ライフサイエンスコーパス: inappropriate

1 f conventional nitrogen budget approaches is inappropriate.

2 riate and 2 results (18% [CI, 3% to 52%]) as inappropriate.

3 for which the OECD 308 test is fundamentally inappropriate.

4 fant antibiotic exposure is common and often inappropriate.

5 r most normal situations would be considered inappropriate.

6 or change an action when it is contextually inappropriate.

7 to mount protective host responses yet avoid inappropriate activation and immunopathology.

8 Inappropriate activation of alveolar neutrophils is beli

9 ers and is thought to result partly from the inappropriate activation of brain reward systems in resp

10 rom p35 under stress conditions leads to the inappropriate activation of Cdk5 and contributes to hype

11 loit Spy1 to stimulate proliferation through inappropriate activation of Cdks, yet the mechanism is u

12 In addition, by preventing inappropriate activation of excitatory memory engrams, i

13 Mutations that cause increased and/or inappropriate activation of FGFR3 are responsible for a

14 Impaired DISC1 allowed inappropriate activation of GSK3beta in beta cells, and

15 rase may play this role more widely and that inappropriate activation of its elimination ability migh

16 Inappropriate activation of PI3K signaling has been impl

17 lomere shortening occurs during aging, while inappropriate activation of telomerase is associated wit

18 Inappropriate activation of the cystic fibrosis transmem

19 s nucleic acids are essential for preventing inappropriate activation of the innate antiviral respons

20 Inappropriate activation of the innate immune response c

21 mutations in the translational machinery or inappropriate activation of the integrated stress respon

22 dehydrogenase type 2 (11betaHSD2), allowing inappropriate activation of the mineralocorticoid recept

23 Inappropriate activation of the NLRP3 inflammasome contr

24 , we show that cep-1 and him-5 also suppress inappropriate activation of the nonhomologous end joinin

25 Inappropriate activation of the renin angiotensin system

26 Inappropriate activation of the renin-angiotensin system

27 Inappropriate activation of the renin-angiotensin system

28 Inappropriate activation of these immune cells may cause

29 idylinositol 3,4,5-trisphosphate (PIP3), and inappropriate activation of this pathway is implicated i

30 The inappropriate activation of transcription factors, inclu

31 to mature efficiently in juveniles owing to inappropriate activity of these alternative repair pathw

32 ent age, 47 years; 69% women) for antibiotic-inappropriate acute respiratory tract infections during

33 that increase postoperative inflammation and inappropriate adipogenesis, resulting in well-documented

34 s (e.g., socioeconomic conditions) but avoid inappropriate adjustment for variables on a causal path

35 w-up of 14 months, 4 patients (21%) received inappropriate and 1 (5%) patient received appropriate sh

36 a post-hoc analysis, rates of patients with inappropriate and appropriate shocks were calculated for

37 ys on the basis of histologic factors may be inappropriate and merits further study.

38 <1%) patients thought their intervention was inappropriate and unhelpful and 1530 (81%) patients thou

39 sceptibility of bacteria is vital to prevent inappropriate and untargeted use of antibiotics and cont

40 had 1885 shock events (56% appropriate, 38% inappropriate, and 6% indeterminate).

41 Secondary end points were inappropriate anti-tachycardia pacing and inappropriate

42 There was a significant reduction in inappropriate anti-tachycardia pacings in both group and

43 Emerging pandemic infectious threats, inappropriate antibacterial use contributing to multidru

44 riven by a diverse set of factors, including inappropriate antibiotic prescribing and sales, use of a

45 Inappropriate antibiotic prescribing contributes to the

46 ral interventions resulted in lower rates of inappropriate antibiotic prescribing for acute respirato

47 Reducing inappropriate antibiotic prescribing for acute upper res

48 obial stewardship programme aiming to reduce inappropriate antibiotic prescribing in paediatric outpa

49 ons based on behavioral science might reduce inappropriate antibiotic prescribing.

50 nt burden on primary care and is a source of inappropriate antibiotic prescribing.

