ライフサイエンスコーパス: incise

1 NA until all dimers have been recognized and incised.

2 d relaxed forms of the uvDNA are effectively incised.

3 that both the Susquehanna and Potomac Rivers incised 10- to 20-meter-deep gorges along steep, convex

4 aeal Holliday junction resolvases evolved to incise 5' flap substrates and how FAN1 integrates with t

5 ficiently remove sugar-phosphate residues at incised 5' AP sites.

6 that removes 2-deoxyribose-5-phosphate at an incised 5' apurinic/apyrimidinic (AP) sites via a beta-e

7 ing 3' incision were rapidly and efficiently incised 5' to the adduct.

8 hile binding was not observed on a substrate incised 5' to the AP-site.

9 5' of the lesion, or endonuclease XPF, which incises 5' to a lesion, exhibited increased clonogenic s

10 MtTGendo does not incise 8-oxodeoxyguanosine or uracil-containing duplexes

11 se, the base excision repair enzyme known to incise 8-oxoG in DNA.

12 ity of nuclear and mitochondrial extracts to incise 8-oxoG lesion in cell lines H1650 and H226 expres

13 the motif VI of the putative helicase domain incised 8-hydroxyadenine in vitro less efficiently than

14 a DNA glycosylase/AP lyase that specifically incises 8-oxoG opposite cytosine.

15 ir complex from Escherichia coli, is able to incise a variety of types of DNA damage and the repair e

16 GST-Rad2p incises a 5'-flap and a 5'-pseudo-Y structure one base 3

17 Human XPF-ERCC1 is a DNA endonuclease that incises a damaged DNA strand on the 5' side of a lesion

18 cture-selective endonuclease Mus81-Mms4/Eme1 incises a number of nicked joint molecule substrates in

19 double mutant proteins with both intact and incised abasic DNA were significantly more stable than c

20 y was inhibited by the presence of nearby 5'-incised abasic residues, which result from the apurinic/

21 se, DNA Pol beta recognizes and binds to the incised abasic site and promotes recruitment of the DNA

22 Pol beta has a 7-fold higher affinity to the incised abasic site containing substrate than DNA ligase

23 ouble-stranded oligonucleotide containing an incised abasic site was supershifted by XRCC1 in a gel r

24 ter dissociation of AP endonuclease from the incised abasic site, both DNA polymerase beta (Pol beta)

25 sidue is located near the 5' terminus of the incised abasic site, repair continues as efficiently as

26 strongly to the enzyme incision product, an incised abasic site, which suggested that Ape1 might exh

27 ortive ligation reactions that take place at incised abasic sites in DNA.

28 a by specifically inhibiting synthesis on an incised abasic substrate but not on single-nucleotide ga

29 -specific 5'nucleases precisely identify and incise aberrant DNA structures during replication, repai

30 of endonuclease IV (Endo IV) to efficiently incise alpha-deoxyadenosine was used as a tool to determ

31 Whereas RnhA does not incise an embedded mono-ribonucleotide, it can efficient

32 eotide when paired to an oxidized base or to incise an oxidized ribonucleotide in a DNA duplex.

33 zed dogs, the skin over the thigh muscle was incised and raised, forming a cradle superfused with hep

34 Various amines can incise AP sites via a similar mechanism, but this non-en

35 itiated repair is delayed at the stage of an incised AP site and the rate of further processing of th

36 ans-4-hydroxy-2-pentenal-5-phosphate at a 3' incised AP site by a Mg2+-dependent hydrolytic mechanism

37 factor responsible for the excision of a 5'-incised AP site in the PCNA-dependent pathway.

38 e and the rate of further processing of this incised AP site is dependent on the position of the rema

39 ose polymerase-1 affinity and turnover on an incised AP site, we find that 8-oxoguanine-DNA glycosyla

40 residue located near the 3' terminus of the incised AP site.

41 sphate from an endonuclease IV (endo IV) pre-incised AP site.

42 rans -4-hydroxy-2-pentenal-5-phosphate at 3' incised AP sites and from intact AP sites.

43 e residues from DNA substrates containing 5'-incised AP sites as well as from DNA substrates containi

44 l-5-phosphate from a substrate containing 5'-incised AP sites occurred via a beta-elimination reactio

45 5-phosphate from the substrate containing 3'-incised AP sites was dependent on the presence of the Mg

46 of this protein on DNA substrates containing incised AP sites was examined.

47 as a deoxyribophosphodiesterase acting on 5'-incised AP sites.

