ライフサイエンスコーパス: inactive state

1 s that restrain Ras dynamics and promote the inactive state.

2 participate in the early maintenance of the inactive state.

3 each factor separately arriving at a stable inactive state.

4 as with SML-8-73-1 renders the protein in an inactive state.

5 mers that secure a therapeutic payload in an inactive state.

6 ons of the GPCR from the active state to the inactive state.

7 ta for Nlh2-linked GAF-ATPase domains in the inactive state.

8 cycle comprising a poised, an active, and an inactive state.

9 lar contacts that lock the Rap protein in an inactive state.

10 nthesized and transported in a predominantly inactive state.

11 tic domain, allosterically clamping it in an inactive state.

12 ery of oligodendrocytes in a translationally inactive state.

13 at the active PHO5 gene in comparison to its inactive state.

14 tions are important in maintaining AKT in an inactive state.

15 whereas Tyr-559 maintains the receptor in an inactive state.

16 that metavinculin can bind to raver1 in its inactive state.

17 by which phyB reverts from the active to the inactive state.

18 ls in the nucleus, albeit in a deacetylated, inactive state.

19 nce increase characteristic of moving to the inactive state.

20 hold that allows the kinetic trapping of the inactive state.

21 il domain that normally clamp vinculin in an inactive state.

22 idues in maintaining calcium-bound TG2 in an inactive state.

23 jority of these cells stay in a nondividing, inactive state.

24 and can stably adopt either an active or an inactive state.

25 exported to the cytoplasm in a functionally inactive state.

26 state, and then increased upon going to the inactive state.

27 binding ACV, the enzyme remains in the open, inactive state.

28 ot alter the structure of rhodopsin from the inactive state.

29 n by trapping the convertase in a stable but inactive state.

30 failed to bind PA, consistent with a locked inactive state.

31 Swi6 (HP1 homologs) are recruited during the inactive state.

32 ion that is in a catalytically active versus inactive state.

33 the infected cell in a hyperphosphorylated, inactive state.

34 se domains simultaneously and keep Src in an inactive state.

35 ydrolysis by myosin that exceeds that of the inactive state.

36 ain interactions hold unliganded dEGFR in an inactive state.

37 thway is functional and can lock Cdk1 in the inactive state.

38 is of the phosphoryl group reestablishes the inactive state.

39 close proximity with the fluorophore in the inactive state.

40 salt bridge that helps maintain the integrin inactive state.

41 s), where they are held in a translationally inactive state.

42 entrapment of the assembled convertase in an inactive state.

43 tein interactions and maintains P-TEFb in an inactive state.

44 conformationally trap a macromolecule in its inactive state.

45 ), become more water exposed compared to the inactive state.

46 nformational equilibrium of HUWE1 toward the inactive state.

47 ntains the JIP-JNK module in a catalytically inactive state.

48 can maintain them in a partially reversible inactive state.

49 s the anaphase-promoting complex (APC) in an inactive state.

50 te and immune-cell activation to maintain an inactive state.

51 inery, thus effectively trapping VAMP4 in an inactive state.

52 er, existing in an immunologically active or inactive state.

53 r B, thereby locking in the convertase in an inactive state.

54 ide exchange factors and thus trapped in its inactive state.

55 traps Cas9 in a DNA-bound but catalytically inactive state.

56 pon a stimulus reversibly can switch into an inactive state.

57 the viral GPCR to destabilize the receptor's inactive state.

58 ates, with an imbalance of rates favoring an inactive state.

59 n flow reflected the fraction of FimH in the inactive state.

60 tions as an RNA decoy to sequester PKR in an inactive state.

61 native exteins, which lock the intein in an inactive state.

62 which converts them between an active and an inactive state.

63 a dual-state model consisting of active and inactive states.

64 hifts the equilibrium between the active and inactive states.

65 ) demonstrated equal affinity for active and inactive states.

66 ructural states that resemble the active and inactive states.