51 s can comply with these guidelines to reduce inappropriate antibiotic usage, decrease antimicrobial r

52 Inappropriate antibiotic use for acute respiratory tract

53 monia (SAP) is challenging and may result in inappropriate antibiotic use or confound research outcom

54 ort to decrease antimicrobial resistance and inappropriate antibiotic use, The Joint Commission (TJC)

55 Inappropriate antimicrobial use has been quantified in v

56 Overuse of urine testing is a driver of inappropriate antimicrobial use.

57 ce of immediate threat and this contextually inappropriate anxiety predicts future symptom developmen

58 eeded to assess contextually appropriate and inappropriate anxiety.

59 Moreover, imposing MVP2 activity promotes inappropriate appetitive memory expression in food-satia

60 among PWUD with TDR may be explained by some inappropriate ART prescribing, as well as undetected min

61 ndothelial progenitor cell levels along with inappropriate attenuated vascular endothelial growth fac

62 t patients in whom extubation was considered inappropriate because of the severity of agitation and d

63 hat represses ubiquitous proteins to prevent inappropriate beta cell function such as elevated basal

64 Here, we provide evidence that the inappropriate biosynthesis of SPM in the lesioned spinal

65 Ischemia was rare among patients rated as "inappropriate" by the ACCF AUC (1 of 39 patients [2.6%])

66 ty improvement initiatives aimed at reducing inappropriate cardiac imaging.

67 d feedback are associated with lower odds of inappropriate cardiac testing.

68 uard against wasteful oxygen consumption and inappropriate cell growth during hypoxia.

69 amidation and apoptosis, thus giving rise to inappropriate cell survival.

70 of donor-cell-specific genes was observed in inappropriate cell types in NT embryos, limiting their d

71 ng a robust mitotic apparatus and correcting inappropriate chromosome attachments.

72 NA damage response at telomeres that promote inappropriate chromosome fusions via the mutagenic alter

73 fundamental behaviors but could also lead to inappropriate circuit refinement and psychopathology in

74 Yet inappropriate CNN architectures can yield poorer perform

75 s traced to another RQC component, Tae2, and inappropriate control of heat shock transcription factor

76 ate-status misinterpretation with the use of inappropriate cutoffs.

77 abling cyclin E destruction in mitosis, when inappropriate cyclin E expression is genotoxic.

78 results suggest that artifacts arising from inappropriate data evaluation might contribute to the va

79 the depth of intramural necrosis may lead to inappropriate decision-making with devastating consequen

80 and 25 female [40%]), 27 patients (43%) had inappropriate decoupling at their baseline speed.

81 The presence of inappropriate decoupling was associated with worse outco

82 Inappropriate decoupling was defined as a >5 mm Hg diffe

83 d during ramp testing, 30 patients (48%) had inappropriate decoupling.

84 developed polyuria and hypernatremia with an inappropriate decrease in urinary osmolality.

85 tery bypass graft surgery that were rated as inappropriate decreased from 2,956 patients in 2010 to 9

86 cess similar to bone formation leading to an inappropriate deposition of calcium phosphate minerals i

87 tress response that is probably secondary to inappropriate derepression of cholesterol biosynthesis.

88 prescribing rates for visits with antibiotic-inappropriate diagnoses (nonspecific upper respiratory t

89 Inappropriate dietary eliminations may impair quality of

90 Inappropriate disclosure of human genomes may put the pr

91 healthcare-associated outbreaks were due to inappropriate disinfection practices.

92 osomes, protecting them from degradation and inappropriate DNA repair processes that can lead to geno

93 n, interactions with other drugs or food, or inappropriate dosing.

94 cessful discontinuation of use of at least 1 inappropriate drug (that is, without relapse or severe w

95 es facing problems with after-hours care and inappropriate emergency department visits.

96 ic demonstrated a high prevalence (91.3%) of inappropriate empirical antibiotic use in women with unc

97 e in ciliary gate function, CEP-290 prevents inappropriate entry of membrane-associated proteins into

98 g interventions may reasonably be considered inappropriate even when the patient would survive outsid

99 Imprinting defects can lead to inappropriate expression from the normally silenced alle

100 gs: Many neurological diseases are caused by inappropriate expression of a protein.

