ライフサイエンスコーパス: inbreeding

1 he Parsi reflects their recent isolation and inbreeding.

2 s but also in their level of relatedness and inbreeding.

3 usceptibility to the genetic perturbation of inbreeding.

4 FP) or by genomic (marker-based) measures of inbreeding.

5 hose that lie between, including selfing and inbreeding.

6 ats, including loss of genetic diversity and inbreeding.

7 l selection, we revealed mutation load using inbreeding.

8 rol the trade-off between diploidization and inbreeding.

9 f the recruit families was not due to higher inbreeding.

10 g the highest diversity and lowest levels of inbreeding.

11 of identity disequilibrium (ID), a proxy for inbreeding.

12 imited levels of within-band relatedness and inbreeding.

13 kers usually provides little power to detect inbreeding.

14 territory, independent of pressures to avoid inbreeding.

15 tend to have large families with evidence of inbreeding.

16 nsion at each generation along the course to inbreeding.

17 the expression of CHT and the past levels of inbreeding.

18 ion from Hardy-Weinberg equilibrium owing to inbreeding.

19 and may reflect responses to the effects of inbreeding.

20 pression may be underestimated in studies of inbreeding.

21 at an arbitrary generation along the path to inbreeding.

22 r an individual's own inbreeding or maternal inbreeding.

23 ably due to differential levels of drift and inbreeding.

24 ations across Europe, potentially indicating inbreeding.

25 tion and breed formation, rather than recent inbreeding.

26 y the expression of a recessive allele under inbreeding.

27 ated with the loss of SI and/or the shift to inbreeding; (2) a population bottleneck may have played

28 onditioned on effects of male coefficient of inbreeding, age and social status.

29 Recent research has found that plant inbreeding alters resistance and tolerance to herbivores

30 de environmental effects of captive rearing, inbreeding among close relatives, relaxed natural select

31 forcement to initial colonists, help relieve inbreeding among founders, or increase the hazard of the

32 evealed few sexual differences in biparental inbreeding among other gynodioecious species.

33 which pistils reject self-pollen to prevent inbreeding and accept non-self pollen to promote out-cro

34 e it measures the rates of genetic drift and inbreeding and affects the efficacy of systematic evolut

35 found that domestication is associated with inbreeding and an excess of deleterious mutations.

36 population, we found no associations between inbreeding and any of our six fitness measurements.

37 both ideal and actual conditions (including inbreeding and double reduction) were compared.

38 such disruptions in the short term, whereas inbreeding and genetic structure may respond more strong

39 cument multiple instances of father-daughter inbreeding and high levels of intraspecific strife, incl

40 generally exacerbates the harmful effects of inbreeding and it has been proposed that this could be e

41 red by BORICE may prove useful in studies of inbreeding and its consequences.

42 computing genealogical measurements, such as inbreeding and kinship coefficients of individuals, depe

43 Ne ) is a key parameter that shapes rates of inbreeding and loss of genetic diversity, thereby influe

44 as 30, suggesting that rates of increase of inbreeding and loss of genetic variation per generation

45 reproductive assurance, but it also fosters inbreeding and potential reduction in fitness.

46 1995-2013, resulting in increased levels of inbreeding and reduced fitness via inbreeding depression

47 ions are expected to shift towards increased inbreeding and reduced pollen diversity, with fitness co

48 for all populations, we found low levels of inbreeding and relatedness between individuals within po

49 ecades of human-driven artificial selection, inbreeding, and adaptation to captivity, is of limited u

50 election showed rapid fitness declines under inbreeding, and all were extinct after generation 10.

51 Most plants are capable of inbreeding, and also exhibit a remarkable suite of adapt

52 Population bottlenecks, inbreeding, and artificial selection can all, in princip

53 e we assess temporal variation in gene flow, inbreeding, and fitness using longitudinal genomic, demo

54 Many generations are required to reach inbreeding, and so a number of investigators have sought

55 revealing reduced heterozygosity, increased inbreeding, and variable introgression of domestic allel

56 e played a role in driving the transition to inbreeding; and (3) the mutation(s) underlying the loss

57 of the populations indicated a low level of inbreeding, as suggested by the high number of alleles.