67 ecting the ratio between assembly active and inactive states.

68 (2)A receptor have been solved in active and inactive states.

69 b partitions between small active and larger inactive states.

70 n-induced heme distortions in its active and inactive states.

71 stal structures of EhRho1 in both active and inactive states.

72 otal and nearly instantaneous, producing two inactive states.

73 ive affinities of agonist for the active and inactive states.

74 nsory TFs quickly transit between active and inactive states.

75 changes to transition between its active and inactive states.

76 es adopted by the tetramer in its active and inactive states.

77 conformation of Kinesin-1 in the active and inactive states.

78 formational switching between the active and inactive states.

79 tral pattern generator to produce active and inactive states.

80 nct conformations of GPCRs in the active and inactive states.

81 otide-dependent switching between active and inactive states.

82 ctivation mechanism consisting of 10 or more inactive states.

83 and Arf1-bound AP-1 trimer in the active and inactive states.

84 results to define the relationships of these inactive states.

85 a GTP-bound "active" state and a GDP-bound "inactive" state.

86 either a bursting (active) or non-bursting (inactive) state.

87 tor (beta2AR): 1), the inverse-agonist-bound inactive state; 2), the agonist-bound intermediate state

88 eptor exists in three predominant states: an inactive state, a weakly active state, and a CRF-bound f

89 in three functional states-an 'open', ATPase-inactive state; a 'closed', ATPase-inactive state; and a

90 oenzyme complex of protein kinase A is in an inactive state; activation involves ordered cAMP binding

91 receptor variants stabilized in the intended inactive state among which two exhibit an apparent therm

92 col detergent micelles revealed two distinct inactive states, an activation intermediate state en rou

93 nce are required for maintaining aPKCs in an inactive state and are targeted by PIP3 for displacement

94 main of RIG-I to maintain the receptor in an inactive state and attenuate its sensing of viral RNA (v

95 ate of an ectotherm in a post-absorptive and inactive state and can constitute a significant portion

96 nct chromosomes spatially associate in their inactive state and dissociate upon activation.

97 an inverse agonist traps the receptor in the inactive state and makes the other conformations inacces

98 olymerase in a promoter-bound, catalytically inactive state and may additionally ensure polymerase pa

99 p to lock the collagen-binding domain in the inactive state and prevent unwarranted signaling by rece

100 on of the promoter region correlated with an inactive state and prevented Sp1 activation.

101 associated with a receptor is locked into an inactive state and receptor binding through the FERM dom

102 cycle that uses the fast binding rate of the inactive state and slow unbinding rate of the active sta

103 that the catalyst was stable in the reduced/inactive state and that extended durations in this state

104 They shuttle between the GDP-bound inactive state and the GTP-bound activated state and the

105 stions about the true conformation(s) of the inactive state and the role of the ionic lock in recepto

106 ch ligand-binding selects the faster-binding inactive state and then induces the active state.

107 cessible binding configurations: one closed, inactive state and two open, active states.

108 iated with enrichment of H3K27me3-associated inactive states and poised (bivalent) enhancer states.

109 Sre1-Scp1 complex exists under "active" and "inactive" states and that the transition between these s

110 PKC toward the anterior but holds aPKC in an inactive state, and a CDC-42-dependent assembly in which

111 2) allosteric inverse agonists stabilize the inactive state, and allosteric agonists stabilize the we

112 ys300 forms a salt bridge with Asp163 in the inactive state, and releases a proton when a sodium ion

113 map to structural elements that maintain the inactive state, and we provide biochemical evidence that

114 kinase is the transition between active and inactive states, and defining the conformational feature

115 ', ATPase-inactive state; a 'closed', ATPase-inactive state; and a 'closed', ligand-bound, ATPase-act

116 Reactivation experiments show that two inactive states are formed by interaction with oxygen an

117 ations closely resembling natural active and inactive states, as well as modulated the morphodynamics

118 Here, we investigated the inactive-state assembly of heterotrimeric G proteins wit

119 CaM suggest that CCaMK is maintained in the inactive state at basal calcium concentrations and is ac

120 ferredoxin-like allosteric domain.Active and inactive state ATP-phosphoribosyltransferases (ATP-PRTs)

121 by the redevelopment of fluorescence as the inactive state became populated.