101 In some instances, the inappropriate expression of AMPs can also induce autoimm

102 s frequently compromised, in part due to the inappropriate expression of genes previously active in t

103 cription factor for proteasomal degradation; inappropriate expression of HIF target genes drives rena

104 Inappropriate expression of MMP9 also contributes to imp

105 ue (AT) in obesity: unresolved inflammation, inappropriate extracellular matrix (ECM) remodeling and

106 rofoundly disrupted, leading to formation of inappropriate fear associations and impaired fear inhibi

107 sults suggest that some patients may receive inappropriate follow-up of incidental imaging findings a

108 agues and supervisors to be either absent or inappropriate following their experience; however, those

109 ch offer drug-consumption opportunities, are inappropriate for addicted individuals seeking treatment

110 inary trait, we show that LMMs are generally inappropriate for analyzing binary traits when populatio

111 nd, further, what methods are appropriate or inappropriate for analyzing genomic data to examine alle

112 ng calcium scores for greater density may be inappropriate for CVD risk prediction in both the abdomi

113 mes suffer from pathologies that render them inappropriate for high-resolution structure determinatio

114 d phased reference panels, and are therefore inappropriate for many data sets.

115 for the 'whole person' and it is considered inappropriate for nurses to think or talk about patients

116 modulation (reprocessing) if the signal was inappropriate for the actual detection system settings (

117 However, this method is inappropriate for the analysis of products that might co

118 9Vdelta2 T cell activation can be considered inappropriate for the host.

119 s make traditional ChIP-Seq analysis methods inappropriate for use with replication timing.

120 f unfavorable physicochemical properties and inappropriate formulation design of the conventional dos

121 r of transcription (STAT) proteins, leads to inappropriate gene expression patterns that can promote

122 erode, rendering target genes susceptible to inappropriate gene expression signals.

123 merged as a key player in repressing lineage-inappropriate genes and shielding them from activation b

124 opmentally poised genes poorly while lineage-inappropriate genes, including extra-embryonic genes, ar

125 to guard cell identity by repressing lineage-inappropriate genes.

126 ibuting to ectopic loci and activate lineage-inappropriate genes.

127 ed task performance, primarily by increasing inappropriate Go responses.

128 s of cancer, but which nutrients support the inappropriate growth of intact malignant tumors is incom

129 founders, bias due to subject selection, and inappropriate handling of missing data.

130 or HAF in immune cell function by preventing inappropriate HIF-1 activation in male mice and identifi

131 This effect was accompanied by inappropriate histone acetylation and genome-wide mis-re

132 Confirmatory testing prevents inappropriate HIV diagnosis, is cost-saving, and should

133 in both group and a significant reduction in inappropriate ICD shock in CRT-D patients.

134 re inappropriate anti-tachycardia pacing and inappropriate ICD shock.

135 rogramming significantly reduced the risk of inappropriate ICD therapy compared with conventional ICD

136 rogramming significantly reduces the risk of inappropriate ICD therapy in both ICD and CRT-D patients

137 effect of CRT-D on ICD programming to reduce inappropriate ICD therapy in patients implanted with CRT

138 implanted with a CRT-D had 62% lower risk of inappropriate ICD therapy than those with an ICD only (h

139 ts implanted with a CRT-D have lower risk of inappropriate ICD therapy than those with an ICD.

140 iring surgical intervention, appropriate and inappropriate ICD therapy, and were reported as 5-year K

141 first appropriate ICD therapy, time to first inappropriate ICD therapy, time to first shock, and over

142 rimary end point of this study was the first inappropriate ICD therapy.

143 -binding site at the Igf2-P0 promoter causes inappropriate Igf2-P0 activation.

144 mechanisms that protect the organism against inappropriate immune activation triggered by self nuclei

145 hma is a chronic lung disease resulting from inappropriate immune responses to environmental antigens

146 RIT) trial showed a significant reduction in inappropriate implantable cardioverter defibrillator (IC

147 because of device-related complications and inappropriate implantable cardioverter defibrillator int

148 s lacking ClpA are particularly sensitive to inappropriate increases in DnaA activity.

149 % of cardiac imaging tests are performed for inappropriate indications.

150 jury, demonstrating that these cells promote inappropriate inflammation in this setting.

