ライフサイエンスコーパス: inactive form

1 ot grow because RNR remains in its oxidized, inactive form.

2 functionally encapsulate biomolecules in an inactive form.

3 ined within cytoplasmic tubulovesicles in an inactive form.

4 o express c-fos, and Rb is maintained in its inactive form.

5 allowing formation of active TFIIIC from the inactive form.

6 ctive oxidized form of cyclo-oxygenase to an inactive form.

7 inus in the active form of ERK2, but not the inactive form.

8 activated kinase in a readily available, but inactive form.

9 reas cytoplasmic ATF2 probably represents an inactive form.

10 e due to a greater balance of PDH toward the inactive form.

11 er to maintain the cytoplasmic complex in an inactive form.

12 ADAR3 remains as a monomeric, enzymatically inactive form.

13 onstraint that locks beta(2) integrin in the inactive form.

14 modimerization, thus constraining CAR in its inactive form.

15 protein builds up in the hyperphosphorylated inactive form.

16 ne, by cleaving membrane hemojuvelin into an inactive form.

17 the nucleus in a truncated and enzymatically inactive form.

18 yclic guanosine monophosphate (GMP) to their inactive form.

19 n of H12 is ligand-inducible to an active or inactive form.

20 osttranscriptional accumulation of DXS in an inactive form.

21 tor undergoes transitions between active and inactive forms.

22 e NTD but not the CTD in both the active and inactive forms.

23 (2) and switch regulators between active and inactive forms.

24 t, cooperative transition between active and inactive forms.

25 homeostasis by catabolizing AR agonists into inactive forms.

26 In cells, P-TEFb exists in active and inactive forms.

27 n growing cells, P-TEFb exists in active and inactive forms.

28 In growing cells, it is found in active and inactive forms.

29 pre-existing equilibrium between active and inactive forms.

30 ractions that keep the molecule in a closed (inactive) form.

31 ed much Rb protein in a hyperphosphorylated (inactive) form.

32 abine (2',2'-difluorodeoxycytidine) into its inactive form, 2',2'-difluorodeoxyuridine.

33 The N-terminal ATPase domains are inactive, forming a symmetric D1 ring, whereas the C-ter

34 (active form) and of phosphorylated 4E-BP1 (inactive form), a translation repressor.

35 PI(4,5)P2, which is loaded into cells in an inactive form and activated by light, allowing sub-secon

36 the CaSR by the transition between its open inactive form and closed active form.

37 for uniformly 2H,13C,15N-labeled TRAP in the inactive form and in the active form (free and bound to

38 CysSOH, and CysSO(2)(-) both in the NO-bound inactive form and in the photolyzed active form.

39 pothesized that UL16 is initially made in an inactive form and is artificially transformed to the bin

40 tion protein mu1, appearing to keep it in an inactive form and to prevent it from interacting with th

41 y of ARD1 GTPase to cycle between active and inactive forms and its autoubiquitination both appear to

42 ion of FBXL19 decreased both Rac1 active and inactive forms and significantly reduced cellular migrat

43 GAPC1 protein accumulation in enzymatically inactive form, and (5) strong relocalization of GAPC1 to

44 n, many metallocofactors can be converted to inactive forms, and pathways for their repair have recen

45 exists in an equilibrium between active and inactive forms, and the effector, cAMP, shifts that equi

46 cense origins by loading Mcm2-7 complexes in inactive form around DNA.

47 We found that there is less phospho-TTP (inactive form), as well as phospho-p38, in old than in y

48 of the Mcm2-7 helicase that is loaded in an inactive form at origins of DNA replication, suggesting

49 inserted domains, which were reverted to an inactive form by dithiothreitol reduction.

50 along the cell membrane and maintained in an inactive form by DivK~P.

51 oteins governs the transition from active to inactive forms by regulating DNA binding.

52 escribe the 1.8 A resolution structure of an inactive form (by replacing the catalytic nucleophile Se

53 of a latent plant PPO, its mature active and inactive form, caused by a sulfation of a copper binding

54 y grown cells is expressed exclusively in an inactive form containing only the as-isolated [2Fe-2S](2

55 Normally, in its inactive form, DFF is a heterodimer composed of a 45-kDa

56 LF4 proteins indicate that transcriptionally inactive forms do not increase involucrin expression.

57 mESCs but accumulates in the cytoplasm in an inactive form due to AKT1-dependent nuclear export and i

58 This finding confirms the existence of the inactive form E* in essentially the same incarnation as

59 earlier biochemical data suggesting that the inactive form exists in an equilibrium among different c

60 ated from a transcript of 1.4 kb, whereas an inactive form from a 1.2 kb mRNA was found in colon and

61 nct in the structure of its unphosphorylated/inactive form from IR/IGF-1R.