58 t may confer considerable benefits including inbreeding avoidance and nepotism.

59 To determine whether inbreeding avoidance and/or biparental inbreeding can ac

60 sex determination, inbreeding depression and inbreeding avoidance in Neodiprion lecontei, a gregariou

61 the conservation of threatened species, and inbreeding avoidance is thought to be a key driver in th

62 tive behavior may have acted as an important inbreeding avoidance mechanism allowing the species to e

63 ed, is often interpreted as a consequence of inbreeding avoidance mechanisms, but we show that it can

64 This pattern cannot be explained by inbreeding avoidance or as a response to more intense lo

65 ss, may evolve one or more of the following: inbreeding avoidance, functional diploid males or altern

66 nge members, thus facilitating gene flow and inbreeding avoidance.

67 t most a 1-14% increase in seed fitness from inbreeding avoidance.

68 ce the evolution of mating systems and other inbreeding-avoidance mechanisms.

69 systems, however, there was selection during inbreeding because the diversity patterns of 337 single-

70 ions and cannot be explained by differential inbreeding, but are consistent with relaxed selection ma

71 Despite the potential for inbreeding by facultative self-fertilisation, substantia

72 nked portions of the genome owing to extreme inbreeding by self-fertilization.

73 plication via self-fertilization and intense inbreeding by simultaneous hermaphrodites.

74 ether inbreeding avoidance and/or biparental inbreeding can account for female persistence in Geraniu

75 Biparental inbreeding can affect relative female fitness only if it

76 Thus, just as inbreeding can elevate the occurrence of rare recessive

77 Furthermore, occasional inbreeding can explain why some multiple-patriline colon

78 e and beyond what pedigree-based measures of inbreeding can explain.

79 Here we show that inbreeding causes early death in the zebra finch Taeniop

80 he population outcrossing rate (t) and adult inbreeding coefficient (F) are key parameters in mating

81 ta, and among inbred individuals of the same inbreeding coefficient (F), those that die early are mor

82 t (IBDG) is predicted better by the pedigree inbreeding coefficient (FP) or by genomic (marker-based)

83 gree, finding strong concordance between the inbreeding coefficient and heterozygosity measured at 13

84 success in both sexes, and between maternal inbreeding coefficient and offspring survival.

85 of our proposed method by applying it to the inbreeding coefficient computation.

86 We compared the inbreeding coefficient estimated using known height asso

87 rogram BORICE (Bayesian Outcrossing Rate and Inbreeding Coefficient Estimation) that effectively esti

88 al and joint posterior distributions for the inbreeding coefficient in females and the male to female

89 Inbreeding coefficient indicated an overall 10% decrease

90 als given that every individual has the same inbreeding coefficient, F.

91 tion in nucleotide diversity, or increase in inbreeding coefficient, relative to history of exposure.

92 eeding date varied with female, but not male inbreeding coefficient, revealing direct, but not indire

93 rates, locus-specific dropout rates, and the inbreeding coefficient; and (3) successfully correct the

94 data, it is necessary to obtain estimates of inbreeding coefficients (F) for each individual before c

95 mes and across individuals, and estimates of inbreeding coefficients are subject to unexpected levels

96 the efficiency of our method for evaluating inbreeding coefficients as compared to previous methods

97 sheep population of St Kilda, using genomic inbreeding coefficients based on 37 037 single-nucleotid

98 In contrast, inbreeding coefficients calculated from a deep and compa

99 Cervus elaphus) in Scotland using individual inbreeding coefficients derived from dense Single-Nucleo

100 We observed significantly higher inbreeding coefficients for the height associated varian

101 Here, we present two methods for estimating inbreeding coefficients from NGS data based on an expect

102 However, the estimation of individual inbreeding coefficients in natural populations has been

103 Genomic inbreeding coefficients may resolve the long-standing pa

104 ser Cakile maritima has replaced an earlier, inbreeding, colonizer Cakile edentula (Brassicaceae).