151 Psychological stressors and inappropriate inflammation increase the risk and severit

152 atory bowel disease is thought to arise from inappropriate inflammation to gut bacteria, yet mechanis

153 implicated as harmful cells in a variety of inappropriate inflammatory conditions where they injure

154 sses, new approaches for quieting chronic or inappropriate inflammatory states may be revealed and th

155 nonresponse at day 1, but only 5% (2/40) had inappropriate initial therapy.

156 Based on in vitro susceptibilities, inappropriate (initial) gram-negative coverage was given

157 When compounded by inappropriate interpretations of histograms constructed

158 s developed to provide a clear definition of inappropriate interventions in the ICU environment.

159 rifampicin, but because of the high rates of inappropriate isoniazid-containing regimens, and treatme

160 ns associated with a heightened tendency for inappropriate laryngeal closure (e.g., inducible larynge

161 Inappropriate learning of conditioned threat responses m

162 al disorder characterised by developmentally inappropriate levels of inattention and hyperactivity or

163 tatic synaptic scaling is thought to prevent inappropriate levels of spiking activity through compens

164 This could result in overly broad or inappropriate management and policy decisions that negle

165 and undermine conservation goals, leading to inappropriate management policies and practices in tropi

166 various diagnostic settings, antigens 5 are inappropriate markers for differential sIgE diagnostics

167 o conflicting reporting and, potentially, to inappropriate medical management.

168 There was no effect on potentially inappropriate medication (odds ratio, 1.86; 95% CI, 0.62

169 To examine successful discontinuation of inappropriate medication use and to improve prescribing

170 The 3MR is effective in discontinuing inappropriate medication use in frail nursing home resid

171 t few interventions have focused on reducing inappropriate medication use.

172 lysis of all participants, use of at least 1 inappropriate medication was successfully discontinued f

173 h antidementia drugs, and use of potentially inappropriate medication.

174 that enables physicians to avoid potentially inappropriate medications, undertreatment, or errors of

175 erstood, there is a growing realization that inappropriate metabolic remodeling underlies many aberra

176 re to a syntactic structure appears to be an inappropriate method for studying invariant properties o

177 Application of inappropriate methods may lead to incorrect and inconsis

178 Inappropriate migration also underpins metastasis.

179 e signals that drive uncontrolled growth and inappropriate migration and invasion, the capacity to ex

180 Contactin-APPL interactions normally prevent inappropriate migration and outgrowth.

181 utative transcription factor Chronologically inappropriate morphogenesis (Chinmo) acts with the canon

182 Patients with inappropriate MPI had significantly higher LAR (median,

183 Inappropriate MPI use is associated with excess cancer r

184 into appropriate/uncertain (n = 823) versus inappropriate (n = 688) use groups according to the 2009

185 ced position may make wrong connections with inappropriate nearby targets in the pre-existing neural

186 iseases that are characterized by altered or inappropriate neural function and behaviour.

187 ital-, and physician-level assessments where inappropriate; not using nonspecific administrative seco

188 xual behaviour in dementia as appropriate or inappropriate often applied in institutional settings, f

189 ntiestrogenic effects, and as such cause the inappropriate or altered expression of genes or proteins

190 ck events were adjudicated and classified as inappropriate or appropriate, and HCU and expenditures,

191 Inappropriate or dysregulated responses to RSV can be pa

192 s the relative permanence of learning may be inappropriate or inefficient when facing environments th

193 to transition-state stabilization suppresses inappropriate or premature cleavage, enhancing processin

194 ic-Resistant Bacteria set a goal of reducing inappropriate outpatient antibiotic use by 50% by 2020,

195 biotic use by 50% by 2020, but the extent of inappropriate outpatient antibiotic use is unknown.

196 adverse outcomes, ranging from intermittent inappropriate pacing to proarrhythmia leading to patient

197 However, these methods may provide inappropriate parameters.

198 hat HPV E6 and E7 allow HR to initiate at an inappropriate part of the cell cycle.

199 The percentage of inappropriate PCIs for all patients dropped from 18.2% i

200 linical rationale for Medicaid patients with inappropriate PCIs.

201 changes over time in the number and rate of inappropriate PCIs.

202 ge phase and displayed frequent urination in inappropriate places without a change in voiding functio

203 sruption of a Gravin-PLK1 interface leads to inappropriate PLK1 activity contributing to chromosome s

204 NIs inhibit particle assembly by stimulating inappropriate polymerization of IN via interactions betw

205 oduction or drilling completion and/or using inappropriate population allocation methods.