48 n length of 26-27 nucleotides are removed by incising approximately 20 phosphodiester bonds 5' and 5

49 e deoxyribose phosphate (dRP) groups from 5'-incised apurinic/apyrimidinic (AP) sites during base exc

50 a 3'-phosphodiesterase on DNA containing 3'-incised apurinic/apyrimidinic (AP) sites to remove the p

51 During BER, Ape1 recruits pol beta to the incised apurinic/apyrimidinic site and stimulates 5'-dRP

52 ma catalyzes release of the dRP residue from incised apurinic/apyrimidinic sites to produce a substra

53 duplex genomic DNA, Ape1 has the ability to incise at AP sites in DNA conformations formed during DN

54 the multifunctional human Ape1 protein is to incise at apurinic/apyrimidinic (AP) sites in DNA via si

55 ility to scan nontarget DNA and processively incise at pyrimidine dimers in UV-irradiated DNA.

56 e (mtODE) from rat liver that recognizes and incises at 8-oxoG and abasic sites in duplex DNA.

57 It is specific for 8-oxoG and preferentially incises at 8-oxoG:C base pairs.

58 For base-substitution mismatches, SP incises at all mismatches except those containing a guan

59 UvrABCI incises at both the 5' and 3' sides of the adduct (UvrAB

60 subtilis lacking RNase HII, the enzyme that incises at single rNMP residues initiating RER.

61 Cerenkov luminescence images from incised BCS specimens were analyzed postoperatively by 2

62 oth UvrABC(Bca) and UvrABC(Tma) specifically incised both BPDE-adducted plasmid DNAs and site-specifi

63 UvrABC incised both strands of the cross-linked DNA, although t

64 strand containing the nick is preferentially incised, but the nick influences the cleavage sites.

65 2-Deoxyribonolactone is not incised by any of the 8 AP lyases tested.

66 ving an abasic site that was subsequently 5'-incised by AP endonuclease 1, introducing a single-stran

67 d even if the AP site has been previously 5'-incised by AP endonuclease, resulting in a 5' 2-deoxyrib

68 ining a synthetic abasic site; this site was incised by apurinic/apyrimidinic endonuclease creating a

69 in which ICLs are recognized and are rapidly incised by ERCC1/XPF independent of DNA replication.

70 ) in an otherwise identical DNA sequence was incised by exonuclease III or endonuclease IV approximat

71 n C or cisplatin-induced DNA lesions are not incised by global genome nucleotide excision repair (GGR

72 Here we show that streams incised by groundwater seepage branch at a characteristi

73 amma-rays, d(G[8-5m]T) can be recognized and incised by purified Escherichia coli UvrABC nuclease.

74 is most efficient when the ribonucleotide is incised by RNase H2, and further excised by the flap end

75 The tandem lesion is also incised by the bacterial nucleotide excision repair syst

76 apyrimidinic (AP) site that is subsequently incised by the lyase activity.

77 Although dL residues are efficiently incised by the main human abasic endonuclease enzyme Ape

78 ) DNA-peptide cross-links can be efficiently incised by the NER proteins and (2) DNA-peptide cross-li

79 in DNA duplexes of known conformations were incised by UvrABC nuclease with efficiencies varying by

80 substrates were also equally and efficiently incised by UvrBC nuclease without UvrA.

81 We report here the discovery of a deeply incised canyon of the Yarlung Tsangpo River, at the east

82 are actually fill terraces, and historically incised channels are not natural archetypes for meanderi

83 mplex stability in the presence of EDTA (non-incising conditions) is significantly weaker for ssDNA t

84 Confinement of the Sutlej to its present incised course after 8 ka likely reduced its propensity

85 ask the deficiency in ability of FA cells to incise cross-linked DNA and could account for the report

86 nts is owing to defects in the processing of incised cross links and the consequential failure to ini

87 entical incision, followed by removal of the incised cylinder of skin, leaving a denervated area in w

88 eneration of the nerve fibers that enter the incised cylinder, leaving a defined zone of denervated d

89 MutY does not incise dA from a duplex containing this nucleotide oppos

90 MutY incises dA when it is opposite Fapy.dG and strongly bind

91 o ultraviolet light but are still capable of incising damaged DNA.

92 orated into the protein complexes capable of incising divergent substrates.

93 alian cell-free extracts incubated with Ape1-incised dL substrates under non-repair conditions give r

94 NER), and knockdowns of ERCC1 and XPG, which incise DNA adjacent to damage, stabilize CAG repeat trac

95 ncoded by the UvrA, UvrB, and UvrC genes can incise DNA containing bulky nucleotide adducts and intra

96 cificities, as evidenced by their ability to incise DNA containing many types of UV and some types of

97 UvrB and UvrC work together to recognize and incise DNA damage during the process of nucleotide excis

98 y of rectification and directs repair to the incised DNA strand.

