 Conversely, TORC1 inactivation upon starvation leads to the inactivation o

289 male cells, with the degree of 'escape' from inactivation varying between genes and individuals.

290 l lineage, in addition to biallelic Nf2 gene inactivation, we generated the first mouse model develop

291 ng in conditions that promote or halt C-type inactivation, we have found (i) that KcsA undergoes mode

292 Male-biased mutations in genes that escape X-inactivation were observed in combined analysis across m

293 hat TrxR1/NADPH directly protects PTP1B from inactivation when present during the H2O2 exposure.

294 he mechanisms underlying nonmutational wtp53 inactivation, which might be of therapeutic relevance.

295 Genetic ablation of complement C3 or its inactivation with Cobra Venom Factor (CVF) result in imp

296 bryonic fibroblast (MEF) model combining p53 inactivation with E1A or HRas-V12 oncogene expression, w

297 ed the efficacy of dark exposure and retinal inactivation with tetrodotoxin to promote anatomical rec

298 ved, and each is seen to give time-dependent inactivation with this enzyme.

299 We report a plasmonically enhanced virus inactivation, with greater than 3.7-log reduction measur

300 chromosomes because stochastic X-chromosome inactivation (XCI) confounds allele-specific epigenomic