206 High underreporting, inappropriate post-exposure practices and impacts of exp

207 Many studies revealed that plants avert inappropriate posttranscriptional gene silencing of endo

208 A high proportion of AP use is inappropriate, potentially exposing many children to avo

209 Inappropriate prescribing is a well-known clinical probl

210 e of "top performers" (those with the lowest inappropriate prescribing rates).

211 h did not allow evaluation of any effects on inappropriate prescribing.

212 RF2 heterodimer in protecting telomeres from inappropriate processing by the HDR pathway.

213 aused by defective NaPi-IIa function induces inappropriate production of 1,25-(OH)2D3 with subsequent

214 ct comprehensive searches (17; 44%), or used inappropriate quantitative methods (3; 8%).

215 nstituted with a UUG start codon, indicating inappropriate rearrangement to the closed state.

216 of PICCs at their facility were inserted for inappropriate reasons (OR 1.7, p=0.002); the finding was

217 and reported percentage of PICCs placed for inappropriate reasons.

218 Inappropriate recognition of nucleic acids by TLRs can c

219 e surveillance strategy is the potential for inappropriate recognition of self-derived nucleic acids

220 in delayed diagnosis of severe diseases and inappropriate referrals.

221 nosing OA when it is not present may lead to inappropriate removal from exposure and unnecessary fina

222 ut fail to repress a DNA damage response and inappropriate repair by A-NHEJ.

223 amme value, including costs and avoidance of inappropriate resource utilisation; and ability of progr

224 the neonatal endothelium might contribute to inappropriate responses of immature arteries to stress o

225 e peptide, although this might contribute to inappropriate responses of immature arteries to stress o

226 fertilization represents a scenario wherein inappropriate responses to exogenous yet non-pathogen-de

227 gs) control immune homeostasis by preventing inappropriate responses to self and nonharmful foreign a

228 s that tilt this balance toward TLR7 promote inappropriate responses, including autoimmunity; therefo

229 The link between inappropriate salt retention in the kidney and hypertens

230 Both aging and inappropriate secretion of aldosterone increase the risk

231 single modality or combine information using inappropriate sensory weights.

232 overuse through documentation of delivery of inappropriate services is challenging given the difficul

233 of the S-ICD by evaluating complications and inappropriate shock rate.

234 ardioverter-defibrillators (ICDs) influences inappropriate shock rates.

235 Nine patients (8.7%) experienced 37 inappropriate shocks (incidence rate 0.9 per 100 person-

236 appropriate (TV-ICD HR: 1.46; p = 0.36) and inappropriate shocks (TV-ICD HR: 0.85; p = 0.64) was sim

237 alyse rates of patients with appropriate and inappropriate shocks according to detection zones in the

238 Inappropriate shocks occurred in 8.1% at 1 year and 11.7

239 oup, higher rates of patients with total and inappropriate shocks were delivered at heart rates >/= 1

240 Expenditures related to appropriate and inappropriate shocks were not significantly different.

241 Rates of appropriate and inappropriate shocks were similar between the 2 groups.

242 Midterm performance rates on complications, inappropriate shocks, and conversion efficacy were compa

243 cular procedures was substantial, even after inappropriate shocks, which comprised 38% of all shocks.

244 as low (6.5% and 5.0%) after appropriate and inappropriate shocks.

245 up (total shocks: 14.3% vs. 12.6%; p = n.s.; inappropriate shocks: 3.9% vs. 3.6%; p = n.s.; appropria

246 m (total shocks: 21.1% vs. 16.6%; p = 0.002; inappropriate shocks: 7.6% vs. 4.5%, p = 0.016; appropri

247 origin of a coronary artery (AAOCA) from the inappropriate sinus of Valsalva is increasingly recogniz

248 has also shown promise in the management of inappropriate sinus tachycardia.

249 nd side sleeping, soft bedding, bed sharing, inappropriate sleep surfaces (including sofas), exposure

250 del, germline mislocalization of Pten causes inappropriate social behavior with intact learning and m

251 ice including exaggerated protein synthesis, inappropriate social behavior, behavioral inflexibility,

252 l renal cell carcinomas (ccRCCs), leading to inappropriate stabilization of hypoxia-inducible factor-

253 n outdated or limited datasets and have used inappropriate statistical methods.