105 rate that a careful choice of the measure of inbreeding combined with LDMS stratification improves bo

106 expression of lethal recessive alleles under inbreeding conditions in wild populations.

107 nt metabolites, suggesting that variation in inbreeding could be a predictor of defence trait variati

108 contribute to variability in the strength of inbreeding depression (ID) observed across adverse envir

109 nbreeding measures commonly used to estimate inbreeding depression (ID).

110 ctions with insects can increase or decrease inbreeding depression (the loss of fitness due to self-f

111 se data to determine the extent and cause of inbreeding depression across other plant genomes.

112 find strong support for interactions between inbreeding depression and environmental variation compar

113 We investigated inbreeding depression and genetic load in a small (N(e)

114 Here, we investigate sex determination, inbreeding depression and inbreeding avoidance in Neodip

115 Siring probability also showed inbreeding depression and increased with male age, while

116 Inbreeding depression and lack of genetic diversity in i

117 tically established, despite being linked to inbreeding depression and sexual selection.

118 species may be particularly at risk because inbreeding depression and stochastic fluctuations in mal

119 The magnitude of inbreeding depression as expressed in the field can be e

120 ought to increase relative female fitness is inbreeding depression avoidance, the magnitude of which

121 We investigated evidence for inbreeding depression by environment interactions in nin

122 depression." There is mounting evidence that inbreeding depression can be exacerbated by environmenta

123 ns and compared mean fitness, heterosis, and inbreeding depression for eight large and eight small po

124 We found significant inbreeding depression for germination rate (delta=0.33),

125 gest evidence to date of an HFC being due to inbreeding depression in a natural population lacking a

126 Here we investigate inbreeding depression in a range of life history traits

127 resolve the long-standing paucity of data on inbreeding depression in adult traits and total fitness.

128 and suggest that, to date, the prevalence of inbreeding depression in adult traits may have been unde

129 We also confirm previous findings of inbreeding depression in birth weight and juvenile survi

130 y, which revealed similar starting levels of inbreeding depression in both breeding systems, but also

131 ing) influence the experimental evolution of inbreeding depression in Caenorhabditis elegans.

132 and comparatively complete pedigree detected inbreeding depression in juvenile survival, but not in a

133 There was no significant inbreeding depression in most traits due to one generati

134 eding provide a powerful tool for evaluating inbreeding depression in natural populations, and sugges

135 study were to: (1) quantify the strength of inbreeding depression in North-American populations of A

136 t tool for mitigating detrimental effects of inbreeding depression in small, inbred populations, but

137 ny genetic disorders in humans and producing inbreeding depression in the majority of sexually reprod

138 y play an important role as a buffer against inbreeding depression in the offspring by alleviating th

139 um effective population size to avoid severe inbreeding depression in the short term is of the order

140 Determining the genetic basis of inbreeding depression is important for understanding the

141 Understanding the genetic architecture of inbreeding depression is important in the context of the

142 Experimental studies often find that inbreeding depression is more severe in harsh environmen

143 Inbreeding depression is of major concern for the conser

144 th America except in southern Florida, where inbreeding depression led to reproductive failure [3-5].

145 Therefore, we identify two ways by which inbreeding depression may be underestimated in studies o

146 Taken together, these findings suggest that inbreeding depression negatively impacts the overall pat

147 Inbreeding depression occurs when inbred individuals exp

148 Inbreeding depression refers to lower fitness among offs

149 We observed preliminary evidence for inbreeding depression related to stress caused by fungal

150 non-lethal mutations, reducing the amount of inbreeding depression relative to that expected without

151 Together, these results suggest that inbreeding depression stemming from CSD has shaped matin

152 nding inconvertible evidence of the cause of inbreeding depression still presents a difficult challen

153 large populations (mean = 7%, SE = 27); and inbreeding depression was lower, although not significan

154 terious mutations, reducing mean fitness and inbreeding depression within populations and increasing

155 anscription play a role in hybrid vigour and inbreeding depression, and also in the absence of parent

