ライフサイエンスコーパス: inactivity

1 (e.g., smoking, overweight/obesity, physical inactivity).

2 vigilance (sustained eye closure and muscle inactivity).

3 ng, unaffected by the confounding effects of inactivity.

4 olic event, and cerebrovascular disease than inactivity.

5 majority of confounding factors, especially inactivity.

6 g high WC were similar to those for physical inactivity.

7 inical disorders characterized by behavioral inactivity.

8 eriods of dehydration and relative metabolic inactivity.

9 early identification of groups vulnerable to inactivity.

10 p21, thus sustaining RB phosphorylation and inactivity.

11 y patterns after periods of induced neuronal inactivity.

12 insulin during their daily phase of relative inactivity.

13 ing status, alcohol consumption and physical inactivity.

14 approximately 15 and approximately 30 min of inactivity.

15 for patients discontinued because of disease inactivity.

16 the respiratory network following months of inactivity.

17 r in 18% of patients discontinued because of inactivity.

18 2012 from the group of patients with disease inactivity.

19 d slow myosin heavy chain proteins caused by inactivity.

20 could be attributable, at least in part, to inactivity.

21 , interspersed by periods of transcriptional inactivity.

22 c flexibility across a range of activity and inactivity.

23 diminished the reduction in growth caused by inactivity.

24 after trauma in response to chronic neuronal inactivity.

25 muscular lipids, is associated with physical inactivity.

26 pubertal delay, low muscle mass and physical inactivity.

27 he unpredictable and pathological effects of inactivity.

28 redictive value of 86% (6 of 7) for clinical inactivity.

29 tivity were seldom incorrectly classified as inactivity.

30 forward to address the pandemic of physical inactivity.

31 sis with restoration associated with disease inactivity.

32 t disease--that are associated with physical inactivity.

33 nterspike intervals and increased periods of inactivity.

34 recurrent synapses resulting from long-term inactivity.

35 skeletal muscle during periods of prolonged inactivity.

36 or low educational attainment, and physical inactivity.

37 attributed to a confounding role of physical inactivity.

38 avy alcohol use, unhealthy diet and physical inactivity.

39 sical activity but not blood pressure during inactivity.

40 kinases, were unaffected by immunoproteasome inactivity.

41 e first clinician-reported grading of lesion inactivity.

42 onditions contribute to obesity and physical inactivity.

43 during relatively brief periods of physical inactivity.

44 r, and colon cancer attributable to physical inactivity.

45 ry and environmental exposures, and physical inactivity.

46 ivity, interspersed with extended periods of inactivity.

47 on is highly individualistic and modified by inactivity.

48 We assessed associations of adult inactivity 1) with factors within domains, 2) with the 3

49 systolic blood pressure (-36 000), physical inactivity (-12 000), smoking (-10 000), diabetes mellit

50 at follow-up (11%), death (9%), and disease inactivity (20%, 120 eyes).

51 17.6%, 95% CI: -6.5% to -56.0%) and physical inactivity (-21.0%, 95% CI: -9.7% to -61.1%) having the

52 (7.5%, 95% CI 5.2-9.7) followed by physical inactivity (5.5%, 2.1-8.5), history of diabetes (2.8%, 2

53 ting poorer amenities) on a 19-point scale), inactivity (8% higher odds per 1-point reduction in acti

54 verweight (82%), smoking (31%), and physical inactivity (81%).

55 of the pieces are in place to make physical inactivity a national priority, and we now have the oppo

56 Diet and physical inactivity accounted for 14.3% (95% UI 12.8-15.9) of UK

57 emerging evidence on brain health, physical inactivity accounts for about 3.8% of cases of dementia

58 Physical inactivity accounts for more than 3 million deaths per y

59 It is well known that inactivity/activity influences skeletal muscle physiolog

60 However, the effects of inactivity/activity on muscle weakness and increased sus

61 urse of health-related responses to physical inactivity/activity patterns are caused in large part di

62 ly because of the variable amounts of muscle inactivity/activity throughout the day.