254 y provide an indication of overheating under inappropriate storage conditions or aging.

255 n of signalling pathway kinases resulting in inappropriate survival and proliferation.

256 Neurodevelopmental disorders are marked by inappropriate synaptic connectivity early in life, but h

257 ion after SCI is dysregulated in part due to inappropriate synthesis of proresolving lipid mediators.

258 or and cytokine signalling pathways to limit inappropriate T-cell responses.

259 s inactivated, seam cell loss occurs through inappropriate terminal differentiation of posterior daug

260 associated with significantly lower odds of inappropriate testing (odds ratio, 0.36 [95% confidence

261 rventions were associated with lower odds of inappropriate testing (odds ratio, 0.44 [95% confidence

262 ria-based quality improvement initiatives on inappropriate testing, but they have not been systematic

263 The primary outcome was the proportion of inappropriate tests based on appropriate use criteria.

264 ism may play an important role in preventing inappropriate Th cell responses under normal conditions.

265 ine profile observed suggests a skew towards inappropriate Th1 immune responses.

266 that the clinician believes are potentially inappropriate, the seven-step process presented in the m

267 coronary interventions (PCIs) classified as "inappropriate." The New York State Department of Health

268 from philosopher's disease: the unnecessary, inappropriate, theoretically driven explanation of behav

269 sis both from the disease process as well as inappropriate therapies.

270 was associated with lower mortality than was inappropriate therapy (132 [38.5%] of 343 patients died

271 atic Defibrillator Implantation Trial-Reduce Inappropriate therapy (MADIT-RIT) trial showed a signifi

272 Delayed response was rarely related to inappropriate therapy but strongly predictive of early t

273 ropriate therapy vs 84 [89%] of 94 receiving inappropriate therapy) and the most frequent carbapenema

274 rted in the first 5 days after infection) or inappropriate therapy, and for patients receiving approp

275 ing clinicians is common and associated with inappropriate therapy.

276 therapy compared with 94 (22%) who received inappropriate therapy.

277 cohort of studies, indicating that it may be inappropriate to combine such dissimilar studies to esti

278 ntific, ethical, and policy questions, it is inappropriate to perform germline gene editing that culm

279 scue the native glycosylation pattern; thus, inappropriate trafficking likely explains why TLR9(471-1

280 n of neurodegeneration via the inhibition of inappropriate transcription.

281 delayed turnover of maternal transcripts and inappropriate transcriptional activation.

282 ation of septic shock patients may result in inappropriate treatment allocation in randomized clinica

283 accurate diagnosis and prevent prolonged or inappropriate treatment with plasma exchange therapy whe

284 link between suboptimal attending handoffs, inappropriate treatment, and serious adverse events that

285 30.8%) reported knowing of an adverse event (inappropriate treatment, cardiac arrest, and death) attr

286 ze the condition can lead to repeated use of inappropriate treatment.

287 ment: Responding to Requests for Potentially Inappropriate Treatments in Intensive Care Units) provid

288 s to resolve disagreements about potentially inappropriate treatments.

289 Care Units) provides examples of potentially inappropriate treatments; however, no clear definition i

290 We propose that SteD is an adaptor, forcing inappropriate ubiquitination of mMHCII by MARCH8 and the

291 aumatic stress disorder (PTSD), manifests as inappropriate, uncontrollable expression of fear in neut

292 nce is antibiotic misuse, especially routine inappropriate use of antibiotics for self-limiting illne

293 spital stays, unnecessary consultations, and inappropriate use of antibiotics.

294 frica are sorely needed to help mitigate the inappropriate use of antimicrobial treatment.

295 ronment cleanliness, and reminders to reduce inappropriate use of proton-pump inhibitors.

296 of computational tools and the corresponding inappropriate use of tools designed for soluble proteins

297 of MMP with ocular involvement leads to the inappropriate use of topical therapy, the standard of ca

298 Inappropriate uses of urine concentration relate primari

299 interventions should generally be considered inappropriate when there is no reasonable expectation th

300 Inappropriate Wnt pathway activation results in diseases