122 nsition of a centromere from an active to an inactive state because of the lack of examples of the sa

123 promoter region when in a transcriptionally inactive state before the onset of actinorhodin producti

124 promoter-proximal regions in a catalytically inactive state bound to the 7SK small nuclear ribonucleo

125 tructures of the D4 dopamine receptor in its inactive state bound to the antipsychotic drug nemonapri

126 y embryonic stages maintaining a poised, but inactive state broadly across the distal limb mesenchyme

127 trix metalloproteinases are maintained in an inactive state by a bond between the thiol of a conserve

128 lds the kinase's catalytic subunit (C) in an inactive state by exerting an allosteric inhibitory effe

129 In the absence of ABA, SnRK2s are kept in an inactive state by forming physical complexes with type 2

130 SFKs are maintained in an inactive state by inhibitory phosphorylation of their C-

131 ctin-tropomyosin-troponin was shifted to the inactive state by mutations that mimic troponin I phosph

132 turn, keeps integrin-associated c-Src in an inactive state by phosphorylating Y(529) in its regulato

133 rconversion between the active state and the inactive state by targeted molecular dynamics simulation

134 The inactive state can also be activated by decreasing the p

135 omoters between transcriptionally active and inactive states, causing transcription to occur in burst

136 alphas, Galphao and Ga12/13), and that these inactive-state complexes are dissociated by WNTs and reg

137 f TCP, H(2)O(2) alone converts oxy-DHP to an inactive state (compound RH) instead of oxidizing the en

138 subset of conformations including active and inactive state conformations, while inverse agonist cara

139 while inverse agonist carazolol selects only inactive state conformations.

140 landscape links the active state to several inactive states, connected via a structurally diverse in

141 igh salt, the active tetramer converts to an inactive state consisting of an inactive-destabilized te

142 beta(1)-adrenergic receptors in a nominally inactive state constituted a major advance toward this g

143 fluorescent behaviour: it equilibrates to an inactive state, converts to an active state under blue l

144 ehaviour of GPCRs not addressable by static, inactive-state crystal structures.

145 s have strong preferences for the active and inactive states depending on their modulatory nature.

146 alleles of a given locus in both active and inactive states, depending on which X chromosome is sile

147 tching of this terminator between active and inactive states dictates the transcription status of the

148 7me3 levels present during transcriptionally inactive states did not interfere with the transition to

149 wild-type TnI with S45E TnI, that favors the inactive state, did not restore the fluorescence change.

150 during transcription as it stalls at various inactive states due to erratic translocation.

151 NF1 complex is crucial to maintenance of the inactive state during growth on high glucose and that th

152 tive state is stabilized relative to the apo/inactive state, dynamics are consistently quenched in a

153 st that a portion of receptors can remain in inactive states even in the presence of saturating conce

154 rmations that are conducive to the assembled inactive state, even when no interactions with the rest

155 rHydA1C169S, the H-cluster was trapped in an inactive state exhibiting g values and vibrational frequ

156 aneously to CRL4A, favouring a deneddylated, inactive state for substrate-free CRL4 complexes.

157 Gi/o proteins and their cognate GPCRs in the inactive state (Gi/o-GPCR preassembly).

158 for which a structure of the protein in its inactive state has been determined.

159 as a kinase switches between its active and inactive states, has been identified.

160 In hINO80, Uch37 is held in an inactive state; however, it can be activated by transien

161 mall GTPases and keep them in a biologically inactive state in cytoplasm, through which it affects ac

162 the paternal genome into a transcriptionally inactive state in late-stage spermatids.

