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1 s, and histopathologic classification remain incapable in terms of treatment decision and prognosis e
3 t oxidative fibers in Mtm1delta4 animals are incapable of a hypertrophic response in this setting.
8 s, which preserve polar interactions but are incapable of acid-base chemistry, had little effect on e
9 n of wild-type S1PR2, but not a point mutant incapable of activating downstream signaling pathways, i
12 olycomb mechanism, the system was frequently incapable of adding new states, whereas with the Polycom
13 Regions smaller than Swi11-32 are either incapable of aggregation or unstably propagate [SWI(+)].
14 ought to be terminally differentiated cells, incapable of altering their gene expression after differ
15 d, lacking in robustness and consistency, or incapable of analysing 5-methylcytosine specifically.
16 shedding of noninfectious particles and are incapable of antagonizing interferon (IFN) effectively.
17 ing site leads to variants (E184Q and E184A) incapable of any amino acid transport, pointing to a pot
19 nopore reads, because existing packages were incapable of assembling the long read lengths (5-50 kbp)
20 Most measurement approaches, however, are incapable of assessing stiffness in the presence of phys
21 iting RPE65, whereas an emixustat derivative incapable of atRAL sequestration was minimally protectiv
26 cinated canines, not from a novel CPV strain incapable of being neutralized by current vaccination ef
28 ed irreversibly developmentally locked, i.e. incapable of being reprogrammed in vivo into entirely di
33 we have determined that a CaM mutant that is incapable of binding calcium binds to RyR1 at the apo si
34 that overexpression of an AKAP79/150 mutant incapable of binding CaN (DeltaPIX; CaN-binding PXIXIT m
36 Finally, we demonstrate that EspB variants incapable of binding EspD fail to adopt the proper host
37 omputed for RetGC1/NPRA chimeras, even those incapable of binding GCAP, remained high, and functional
40 ylated STAT1, but not that of a STAT1 mutant incapable of binding its nuclear import adaptor karyophe
41 6A mice carrying a mutant form of fibrinogen incapable of binding leukocyte alphaMbeta2-integrin were
42 hift mutations resulting in a truncated Riz1 incapable of binding PR-Set7 occur frequently in various
44 n atom to carbon appear to render the enzyme incapable of binding the analog in the active conformati
47 residues on B', which when mutated render B' incapable of binding to and stimulating HTLV-1 and -2 IN
49 r mutated CD28 in its cytosolic tail that is incapable of binding to Lck, phosphoinositide 3-kinase (
52 cells transfected with beta-catenin mutants incapable of binding to TCF/LEF increased BACE1 gene pro
54 strated when blocked mutants of both strains incapable of biosynthesizing 3-amino-5-hydroxybenzoic ac
55 phosphorylation-mimicking mutant, S381E, was incapable of bundling microfilaments, it retains the abi
56 le hydrogen activation and spillover but are incapable of C-C bond scission that leads to loss of sel
59 as reduced upon infection, and the mice were incapable of Chlamydia-specific immunoglobulin M or immu
60 , B, and L; and MMP-3, -7, -12, and -13 were incapable of cleavage of chondroadherin at this site and
62 n the NCR169 peptide with serine rendered it incapable of complementation, demonstrating an absolute
66 oportion of persons with AD who were thought incapable of consenting to lower-risk or higher-risk stu
68 In contrast, most synthetic materials are incapable of continuous self-monitoring and self-regulat
70 and exogenous (community) viruses, and to be incapable of controlling them as quickly and effectively
71 s of cells, such as liposomes, are typically incapable of cooperation and therefore cannot readily di
74 ration to the E-enal, which is geometrically incapable of cyclization, and (ii) the functionality at
86 of anti-B5, anti-A33, and anti-A56 MAbs was incapable of directly neutralizing EV, even at high conc
89 ds to measure formaldehyde-induced DPCs were incapable of discriminating between endogenous and exoge
91 his mutant enzyme, whereas still active, was incapable of DNA binding and could no longer be stimulat
93 1 or mt-long alpha/beta 317-323 hOgg1 mutant incapable of DNA repair (mt-hOgg1-Mut) each blocked A549
95 ntrolling individual gene expression, remain incapable of dynamically coordinating complex transcript
96 nfortunately, most gene delivery vectors are incapable of efficient or specific gene delivery to NSCs
98 tion of MHCII renders IL-13-expressing ILC2s incapable of efficiently inducing Nippostrongylus brasil
100 ed IgE binding to FcepsilonRI, rendering IgE incapable of eliciting mast cell degranulation, thereby
101 managing chronic myeloid leukemia (CML) but incapable of eliminating leukemia stem cells (LSCs), sug
104 scherichia coli K12 MG1655 DeltamotA that is incapable of encoding the motor torque generator for fla
105 k the intracellular domain and are therefore incapable of endocytosis in the ligand-expressing cell.
