ライフサイエンスコーパス: inasmuch as

1 at mimics progressive forms of human disease inasmuch as 100% of males develop histological PIN by 8-

2 are sufficient to confer capsid association inasmuch as a carboxyl-terminally truncated form of the

3 for normal cell proliferation and survival, inasmuch as a dramatic cell-cycle arrest at G(2)/M phase

4 Inasmuch as a site for CD4 binding in the beta 2 domain

5 deration of the potential functions of GP63, inasmuch as African trypanosomes are not known to intera

6 ificantly alter the activity of the enzymes, inasmuch as all four caspases are optimally active withi

7 ation of fibroblast phenotype was transient, inasmuch as alpha-SM actin immunostaining declined at 28

8 Inasmuch as an oxo-reductase requires NADPH, we reasoned

9 R is due in large part to rapid proteolysis, inasmuch as apo-TraR accumulated to high levels in an E.

10 ascade upstream of mitochondrial involvement inasmuch as Bac-U(S)3 blocks release of cytochrome c in

11 Inasmuch as BAG-1 has been found in association with sev

12 These results are important inasmuch as beta-glucan, an agent without evident toxici

13 rangin on NF-kappaB activation was specific, inasmuch as binding of activator protein-1 and octameric

14 Inasmuch as both of the PAF antagonists previously used

15 Inasmuch as brain glucose metabolism is a sensitive mark

16 Inasmuch as Ca2+ can enter the nucleoplasm via the nucle

17 Inasmuch as caloric restriction lowers blood glucose lev

18 apoptosis by a caspase-3-independent pathway inasmuch as caspase 3 was not activated and DNA fragment

19 was regulated by ICP22 and or US1.5 protein inasmuch as cells infected with a mutant from which thes

20 rim required the presence of U(L)34 protein, inasmuch as cells infected with a U(L)34 null mutant vir

21 Inasmuch as close homologues of the orn gene are found i

22 Inasmuch as CNS structures develop along different time

23 d in two distinct ways with mGlu1 receptors, inasmuch as competitive mGlu1 receptor antagonists that

24 Inasmuch as complement plays a critical role in many pat

25 Inasmuch as components of the translation machinery may

26 Our results suggest that, inasmuch as contiguity between T- and B-cell epitopes pr

27 d MMP-2 appeared to be specific to collagen, inasmuch as culture of the endothelial cells on top of,

28 no significant impact on long-term function, inasmuch as cultured islets functioned for more than 120

29 ock succumbed to caspase-dependent apoptosis inasmuch as cytochrome c was released, the inner mitocho

30 ty was shown to be dependent on N-sulfation, inasmuch as de-N-sulfated heparin had little or no inhib

31 played a crucial role in Th differentiation, inasmuch as deletion of CD44 inhibited Th1/Th17 differen

32 PS) from Porphyromonas gingivalis is unusual inasmuch as different studies have reported that it can

33 These results are highly relevant, inasmuch as EC and UW are the most common clinically use

34 of endothelin-1 (ET-1) is induced by OA-NO2 Inasmuch as ET-1 is one of the key regulators of vascula

35 Inasmuch as excessive NE release is clinically recognize

36 Inasmuch as excessive norepinephrine exocytosis is a lea

37 role in the maintenance of the latent state, inasmuch as expression of ATF3 bereft of the C-terminal

38 Inasmuch as FADS is essential for cellular supply of FAD

39 Inasmuch as fat cell size, but not number, was increased

40 n stabilize a regular spacing of nucleosomes inasmuch as favorable stacking interactions between nucl

41 be mediated through an excitotoxic pathway, inasmuch as ganglion cells are rendered sensitive to nor

42 Inasmuch as GDNF can increase levels of both EAAT1 and N

43 r-binding protein homologous protein (CHOP), inasmuch as gene silencing of CHOP abolished the inducti

44 Inasmuch as generation of APPs precludes the formation o

45 Inasmuch as glucose is believed to be the principal, if

46 e existence of ligand bias at this receptor, inasmuch as glutamate induced both effects, whereas quis

47 ved at 90 minutes that is not related to CBF inasmuch as Groups II and V had CBF equal to Group I but

48 ese mutants are not physiologically starved, inasmuch as growth rates are normal at 25 degrees C.