163 ATM exists in an inactive state in resting cells but can be activated by

164 odimeric kinesin-2 motor KIF17 is kept in an inactive state in the absence of cargo.

165 ubunit that function to hold the dimer in an inactive state in the absence of the Fis/enhancer system

166 is ordinarily maintained in a catalytically inactive state in the intestine and other organs.

167 basal and spinous epidermal cells to a fully inactive state in the keratinized cells of the cornified

168 h it is bound to Miro only via milton, to an inactive state in which direct binding to Miro prevents

169 riven chloride pumps that enter long-lasting inactive states in response to light.

170 the intrinsic equilibrium between active and inactive states in the absence of agonist, and the energ

171 osteric sites on the enzyme, which stabilize inactive states in the conformational ensemble.

172 To examine the interconversion of active and inactive states in the ensemble, we used detection of re

173 ce, shifting its conformation from a closed (inactive) state in water to an open (active) state at th

174 ions restrain integrin family members in the inactive state, including a set of salt bridges on the c

175 entry into, and exit from, transcriptionally inactive states, including pausing and arrest.

176 apo CBD dynamically samples both active and inactive states independently of the adjacent CBD within

177 The enzyme is held in an inactive state inside of the bacterium due to the absenc

178 ays indicated that Galpha13 in its active or inactive state interacts with R7-RGS heterotrimers conta

179 nd hydrogen bonds that regulates hMGL active-inactive state interconversion.

180 These findings suggest the inactive state is a biologically relevant alternate conf

181 at the active state is extended, whereas the inactive state is compact.

182 opsin for which the crystal structure of the inactive state is known.

183 The inactive state is less dynamic compared with the interme

184 onstrated that PheVI:09 (6.44), which in the inactive state is locked between the backbone and two hy

185 Solution studies suggest that the assembly-inactive state is more accurately an ensemble of conform

186 wild-type-arrested prophase blastomeres, the inactive state is not detected in the anoxia exposed npp

187 equencing, we could show that the methylated inactive state is the default status of Fie1 in most tis

188 In the inactive state, KaiC binds KaiB, which not only stabiliz

189 apid engagement by a counterstructure in the inactive state leads to a requirement for a selectin-med

190 on the IL-10 gene because its locus is in an inactive state, likely reflecting a neutrophil-specific

191 t the maintenance of unliganded RNF146 in an inactive state may serve to maintain the stability of th

192 Glide docking studies in our cannabinoid CB2 inactive state model that were then tested via compound

193 three electrons needed to form the oxidized inactive state "Ni-B" or "Ready" (Ni(III)-OH).

194 The transition between active and inactive states occurs through multiple pathways, facili

195 onin I that reduce activity do stabilize the inactive state of actin, we introduced negative charges

196 c and functional sites exists already in the inactive state of all three proteins.

197 'lariat loop' implicated in maintaining the inactive state of beta-arrestin-1.

198 lock and other interactions stabilizing the inactive state of beta2AR are weaker.

199 contributes to the maintenance of the closed inactive state of CARD11 that predominates in the absenc

200 cular dynamics simulations starting from the inactive state of D3R in complex with these enantiomers.

201 exposure to UCPH-101 induces a long-lasting inactive state of EAAT1, whereas the inhibition exerted

202 ormational transition between the active and inactive state of hTS.

203 membrane conjointly determine the active or inactive state of K-Ras4B.

204 nds that stabilize a previously unrecognized inactive state of KSR.

205 3 histone mark are essential to maintain the inactive state of many of these genes.

206 an outward partially occluded and an outward inactive state of MelBSt.

207 ed ligand stabilize an inward-facing, ATPase-inactive state of MetNI to inhibit further ligand transl

208 In addition to the inactive state of NF-kappaB, the deficiency in the infla

209 ional change pathways between the active and inactive state of nitrogen regulatory protein C (NtrC).

