ライフサイエンスコーパス: inactive

1 mation, the TCR is not phosphorylated and is inactive.

2 DBS or electrode implantation that remained inactive.

3 inds the small GTPase ARL2 but appears to be inactive.

4 hat the poised ZRS remains transcriptionally inactive.

5 pes, in which this tissue may be present but inactive.

6 ication, whereas 21-3U was almost completely inactive.

7 dual-partner defensive system conditionally inactive.

8 Li2S, which is shown to be electrochemically inactive.

9 are only available at low pH, where NhaA is inactive.

10 L-tryptophan and 11 other D-amino acids were inactive.

11 Strikingly, trimerization renders the ligase inactive.

12 rming a 100S complex that is translationally inactive.

13 y, while proinflammatory cells are virtually inactive.

14 e high molecular weight (HMW) and relatively inactive.

15 ifferent phases and tagged them as active or inactive.

16 e the solubilized protein became practically inactive.

17 obin domains of the active Fe(III)-CN(-) and inactive 5-coordinate Fe(II) forms, revealing striking s

18 tive coding sites, whereas the catalytically inactive ADAR3 predominantly acts as an inhibitor of edi

19 As purified PvdO was inactive, additional factors are required for catalysis.

20 Here, we present an inactive ADP-bound structure of KtrAB from Vibrio algino

21 -based walking intervention in predominantly inactive adults, delivered by post or through primary ca

22 ognize foreign capped mRNAs, while remaining inactive against host mRNAs marked by ribose 2'-O methyl

23 of Rab11A prenylation, simultaneously being inactive against Rap1A/Rap1B modification, with the abil

24 rive a sharp pH-triggered transition between inactive and active configurations with apparent pKa val

25 hat occurs when the promoter toggles between inactive and active states.

26 or by shifting a dynamic equilibrium between inactive and active states.

27 ions for the relative stability of autophagy-inactive and autophagy-active BECN1 complexes.

28 ch leaves them frequently photosynthetically inactive and difficult to assess.

29 substructure was often found in consistently inactive and frequently active compounds, indicating tha

30 ding to states sampled by non phosphorylated/inactive and phosphorylated/active forms of the kinase.

31 ve) for the anti-HER2 ADCs (HER2 0 MCF7, all inactive) and 0.10-1.73 mug/mL (7 inactive) in CD22 3+ B

32 ce of the pH control signal, the catalyst is inactive, and the cargo remains encapsulated within the

33 A comparison of this structure with inactive- and active-state structures of the beta2AR rev

34 Z[Cu(II)OH] complexes, although shown to be inactive, are identified as the precursors to the methan

35 Active and inactive arrays on the same chromosome produce discrete

36 duced [2Fe-2S](+)-mitoNEET is present and is inactive as an Fe/S cluster transfer protein; under cond

37 with type 1 diabetes tend to be at least as inactive as the general population, with a large percent

38 DLCL2 for anti-CD22 ADCs (CD22 0 Jurkat, all inactive at low doses).

39 2R-HC (3) at LXRbeta, while it was virtually inactive at LXRalpha (EC50 = 14.51 muM).

40 approximately van der Waals contact, plus an inactive (b) conformer with even longer DAD, establishin

41 match the free-energy difference between the inactive (bent-closed) and active (extended-open) confor

42 e plexin-semaphorin-integrin (PSI) domain of inactive, beta3 integrins.

43 effective tool to monitor photosynthetically inactive biocrusts.

44 Abeta assemblies in AD cortex are large and inactive but under certain circumstances can dissociate

45 The pathogenic cells were mitotically inactive, but proliferating precursors were detected in

46 onstrated RNA editing by using catalytically inactive Cas13 (dCas13) to direct adenosine-to-inosine d

47 efficient targeted DNA methylation by fusing inactive Cas9 (dCas9) with an engineered prokaryotic DNA

48 to block transcription using a catalytically inactive Cas9 (dCas9).

49 t palindromic repeats (CRISPR)-enzymatically inactive Cas9 in MVM-infected cells increased both cycli

50 ossessed cytoplasmic complexes that included inactive caspase 8, RIPK-1, and RIPK-3, and the composit

51 ing on dicentric chromosomes reveals that an inactive centromere cannot maintain H3T3ph at metaphase,

52 otent form of chemerin, chem157S, as well as inactive chem155A, increased.

53 communities of iron-sulfides from active and inactive chimneys in deep-sea environments.