49 ss GSTP1, they remain capable of expression, inasmuch as GSTP1 promoter hypermethylation is not detec

50 thway in human cancer has remained enigmatic inasmuch as Hippo pathway components are rarely mutated

51 Inasmuch as HLA-identical siblings, but not HLA-identica

52 expressed on virions and functions in entry, inasmuch as HSV-1(KOS) virions devoid of gK enter cells

53 Inasmuch as HTR.C tumor cells themselves express ICAM-1,

54 with the apoptotic influence of either lipid inasmuch as (i) ceramide-mediated lethality is primarily

55 Inasmuch as (i) none of these proteins were detectable i

56 3 (NS3) is responsible for FASN recruitment, inasmuch as (i) NS3 expressed in the absence of other vi

57 racteristics of a ribotoxic stress response, inasmuch as (i) the activation of stress kinases and gen

58 in WT virus-infected cells, a contradiction, inasmuch as if the rates of accumulation were identical

59 Inasmuch as IL-13 can promote airway inflammation and ca

60 Inasmuch as IL-2R beta and IL-2R gamma subunits also ser

61 Inasmuch as IL-7 and HGF are known to have antitumor and

62 Inasmuch as IL-7 is one of the cytokines most closely as

63 ormal B-lymphocyte developmental checkpoints inasmuch as immunoglobulin light-chain gene rearrangemen

64 ding the evolution of chromosomes 11 and 12, inasmuch as in other species the process of sequence exc

65 Inasmuch as increased I(KA) is associated with excitotox

66 cells and to promote humoral responses, and inasmuch as induction of humoral responses by central ne

67 Inasmuch as inhibition of Ebola requires 100-fold higher

68 ing IR correlated with expression of IFNbeta inasmuch as inhibition of IFNbeta by neutralizing antibo

69 oplasm by a process mediated by proteasomes, inasmuch as interference with proteasomal function cause

70 of the neural basis of numerical cognition, inasmuch as it bolsters the cross-species continuity of

71 metabolism of at least one phenolic inducer inasmuch as it converts ferulic acid, a potent vir gene

72 fect of U(L)13 kinase appears to be specific inasmuch as it did not affect the accumulation of glycop

73 termediate in the overall reaction sequence, inasmuch as it is too unstable to isolate and decays by

74 Palytoxin acted as a ribotoxic stressor, inasmuch as it required actively translating ribosomes a

75 alternative to N-BNP in the diagnosis of HF, inasmuch as its levels are elevated irrespective of age,

76 phenomenon to generate robust oscillations, inasmuch as its time constants satisfy precisely the con

77 Inasmuch as large populations are regularly exposed to m

78 Inasmuch as local cerebral glucose utilization is closel

79 Inasmuch as many human leukemias show dysregulated expre

80 Inasmuch as MCp are preserved in the lungs of beta7 inte

81 Inasmuch as most chickens worldwide are vaccinated with

82 l is a hallmark of AGC functional divergence inasmuch as most of the conserved core residues that dis

83 Inasmuch as multilocus enzyme electrophoresis and pulsed

84 by a mutation-induced conformational change, inasmuch as mutation of another site (Ser471 to Ala) in

85 Inasmuch as myocardial interstitium contains angiotensin

86 ound to play a key role in MDSC mobilization inasmuch as neutralizing G-CSF caused a significant decr

87 Inasmuch as neutrophils replaced monocytes and led to de

88 Inasmuch as no direct comparison between these two graft

89 Inasmuch as only a 1% DNA base sequence change is expect

90 Inasmuch as oxidative stress has also been implicated in

91 -1 signaling is highly contextual in nature, inasmuch as PAR-1 activates extracellular signal-regulat

92 Inasmuch as patient survival in the chronic hemodialysis

93 ires a function expressed late in infection, inasmuch as phosphonoacetate blocked the translocation o

94 Inasmuch as photoreceptors elaborate an exceptionally en

95 the cytoplasm, (iii) caspase-3 was activated inasmuch as poly(ADP-ribose) polymerase was cleaved, and

96 s not to contribute towards neuroprotection, inasmuch as preconditioning with MDMA at a low ambient t

97 (ICP22)/U(S)1.5 or of interaction with ICP0, inasmuch as preferential accumulation of hyperphosphoryl

98 generation of reactive oxygen intermediates, inasmuch as preincubation of cells with a variety of ant

99 sphoproteins depends on 14-3-3 dimerization, inasmuch as proteins associated in vivo with a monomeric

100 Inasmuch as proteins bearing the Nt-acetylated N-termina

101 Inasmuch as proteolytically active SCP is required for t

102 Inasmuch as Rabs are likely GTP-bound after synthesis an

103 Inasmuch as recombinant HCV viral antigens perform as re

104 Inasmuch as rheumatoid arthritis and aging are also asso

105 e 18S rRNA mutations appeared to be specific inasmuch as ribosomes containing these mutations did not

106 ion was also found to require PKC activation inasmuch as RO-31-8425 and GF 109203x both attenuated th

107 ubstrate is delivered to the 26S proteasome, inasmuch as Rpn10p, the only known proteasomal subunit t

108 Inasmuch as SC's cellular phenotype is mimicked by kinas

109 Inasmuch as SMN-containing complexes have been implicate

110 Inasmuch as specificity and sensitivity are maximum at t

111 Inasmuch as Src kinase is capable of upregulating the NM

112 Inasmuch as T15-Id+ Abs dominate the primary immune resp

113 two pathways was not necessary for apoptosis inasmuch as TCDD-treated Bid KO mice showed thymic atrop

114 oscillations were action potential mediated inasmuch as tetrodotoxin eliminated their occurrence.