63 nalyses indicate that the changes induced by inactivity/activity were not related to fiber-type trans

64 in vivo eccentric contractions, or physical inactivity after mild exercise.

65 ycling are significantly decreased by muscle inactivity, agrin maintained the amount of recycled AChR

66 life were associated with adult leisure-time inactivity, allowing for early identification of groups

67 beta1,2,3delta GABAAR subtypes, ranging from inactivity (alpha4beta1delta), through negative (alpha6b

68 Inactivity also mimicked these two dystrophic features i

69 EAAT inactivity also results in elevated internalization and

70 IP(3)R switches between extended periods of inactivity alternating with intervals of bursting activi

71 e been monitoring the prevalence of physical inactivity, although evidence of any improvements in pre

72 tship frequency was not a simple function of inactivity among hybrids.

73 ificantly contribute to obesity and physical inactivity among nurses.

74 t the known effects of drug-induced neuronal inactivity and can be used to investigate the extensive

75 Compared with inactivity and category 1 activities (eg, swimming), cat

76 Physical inactivity and disuse are major contributors to age-rela

77 mechanical ventilation results in diaphragm inactivity and elicits a rapid development of diaphragm

78 Western" lifestyle characterized by physical inactivity and excess weight is associated with a number

79 Physical inactivity and exposure to air pollution are important r

80 ncing is one such mechanism that ensures the inactivity and hence the maintenance of a silenced state

81 stimate within-urban variability in physical inactivity and home-based air pollution exposure [partic

82 ronic diseases that are promoted by physical inactivity and improved by exercise.

83 e community who are at high risk of physical inactivity and metabolic syndrome.

84 combating the worldwide epidemic of physical inactivity and obesity.

85 alth) life-style programs targeting physical inactivity and overweight/obesity has been established i

86 redict metabolic flexibility, while physical inactivity and sedentary behaviours trigger a state of m

87 riate logistic regression analysis, physical inactivity and smoking were found to be independent risk

88 Physical inactivity and smoking were more strongly associated wit

89 able to curb the global pandemic of physical inactivity and the associated 5.3 million deaths per yea

90 representing an early indicator of beta cell inactivity and the subsequent deficit of more impactful

91 h falls in systolic blood pressure, physical inactivity and total cholesterol providing the largest c

92 ty, smoking, heavy alcohol use, and physical inactivity) and with a 2.25-fold (95% confidence interva

93 ars for hypertension, 2.4 years for physical inactivity, and 4.8 years for current smoking.

94 ssure, high fasting plasma glucose, physical inactivity, and alcohol use.

95 re have been extensive reports on adiposity, inactivity, and certain diets, particularly those high i

96 association with air pollution and physical inactivity, and estimated attributable health risks.

97 lowed walking speed, poor appetite, physical inactivity, and exhaustion.

98 l mechanisms (alcohol use, smoking, physical inactivity, and medication non-adherence).

99 Obesity, physical inactivity, and reduced physical fitness contribute to t

100 itus, smoking, overweight, obesity, physical inactivity, and statin use resulted in a decrease in the

101 uggests that these variants lead to receptor inactivity, and they are mostly mutually exclusive with

102 haviors, including suboptimal diet, physical inactivity, and tobacco use, are leading causes of preve

103 ss index >27 kg/m(2), self-reported physical inactivity, and/or smoking) were included.

104 le hypertension, smoking, diet, and physical inactivity are among some of the more commonly reported

105 Our findings argue that obesity and physical inactivity are associated with a higher risk of CTNNB1-n

106 Undernutrition and physical inactivity are both associated with lower bone mass.

107 Sedentary behaviors and physical inactivity are not only increasing worldwide but also ar

108 g tobacco use, unhealthy diets, and physical inactivity are prevalent, and obesity in adults and chil

109 Fat and physical inactivity are the most evident factors in the pathogene

110 Stress, malnutrition and physical inactivity are three maternal behavioral lifestyle facto

111 deleterious health consequences of physical inactivity are vast, and they are of paramount clinical

112 confidence interval, 1.02-1.08), and sexual inactivity at baseline (relative risk, 1.11; 95% confide

113 g aging (sarcopenia), disease (cachexia), or inactivity (atrophy).

