ライフサイエンスコーパス: incisor

1 and their progeny during growth of the mouse incisor.

2 n, and decreased cell migration in the mouse incisor.

3 ion, cell proliferation and migration in the incisor.

4 and 4) root width and length of the central incisor.

5 tem cells, signals to several regions of the incisor.

6 ssion defect on the mandibular right central incisor.

7 by the absence of enamel on one side of the incisor.

8 xillary canine, lateral incisor, and central incisor.

9 d, we analyzed enamel formation in the mouse incisor.

10 vertical KT height labial to each mandibular incisor.

11 iferation, and enamel formation in the mouse incisor.

12 ntiating ameloblast cells of the mouse lower incisor.

13 ifferentiation in the anterior region of the incisor.

14 different canal configurations of mandibular incisors.

15 periapical radiographs of maxillary central incisors.

16 ntal sites around permanent first molars and incisors.

17 ed severe dental abnormalities affecting the incisors.

18 were downregulated in Wnt1-Cre; Alk5(fl/fl) incisors.

19 ndibular defects including the lack of lower incisors.

20 the epithelial stem cell population in mouse incisors.

21 manent canines, premolars and to some extent incisors.

22 difference between a portrait's two central incisors.

23 e of enamel formation and degradation of the incisors.

24 res called cervical loops at the base of the incisors.

25 rely reduced or completely missing in mutant incisors.

26 l recession involving both maxillary central incisors.

27 n the facial aspect of her maxillary central incisors.

28 pic enamel formation and deposition in these incisors.

29 r rapidly where they contacted the maxillary incisors.

30 were characterized followed by unloading the incisors.

31 rt-lived anesthesia of the maxillary central incisors.

32 ndibular hypoplasia and malformed mandibular incisors.

33 imb, trunk, tongue, lower incisor, and upper incisors.

34 MSX1second bicuspids and mandibular central incisors.

35 ing of enamel rods was noted in posteruption incisors.

36 gion of far lateral cortex responded to both incisors.

37 ar incisors, and weakened abnormal maxillary incisors.

38 ermanent dentition, particularly the lateral incisors.

39 different canal configurations of mandibular incisors.

40 the ectomesenchymal derivatives of the lower incisors.

41 pped onto the gingiva between the mandibular incisors.

42 ent postnatal growth potential of molars and incisors.

43 o plays a role in continuously growing mouse incisors.

44 ruled out resorption of roots of mandibular incisors.

45 he alveolar bone of molars (buccal side) and incisors.

46 right central incisor - 33.5%, left central incisor - 30%, right lateral incisors - 33.5% and left l

47 second canals was as follows: right central incisor - 33.5%, left central incisor - 30%, right later

48 %, left central incisor - 30%, right lateral incisors - 33.5% and left lateral incisor - 36.5%.

49 ht lateral incisors - 33.5% and left lateral incisor - 36.5%.

50 The majority of mandibular incisors (66.5%) had a single root with a single canal.

51 o bilateral enamel deposition, thus impeding incisor abrasion and resulting in unchecked tooth elonga

52 tissue (KT) height labial to the mandibular incisors after active orthodontic treatment (AOT) with a

53 In the present study, amongst 102 mandibular incisors, all had one root, 36% of them had a second can

54 ower canine, and small, non-procumbent lower incisors; all more primitive states than in Megantereon

55 espite these differences, pulps from erupted incisors also displayed extensive osteo-dentinogenic pot

56 Bsp(-/-) incisors also erupt at a slower rate, which likely leads

57 uma such as fractured molar roots, distorted incisors, alveolar bone loss and compressed temporomandi

58 e lower second premolar and lower canine and incisor alveoli, reveal a number of derived morphologica

59 We also demonstrate that mouse incisor ameloblasts are sensitive to the toxic effects o

60 human data also predicts waves in the mouse incisor and an ordering transition at the chimpanzee cin

61 ts without a history of periodontal disease, incisor and canine (zone 1), premolar (zone 2), and mola

62 migrate along the proximo-distal axis of the incisor and differentiate into enamel-forming ameloblast

63 e-forces were measured during right and left incisor and molar biting.