106 and slow relaxation time and, therefore, are incapable of ensuring complex inter-pulse dynamics and b
107 , we show that two load-bearing kinesins are incapable of equally sharing the load unless they are ve
111 ation because the recovery of chimeric mice, incapable of expressing p57 in HSPCs, phenocopies blocka
112 In this work, we generated a recombinant MuV incapable of expressing the V protein (rMuVDeltaV).
113 r the wild-type HBV genome or the HBV genome incapable of expressing the X gene, we found that liver
114 sp-AT-PLP-AFPA complex revealed that GabR is incapable of facilitating further steps of the transamin
119 A-oligonucleotides of opposite chirality are incapable of forming contiguous Watson-Crick base pairs
121 ssium channel alpha-subunit, Kv8.2, which is incapable of forming functional channels on its own.
123 -donor compound having an innocent backbone (incapable of forming hydrogen bond) namely 4,4'-bipyridi
124 rat E18 hippocampal neurons, only the mutant incapable of forming intermolecular bonds (CC39,147AA) h
125 cells, expression of a PKCtheta point-mutant incapable of forming microclusters had little to no effe
126 monomers, bending them into a shape that is incapable of forming ordered beta-sheets or fibrils.
130 he stalled fork (fork collapse) rendering it incapable of further DNA synthesis unless recombination
136 olutionarily related to small GTPases but is incapable of GTP-binding and conformational switching.
138 se-dead RelMtb mutant, RelMtb(H80A), that is incapable of hydrolyzing (p)ppGpp but still able to synt
145 at recognize bacterial ligands were not only incapable of inducing CD8 T cell priming, but they had a
147 iously that encephalitogenic CD4 T cells are incapable of inducing EAE when B cells are the sole APC.
148 ensitized DOV13, an ovarian cancer cell line incapable of inducing REDD1, to orlistat-induced cell de
149 optical response of a molecular monolayer is incapable of inducing such a large chiroptical effect, a
150 uired HIF-1alpha, but its presence alone was incapable of inducing target gene expression under normo
153 in formation of fewer sporozoites which were incapable of infecting naive mice or hepatocytes in vitr
155 the (-)-JQ1 enantiomer that is structurally incapable of inhibiting BET bromodomains, which resulted
157 these amino acids are mutated, rendering it incapable of inhibiting the transcriptional activity of
158 ly, DCs generated from Ifnar1(-/-) mice were incapable of initiating Th2 responses in vivo These data
159 t to A416P, either A420P or A425P mutant was incapable of interacting and regulating cellular Src.
162 ation in MLL5-KD cells, whereas MLL5 mutants incapable of interacting with the PBD failed to do so.
163 ng of palmitic acid renders these regulators incapable of interacting with their respective operator
164 a noncytopathic VEEV capsid protein that is incapable of interfering with the innate immune response
165 scription factors (T-bet and Eomes) and were incapable of interferon-gamma production or cytotoxic re
166 nsis subsp. tularensis Schu S4 avirulent and incapable of intracellular replication, owing to an inab
167 merization dynamics will render the parasite incapable of invading a host cell and thereby unable to
168 axo-dendritic and axo-spinous synapses, was incapable of long-term potentiation, and less effectivel
169 we report that geriatric satellite cells are incapable of maintaining their normal quiescent state in
171 -type allele, as were FtsN levels in strains incapable of making disulfide bonds (dsb(-) ) exposed to
172 models to convert a naturally occurring ChR incapable of mammalian localization into one that locali
176 (A795P) enhances NF-kappaB activation but is incapable of mediating TRIF-dependent IFN response facto
178 of 5-aza was dissociated, CHOP ablation was incapable of modulating cytotoxicity; however, neutraliz
179 anti-CD20 during Pneumocystis infection are incapable of mounting a protective immune response when
180 nvertebrates, mammalian somatic cells appear incapable of mounting an RNAi response and few, if any,
185 type single-chain uPA, but not uPA variants incapable of nuclear transport, increases the expression
186 c moieties (4-Me), displaying a Ag(I) center incapable of O2 binding (7-H) or a cationic Pd-H motif (
189 wever, CgrAlcOx and CglAlcOx are essentially incapable of oxidizing galactose and galactosides, but i
190 the capsid protein make this protein almost incapable of packaging the PIV genome, and most of the r
191 the nucleic acids (e.g. pDNA and siRNA) are incapable of passively crossing the endothelium, cell me
192 s incident to a highly scattering medium are incapable of penetrating deep into the medium due to the
193 stly compromised, the nanoparticles remained incapable of penetration beyond the most superficial lay
194 density display of specific epitopes but are incapable of peptide library display and affinity select
195 sing a late-model Q-TOF instrument otherwise incapable of performing electron-based fragmentation, we
196 f translation inhibition, as lamotrigine was incapable of perturbing protein synthesis in vivo or in
197 ble hemagglutinin (HA) proteins are rendered incapable of pH-induced triggering for membrane fusion,
199 by two-photon microscopy that mouse retinas incapable of phagocytosis due to a deficiency of the c-M
200 into mammalian cells that an HP1alpha mutant incapable of phase separation in vitro forms smaller and
202 expressing a mutant glucocorticoid receptor incapable of phosphorylation at Ser134 (S134A-GR) had si
205 mice had normal resting heart rates but were incapable of physiological fight or flight heart rate ac
209 ild-type cells expressing a vimentin variant incapable of polymerization exhibit deficient endoplasmi
210 igand-binding pocket and renders the protein incapable of prenyl binding, is supported by molecular d
211 ylori mutants lacking either GGT or VacA are incapable of preventing LPS-induced DC maturation and fa
214 aracterized an msbB in-frame deletion mutant incapable of producing an acyltransferase that is respon
217 erely altered in gametocyte development, are incapable of producing mature-stage gametocytes, and are
218 ordingly, neutrophils from this patient were incapable of producing neutrophil extracellular traps (N
219 Notably, an E. coli rnhA mutant, which is incapable of producing RNase H and thus harbors increase
222 iratory fate in otherwise wild-type mice, is incapable of promoting respiratory fate in the absence o
224 unlike the isogenic wild-type parent, it is incapable of propagating on certain groEL mutant hosts.