54 An inactive chloride-ligated complex can be activated by ha

55 e choroidal neovascularization in 3 eyes and inactive choroidal neovascularization in 1 eye.

56 S proteasome also regulates the spreading of inactive chromatin referred to as heterochromatin, sugge

57 ally showed early cGH responses; genes in an inactive chromatin state often responded late.

58 A and B compartments, reflecting active and inactive chromatin, respectively.

59 activity of IcmF powers the ejection of the inactive cob(II)alamin cofactor and requires the presenc

60 yl-CoA mutase (MCM) and precludes loading of inactive cofactor forms.

61 r by using the GTP-binding energy to offload inactive cofactor.

62 rengths at borders between A (active) and B (inactive) compartments, and reduces chromatin loop inten

63 s coated with intravenous immunoglobulin and inactive complement component 3b.

64 s and perfused with 100 mumol/L CORM-401 (or inactive compound iCORM-401)-pretreated PMN for 5 minute

65 m of epidermal barrier formation, to a fully inactive condition and finally becomes a part of the ker

66 active-like state of BAK1 and stabilizes an inactive conformation known to recur in protein kinases.

67 therefore, not essential for maintaining the inactive conformation of ADAMTS13.

68 We investigated the inactive conformation of hTS and found that the two inse

69 In the absence of DNA damage, an inactive conformation of the ATPase is maintained by jux

70 g that these complexes adopt a catalytically inactive conformation probably important for transcripti

71 ymerization, whereas GTP promotes a compact, inactive conformation whose ability to polymerize is unk

72 plex, they each induced an "open" nucleation-inactive conformation.

73 llular domain and transmembrane domain in an inactive conformation.

74 elease of ADP from CI slows down, making the inactive conformational state of KaiC more stable.

75 s the balance between kinesin-1's active and inactive conformations and roles in microtubule dynamics

76 tiple switching steps between the active and inactive conformations can be performed consistent with

77 des shift the equilibrium between active and inactive conformations in both the octamer and the filam

78 ased classification of protein kinase active/inactive conformations, taking into account more structu

79 structures of EPOR truly represent active or inactive conformations.

80 aluating test accuracy, RCTs of treatment vs inactive controls, and cohort studies or case-control st

81 between physical activity interventions and inactive controls.

82 porphyrins, corrole derivatives with a redox-inactive coordinated atom follow the Gouterman four-orbi

83 Inactive copies of the sup-35/pha-1 element show high se

84 tes with PMN-free medium containing CORM-401/inactive CORM-401.

85 etabolism by converting active cortisol into inactive cortisone.

86 We engineered drug-inducible catalytically inactive Cpf1 nuclease fused to transcriptional activati

87 strategy to enable use of diverse otherwise inactive CRISPR-Cas systems for genome-editing applicati

88 scriptional shutdown and switches Csr2 to an inactive, deubiquitylated form.

89 hat mutations that allow the formation of an inactive dimer, alter substrate/coenzyme binding, or imp

90 inal half of the protein and a catalytically inactive dioxygenase-related N-terminal domain, which is

91 distinguish between metabolically active and inactive disease, this technique is now the preferred fu

92 sulfide-bonded heterodimer, whereas it forms inactive disulfide-bonded oligomers at neutral pH that a

93 As thiols can be oxidized into catalytically inactive disulfides, the isomerization rates can be cont

94 is rarely elucidated since rate-limiting or inactive domain(s) remain unidentified.

95 der mildly denaturing conditions, CysC forms inactive domain-swapped dimers.

96 A catalytically inactive dominant-negative GODZ construct significantly

97 for loading and the post-catalytic MCM is an inactive double hexamer that encircles duplex DNA.

98 ted protein 9 (SpCas9) and the catalytically inactive dSpCas9 protein fused to the amino-terminus of

99 herally active" (perilesional DVR highest), "inactive" (DVR highest in surrounding NAWM), or "undiffe

100 site (A site) of an open 30S subunit, while inactive EF-Tu is separated from the 50S subunit.

101 ndependent manner, facilitates conversion of inactive enhancers in embryonic stem cells to an active

102 levels of H3K27ac, has been reported to mark inactive enhancers that are poised for future activation

103 l for Eph-B4 signaling and administration of inactive Eph-B4-Y774F increased fistula wall thickness.

104 tanoyl-ACP (6a) with redox-active, epimerase-inactive EryKR6 from module 6 of the 6-deoxyerythronolid

105 s, inhibit the material performance by being inactive for the conversion.