64 ad4 in neural crest derived cells results in incisor and molar development arrested at the dental lam

65 ars, and change in incisor patterning and in incisor and molar size and shape.

66 the differential osteogenic potency between incisor and molar, which can be further attributed to th

67 murine maxillary right diastema between the incisor and the first molar.

68 entify Hh-responsive stem cells in the mouse incisor and we show that sonic hedgehog (SHH), which is

69 ere predominant on noncontacting surfaces of incisors and canines and nonfunctional cusps of posterio

70 Incisors and canines responded better than premolars and

71 III defects) located at the upper and lower incisors and canines were treated with a laterally posit

72 ts has evolved to enable both gnawing at the incisors and chewing at the molars.

73 results in multiple and branched enamel-free incisors and cuspless molars, and change in incisor patt

74 ng is essential for the development of mouse incisors and for maintenance of the CL during prenatal d

75 Mutant incisors and molars were reduced in size and exhibited h

76 ariable hypodontia, occasional supernumerary incisors and molars, as well as crown and root patternin

77 displayed very thin to absent enamel in both incisors and molars, hereby recapitulating the AI phenot

78 iameter, 2-mm depth) were prepared in bovine incisors and restored using Bond Force (BF), Scotchbond

79 Cavities (4 x 2 mm) were prepared in bovine incisors and restored using Clearfil SE Protect (SP), Bo

80 nce of ameloblast progenitor cells in rodent incisors and that its deletion results in the absence of

81 eo/neo) exhibit hypoplastic or missing lower incisors and third molars, and when combined with the nu

82 e between the left maxillary canine, lateral incisor, and central incisor.

83 ae, forelimb, hindlimb, trunk, tongue, lower incisor, and upper incisors.

84 hich produces rapidly growing long tusk-like incisors, and Lef-1 epithelial overexpression partially

85 ically on the lingual aspect of mutant lower incisors, and the morphology, polarization, and adhesion

86 PCA clustered first molars, incisors, and the other teeth into three groups.

87 s lacking roots, thin and brittle mandibular incisors, and weakened abnormal maxillary incisors.

88 th stem/progenitor populations in the rodent incisor apex, the dental pulp, the alveolar bone, the pe

89 he cervical loops of adult Ank (KI/KI) lower incisors are at the level of the third molars, while the

90 Incisors are completely missing, and molars are enlarged

91 idation to identify the time when developing incisors are most sensitive to fluorosis development.

92 lar second molar and their maxillary central incisors are most susceptible to microdontia.

93 FoxJ1(-/-) mice maxillary and mandibular incisors are reduced in length and width and have reduce

94 rved in Dlx5/Dlx6(-/-) embryos, though lower incisors are still present in both mutant embryos.

95 Using the adult mouse incisor as a model for a continuously renewing organ, we

96 Using the continuously growing mouse incisor as a model of stem cell-based tissue renewal, we

97 n this issue, Ahtiainen et al. use the mouse incisor as a model to advance our understanding of the c

98 Here, we utilized the mouse incisor as a model to study how the MAPK and PI3K pathwa

99 Here we report, using the murine incisor as a model, that alphaE-catenin is essential for

100 ciated with macrodontia of the upper central incisors as well as distinct craniofacial findings, shor

101 roRNAs are expressed in molars compared with incisors as well as epithelium compared with mesenchyme.

102 l expression on the labial side of the lower incisors, as well as enamel hypoplasia-consistent with t

103 The rodent incisor, because of its unusual morphogenesis and remark

104 metalloproteinase-20 null (Mmp20(-/-)) mouse incisors, because enamel thickness is reduced by approxi

105 ing left molar biting in +DD individuals and incisor biting in men (all p < 0.03).

106 Incisor biting symmetry in muscle organization was signi

107 hind and front paws and malocclusion of the incisors, both groups of mice present with dysregulated

108 have normal morphology of erupted molars and incisors but excessive cementum deposition with increase

109 ressed in epithelial cells of the developing incisors but not during molar development.