114 olescents' academic achievement via physical inactivity (B = -0.023, 95% confidence interval = -0.031

115 tently associated with time-varying physical inactivity, baseline weight status, or sociodemographic

116 lus for axon growth is not postsynaptic cell inactivity because axons grow into unoccupied sites even

117 isk factors of CRC include smoking, physical inactivity, being overweight and obesity, eating process

118 a non-homogeneous Poisson process for longer inactivity between bursts.

119 ef2c translation and protein level following inactivity; blocking eIF4EBP3L function increased Mef2ca

120 Center-specific PAF associated with inactivity, body mass index (BMI; in kg/m(2)) (>30), and

121 ncluding tobacco use, poor diet and physical inactivity (both strongly associated with obesity), exce

122 hippocampus occur not only during behavioral inactivity but also during successful visual exploration

123 overexpression of active eIF4EBP3L mimicked inactivity by decreasing the proportion of mef2ca mRNA i

124 est that recurrent circuits adapt to chronic inactivity by reallocating presynaptic weights heterogen

125 adaptive presynaptic enhancement to neuronal inactivity by two principle mechanisms: First, neuronal

126 lly motivated hypothesis is that a period of inactivity can reduce the threshold for synaptic potenti

127 NDINGS: Worldwide, we estimate that physical inactivity causes 6% (ranging from 3.2% in southeast Asi

128 Inactivity causes 9% (range 5.1-12.5) of premature morta

129 Inactivity causes muscle wasting by triggering protein d

130 ould help address the public health physical inactivity challenge.

131 Dietary risk factors and physical inactivity collectively accounted for 10.0% (95% UI 9.2-

132 er of deaths reduced by eliminating physical inactivity compared with overall and abdominal obesity r

133 que/kg leg lean mass) after 14 d of bed-rest inactivity (CON compared with LEU: -9% +/- 2% and +1% +/

134 ally, our data suggest that exercise-induced inactivity correlates with loss of sarcolemmal neuronal

135 Conservatively estimated, physical inactivity cost health-care systems international $ (INT

136 risk factors (high alcohol intake, physical inactivity, current smoking, hypertension, diabetes, and

137 as homeostatically scaled down after chronic inactivity, decreased endocannabinoid tone specifically

138 t (followed from 1958 to 2008), leisure-time inactivity, defined as activity frequency of less than o

139 life hypertension, midlife obesity, physical inactivity, depression, smoking, and low educational att

140 high cholesterol, smoking, obesity, physical inactivity, diabetes, and other factors.

141 ested to increase the likelihood of physical inactivity during leisure time, but this has not been ve

142 tive to demand, resulting from diaphragmatic inactivity during MV, could play an important role in th

143 nversion of locomotor activity to "Locomotor Inactivity During Sleep" (LIDS), movement patterns are e

144 mains were combined, factors associated with inactivity (e.g., at age 50 years) were prepubertal stat

145 n addition, we demonstrated that sympathetic inactivity eliminated pineal function and markedly decre

146 refugia during periods of daily or seasonal inactivity, emerging only during rainfall [1].

147 in a physiological system in which prolonged inactivity ends life.

148 ins of frailty-slow walking speed, weakness, inactivity, exhaustion, and shrinking-as measured by phy

149 le fractions (PAFs) associated with physical inactivity for each disease outcome and all-cause mortal

150 on, active repression (hypoacetylation), and inactivity (H3K27me3).