210 umor cell proliferation and implies that the inactive state of PKM2 is associated with the proliferat

211 previously unrecognized role in forming the inactive state of regulated actin.

212 hydrogen-bonding network on stabilizing the inactive state of rhodopsin and contribute to our curren

213 flip back to the orientation observed in the inactive state of rhodopsin under conditions favoring th

214 he CRD, linker domain and TMD stabilizes the inactive state of Smoothened.

215 provide a more comprehensive picture of the inactive state of the beta-adrenergic receptors, reconci

216 a three-dimensional structural model of the inactive state of the C5a receptor, the preserved residu

217 A homology model of the inactive state of the CB(1) receptor was constructed usi

218 are the molecular constraints imposed on the inactive state of the CB(1) receptor.

219 rine 637 (P-DRP1(S637)), associated with the inactive state of the DRP1 GTPase.

220 e formation of sulfcatalase, an irreversible inactive state of the enzyme, without the intervention o

221 mediate compound II formation, a temporarily inactive state of the enzyme.

222 eak critical interactions that stabilize the inactive state of the kinase, thereby facilitating struc

223 whereas the GCN2 structure may represent an inactive state of the kinase.

224 these results and an X-ray structure of the inactive state of the M3 receptor bound by the antagonis

225 at were proposed to represent the active and inactive state of the protein, and a domain-forming mode

226 egatively regulates CCaMK by stabilizing the inactive state of the protein.

227 pair that was attributed to a catalytically inactive state of the PTC.

228 egulates the transition from an active to an inactive state of the RAF-1 kinase.

229 Active retinal destabilizes the inactive state of the receptor, whereas the active ensem

230 rich (Pr) peptide segment and stabilizes the inactive state of the repressor.

231 Using NMR, we solve the structure of the inactive state of the ribozyme in the absence of magnesi

232 Hence, the primed but inactive state of the ZRS is induced by FGF signalling a

233 ECL2 in the N111G mutant was similar to the inactive state of wild-type AT1R.

234 e transition from active to intermediate and inactive states of actin-tropomyosin-troponin.

235 e dynamic auto-inhibitory equilibrium toward inactive states of HCN4 and broadens the free-energy wel

236 a reversible equilibrium between active and inactive states of human MGL (hMGL) that is slow on the

237 al, AAPs cross-linked to both the active and inactive states of kinases but performing phosphopeptide

238 conformational transition between active and inactive states of L1L.

239 ctural analyses of the signaling-active and -inactive states of RhoA have been performed, thus far, t

240 ent crystal structures provide insights into inactive states of several GPCRs.

241 However, unlike the Ni-A and Ni-B inactive states of standard [NiFe]-hydrogenases, both of

242 is required for the modulation of active and inactive states of the 7TM by agonists, but is not neces

243 vation, indicating that 1-octanol stabilized inactive states of the channel.

244 e present structures representing active and inactive states of the PP2C phosphatase SpoIIE from Baci

245 Thus, our data suggest that signaling and inactive states of the receptor are related by receptor

246 lished by nuclei randomly adopting active or inactive states of transcription, leading to a collectiv

247 lated motifs and facilitate either active or inactive states of transcription.

248 rtantly, K-Ras4B-GTP can exist in active and inactive states; on its own, GTP binding may not compel

249 HT 1864 therefore places Rac in an inert and inactive state, preventing its engagement with downstrea

250 oove at Arp3's barbed end to destabilize the inactive state, providing a mechanism by which WASP stim

251 e free RNA exist as a dynamic equilibrium of inactive states rapidly interconverting with a low popul

252 C(ox) and forming a modified version of this inactive state rather than reacting directly with C(red1

253 ell, or refold the cargo-free motors into an inactive state ready for the next cellular calcium flux.

254 helix of the HisKA domain that destroys the inactive state residue contacts and suggests how signal-

255 are presumed to correspond to the active and inactive state, respectively.