110 ble at the mucogingival junctions above both incisors but were not an esthetic concern because of the

111 d that after dissociation and reaggregation, incisor, but not molar, mesenchyme exhibits a strong ost

112 cues the development of molars and maxillary incisor, but the rescued teeth exhibit a delayed odontob

113 +/-) mice was nearly normal in the maxillary incisors, but the mandibular incisors were discolored an

114 sessed in 29 interimplant areas in the upper incisor, canine, and premolar regions of 18 patients.

115 p1 gene was originally identified from a rat incisor cDNA library and has been shown to play an impor

116 P activity was correlated significantly with incisor cementum thickness.

117 and beta-catenin are expressed in the labial incisor cervical loop or epithelial stem cell niche, wit

118 h ratio was 87% to 88% for maxillary central incisors, clearly above the accepted "ideal." In additio

119 The lower incisors collected from 7-d-old and 7-wk-old mice were a

120 n, and immunohistochemical staining of mouse incisors confirmed DPPI expression by ameloblasts.

121 We show that pulps from unerupted incisors contain a significant mesenchymal-stem-cell (MS

122 d-trimester fetal compared with one-year-old incisor crowns showed that virtually all maturation stag

123 re predominant on the contacting surfaces of incisors, cusps of canines, and functional cusps of post

124 ave agenesis of molar tooth roots and severe incisor defects.

125 red dental stem cell proliferation, arrested incisor development and abnormal molar development.

126 x9 interact synergistically throughout lower incisor development and affect multiple signaling pathwa

127 The murine incisor develops initially but is absorbed independently

128 In general, healthy deciduous incisors displayed a higher degree of crystal organizati

129 Dental pulps from erupted incisors displayed increased percentages of CD45+ and de

130 Unexpectedly, these mice also show a severe incisor enamel defect, although there is no apparent cha

131 measured the mineral and chloride content in incisor enamel of amelogenin-knockout (AmelX(-/-)) mice

132 cent whole-genome microarray analysis of rat incisor enamel organ cells derived from the secretory an

133 RNA transcripts for Dra and Slc26a6 in mouse incisor enamel organs, and Western blotting confirmed th

134 Interestingly, in 100-day-old rats, erupting incisor enamel was normal, suggesting amelogenesis is on

135 microhardness and fracture toughness of rat incisor enamel, we mechanically tested specimens in whic

136 maturation and hypomineralization of the CF incisor enamel.

137 mbers Lrig1 and Igfbp5 define populations of incisor epithelial and mesenchymal stem cells.

138 l Wnt signaling is upregulated in evaginated incisor epithelium of both Ikkalpha and Irf6 mutant embr

139 tosis that is normally observed in wild-type incisor epithelium was reduced in K5-Ikkbeta mice.

140 incisor tooth cervical loop, outpouching of incisor epithelium, abnormal morphology of the epithelia

141 family, Irf6 also results in evagination of incisor epithelium.

142 In addition, 61% to 71% of maxillary central incisors exceeded allowable crown width-to-length ratios

143 y male Wistar rats had their maxillary right incisor extracted.

144 with a V-shaped thread design, in maxillary incisor extraction sockets.

145 mplanted orthotopically following mandibular incisor extraction, whereas a human molar scaffold was i

146 odontic proclination or expanding mandibular incisors facially.

147 on of Shh and Bmp2 indicates that a smaller "incisor field" forms in Pax9(+/-);Msx1(+/-) mutants, and

148 The upper and lower incisors flanked the tongue representation.

149 ment being highest for the maxillary central incisors, followed by maxillary posterior premolars and

150 -positive cells probably contribute to lower incisor formation.