156 scue in facilitating adaptation and reducing inbreeding depression, and suggest that demographic resc

157 luding the rate of adaptation, the extent of inbreeding depression, and the load of deleterious mutat

158 levels of inbreeding and reduced fitness via inbreeding depression, even as the population remained d

159 inance was responsible for the observed high inbreeding depression, heterozygote advantage could not

160 The cost of inbreeding (inbreeding depression, ID) is an important variable in t

161 and improvements in biomedical correlates of inbreeding depression, provide strong evidence that gene

162 t in captivity may decrease the intensity of inbreeding depression, relative to the stressful conditi

163 as the potential to moderate the severity of inbreeding depression, which in turn may favor inbreedin

164 fects on viability, are contributing to this inbreeding depression.

165 to strong genetic drift and at high risk of inbreeding depression.

166 lations have rendered the species at risk of inbreeding depression.

167 als dynamic genome evolution and hotspots of inbreeding depression.

168 aphroditic selfing rates and the strength of inbreeding depression.

169 ay express recessive genetic load and suffer inbreeding depression.

170 S-linked genetic load compared with overall inbreeding depression.

171 itland approach for field-based estimates of inbreeding depression.

172 while simultaneously estimating sex-specific inbreeding depression.

173 or inviable, sl-CSD can generate substantial inbreeding depression.

174 ficient, revealing direct, but not indirect, inbreeding depression.

175 eduction in fitness-related traits known as "inbreeding depression." There is mounting evidence that

176 lower fertility; (ii) offspring suffer from inbreeding depression; (iii) parents have more grandchil

177 Moreover, inbreeding disrupted growth trait responses to damage, i

178 versity remained high, suggesting occasional inbreeding does not impair local population persistence.

179 ges in population size, arbitrary amounts of inbreeding, dominance and distributions of selective eff

180 ing season while reducing the risk of hidden inbreeding due to related founders from the same habitat

181 Further, we show that inbreeding effects on breeding date can also be sex spec

182 ct) and male (indirect) additive genetic and inbreeding effects on breeding date, and estimated the c

183 eeding, indicating a phytohormonal basis for inbreeding effects on growth and defence trait regulatio

184 Our results indicate that inbreeding effects on plant-herbivore interactions are m

185 nagement methods are performed, one avoiding inbreeding (equalisation of parental contributions (EC))

186 ual maturity provides evidence that realized inbreeding, estimated from a high density of markers spr

187 ed and pollen dispersal can create localized inbreeding even within outcrossing plants.

188 First, via inbreeding experiments and flow cytometry, we demonstrat

189 African American cohort had a low degree of inbreeding (F ~ 0.006).

190 gether, this evidence strongly suggests that inbreeding, favored by postdomestication selection for c

191 land plants, and the significance of extreme inbreeding for fern evolution has been a subject of deba

192 en -2.3 and -5.2 phenotypic SDs for complete inbreeding; [Formula: see text]).

193 27 individuals of varying levels of apparent inbreeding from 6 human populations.

194 ariation to facilitate adaptation and reduce inbreeding (genetic rescue).

195 Inbreeding had negative effects, whereas outbreeding gen

196 (SI) and subsequent mating system shifts to inbreeding has intrigued evolutionary geneticists for de

197 onsequences of mating system variation (e.g. inbreeding) have been studied for at least 200 years, ye

198 ddition, we describe how individual maternal inbreeding histories inferred by BORICE may prove useful

199 Here, we present a new method for estimating inbreeding IBD tracts from low coverage NGS data.

200 retical examination of the genomic effect of inbreeding in a forest tree and provides an approach to

201 nean for I. fasciculata, with high levels of inbreeding in all locations and bottleneck signs in most

202 lity (SI) is a biological mechanism to avoid inbreeding in allogamous plants.

203 mechanism to prevent self-fertilization and inbreeding in higher plants and also is known to utilize

204 enetically controlled system used to prevent inbreeding in higher plants.

205 genetically controlled mechanism to prevent inbreeding in higher plants.