256 HER2) inhibitors and modeled HER2 active and inactive state structures.

257 the known microscopic characteristics of the inactive states, such as the ionic lock, the inward posi

258 A structural model of PKCdelta in the inactive state suggests that the nuclear localization se

259 erium tuberculosis may enter a metabolically inactive state that is less susceptible to antibiotics.

260 eatures allow RasGRP1 to be maintained in an inactive state that is poised for activation by calcium

261 laments of DrRecA protein exhibit active and inactive states that are readily interconverted in respo

262 Our data revealed that, in the inactive state, the intracellular lipid/aqueous border o

263 In addition, in the inactive state, the KHC motor domains are pushed apart b

264 lls, also plays a role in maintenance of the inactive state through regulation of BMP/TGF-beta signal

265 tion maintains these catalytic ligases in an inactive state through several mechanisms.

266 ransiently requiring excess molecules in the inactive state to achieve at least one molecule (rather

267 witches the RING domain from a catalytically inactive state to an active one.

268 is conformationally converted from a largely inactive state to an active state upon UPF2 binding.

269 CARD11 undergoes a transition from a closed, inactive state to an open, active conformation that recr

270 in adapter CARD11 transitions from a closed, inactive state to an open, active scaffold that assemble

271 es the Trp-356(6.48) rotameric switch in the inactive state to promote the formation of an extensive

272 moves the target protein from an ensemble of inactive states to a well-defined active conformation.

273 lb3 translocase drive cpSRP43 to a partially inactive state, triggering selective release of LHCP's t

274 by mobilizing a pool of syntaxin4 held in an inactive state under basal conditions.

275 ycling of the protein between its active and inactive states under aerobic conditions without apparen

276 Ks) hold the CENP-A assembly machinery in an inactive state until mitotic exit and entry into G1, at

277 mparison of RhoC in its GDP-bound (signaling-inactive) state versus its GTP-bound (signaling-active)

278 the ErbB2 kinase domain is stabilized in an inactive state via a hydrophobic interaction between the

279 To maintain target promoters in an inactive state, VprBP stably binds to nucleosomes by rec

280 erminal epitope expected to be masked in its inactive state was rendered immunoreactive.

281 more frequent transitions between active and inactive states was associated with equivalent self-repo

282 lexibility and to potentially trap a closed, inactive state, we generated a series of disulfide bond

283 affold predicted to stabilize kinases in the inactive state, we generated a series of selective type

284 el analysis suggested that the R2 active and inactive states were determined by R2 distribution withi

285 pCas9-HF1 and eSpCas9(1.1) are trapped in an inactive state when bound to mismatched targets.

286 nts: a wild-type FimH variant that is in the inactive state when not bound to its target mannose, and

287 nsitions among the active, intermediate, and inactive states when S1 is rapidly detached from actin-t

288 onfines GBR1 to the open conformation of the inactive state, whereas an agonist induces its domain cl

289 and preladenant) bound preferentially to the inactive state, whereas neutral antagonists (theophyllin

290 nal switch allows for the transition from an inactive state (wherein the adamantane protein-binding h

291 rucial to the active state, is absent in the inactive state, which comprises a heterogeneous collecti

292 formational transition between an active and inactive state, which is difficult to capture experiment

293 rmational equilibrium of RORgammat toward an inactive state, which underlies the molecular mechanism

294 neously decays to that characteristic of the inactive state with a lifetime of approximately 16 min a

295 DT concentration, adsorbed DT passes from an inactive state with a monomeric dimension normal to the

296 g(2+) into its place and are locked in their inactive state with dominant negative properties.

297 steric sodium ion and confined mostly in the inactive state with remarkably reduced flexibility.

298 (2)-symmetric complexes constitute either an inactive state [with Pb(II)] or a resting state [with Bi

299 p explain how Arp2/3 complex is locked in an inactive state without activators and how autoinhibition

300 phase-transition between globally active and inactive states would emerge near this threshold number