62 he translocation of phosphorylated FoxO3 (an inactive form) from nucleus to cytoplasm and the release

63 lls anergic, however, when the enzymatically inactive form H2N2 GRAIL was expressed, it functioned as

64 in lymphocytes (GRAIL), or an enzymatically inactive form, H2N2 GRAIL, allowed analysis of the role

65 However, an inactive form has also been isolated that lacks one of t

66 g the pool of nuclear beta-catenin toward an inactive form, having reduced binding to TCF/LEF transcr

67 K1 increased, whereas expression of a kinase-inactive form (HIPK1-D315N) or small interference RNA of

68 r factor I-mediated cleavage of C3b into the inactive form iC3b and thus prevents formation of inflam

69 virion-associated C3 component includes the inactive form iC3b, suggesting that SV5 may have mechani

70 ection is lost when CORM-3 is replaced by an inactive form (iCORM-3) that is incapable of liberating

71 an be further cleaved into a smaller and yet inactive form if matriptase-mediated proteolysis persist

72 logical conditions AMPK mainly exists in its inactive form in complex with Mg.ATP, which is much more

73 ated form in malignant cells but in a latent inactive form in normal tissues, suggesting that inhibit

74 that the photoswitch quickly relaxes to its inactive form in the dark.

75 ermore, the gingipain RgpB is excreted in an inactive form in the vimA mutant.

76 e form composed of cyclin T1 and CDK9 and an inactive form, in which cyclin T1/CDK9 is sequestered by

77 Levels of phospho-FoxO3a (inactive form) increased in the cytosolic fraction of ce

78 equires the enzyme PO that is present in its inactive form inside haemocytes.

79 aintaining microbial virulence factors in an inactive form inside the pathogen until secretion.

80 Because active AtMCP2d can cleave its inactive form, intermolecular cleavage (autolysis) of At

81 The dATP-induced inactive form is an alpha4 complex, which can interact w

82 or substitution of jmj2 with a catalytically inactive form is correlated with increased reporter gene

83 The inactive form is favored while unbound but the active fo

84 The balance between its active and inactive form is tightly controlled to ensure cellular i

85 nograft model and may have an advantage over inactive form kinase inhibitors due to equal potency aga

86 uggested that a compact and more symmetrical inactive form may predominate in solution in the absence

87 -sheet-rich, protease-resistant, aggregated, inactive form (Mcc(ia)), and a soluble, protease-sensiti

88 a tetramer, mR1(4a), which isomerizes to an inactive form, mR1(4b), and ATP binding to the hexameriz

89 her due to the generation of a catalytically inactive form of 5-LO, which assumes a new function.

90 inhibition is mediated by the enzymatically inactive form of 5-LO, which hinders nuclear translocati

91 reviously that a knockin mouse expressing an inactive form of ABIN1 (ABIN1[D485N]) develops lupus-lik

92 ly, we show that a soluble and catalytically inactive form of ACE2 potently blocked infection by S-pr

93 knock-in mice, which express a catalytically inactive form of AOC3, were also protected from lung fib

94 A proteolytically inactive form of APC with reduced anticoagulant activity

95 IAR3 hydrolyzes an inactive form of auxin (indole-3-acetic acid [IAA]-alani

96 s for the unphosphorylated and catalytically inactive form of biotin-p38alpha.

97 type mice, enhanced expression of the kinase-inactive form of BMPR-IB mediated by an adenovirus vecto

98 ATR and FA core complex, and represents the inactive form of both proteins.

99 oters and that expression of a catalytically inactive form of BRG1 results in derepression of PRMT7 t

100 Expression of a kinase-inactive form of c-Src (K(-) c-Src) or pharmacological i

101 Molecularly, mSH3BGRL specifically bound the inactive form of c-Src phosphorylated at Tyr527, promoti

102 he Src inhibitor PP2, expression of a kinase-inactive form of c-Src, and c-Src depletion by small int

103 pression of dominant-negative, catalytically inactive form of c-Src.

104 This process was abolished when a dominant inactive form of CaMKIV was expressed in normal T cells.

105 ISPR-dCas9 epigenetic editing tool, where an inactive form of Cas9 is fused to DNA methyltransferase

106 n increased the amount of the phosphorylated inactive form of Cdc2 by approximately 3-fold.