151 r persistent physical activity compared with inactivity has a global effect on serum metabolome towar

152 INTERPRETATION: Physical inactivity has a major health eff ect worldwide.

153 Physical inactivity has been associated with higher mortality ris

154 Physical inactivity has been associated with poor oral health.

155 Skeletal muscle wasting attributed to inactivity has significant adverse functional consequenc

156 Age and inactivity have been associated with intramuscular trigl

157 We conclude that food withdrawal-induced inactivity, hypothermia, and reduction in EE are novel p

158 Independent of FEV1, sustained physical inactivity (i.e., PAL(T0andT1) < 1.40) was related to a

159 In the present study, we demonstrate that inactivity (ie, leg immobilization) worsened the muscle

160 rk characteristics and leisure-time physical inactivity in a total of 170,162 employees (50% women; m

161 Given the prevalence of obesity and inactivity in cancer survivors in the United States and

162 between job strain and leisure-time physical inactivity in combined data from 14 cohort studies.

163 drawal lowers energy expenditure and induces inactivity in long-chain fatty acid oxidation-deficient

164 l hypothalamus (LH) causes profound physical inactivity in mammals.

165 interventions targeting smoking and physical inactivity in patients with CHD and comorbid depression.

166 Transcriptional inactivity in response to a second LPS exposure in toler

167 S. habrochaites and that the gene mutates to inactivity in the absence of selection.

168 signal peptides where one can compensate for inactivity in the other.

169 The highest estimated PAR was for physical inactivity in the USA (21.0%, 95% CI 5.8-36.6), Europe (

170 ed and the abnormalities caused by VEGF/SphK inactivity in these cells are corrected by replenishment

171 We also modeled cofilin inactivity in vitro by using pharmacological and genetic

172 lation of inhibitory transmission by chronic inactivity, in part through the reduction of vesicular t

173 Physical inactivity, inadequate dietary protein, and low-grade sy

174 be several mechanisms responsible for FOXO3a inactivity, including chromosomal deletion (chromosome 6

175 ities of red meat, constipation, or physical inactivity increase risk for asymptomatic diverticulosis

176 Strong evidence shows that physical inactivity increases the risk of many adverse health con

177 Physical inactivity independently predicts poor outcomes across s

178 ppaB contributes to proteolytic signaling in inactivity-induced atrophy in locomotor muscles, the rol

179 d expression of shRNA prevented the synaptic inactivity-induced increase in GluA1, as did treatment w

180 together, our results indicate that synaptic inactivity-induced increases in betaCaMKII expression se

181 d activity in the phrenic motor pool and (2) inactivity-induced increases in phrenic inspiratory outp

182 e present findings demonstrate that physical inactivity-induced insulin resistance in muscle is assoc

183 ate the molecular mechanisms behind physical inactivity-induced insulin resistance in skeletal muscle

184 tivity elicits a form of plasticity known as inactivity-induced phrenic motor facilitation (iPMF), a

185 y in circuits driving the diaphragm known as inactivity-induced phrenic motor facilitation (iPMF), a

186 ur data reveal an important role of PICK1 in inactivity-induced synaptic scaling by regulating the su

187 e of GRIP1-mediated AMPAR trafficking during inactivity-induced synaptic scaling.

188 via the ubiquitin-proteasome system, whereas inactivity induces synaptic accumulation of GKAP in rat

189 Thus, MV-induced diaphragm inactivity initiates catabolic changes via rapid activat

190 Physical inactivity is a global pandemic responsible for over 5 m

191 Physical inactivity is a leading cause of obesity and premature m

192 Physical inactivity is an important risk factor in the developmen

193 Sustained physical inactivity is associated with a progression of exercise

194 The pandemic of physical inactivity is associated with a range of chronic disease

195 Physical inactivity is common in patients with chronic obstructiv

196 enting the catalytic cycle suggests that the inactivity is due to a role for the lid domain in the fo

197 Our data suggest that the inactivity is ensued by a C-terminal domain that interac

198 in synaptic strength in response to synaptic inactivity is occluded in neurons generated from PICK1 k

199 morbidity and premature mortality, physical inactivity is responsible for a substantial economic bur

200 Physical inactivity is the fourth leading cause of death worldwid

201 Given their hypothesized catalytic inactivity, it is striking that deletion of the ROP5 clu

202 Conversely, high inactivity levels may be associated with increased risk

203 dly unaffected indicating that in blood EPT1 inactivity may be compensated for, in part, via alternat

204 The global epidemic of obesity and physical inactivity may have detrimental implications for young p

205 and X-ray crystallography indicated that the inactivity might be due to bound waters and high flexibi

206 e of TOR-eIF4EBP in a novel zebrafish muscle inactivity model.