228 hnique for all traumatic brain injury, it is incapable of providing long-term prognostic information
230 malaria parasite, Plasmodium falciparum, is incapable of pyrimidine salvage for mRNA biogenesis.
232 the interstellar medium) has been considered incapable of rapidly terminating star formation on galac
233 both acyl groups at C93 and S239 renders Wg incapable of reaching the plasma membrane for secretion.
238 ural IgG and natural IgA because they appear incapable of recognizing Ags on their own and are percei
239 ted by the polar orientation of KOPS, and is incapable of recognizing KOPS while translocating along
242 bind substrate similar to wild type but was incapable of releasing substrate during its transfer to
245 viral response in infected cells, (iii) were incapable of replication in cells of mosquito origin, an
246 that bare doped silicon microelectrodes are incapable of resolving different grades of attached cell
247 urrent liquid-metal-based strain sensors are incapable of resolving small pressure changes in the few
250 the other hand, are axiomatically considered incapable of responding to damage and healing it, leadin
256 al thiols, consistent with C119S/C162S being incapable of sensing H2O2 Similarly, disulfide heterodim
257 s are ineffective at capturing CTC clusters, incapable of separating clusters from single cells and/o
258 g a mutated TNFR1 ectodomain (p55(Deltans)), incapable of shedding and dampen the inflammatory respon
259 subjective, labor-intensive, slow, and often incapable of showing the detailed features of each uniqu
261 According to this hypothesis, individuals incapable of simulating observed movements in their moto
262 which is ineffective, poorly controlled, and incapable of simultaneous delivery of both genes and pro
263 n) revealed that two of the four clones were incapable of spontaneously activating EMT, whereas the o
265 entities, conventional optical microscopy is incapable of statistically relevant screening of large p
266 intracellular parasite Toxoplasma gondii is incapable of sterol synthesis and unremittingly scavenge
267 ed basal ATPase activity, but PC lipids were incapable of stimulating ATPase activity highlighting th
268 rominently the D129G CaM mutation, which was incapable of stimulating Thr(286) autophosphorylation.
269 evalent view that the adult mammalian CNS is incapable of structural reorganization to adapt to an al
270 issions, but would also create a food supply incapable of supporting the US population's nutritional
274 n to recover in lakes that were historically incapable of sustaining wild fish due to acidic conditio
277 many culture-expanded therapeutic cells are incapable of targeting diseased tissues following system
280 at many tropical taxa may be physiologically incapable of tolerating dry conditions, and that their d
282 The matrix is extensible, which makes it incapable of transducing strong mechanical forces via ce
283 chromatin remodeling can render splenocytes incapable of transferring diabetes into immunodeficient
284 d with free virus, infected MDMs or DCs were incapable of transferring MeV to HAE when applied to the
287 Rendering populations of vectors of diseases incapable of transmitting pathogens through genetic meth
292 , we found that beta-catenin null cells were incapable of undergoing acinar to ductal metaplasia, a p
294 w that inexperienced observers are generally incapable of using motion cues to detect inflation/defla
295 ing both permeases, DeltafpuBDeltafatCD, was incapable of using petrobactin as an iron source and exh
296 mental evolution of two isolates lacking (or incapable of using) MaDH to uncover the physiological ch
297 lly, we identified a 1,2,3-triazol-4-yl base incapable of W/C H-bonding that performs well at guide s
298 glutamate to alanine in its active site was incapable of XfDSF production yet enabled a response to
300 o the fraction of beaded dendrites that were incapable to recover during repolarization, thus facilit
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