106 11-48 ng/mL in HER2 3+ SK-BR-3 and KPL-4 (7 inactive) for the anti-HER2 ADCs (HER2 0 MCF7, all inact

107 PI(4,5)P2, which is loaded into cells in an inactive form and activated by light, allowing sub-secon

108 ISPR-dCas9 epigenetic editing tool, where an inactive form of Cas9 is fused to DNA methyltransferase

109 wild-type METTL3, but not of a catalytically inactive form of METTL3, inhibits cell differentiation a

110 small organic molecules such as glucose, an inactive form of SA is generated which can be transporte

111 sses HBV replication, while an enzymatically inactive form of TAK1 exerts no effect.

112 vivo Accordingly, exogenous expression of an inactive form of the 5-HT2C receptor in the locus cerule

113 d with its allosteric inhibitor AMP shows an inactive form of the tetramer, in which the dimer pairs

114 diminished by expression of a catalytically inactive form of Usp14.

115 erts cellular cullin 3 into an un-neddylated inactive form with no or minimum effect on other cullin

116 abine (2',2'-difluorodeoxycytidine) into its inactive form, 2',2'-difluorodeoxyuridine.

117 modimerization, thus constraining CAR in its inactive form.

118 acterize the conformations of the active and inactive forms of full-length AfGcHK in solution, we inv

119 Major differences between the active and inactive forms were observed on the heme-proximal side (

120 ng the ratio of S-S to the electrochemically inactive framework.

121 We report that BH3-only proteins bind inactive full-length BAK at mitochondria and then dissoc

122 Consistent with this interpretation, the inactive G457A mutant was partially rescued by removing

123 pare the effects of both variants with known inactive GDP- and active GTP-bound RAB11B mutants, we mo

124 the status of signaling by switching between inactive GDP-bound and active GTP-bound forms.

125 Increased tag diversity in inactive genes is indicative of a protracted clonal evol

126 chromatin accessibility of transcriptionally inactive genes: In undifferentiated cells, PBX1 is bound

127 defective hair growth was observed in kinase-inactive GK5 mutant mice.

128 a growth defect not rescued by catalytically inactive Glt1, indicating that the glycan acts in concer

129 dark states of Dendra2 are observed both in inactive (green fluorescent) and active (orange fluoresc

130 the histone demethylase KDM4A is depleted or inactive, H3K9me3 accumulates at the HIF-1alpha locus, l

131 guration that can be converted to either the inactive homodimer or the active heterodimer.

132 CAR undergoes a conversion from inactive homodimers to active heterodimers with retinoid

133 ne-active (IA), immune-tolerant (IT), immune-inactive (IC), and grey zone (GZ), respectively, showed

134 tin is partially attenuated in cells with an inactive IGF-1R.

135 A KDM2A mutant deficient in HP1-binding is inactive in an in vivo overexpression assay in zebrafish

136 e, suppressing proteasome activity even when inactive in deubiquitination.

137 tes indicated that CYP3A1/2 was functionally inactive in double KO rats.

138 Fe is mostly inactive in DTT oxidation, but shows synergistic effect

139 d enzymatic properties, but many of them are inactive in mammalian cells and are thus precluded from

140 ctive in the tumor environment and absent or inactive in normal tissues; therefore they represent via

141 A higher proportion of lesions were inactive in patients with SPMS (35%) than RRMS (23%), bu

142 Other hypomethylated regions occur at sites inactive in progenitors and reflect the de novo acquisit

143 The full-length p53 protein is largely inactive in stem cells but, when activated, helps to com

144 This ensures that gene expression remains inactive in the germ-line precursors during adverse cond

145 MCF7, all inactive) and 0.10-1.73 mug/mL (7 inactive) in CD22 3+ BJAB and WSU-DLCL2 for anti-CD22 AD

146 ay structures are mostly restricted to their inactive inhibitor-bound state.

147 e, indicating that they represented catalase-inactive intermediates.

148 expression of IRE1alpha but not by the RNase-inactive IRE1alpha or the activated X-box binding protei

149 pression of an endogenous Braf(D631A) kinase-inactive isoform in mice (corresponding to the human BRA

150 and salinomycin (4) harbor a number of redox-inactive ketoreductase (KR(0)) domains that are implicat

151 elease of the mature cytokine dimer from the inactive, latent TGF-beta precursor.