151 The upper deciduous incisor from Grotta di Fumane contains ancient mitochond

152 The lower deciduous incisor from Riparo Bombrini is modern human, based on i

153 intra-tooth variability of a human deciduous incisor from the Middle Pleistocene layers of the Iserni

154 Etched enamel surfaces of incisors from Amelx knock-out (AmelxKO) mice appeared ra

155 , ectopic expression of Tbx1 was observed in incisors from mice with upregulated Fibroblast Growth Fa

156 Incisors from Mmp20(+/+) mice expressing the Mmp20 Tg ha

157 Periapical radiographs of mandibular incisors from subjects with > or =10 years of follow-up

158 f 200 patients with 800 permanent mandibular incisors, fulfilling necessary inclusion criteria and ag

159 es most heavily weighted on first molars and incisors gave the best model of disease susceptibility,

160 Likewise, incisor Gli1(+) cells, but not NG2(+) cells, exhibit typ

161 ent at muscle-bite force transmission during incisor gnawing than guinea pigs, and that guinea pigs a

162 Mouse incisors grow continuously throughout life.

163 Rodent incisors grow throughout adult life, but are prevented f

164 ttenuation of signaling resulted in impaired incisor growth, characterized by failure of enamel forma

165 isms that regulate dental stem cell fate and incisor growth.

166 All the permanent mandibular incisors had a single root.

167 ed, cells giving rise to the odontoblasts in incisors have not been fully characterized.

168 Anecdotally, molar incisor hypomineralization (MIH) is increasing concurren

169 oot canal morphology of permanent mandibular incisors in an Indian sub-population of Pune, Maharashtr

170 for the first time the presence of vestigial incisors in Bradypus.

171 example, in contrast to humans, who have two incisors in each dental quadrant, rodents only have one

172 The supernumerary incisors in K5-Ikkbeta mice were found to phenocopy extr

173 5-Ikkbeta mice were found to phenocopy extra incisors in mice with mutations of Wnt inhibitor, Wise.

174 Moreover, the independent development of two incisors in mutants with large decreases in sprouty dosa

175 the embryo and the regenerative capacity of incisors in the adult.

176 Proper alignment of the incisors in the anterior-posterior plane and correct mid

177 Mandibular incisor inclination and prominence explained neither the

178 ve small, malformed maxillary and mandibular incisors, indicating that Grem2 has important roles in n

179 tructures, including the contralateral upper incisor, ipsilateral lower incisor, tongue, chin, gums,

180 The mouse incisor is a remarkable tooth that grows throughout the

181 of epithelial stem cells in mouse molars and incisors is controlled by this BMP/SHH signaling network

182 l and lingual sides of unerupted and erupted incisors is supported by a progenitor population and not

183 Furthermore, the developing incisors lack mesenchymal Notch1 expression at the bud s

184 illa, are flanked by a supernumerary pair of incisor-like teeth.

185 hout periodontitis at the lower-left lateral incisor (LLLI).

186 Immunohistochemistry of mouse mandibular incisors localized ITGB6 to the distal membrane of diffe

187 Soft powder diet reduced severe incisor malocclusion incidence to 3% in Bsp(-/-) mice, s

188 wk of age, Bsp(-/-) mice exhibited molar and incisor malocclusion regardless of diet.

189 iet exhibited high incidence (30%) of severe incisor malocclusion, 10% lower body weight, 3% reduced

190 likely contributing to the high incidence of incisor malocclusion.

191 in some individuals by cranial asymmetry and incisor malocclusion.

192 alveolar bone and tooth root resorption, and incisor malocclusion.

193 lack of FGF retention on the cell surface of incisor mesenchyme appears to account for the differenti

194 let1 expression requires distal (presumptive incisor) mesenchyme.

195 Analyses of the Tbx1 null mice reveal incisor microdontia, small cervical loops and BrdU label

196 is issue, we used lineage tracing in a mouse incisor model and identified the neurovascular bundle (N

197 We have identified specific defects in incisor, molar, mandible, bone, and root development and

198 Plaque samples from incisors, molars, and the tongue from 195 children atten

199 he representation of the contralateral lower incisor normally accounts for approximately 15% of somat

200 cult to trace, and the genetic regulation of incisor number remains a largely open question.