206 ntal inbreeding only, the amount of observed inbreeding in natural populations is generally low compa

207 ted activities of CHT and GLU in response to inbreeding in plants from 13 Ragged Robin (Lychnis flos-

208 to intrinsic genetic stress brought about by inbreeding in some populations depending on the allele f

209 nvestigated both long distance dispersal and inbreeding in the bird's nest fungus Cyathus stercoreus,

210 ect of parental care on the fitness costs of inbreeding in the burying beetle Nicrophorus vespilloide

211 st diversity that is related to the level of inbreeding in the population.

212 nificant evidence of variation in individual inbreeding in this population, we found no associations

213 are neither a peculiarity of cultivation nor inbreeding in Z. mays.

214 The cost of inbreeding (inbreeding depression, ID) is an important v

215 idence indicate that CentC loss is linked to inbreeding, including (i) CEN10 of temperate lineages, p

216 Because inbreeding increases the probability of producing diploi

217 ic acid were all significantly reduced under inbreeding, indicating a phytohormonal basis for inbreed

218 sity to elucidate how ancestry, kinship, and inbreeding interact in three populations with different

219 We assess the impact of taking inbreeding into account when calling genotypes or estima

220 llen donors occur, an increase in biparental inbreeding is a potential problem.

221 Quantifying the effects of inbreeding is critical to characterizing the genetic arc

222 Thus, measuring individual inbreeding is crucial for ecology, evolution and conserv

223 ferns to date that the capacity for extreme inbreeding is prevalent in this lineage, and we discuss

224 e population size, rather than just avoiding inbreeding, is a critical factor for preventing the accu

225 lo has been associated with higher levels of inbreeding, leading to an increase in the prevalence of

226 utcrossing) to self-compatibility (increased inbreeding) leads to the evolution of an inducible (vs.

227 n, they also appear to be constrained by the inbreeding-like effect of loss of heterozygosity that ac

228 e evaluate the effects of genetic purging of inbreeding load in small populations, assuming genetic m

229 that genetic purging efficiently removes the inbreeding load of both lethal and non-lethal mutations,

230 d two past bottlenecks that resulted in some inbreeding load.

231 We show that, for the inbreeding loads considered, CM leads to unacceptably hi

232 When there is no inbreeding loop in the pedigree, the Elston-Stewart algo

233 If there are inbreeding loops in the pedigree, we recommend the Bayes

234 ork algorithm that copes with pedigrees with inbreeding loops without losing calculation precision on

235 ozygotes for strongly deleterious mutations, inbreeding magnifies the occurrence of mildly deleteriou

236 Inbreeding (mating between relatives) can dramatically r

237 sequent phenotypic changes in inbred plants, inbreeding may alter plant-insect interactions.

238 Although inbreeding may facilitate colonization by the fungus, it

239 trengths and shortcomings of three SNP-based inbreeding measures commonly used to estimate inbreeding

240 of wheat hybrids is difficult because of the inbreeding nature of wheat and the lack of a practical f

241 etics because they bypass the generations of inbreeding needed for fixation of recessive mutations.

242 t record differences in genetic diversity or inbreeding, nor did we record any differences between ad

243 s, such as the loss of genetic diversity and inbreeding on an evolutionary timescale.

244 We examined the effects of inbreeding on constitutive and herbivore-induced volatil

245 ess well studied is the effect of biparental inbreeding on female fitness.

246 nging, and, consequently, the full effect of inbreeding on fitness remains unclear.

247 The total effect of inbreeding on lifetime breeding success (LBS) was substa

248 orophyte level, we observed a weak effect of inbreeding on offspring fitness, but no effect of brood

249 We tested the consequences of experimental inbreeding on phenotypic plasticity in resistance and gr

250 de novel information on the effects of plant inbreeding on plant-enemy interactions on a biochemical

251 derlying genetic variation in the effects of inbreeding on plant-insect interactions and the conseque

252 gametophytic selfing, is an extreme form of inbreeding only possible in homosporous groups.