99 T4 endonuclease V-incised DNA was processed in the same way.

100 -Pdg) is a base excision repair protein that incises DNA at cyclobutane pyrimidine dimers that are fo

101 is study, we report that purified MUS81-EME1 incises DNA at the 5' side of a psoralen ICL residing in

102 alpha is a strand-directed endonuclease that incises DNA in a reaction that depends on a mismatch, yM

103 The UvrABC nuclease incises DPCs with a moderate efficiency.

104 Ape1 surface that contacts the 3' end of the incised duplex (downstream of the incision site).

105 g a more relaxed grip on this section of the incised duplex to facilitate the handoff to the downstre

106 Moreover, mimivirus TopIB is capable of incising duplex DNA at the 5'-CCCTT cleavage site recogn

107 In contrast, the Ntg2 protein does not incise duplexes containing 8-OH-Gua mispaired with any o

108 Recently, Ape1 was found to incise efficiently at AP sites positioned within the sin

109 ivation of MutLalpha endonuclease, which can incise either DNA strand.

110 MutY also does not incise Fapy.dA when the lesion is opposite dG.

111 Endo IV incises Fapy.dG to less than 5% under comparable reactio

112 precursors, especially including abstractly incised fragments of ocher and perforated shells interpr

113 ision provoked by MeG-T is restricted to the incised heteroduplex strand, leading to removal of the M

114 initiate mismatch-dependent unwinding of an incised heteroduplex.

115 y a large number of delicate black, red, and incised hieroglyphs.

116 The inability of Uvr(A)BC to incise highly positively supercoiled uvDNA results from

117 elium after direct application of taurine on incised human gingival samples.

118 cation or transcription, as the GGR does not incise ICL-lesions.

119 However, the incised ICLs are then processed further and DNA double-s

120 iteria for groundwater sapping because it is incised into a basaltic plain with no drainage network u

121 lakes periodically drained through channels incised into bed substrate (canals).

122 ediment-infilled depressions that are deeply incised into bedrock that we interpret as giant plunge p

123 tranded 5' flap and the duplex, whereas FAN1 incised it three to four nucleotides in the double-stran

124 Similarly, endonuclease IV (Nfo) does not incise L or F when they are in tandem with Tg.

125 C2-AP is incised less efficiently by exonuclease III and endonucl

126 nd that offset channels in the Carrizo Plain incised less frequently than they were offset by earthqu

127 UvrABC incised linear substrates containing these intrastrand c

128 ion nuclease system removes bulky lesions by incising mainly at the 22nd-25th phosphodiester bonds 5'

129 Thermally incised meltwater channels that flow each summer across

130 ghly S/W-conformeric G(3) and -G(1) duplexes incised more efficiently than the B-type G(2) duplex (G(

131 s adducts on oligonucleotide substrates were incised more efficiently than trans adducts by both UvrA

132 on rainfall is recorded in the meandering of incising mountain rivers in the western North Pacific.

133 heir inference that the western Grand Canyon incised much earlier than previously thought.

134 e G*[C8-N3]T* lesions in 17-mer duplexes are incised on either side of G*, that none of the recovered

135 to possess an endonucleolytic activity that incises on the 5' side of damage.

136 mplate at a stalled replication fork site by incising on both sides of the ICL and then translesion s

137 een postulated to require endonucleases that incise one strand of the duplex on either side of the IC

138 Remarkably, UvrABC(Bca) incised only at the eighth phosphodiester bond 5' to the

139 of the adduct (UvrABCI cut), while UvrABCII incises only at the 5' side (UvrABCII cut).

140 an ICL dG-MC-dG adduct, we found (i) UvrABC incises only at the strand containing MC-mono-dG adducts

141 y of Ape and the human protein was unable to incise or specifically bind 'bulged' DNA substrates.

142 With the introduction of the tubularized incised plate technique it is possible to simplify decis

143 The tubularized incised plate urethroplasty has challenged more traditio

144 , Hap1, or Apex), with its DNA substrate and incised product using electrophoretic assays and site-sp

145 vers draining the Atlantic passive margin to incise quickly into bedrock beginning about 35,000 years

146 fore the excess, over-replicated regions are incised, resected, and joined.

147 e molecules, the strand opposite the nick is incised, resulting in a more toxic double-strand break.

148 that the "dirty" DNA ends created when Top1 incises ribonucleotides in DNA are responsible for the a

149 der propagation and sinuosity development in incising rivers.

150 ere, we report that while purified XPF-ERCC1 incises simple ICL-containing model replication fork str

151 clustered DNA damage site, both AP-sites are incised simultaneously, giving rise to double-strand bre

152 The purified enzyme incises single-stranded DNA, RNA, and double-stranded DN

153 as well as from DNA substrates containing 3'-incised sites.