107 diated by accumulation of the phosphorylated inactive form of Cdc2.

108 t Cdk sites triggers the stabilization of an inactive form of Cdh1 that accumulates in the cytoplasm,

109 ppocampal neurons, the expression of DNcdk5 (inactive form of cdk5) or of the triple alanine mutant (

110 rylation is blocked by a dihydroceramide, an inactive form of ceramide, and manumycin, an inhibitor o

111 ntional amplicon DNA were associated with an inactive form of chromatin immediately after infection.

112 Interestingly, an inactive form of CORM-A1 that is incapable of releasing

113 ction of acetaminophen in mice expressing an inactive form of Cot/tpl2 compared with Wt mice, suggest

114 mulated in G2/M showed elevated levels of an inactive form of cyclin B1/p-Cdc2 (Tyr15) complex that w

115 Although the inactive form of cyclin-dependent kinase (CDK-1) is dete

116 liposomes reconstituted with a catalytically inactive form of Drs2p showed no translocation activity.

117 tion: Krz can directly bind and sequester an inactive form of ERK, thus preventing its activation by

118 endent inhibitors using either the active or inactive form of ERK2.

119 icial effects were less apparent for a redox-inactive form of Ero1.

120 e and lack of TLR5 binding to a biologically inactive form of flagellin or to a His-tagged non-flagel

121 The second form, a tetramer, may be an inactive form of FRP.

122 tural information is available for the free, inactive form of FVIIa that circulates in the blood prio

123 suggested the existence of a membrane-bound inactive form of FXa.

124 The structure of an inactive form of gelsolin shows that the equivalent acid

125 ctivity, since expression of a catalytically inactive form of GK did not alter endogenous hepatic GK

126 lycogen synthase kinase 3 beta (pGSK-3B), an inactive form of GSK-3B degrading glioblastoma 2 (GLI2),

127 the CDP-bound Hda dimer likely represents an inactive form of Hda.

128 Structural implication on how the inactive form of HrcA may be converted to the active for

129 phants with an mRNA encoding a catalytically inactive form of human DNMT1.

130 is effect, we also expressed a catalytically inactive form of human EL (ELS149A); unexpectedly, expre

131 Our results demonstrate that MeIAA is an inactive form of IAA, and the manifestations of MeIAA in

132 enzyme that hydroxylates JA to 12-OH-JA, an inactive form of JA that accumulates after wounding and

133 Moreover, a methyltransferase-inactive form of KsgA, which we show to be deleterious t

134 In addition, a relatively inactive form of LPA (LPA 8:0) was relatively ineffectiv

135 domain of an exogenously added enzymatically inactive form of LytA revealed a potential substrate for

136 within the trans-Golgi network leading to an inactive form of matrix metalloproteinase-2 (MMP-2).

137 We used a kinase inactive form of MEKK3 (MEKK3(KI)) in an in vitro assay

138 1 associated with MEKK3, and a catalytically inactive form of MEKK3 inhibited TNF-alpha-induced c-Jun

139 e absence of adenosylcobalamin but due to an inactive form of methylmalonyl-CoA mutase.

140 wild-type METTL3, but not of a catalytically inactive form of METTL3, inhibits cell differentiation a

141 d accelerating MPO compound II formation, an inactive form of MPO.

142 trans expression of the non-phosphorylated, inactive form of MtrA in wild-type M. smegmatis resulted

143 In the inactive form of MtrA, these two domains form an extensi

144 cted, thus representing the NCC bound to the inactive form of NOP.

145 OCE, we generated mice expressing a mutated, inactive form of Orai1 in blood cells only (Orai1(R93W))

146 Mice expressing a catalytically inactive form of p110delta (p110delta(D910A)) were gener

147 ssues from mice expressing the catalytically inactive form of p110delta (p110delta(D910A)).

148 Previously we showed that the inactive form of p90 ribosomal S6 kinase 1 (RSK1) intera

149 Furthermore, a full-length kinase-inactive form of PAK2 blocked both TCR-induced CD69 up-r

150 nificant correlation between MICU1 and pPDH (inactive form of PDH) expression with poor prognosis.

151 Expressing a catalytically inactive form of Pet PLC1 in pollen tubes caused expansi

152 Whereas an inactive form of PKC-theta or knockdown of endogenous PK

153 or rottlerin or the expression of the kinase-inactive form of PKCtheta.