253 First, for species with biparental inbreeding only, the amount of observed inbreeding in na

254 ession because of either an individual's own inbreeding or maternal inbreeding.

255 ctivity do not undergo dramatic changes upon inbreeding or outcrossing.

256 necks (that is, founder effects), biparental inbreeding or self-fertilization, any of which might inc

257 implications of these diverse mechanisms for inbreeding/outbreeding balance regulation.

258 ozygosity and an upward bias in estimates of inbreeding, owing to mistaken classifications of heteroz

259 dual variations that probably reflect recent inbreeding patterns, with higher values occurring more o

260 et of PEGs maintains functional roles in the inbreeding plant Arabidopsis that become evident upon de

261 but only two, S1 and S19, are shared by most inbreeding populations.

262 We find that: inbreeding promotes paternal genome elimination in the h

263 ults demonstrate that SNP-based estimates of inbreeding provide a powerful tool for evaluating inbree

264 wever, complex mating schemes and systematic inbreeding raise substantial computational difficulties.

265 aculatum, we measured selfing and biparental inbreeding rates in four populations and the spatial gen

266 ure was found in all populations, biparental inbreeding rates were low and only differed between sexe

267 levels of herbivore or pathogen damage, but inbreeding reduced CHT activity in these populations dis

268 Inbreeding reduced phenolic expression both qualitativel

269 Inbreeding reduced the ability of plants to up-regulate

270 arwin was one of the first to recognize that inbreeding reduces evolutionary fitness.

271 Because inbreeding results in elevated homozygosity, greater exp

272 athematical model to determine how degree of inbreeding, sex determination, genomic location, pattern

273 ds aimed at enhancing purging by intentional inbreeding should not be generally advised in captive br

274 ive size, with limited kinship and levels of inbreeding similar to HG populations.

275 rived from interspecific comparisons between inbreeding species and their outcrossing relatives, wher

276 In the inbreeding species Arabidopsis thaliana, both paternal a

277 ned the joint influence of maternal care and inbreeding status on fitness-related offspring traits to

278 t this, Hymenoptera with traits that promote inbreeding, such as gregariousness, may evolve one or mo

279 tain gorilla population has led to extensive inbreeding, such that individuals are typically homozygo

280 utcrossed (t(m)=1.02) with little biparental inbreeding (t(m)-t(s)=-0.005) and an average of 5.4 effe

281 but it may also increase the probability of inbreeding that can compromise persistence.

282 We detected significant levels of inbreeding through heterozygote deficiencies at four loc

283 00) and experienced low levels of biparental inbreeding (tm-ts=0.00-0.04).

284 breeding depression, which in turn may favor inbreeding tolerance and influence the evolution of mati

285 notyping can be done in the F1 generation by inbreeding two injected founder fish, significantly redu

286 Inbreeding typically reduces fitness.

287 It is more common in association with inbreeding, under male heterogamety, in males, and in th

288 s data set shows that the extent of apparent inbreeding varies across chromosomes and across individu

289 ternative strategies of sexual reproduction (inbreeding vs. outcrossing) have divergent effects on po

290 However, successful inbreeding was rare, and genetic diversity remained high

291 neage bred endogamously and, despite intense inbreeding, was ecologically successful and showed trans

292 ossible to obtain detailed information about inbreeding when a relatively small set of whole-genome s

293 results accord with a hypothesis that recent inbreeding, which generates long ROH, enables rare delet

294 her these PR proteins are also influenced by inbreeding, which has been suggested to constitute intri

295 ns, they show increased but varied levels of inbreeding, which result in reduced fitness.

296 dentified mating type bias strongly promotes inbreeding, which we consider to be a potential speciati

297 ity, thereby avoiding deleterious effects of inbreeding while maintaining enough variation from which

298 induced responses is negatively affected by inbreeding, with implications for fragmented populations

299 to the distribution of genetic diversity and inbreeding, with northern populations having the highest

300 t to extinction and maintained fitness under inbreeding, with some families continuing to survive aft

301 There was more inbreeding within pasture trees (outcrossing=0.828+/-0.0