154 modified DNA in the same fashion; i.e., they incise six to eight nucleotides 5' to and three to five

155 x isolated from Escherichia coli, is able to incise specifically and quantitatively DNA fragments mod

156 e find that MutH endonuclease, which in vivo incises specifically the newly replicated strand of DNA,

157 We find that AdnAB incises ssDNA by measuring the distance from the free 5'

158 atch BER subpathway, where the 5'-end of the incised strand is blocked, the intermediate after DNA po

159 and colony persistence in a highly degraded incised stream affects the freshwater production of stee

160 The incised stream channel is bounded on the east by a narro

161 to recover ecosystem function of previously incised streams and to increase the production of imperi

162 omologous recombination (GEN1) paradoxically incise structurally distinct bubbles, ends, or Holliday

163 ferentially to a single-nucleotide gap or 5'-incised synthetic AP site on double-stranded DNA.

164 that both full-length UVDE and Delta228-UVDE incise the CPD-containing strand immediately 5' to the l

165 The abilities of the DNA glycosylases to incise the DNA strand adjacent to G*, while this base is

166 Engineered nucleases, which incise the genome at predetermined sites, have a number

167 biosphere; they both recognize AP sites and incise the phosphodiester backbone 5' to the lesion, yet

168 nked by basic ones, such as Lys-Trp-Lys, can incise the phosphodiester backbone of duplex DNA at an A

169 nuclease (VRR nuc) domain, enabling FAN1 to incise the scissile phosphate a few bases distant from t

170 Yet, how FEN1 selects for but does not incise the ss 5'-flap was enigmatic.

171 and its homologs remove 5-methylcytosine and incise the sugar backbone at the abasic site, thus initi

172 x region because FAN1, unlike EXO1 and FEN1, incised the substrate predominantly beyond the ICL and,

173 igonucleotide product, and the AdnB nuclease incises the 3' strand on which the motor translocates.

174 1Delta cells against a fungal ribotoxin that incises the anticodon loop of cellular tRNAs.

175 The endonuclease ERCC1-XPF incises the damaged strand of DNA 5' to a lesion during

176 d to DNA lesions by interaction with XPA and incises the DNA 5' to the lesion.

177 ay, exhibiting AP endonuclease activity that incises the DNA backbone 5' to an abasic site.

178 It incises the double-stranded DNA without obvious specific

179 The enzyme incises the oligonucleotide 5' to the adduct and generat

180 jor human repair enzyme for abasic sites and incises the phosphodiester backbone 5' to the lesion to

181 rocessed by an AP endonuclease activity that incises the phosphodiester bond adjacent to the AP site

182 ndent activation of MutH endonuclease, which incises the unmethylated strand at the d(GATC) sequence,

183 Laparoscopic myotomy was performed by incising the distal 4 to 6 cm of esophageal musculature

184 ME1 in ICL repair is to unhook the damage by incising the leading strand at the 3' side of an ICL les

185 itiating repair of this common DNA lesion by incising the phosphodiester backbone 5' to the damage si

186 in the genome and initiate their removal by incising the ribonucleotide-containing strand of an RNA:

187 otoproducts in the form of 10- to 11-mers by incising the sixth to seventh phosphodiester bond 5' to

188 g activity for acyclic P-DNA, were unable to incise this substrate in EDTA, pointing to an alternativ

189 is variant was also devoid of the ability to incise thymine glycol-containing oligonucleotide, sugges

190 Furthermore, nuclear extracts incised thymine glycol with a much higher efficiency tha

191 eveloped to decrease the energy necessary to incise tissues and to decrease damage to surrounding tis

192 3+/+ mitochondrial extracts more efficiently incised uracil or 8-oxo-G oligonucleotides, although rec

193 from human cadaveric corneal rim tissue was incised using 3 instruments: (1) novel dual-blade device

194 , in the presence of UvrA and UvrB, actively incise UV-irradiated and CC-1065-modified DNA in the sam

195 d DNA enhances the efficiency of UvrABCII in incising UV-irradiated DNA, it does not enhance UvrABCII

196 crococcus luteus UV endonuclease efficiently incises uvDNA regardless of its topological state.

197 is predicted as the canyon was progressively incised, which is at odds with the discharges expected f

198 the large Himalayan rivers in Punjab stopped incising, while downstream, sedimentation slowed on the

199 erminus of a complementary primer strand are incised with an efficiency similar (less than twofold di

200 taining a reduced abasic site, which was pre-incised with APE1, was employed to reconstitute the exci

201 The TG*T-43-mer duplexes are incised with consistently greater efficiency by UvrABC p

202 opened, single-stranded DNA region, were all incised with similar efficiencies and with enhanced rate

203 In 14 and 21 d incised wounds and in chronic granulation tissue from no