152 ophase form of the CDC20-MAD2 complex but is inactive later in mitosis.

153 In inactive lesions, the density of microglia/macrophages w

154 In eukaryotes, transcriptionally inactive loci are enriched within highly condensed heter

155 xpression with active, but not enzymatically inactive LOG2.

156 loading of active materials, minimization of inactive materials, and good electrode-electrolyte inter

157 res, compared to expression of catalytically inactive MCR-1 (E246A) or MCR-1 soluble component.

158 KIR2DP1 is an inactive member of the human lineage III KIR family, whi

159 iRhoms, catalytically inactive members of the rhomboid-like superfamily, have

160 single-stranded DNA and requires only redox-inactive metal ions.

161 HP triggers Mrr activity by directly pushing inactive Mrr tetramers to dissociate into active Mrr dim

162 We have determined the crystal structure of inactive mutant (D88N) of RecU from Bacillus subtilis in

163 Unexpectedly, we find that a catalytically inactive mutant of PBP 2B supports cell division, but in

164 Rescue experiments with catalytically inactive mutants of MOF showed that its enzymatic activi

165 tallographic structures of two catalytically inactive mutants of protein-tyrosine phosphatase-like my

166 Depletion or introduction of catalytically inactive mutation of ClpP increases DmLRPPRC1 and causes

167 Phosphor-inactive mutations of ICE1 complement freezing sensitivi

168 s subpopulations of metabolically active and inactive Mycobacterium tuberculosis with unknown implica

169 s between a group of active neurons to their inactive neuron neighbors in a variety of network config

170 e phenol product and to prevent formation of inactive Ni(I) dimers.

171 ransferred to a heme-depleted, catalytically inactive nitrate reductase, restoring its nitrate-reduci

172 to conceive when disease has been stable and inactive on appropriate medications, and assess relevant

173 to the common assumption that temocillin is inactive on P. aeruginosa, we show here clinically-explo

174 s phosphorylation level tends to rise and an inactive one in which it tends to fall; ii) phosphorylat

175 wherein active Ded1 promotes translation but inactive or excess Ded1 leads to translation repression.

176 ter the initial infection, the virus remains inactive or latent in nerve cells that sense the region

177 increase in HBV replication in patients with inactive or resolved HBV infection, may result in clinic

178 onal state of each gene is represented by 0 (inactive) or 1 (active), and the relationship among gene

179 emonstrated a high proportion of molecularly inactive pAMR1(I+), and there was significant molecular

180 cellular proteolytic capacity and eliminates inactive particles.

181 nly results in attenuated yields or entirely inactive pathways, and the mechanistic basis for comprom

182 red with administration of vehicle or mutant inactive peptide, administration of the SOCS1 peptidomim

183 s unexpectedly enriched at transcriptionally inactive pericentromeric heterochromatin in P. falciparu

184 onses when LPS challenge occurred during the inactive phase (ZT0); this did not result in enhanced ba

185 es TFEB activity by preferentially targeting inactive phosphorylated TFEB for degradation by the ubiq

186 JF-NP-26 is an inactive photocaged derivative of the metabotropic gluta

187 tors occupy multiple sites in epigenetically inactive placental genes and in OCT4 Functional manipula

188 was observed in PAI-1(-/-) mice that express inactive plasmin (Pm) but normal levels of zymogen Pg (P

189 -Rrn3 complexes, followed by the assembly of inactive Pol I homodimers.

190 to the presence of a distinct metabolically inactive pool of Phe, likely localized in the vacuole.

191 so reduced inhibition by morphine, while the inactive PP3, and the MEK inhibitor, SL327, had no effec

192 FXa cleaves ProT at Arg-271, generating the inactive precursor prethrombin-2 (Pre2), which is furthe

193 ssion yeast and human Sde2 are translated as inactive precursor proteins harbouring the ubiquitin-fol

194 was formed in a mobile equilibrium from the inactive, predominantly dimeric (Z)-1.

195 The inactive PRMT paralog, TbPRMT1(PRO), is essential for ca

196 Daun02 is an inactive prodrug that is converted to the inhibitory mol

197 ctional mechanism, forming transcriptionally inactive promoter complexes that require activation by s

198 domains (KIVs), one kringle V domain, and an inactive protease domain.

199 steric effects thus reduce ATP hydrolysis by inactive proteasomes and nonspecific proteolysis and enh

200 APOBEC3H co-purifies with RNA as an inactive protein, and RNase A treatment enables strong D

201 uted for Tyr72, which led to a catalytically inactive protein.