207 included staining without leakage suggesting inactivity (n = 6) and leakage (n = 2).

208 us on fatigue, concentration, early satiety, inactivity, night sweats, itching, bone pain, abdominal

209 Neither physical inactivity nor intake of fat or red meat was associated

210 Physical inactivity, obesity, higher red meat consumption or West

211 l enrichment, midlife risk factors (physical inactivity, obesity, smoking, diabetes, hypertension, an

212 n-electron clusters, we demonstrate that the inactivity of Ag(13)(-) is associated with its large spi

213 Inactivity of AMG 416 on the pig CaSR resulted from a na

214 sensitive to the reduction, absence, and/or inactivity of any components of the classical and termin

215 The Y114F, R194A, and F261A mutations led to inactivity of diadenosine tetraphosphate and to a reduce

216 This mechanism relies on the catalytic inactivity of domain DI, revealing a surprising role of

217 itness costs and the biochemical activity or inactivity of drug-enzyme complexes.

218 rpetually open pores are consistent with the inactivity of hornwort stomata.

219 Catalytic inactivity of KLK7 was however achieved by additional mu

220 Although physical inactivity of many smokers contributes to some alteratio

221 open" conformation not only rationalizes the inactivity of single-chain insulin (SCI) analogs (in whi

222 N activation maintains breathing despite the inactivity of the carotid bodies.

223 demonstrate in situ the relative cell cycle inactivity of the CD200+/K15+ bulge compared to other no

224 Conversely, inactivity of the presynaptic terminal results in remova

225 In this work we confirm inactivity of unprocessed protein clusters and demonstra

226 The absence or inactivity of vcrA-containing Dehalococcoides results in

227 in CCR5 activation was supported by complete inactivity of W248A-CCR5 despite maintaining chemokine b

228 ficacy of Y5-selective peptide agonists, the inactivity of Y1-selective antagonists, and a change fro

229 driving the effects of obesity and physical inactivity on academic underachievement.

230 Ab uptake), mimicking the effect of synaptic inactivity on both sides of the synapse.

231 the differential effects of age and physical inactivity on the regulation of substrate metabolism dur

232 We aimed to quantify the eff ect of physical inactivity on these major non-communicable diseases by e

233 nvironments by entering a state of metabolic inactivity or dormancy.

234 life obesity, smoking, depression, cognitive inactivity or low educational attainment, and physical i

235 s not the result of higher rates of waitlist inactivity or removal from the waitlist.

236 ted into synapses to compensate for neuronal inactivity or removed to compensate for hyperactivity.

237 eline smoking (ORs, 4.69 and 7.97), physical inactivity (ORs, 2.11 and 2.78), small social network (O

238 c regression, with body mass index, physical inactivity, other breast cancer risk factors, and calori

239 ssociations were weak or modest for physical inactivity, overweight or obesity, and diabetes (ORs of

240 e proportion of SCD attributable to smoking, inactivity, overweight, and poor diet was 81% (95% CI, 5

241 uce the health burden of the global physical inactivity pandemic.

242 We observe two daily inactivity periods in the people's aggregated mobile pho

243 risk factors (e.g., aging, cigarette smoke, inactivity, persistent low-grade pulmonary and systemic

244 tabolic and cardiovascular responses through inactivity physiology that are not sufficiently prevente

245 Analyses were based on national physical inactivity prevalence from available countries, and adju

246 nteractions among the correlates of physical inactivity, rather than solely a behavioural science app

247 In addition, physical inactivity related deaths contribute to $13.7 billion in

248 d with a friction cost approach for physical inactivity related mortality.

249 These inactivity-related structural and functional changes may

250 Our data support a cellular cascade in which inactivity relieves EVI1/HDAC-mediated inhibition of miR

251 ease burden, the economic burden of physical inactivity remains unquantified at the global level.