154 agmentation, which was inhibited by a kinase inactive form of PKD.

155 ctivation, as did overexpression of a kinase-inactive form of PKD1.

156 Using an inactive form of PleC (PleCH610A) that lacks the catalyt

157 In contrast, a catalytic inactive form of PP2A or PP2A small interfering RNA blun

158 Surprisingly, expression of a catalytically inactive form of Psd1 still supported PDR5 transcription

159 suggest that stabilization of the oxidized, inactive form of PTP1B with appropriate therapeutic mole

160 ts PTP1B activity by increasing the oxidized inactive form of PTP1B.

161 A1 binding is preferential for the GDP-bound inactive form of Rab14.

162 We show that the inactive form of Rab1b (the N121I mutant with impaired g

163 channels can catalyze the conversion of the inactive form of Rho to the active form, we show mathema

164 ormation is consistent with the dimer of the inactive form of rhodopsin modeled with constraints from

165 g, we introduced wild type Rip1 and a kinase-inactive form of Rip1, Rip1D138N, into rip1-/- murine em

166 small organic molecules such as glucose, an inactive form of SA is generated which can be transporte

167 Overexpression of the phosphatase-inactive form of SHP-2 inhibited EGFRvIII pTyr by decrea

168 rthermore, overexpression of a catalytically inactive form of SHP2 or pretreatment with pervanadate m

169 sses HBV replication, while an enzymatically inactive form of TAK1 exerts no effect.

170 ress other T cells by converting the latent, inactive form of TGF-beta1 into active TGF-beta1.

171 vivo Accordingly, exogenous expression of an inactive form of the 5-HT2C receptor in the locus cerule

172 uscle-specific transgenic mice expressing an inactive form of the AMPK alpha2 catalytic subunit (alph

173 ke persists in transgenic mice expressing an inactive form of the AMPKalpha2 catalytic subunit in ske

174 itrosoamino)-2,4-dinitrobenzene (C6') and an inactive form of the compound [1,5-bis-(dihexylamino)-2,

175 A nearly inactive form of the enzyme, ALDH2*2, is found in about

176 of ATR kinase and overexpression of a kinase-inactive form of the enzyme, I show here that ATR promot

177 The other pathway leads to an inactive form of the enzyme, which was shown by chemical

178 histidine, an arrangement consistent with an inactive form of the enzyme.

179 nd between these residues might stabilize an inactive form of the enzyme.

180 ors of human RR which act by stabilizing the inactive form of the enzyme.

181 PI recruitment to membranes by expressing an inactive form of the GBF1 guanine nucleotide exchange fa

182 urons of the active, but not a catalytically inactive form of the Grx1 homolog rescued the exacerbate

183 Overexpression of the inactive form of the GTP exchange factor ARNO (ARF nucle

184 suggest that our structure may represent an inactive form of the HrcA repressor.

185 Mice expressing a kinase-inactive form of the inhibitor of kappa B kinase alpha (

186 ordetella pertussis, preferentially binds an inactive form of the integrin complement receptor 3 (CR3

187 nerated from mice expressing a catalytically inactive form of the p110delta subunit of phosphatidylin

188 LR (LSCQLYQR), allosterically stabilizes the inactive form of the protein and inhibits ovarian cancer

189 Because the ligand binds to an inactive form of the protein in which an Asp-Phe-Gly str

190 st the toxin, it is imperative to achieve an inactive form of the protein which preserves the overall

191 sults in the accumulation of a catalytically inactive form of the protein, which may contribute to ag

192 n the absence of calcium ions represents the inactive form of the protein.

193 ind to the dimer interface and stabilize the inactive form of the protein.

194 (Pdk2) and the product of its activity, the inactive form of the pyruvate dehydrogenase complex (P-P

195 ns 2, 3, and 7 that appears to stabilize the inactive form of the receptor.

196 Cells expressing the enzymatically inactive form of the secreted isoform, ADAM12-S, had tum

197 By combining J8-DT with an inactive form of the streptococcal CXC protease, S. pyog

198 d with its allosteric inhibitor AMP shows an inactive form of the tetramer, in which the dimer pairs

199 OriP-dependent DNA replication, while a PARP-inactive form of TNKS2 (M1045V) was compromised for this

200 half a charge less upon binding DNA than an inactive form of topoisomerase I.