202 more frequently observed in FL and yield an inactive protein.

203 nd found that they all yielded enzymatically inactive proteins.

204 y both have localization patterns similar to inactive RAB11B.

205 binding to the GEF SH3BP5, again similar to inactive RAB11B.

206 guanosine triphosphate, activating Ras into inactive Ras is bound to guanosine diphosphate, inactiva

207 second messenger kinase-phosphorylated, but inactive receptors as well.

208 ekeeper" mechanism that ensures targeting of inactive receptors to axons to engage with ligand.

209 died contain a unique spectrum of active and inactive receptors.

210 antities of NADP(+) in the presence of redox-inactive, recombinant NanKR1(0) or NanKR5(0), from modul

211 We found that inactive respiratory motoneurons exhibit a classic form

212 One state contains a compact inactive RF2 conformation.

213 Here we show that the inactive rhomboid protease RHBDF2 (iRHOM2) regulates thi

214 Notably, ectopic expression of catalytically-inactive RICE1 not only significantly reduced miRNA leve

215 ative RNase 7 and a recombinant ribonuclease-inactive RNase 7 mutant.

216 nformation and also locks the tetramer in an inactive rotated T-state.

217 In inactive scars, the areas of retinal and choriocapillari

218 ly passive immunization, or vaccination with inactive SpeA, resulted in high-titer SpeA-specific anti

219 nst each of these six genes down-regulated X-inactive specific transcript (XIST), a key player in X-c

220 cruited to Xi in response to expression of X inactive-specific transcript (Xist) RNA during the earli

221 ve sites that exist within a distribution of inactive spectator metal centers.

222 Gi/o proteins and their cognate GPCRs in the inactive state (Gi/o-GPCR preassembly).

223 main of RIG-I to maintain the receptor in an inactive state and attenuate its sensing of viral RNA (v

224 ate of an ectotherm in a post-absorptive and inactive state and can constitute a significant portion

225 tructures of the D4 dopamine receptor in its inactive state bound to the antipsychotic drug nemonapri

226 y embryonic stages maintaining a poised, but inactive state broadly across the distal limb mesenchyme

227 ays indicated that Galpha13 in its active or inactive state interacts with R7-RGS heterotrimers conta

228 cular dynamics simulations starting from the inactive state of D3R in complex with these enantiomers.

229 ormational transition between the active and inactive state of hTS.

230 In addition to the inactive state of NF-kappaB, the deficiency in the infla

231 pair that was attributed to a catalytically inactive state of the PTC.

232 Hence, the primed but inactive state of the ZRS is induced by FGF signalling a

233 lls, also plays a role in maintenance of the inactive state through regulation of BMP/TGF-beta signal

234 pCas9-HF1 and eSpCas9(1.1) are trapped in an inactive state when bound to mismatched targets.

235 PKC toward the anterior but holds aPKC in an inactive state, and a CDC-42-dependent assembly in which

236 In the inactive state, KaiC binds KaiB, which not only stabiliz

237 s that restrain Ras dynamics and promote the inactive state.

238 by which phyB reverts from the active to the inactive state.

239 hold that allows the kinetic trapping of the inactive state.

240 exported to the cytoplasm in a functionally inactive state.

241 traps Cas9 in a DNA-bound but catalytically inactive state.

242 e dynamic auto-inhibitory equilibrium toward inactive states of HCN4 and broadens the free-energy wel

243 e present structures representing active and inactive states of the PP2C phosphatase SpoIIE from Baci

244 more frequent transitions between active and inactive states was associated with equivalent self-repo

245 otide-dependent switching between active and inactive states.

246 apsulating recombinant StI or the reversibly inactive StI W111C dimer.

247 ins, and show that the greatest variation in inactive structures comes from kinase group and family s

248 Further, our unbiased classification of inactive structures reveals residues associated with kin

249 and alkynes, among other groups) but carried inactive substituents having specifically designed diffe

250 ison to previous NMR structures of isolated, inactive substrates provides a physical description of s

251 ers containing mixtures of ATPase active and inactive subunits at defined positions in the hexameric

252 f the inhibitors MLN8054 and CD532 favors an inactive T-loop.

253 -TAK1 expression, but not with catalytically inactive TAK1-K63W, suggesting that TAK1 enzymatic activ

254 chromosome, which pull the equilibrium from inactive tetrameric Mrr toward active dimer.