201 prouty gene dosage led to a graded change in incisor number, with progressive decreases in sprouty do

202 Different sets of mouse mandibular incisors of C57BL/6 mice were used for dissections and m

203 tions from unerupted parts of the mandibular incisors of Mmp20 null mice were characterized by scanni

204 Although the incisors of nectin-1-null mice were hypomineralized, the

205 All cultured incisors of Tbx1-/- mice were hypoplastic and lacked ena

206 Incisors of Wnt1-Cre; Alk5(fl/fl) mice lost their abilit

207 ally identified areas representing the lower incisor (OM1) and tongue (OM2) regions of S1 and the mix

208 Agenesis of the lateral incisor on the non-cleft side was the most remarkable ob

209 We designed two approaches using incisor organ culture and bromodeoxyuridine (BrdU) pulse

210 Various factors affect the central maxillary incisor papilla height (PH) and central clinically obser

211 incisors and cuspless molars, and change in incisor patterning and in incisor and molar size and sha

212 each dental quadrant, rodents only have one incisor per quadrant.

213 Although the mandibular incisor phenotype has been briefly described, very littl

214 reased extracellular PPi levels and that the incisor phenotype is likely due to hyperostosis of mandi

215 in Ank (+/+) mice replicate the Ank (KI/KI) incisor phenotype.

216 Two implants in the central incisor positions of one patient demonstrated 2 mm of bu

217 DPCs extracted from rat incisors positive for CD44, alkaline phosphatase activit

218 icular fluid (GCF) samples were taken at one incisor, premolar, and molar tooth and stored with serum

219 tosis was associated with subdivision of the incisor primordium and a multiplication of its stem cell

220 migration for both the human molar and mouse incisor, providing a possible signal for the termination

221 Application of FGF3 to incisor reaggregates inhibits beta-catenin signaling act

222 Rodent incisors regenerate throughout the lifetime of the anima

223 dental-like structures were formed from the incisor region following implantation into immunodeficie

224 atients underwent therapy in their maxillary incisor region.

225 These findings reveal novel mechanisms of incisor renewal and illustrate how gene co-expression an

226 Incisor replacement is prolonged until well after molars

227 to the lower lip region of S1, and the upper incisor representation was lateral to the buccal pad reg

228 The lower incisor representation was rostral to the lower lip regi

229 The continuous growth of rodent incisors requires the presence of stem cells capable of

230 blast growth factor 10 (FGF10) into cultured incisors rescued dental epithelial stem cells in Wnt1-Cr

231 miR-224 agomir injection in mouse neonatal incisors resulted in normal enamel length and thickness,

232 Upon release of the signaling blockade, the incisors resumed growth and reformed an enamel layer, de

233 se the ability to grow continuously, whereas incisors retain this ability.

234 tive cells in the apical ends of Ank (KI/KI) incisors revealed decreased osteoclast numbers and osteo

235 entum formation on Bsp (-/-) mouse molar and incisor roots, and the cementum deposited appeared hypom

236 In each of 22 rats, an incisor scaffold was implanted orthotopically following

237 new bone regenerated at the interface of rat incisor scaffold with native alveolar bone.

238 mically shaped human molar scaffolds and rat incisor scaffolds were fabricated by 3D bioprinting from

239 uous row of teeth, mice have only molars and incisors separated by a toothless region called a diaste

240 efine the role of ISL1 in the acquisition of incisor shape, we have analysed regulation of Islet1 exp

241 canal and the roots of the central maxillary incisors should be kept in mind during dental-implant tr

242 Furthermore, Ank (KI/KI) incisors show decreased eruption rates, decreased prolif

243 istochemistry of developing mouse molars and incisors showed positive STIM1 and SLC24A4 signal specif

244 ridization and qPCR in mouse and fetal human incisors showed that NBCe1 mRNA was up-regulated as amel

245 t multiple signaling pathways that influence incisor size and symmetry.

246 lement models comprising a maxillary central incisor socket and 4.5 x 13 mm outer-diameter implants w

247 ling regulates both the establishment of the incisor stem cell niches in the embryo and the regenerat

248 vels of E-cadherin are highly dynamic in the incisor, such that E-cadherin is expressed in the stem c

249 oot canal morphology of permanent mandibular incisor teeth in the Indian subpopulation with the use o

250 mensions around molar, premolar, canine, and incisor teeth in upper and lower jaws.

251 ng tasks which produced moments on molar and incisor teeth were modeled based on MJL or MME.