201 A relatively inactive form of tPA was constructed by conjugating tPA

202 y generated mouse strain expressing a kinase-inactive form of TPL-2, we demonstrated that stimulation

203 Over-expression of a catalytically inactive form of USP14 rescues the PPF deficit and resto

204 diminished by expression of a catalytically inactive form of Usp14.

205 educed in animals expressing a catalytically inactive form of VAP-1, implicating enzyme activity in t

206 The circulating, inactive form of vitamin D, 25(OH)D(3), is generally use

207 However, TIMP-1JD38 cells expressed an inactive form of XBP-1, lacking antibody production/secr

208 escued with catalytically active but not the inactive forms of ADAMTS5 or ADAMTS15.

209 ression of either wild-type or catalytically inactive forms of AKR1C3 partially rescued AR activity a

210 Inactive forms of all G protein alpha subunits can be pr

211 When catalytically inactive forms of CaI were used in CdS-CaI complexes, ET

212 , this effect is observed with catalytically inactive forms of Cdc9p protein, but only if they posses

213 r the protective effects of CORM-2 in AP, as inactive forms of CORM-2 were ineffective.

214 receptors MiD51 and MiD49 appear to recruit inactive forms of Drp1, because their overexpression inh

215 it adopts a tethered conformation similar to inactive forms of ErbB1 and ErbB3.

216 In both active and inactive forms of ERK2, protection from hydrogen exchang

217 n ELMO1 interaction with both the active and inactive forms of ERM proteins and implying a possible r

218 Overexpression of dominant inactive forms of ezrin leads to fragilization of the me

219 10 occurred even with mutated, catalytically inactive forms of F10.

220 acterize the conformations of the active and inactive forms of full-length AfGcHK in solution, we inv

221 nteracts with Gbeta3 and with the active and inactive forms of Galphao.

222 of RGS14 outside of the RGS domain can bind inactive forms of Go and Gi to confer previously unappre

223 t of exosome secretion because enzymatically inactive forms of heparanase, even when present in high

224 fects of overexpressing wild-type or mutated inactive forms of HER2 in primary human breast cells.

225 , as exosome-mediated delivery of active and inactive forms of HIF1alpha results in reciprocal change

226 Unexpectedly, mutated, inactive forms of HS2 impeded the activation of the beta

227 dox-dependent conversions between active and inactive forms of hydrogenase, but the voltammetric sign

228 by coexpression of wild-type but not kinase inactive forms of IKKalpha, suggesting that IKKalpha may

229 dies suggest that cycling between active and inactive forms of KrsB may provide the dynamic regulatio

230 h slightly greater flexibility is present in inactive forms of MntR.

231 These inactive forms of OhrR can be reactivated by thiol-disul

232 1Delta mutant cells expressing catalytically inactive forms of Pah1p and dgk1Delta mutant cells with

233 Catalytically inactive forms of phosphorylated SHP-2 proteins were als

234 reoxygenation and promoted an association of inactive forms of PKC with Bax.

235 ignaling, the wild-type or the catalytically inactive forms of PLD1 or PLD2 were stably overexpressed

236 he interaction of RhoGDI with the active and inactive forms of prenylated and unprenylated RhoA.

237 Inactive forms of Rac, including the human Rac2(D57N) mu

238 nhanced GFP-tagged constitutively active and inactive forms of rap1B demonstrated that the active GTP

239 t other RPTP family members or catalytically inactive forms of RPTP-beta, reduces hepatocyte growth f

240 Phosphatase-inactive forms of SCP interfere with REST/NRSF function

241 subfamily, GRK5/6 effectively phosphorylate inactive forms of several GPCRs, including beta2-adrener

242 he Shp2 catalytic domain and result in open, inactive forms of Shp2.

243 Constitutively active or inactive forms of STAT1 did not promote lumen maturation

244 permitting completion of splicing generates inactive forms of TER1 and causes progressive telomere s

245 atinib and GNF-2 or overexpression of kinase-inactive forms of the Abl family kinases also impairs pa

246 nzyme quickly to form hydrolytically stable, inactive forms of the enzyme that have been characterize

247 nts can differentiate between the active and inactive forms of the enzyme, indicating that they are a

248 Modulation of the active versus inactive forms of the Galpha protein is critical for the

249 y provide models for the proposed active and inactive forms of the H. influenzae and E. coli enzymes.

250 ed by constitutively active c-Src but not by inactive forms of the kinase.

251 3 activation by H2O2 was inhibited by kinase-inactive forms of the PDGF beta receptor or ATM.