255 mmalian transcriptional machinery is largely inactive, thereby effectively 'freezing in' the in vivo

256 olution structure and dynamics of active and inactive TNFalpha using NMR spectroscopy.

257 ated by the transition of NF-kappaB from its inactive to active state.

258 tion; however, they are generally considered inactive toward hydrogen evolution reaction.

259 against HeLa and HT-29 cell lines, but were inactive towards MRC-5 and MCF7.

260 Enzymatically active and inactive tPA demonstrated similar immune modulatory acti

261 The reexpression of E3 ligase-inactive TRAF6 mutants partially restored IL-1 signaling

262 for signaling in cells expressing E3 ligase-inactive TRAF6 mutants.

263 s from knockin mice expressing the E3 ligase-inactive TRAF6[L74H] mutant, but the late-phase producti

264 sing mixtures of wild-type and catalytically inactive transposases, we show that all the catalytic st

265 AP1 found in cancers are predicted to encode inactive truncated proteins, suggesting that loss of enz

266 Here we also show that mice immunized with inactive typhoid toxins and challenged with wild-type ty

267 119, whereas overexpression of catalytically inactive UbE2E1_C131A or UbE2E1 knockdown results in dec

268 trometry and immunoblots, we discovered that inactive, unphosphorylated CPC interacts with nucleophos

269 of animal embryos remains transcriptionally inactive until the maternal-to-zygotic transition.

270 strate alpha-tubulin-acetylLys40 peptide and inactive up to 100 muM against Sirt1, -3, and -5 (deacet

271 esses allosterically because a catalytically inactive Usp14 mutant also inhibited them.

272 significantly higher ARI index compared with inactive uveitis and controls (both P < 0.0001).

273 Uveitis patients were divided into active or inactive uveitis status according to clinical grading.

274 ent taking 10 mg/day, whereas a patient with inactive uveitis taking 35 mg/day of prednisone will exp

275 red thirty-seven eyes (70 active uveitis, 97 inactive uveitis, and 70 controls) were included.

276 Interestingly, the irreversibly inactive variant of the StI mutant StI W111C, encapsulat

277 oids (cortisol and corticosterone) and their inactive versions (cortisone and 11-dehydrocorticosteron

278 trials of adults with active (VISUAL-1) and inactive (VISUAL-2) noninfectious intermediate uveitis,

279 nsisted of adults with active (VISUAL-1) and inactive (VISUAL-2) noninfectious intermediate, posterio

280 n was observed compared with that during the inactive volcanic eruption period (1936-1962).

281 Although this chimera was inactive, we demonstrate fructose transport after introd

282 One mutation, R36C, renders PIMT completely inactive, whereas two others, A7P and I58V, exhibit acti

283 Mn2+, Mg2+ or Co2+ ions for activity, but is inactive with Zn2+ and Ca2+.

284 that social insect colonies commonly contain inactive workers: these may be a 'surplus' set of worker

285 s been to reawaken the healthy allele on the inactive X (Xi).

286 st's function, how Xist RNA localizes to the inactive X chromosome (Xi) and spreads in cis remains un

287 The extent of reactivation along the inactive X chromosome (Xi) and the determinants of locus

288 Here, we show that the inactive X chromosome (Xi) of primed hESCs was reactivat

289 pression, including at genes silenced on the inactive X chromosome in females.

290 revent induction of transcribed genes on the inactive X chromosome, a mode of PRC2 function that may

291 ed at promoters of silenced genes across the inactive X chromosome.

292 genes are expressed from both the active and inactive X chromosomes (Xa and Xi, respectively) in fema

293 , upon X-chromosome inactivation, active and inactive X chromosomes localize to different subnuclear

294 of transcriptional and chromatin features of inactive X-linked genes in WT and Eed (-/-) TSCs suggest

295 by XIST, the noncoding RNA that silences the inactive X.

296 riched for active chromatin hallmarks on the inactive-X, including RNA PolII, H3K27ac, and H3K36me3,

297 ut differences in mCH on the active (Xa) and inactive (Xi) X chromosomes because stochastic X-chromos

298 ere the crystal structure of a catalytically inactive (Y324F) mutant of this engineered Tre recombina

299 ively synthesized in liver hepatocytes as an inactive zymogen (proprotein C).

300 rge family of proteases that are secreted as inactive zymogens.