115 Inasmuch as the A.T base pair is known to resist Z-DNA f

116 Inasmuch as the activities of the principal enzymes that

117 rottlerin-sensitive element is not PKCdelta, inasmuch as the alternate pathway is not blocked in PKCd

118 Inasmuch as the anionic ganglioside GM1, a compound stru

119 n and impaired smooth pursuit eye movements, inasmuch as the brain regions responsible for processing

120 the difference between MDL 101,002 and PBN, inasmuch as the calculated octanol/water partition coeff

121 Inasmuch as the cleavage of DSEB/RF-C140 separates its D

122 Inasmuch as the clinical features of the idiopathic infl

123 Inasmuch as the data in the literature on the function o

124 Inasmuch as the decreased expression of IL-32, which is

125 viral genes is mediated by the p38 pathway, inasmuch as the enhancement is abolished by p38 inhibito

126 Inasmuch as the expression of OspC is influenced by a no

127 Inasmuch as the genomewide effects of CcpA in a human pa

128 Inasmuch as the HCV genome does not encode a canonical g

129 This is a surprising finding inasmuch as the Indo-Pacific family is located on New Gu

130 d fatty acids with odd-numbered double bonds inasmuch as the isomerase-dependent pathway facilitates

131 Inasmuch as the level of YB-1 drastically increases in t

132 Inasmuch as the neurohormone melatonin is synthetically

133 d, NhaC has no required role in alkaliphily, inasmuch as the nhaC deletion strain of B. firmus OF4811

134 archetypal problem in chemical selectivity, inasmuch as the nucleobase (an undesired site of reactio

135 Inasmuch as the overall turnover number at 4 degreesC is

136 the nonselective scheme then performs better inasmuch as the percentage of estimated confidence inter

137 ility of template-assisted cluster synthesis inasmuch as the reduced (Tp*)WS(3) unit is present in al

138 Furthermore, the soluble FasL was functional inasmuch as the sera from tumor-bearing mice were able t

139 f the more general ribotoxic stress response inasmuch as the transduction of the UVB-generated inhibi

140 Inasmuch as the value of k(cat)/K(m) for the reaction of

141 Inasmuch as the wild-type uridylyltransferase catalyzes

142 Inasmuch as there are thousands of identical microchanne

143 Inasmuch as these agents prevented T cell proliferation,

144 Inasmuch as these data suggested that muscle inoculation

145 nd L861R as rare cancer-associated mutations inasmuch as these mutations increase EGFR activity in th

146 Inasmuch as these plasmids might contribute to significa

147 ntial sources of information in this regard, inasmuch as these presumably are due to and thus reflect

148 Some constraints are subtle inasmuch as they are unique to certain bacteria.

149 ve no defect at the local inflammatory site, inasmuch as they form protective granulomas and control

150 Inasmuch as this conclusion applies to the idea of an "i

151 Inasmuch as this effect of gliadin is not seen in cultur

152 Inasmuch as this mouse B cell pIgR binds IgM better than

153 Inasmuch as this work reveals a carbohydrate-recognition

154 late the receptor-mediated actions of TIMPs, inasmuch as TIMPs are themselves inhibitors of MMP-media

155 Inasmuch as TNF and IL-1 are present at the site of infl

156 Inasmuch as TORC2 is activated by association with ribos

157 Inasmuch as total glucose Ra was significantly increased

158 sites of Glu-Pg contributed to cell adhesion inasmuch as tranexamic acid and epsilon-aminocaproic aci

159 act Rho/Rho kinase (ROCK) and myosin signals inasmuch as treatment with Y27632 or blebbistatin attenu

160 of HCV RNAs was dose dependent and specific, inasmuch as two HCV variants that differ by 3 nt within

161 red the presence of the U(L)31 gene product, inasmuch as U(L)34 protein was detectable at the nuclear

162 osphorylation involved a Gq-coupled receptor inasmuch as U73122, a specific PLC inhibitor, abolished

163 Inasmuch as we have previously shown that NK cells can m

164 Inasmuch as we recently demonstrated that IL-4 is a stro

165 Inasmuch as we recently implicated an upstream region of

166 Inasmuch as weight varies substantially over treatment,

167 ctive infection maps to the D199 amino acid, inasmuch as wild-type ICP0 delivered in trans to cells i

168 Inasmuch as WNV-infected humans can also experience a po