252 ne, possibly corresponding to the active and inactive forms of the receptor, and can "switch" between

253 The modeled systems include the active and inactive forms of the wild-type Galpha(t) and three of i

254 ild type GRK2 or GRK5, whereas catalytically inactive forms of these kinases were without effect.

255 ll death, indicating that viruses expressing inactive forms of these proteins can contribute to the C

256 filaments, resembling polymers formed by the inactive forms of this protein.

257 erologous expression of wild-type and kinase-inactive forms of TLK-1 suppresses the lethality of temp

258 strains that secrete functionally active or inactive forms of YopJ.

259 detectable increases in the CaM-free (i.e., inactive) form of iNOS within the first 2 h; it remains

260 Both reduced (active) and disulphide bonded (inactive) forms of IL-33 can be detected in lung lavage

261 genetically wild-type, but transcriptionally inactive, form of p53, often localized in the cytoplasm.

262 yze the interconversion of the GDP-bound, or inactive, form of Rab to the GTP-bound, or active, form.

263 Rab9 is likely sequestered in an inactive form on Niemann-Pick type C membranes, as catio

264 m of RNA polymerase 2 (RNAPII) compared with inactive forms only in interactions between promoters an

265 , however, represent the open, catalytically inactive form or harbor nonproductive substrate analogs.

266 ock divisome activity by locking FtsA in the inactive form or preventing FtsA from communicating with

267 mplexes either with sigmaF, holding it in an inactive form, or with the anti-anti-sigma factor SpoIIA

268 tively regulate the CPC and/or stabilize its inactive form, preventing CPC autophosphorylation and re

269 tractant circulates in blood in a relatively inactive form (prochemerin) and is activated by carboxyl

270 shift of the equilibrium between active and inactive forms raises constitutive activation in one rec

271 Chd7 or overexpression of its catalytically inactive form recapitulates all major features of CHARGE

272 y shRNA or overexpression of a catalytically inactive form rescued neurons from zinc-induced cell dea

273 On the other hand, expression of a kinase-inactive form reverted the anchorage-independent growth

274 al using the crystal structure of MOR in the inactive form showed a unique binding mode with the two

275 host sec system, where they accumulate in an inactive form tethered to the membrane by their N-termin

276 The Dd FDH is suggested to be purified in an inactive form that has to be activated through a reducti

277 , we engineered the same antibody in an ADCC-inactive form that is similarly capable of blocking HGF/

278 nocyte-stimulating hormone (alpha-MSH) to an inactive form that is unable to inhibit food intake.

279 nusually, these toxins are synthesized in an inactive form that requires posttranslational activation

280 , Mot1-TBP complexes can exist in active and inactive forms that are regulated by environmental stres

281 In its inactive form, the prototype SAR endolysin, Lyz(P1), of

282 The structure is in an inactive form; the side-chain of His409, one of the cata

283 of this neurotrophin receptor, favoring the inactive form throughout multiple corticolimbic brain re

284 AMPK is converted from an inactive form to a catalytically competent form by phosp

285 eutral pH conformation or its switch from an inactive form to an activated form.

286 ational change in the dimer from an assembly-inactive form to an assembly-active form.

287 opose the basis for the stabilization of the inactive form to be through a salt interaction between A

288 ystal structure of CSN5 in its catalytically inactive form to illuminate the molecular basis for its

289 tch for transitioning beta-arrestin from its inactive form to its active receptor-binding state.

290 itionally, IL-18 processing of its precursor inactive form to its bioactive state is inhibited by LXR

291 the pocket remains open in the catalytically inactive form upon removal of an inhibitor from the pock

292 76, ADAP, or Pyk2, or expressing Pyk2 kinase-inactive forms, we show that SLP-76 and ADAP stimulate c

293 Major differences between the active and inactive forms were observed on the heme-proximal side (

294 exists in two forms in cells as follows: an inactive form where the core components cyclin T1 and CD

295 toxin, which poses a threat to life, to the inactive form which can bind to antibodies but show no t

296 and RhoA, bind to smgGDS in both active and inactive forms which requires the presence of poly-basic

297 P-TEFb is found in two major complexes: the inactive form, which is associated with inhibitory subun

298 T represents an oxidized, previously unknown inactive form, whilst ScKAT is the reduced and active en

299 erts cellular cullin 3 into an un-neddylated inactive form with no or minimum effect on other cullin

300 of G-proteins switch between the active and inactive forms without a GEF.