252 In both cases, neuronal inactivity removes tonic block imposed by the presynapti

253 The global pandemic of physical inactivity requires a multisectoral, multidisciplinary p

254 Much adult physical inactivity research ignores early-life factors from whic

255 o the groundwater despite 18 and 20 years of inactivity, respectively.

256 provide evidence that both age and physical inactivity result in intramuscular lipid accumulation, b

257 e in lifestyle risk factors such as physical inactivity (risk ratio [RR]: 1.19; 95% CI: 1.14, 1.24),

258 Long-term physical inactivity seems to cause many health problems.

259 ecifically elevated blood pressure, physical inactivity, smoking, and poor glucose control) are assoc

260 olesterol, systolic blood pressure, physical inactivity, smoking, diabetes mellitus, and obesity) and

261 lence of vascular risk factors (eg, physical inactivity, smoking, midlife hypertension, midlife obesi

262 Poor diet and physical inactivity strongly affect the growing epidemic of cardi

263 igns of aging yet may be more susceptible to inactivity than younger adults.

264 Physical inactivity that accompanies ageing and disease may haste

265 excessive alcohol consumption, and physical inactivity--that people recognize as health-harming and

266 impacts intermixed with sporadic periods of inactivity; the VI-dormant behavior, which was prevalent

267 as highest for smoking, followed by physical inactivity then socioeconomic status.

268 respiratory motor output following months of inactivity, thereby supporting a major neuroscience hypo

269 Most studies use duration of inactivity to measure sleep.

270 MKP-1 oxidation-induced oligomerization and inactivity toward p38MAPKalpha.

271 Inactivity triggered up-regulation of eIF4EBP3L (a zebra

272 Physical inactivity triggers a rapid loss of muscle mass and func

273 RBs-alcohol use; cigarette smoking, physical inactivity, unhealthy diet, and illicit drug use-accordi

274 le fractions (PAFs) associated with physical inactivity using conservative assumptions for each of th

275 Recent work has shown that physical inactivity versus activity alters neuronal structure in

276 physical activity established that physical inactivity was a global pandemic, and global public heal

277 Physical inactivity was associated with hand weakness and decreas

278 Leisure time inactivity was associated with increased risk of catarac

279 finding specific to LMICs was that physical inactivity was higher in urban (vs rural) residents, whi

280 the increased risk of type 2 diabetes due to inactivity was lower in normal weight men.

281 mated IHD mortality attributable to physical inactivity was modest (7 fewer IHD deaths/100,000/year i

282 Unexpectedly, inactivity was not explained by rhabdomyolysis, but rath

283 een discontinued because of apparent disease inactivity was reexamined.

284 billion in productivity losses, and physical inactivity was responsible for 13.4 million DALYs worldw

285 ss-sectional analyses, the odds for physical inactivity were 26% higher (odds ratio = 1.26, 95% confi

286 ow much disease could be averted if physical inactivity were eliminated.

287 life-years (DALYs) attributable to physical inactivity were estimated with standardised methods and

288 uctures related to OATP1B1/1B3 inhibition or inactivity were identified.

289 If inactivity were not eliminated, but decreased instead by

290 disease that was interspersed by periods of inactivity when they did not require medical attention a

291 KEY POINTS: Physical inactivity, which drastically increases with advancing a

292 Physical inactivity, which drastically increases with advancing a

293 Tonic spiking is prevalent during periods of inactivity while bursting strongly correlates with locom

294 cs of miRNA-AuNPs and their surface-exchange inactivity with a highly charged surfactant.

295 lent in the summer, involved long periods of inactivity with sporadic VI impacts.

296 r and lighter sleep within extended bouts of inactivity, with deeper sleep intensities after approxim

297 , tobacco use, unhealthy diets, and physical inactivity within LLMICs.

298 We estimated that elimination of physical inactivity would increase the life expectancy of the wor

299 Avoiding all inactivity would theoretically reduce all-cause mortalit

300 ce, years of labor market experience, career inactivity, years with the employer, and responsibilitie