252 program of tooth development in adult rodent incisor teeth.

253 exhibit defective enamel formation in their incisor teeth.

254 ) mice exhibited a solitary median maxillary incisor that developed from a single dental placode, ear

255 h was performed to treat a maxillary central incisor that presented with a sinus tract.

256 milunar incisions over the maxillary central incisors that blended into a frenectomy.

257 ion in dental pulps of unerupted and erupted incisors that give rise to odontoblasts.

258 rage was achieved over the maxillary central incisors that initially presented with 2 mm of recession

259 For the maxillary right and left lateral incisors, the crestal bone thickness averaged 1.73 and 1

260 terus, skin, and periodontal ligament of the incisors, the latter resulting in dental dysplasia.

261 e bud stage but allowed maxillary molars and incisors to develop to mineralized teeth.

262 ches in the cervical loop (CL) enables mouse incisors to grow continuously throughout life.

263 ntralateral upper incisor, ipsilateral lower incisor, tongue, chin, gums, and buccal pad.

264 Here, we use the mouse incisor tooth as a model to study budding morphogenesis.

265 This caused increased proliferation of the incisor tooth cervical loop, outpouching of incisor epit

266 uired maxillary premolar, canine, or central incisor tooth extraction.

267 tulous region between the sites of molar and incisor tooth formation.

268 In this study we used early mouse molar and incisor tooth germs that possess distinct tooth-forming

269 The continuously growing mouse incisor tooth offers an excellent model to address the o

270 tant mice show protrusions (evaginations) of incisor tooth, whisker and hair follicle epithelium rath

271 with congenitally missing maxillary lateral incisors underwent implant surgery for prosthetic replac

272 The rodent incisor, unlike human teeth, grows throughout the life o

273 techniques that allow the unharmed growth of incisors until their full maturity.

274 Wise suppresses survival of the diastema or incisor vestigial buds by serving as an inhibitor of Lrp

275 from the CEJ for the maxillary right central incisor was 1.41 mm and for the maxillary left central i

276 s 1.41 mm and for the maxillary left central incisor was 1.45 mm.

277 In five mole-rats the lower right incisor was extracted on either postnatal day 7 or 21.

278 tion of keratinized gingiva at upper central incisors was measured by spectroradiometer and converted

279 n normal, the enamel covering the molars and incisors was of normal thickness, had clearly defined ro

280 In vivo, rat maxillary incisors were atraumatically extracted (without any toot

281 r, in double heterozygous mutants, the lower incisors were consistently missing and we find that tran

282 n the maxillary incisors, but the mandibular incisors were discolored and tended to wear rapidly wher

283 One hundred mandibular incisors were evaluated for the number of root, root can

284 Freshly dissected incisors were immersed in pH indicator or glyoxal bis (2

285 nectomy in a case in which maxillary central incisors were impinged upon by a broad aberrant frenum,

286 Only maxillary incisors were included to eliminate any potential volume

287 Upper incisors were tested by nanoindentation.

288 ical cord blood at birth; and shed deciduous incisors when the child was approximately 7 years of age

289 enamel formation of the continuously growing incisors, whereas molars exhibit increased attrition and

290 enesis, Lhx6/7-deficient animals have normal incisors which, in the maxilla, are flanked by a supernu

291 A well-studied model is the mouse incisor, which contains dental epithelial stem cells in

292 The cervical loop area of the incisor, which contains the niche for the epithelial ste

293 The rodent incisor-which grows continuously throughout the life of

294 for root coverage over the maxillary central incisors while simultaneously performing a frenectomy.

295 K5-Ikkbeta mice showed supernumerary incisors whose formation was accompanied by up-regulatio

296 t of the first molar mesially to the central incisor with a single injection while avoiding undesirab

297 .02) of EARR affecting the maxillary central incisor with the microsatellite marker D18S64 (tightly l

298 tem for testing shear bond strength of mouse incisors with AI variants, and analysis of these data ma

299 e observed that Evc2 mutant mice had smaller incisors with enamel hypoplasia.

300 Staining of wild-type and Mmp20(-/-) incisors with pH indicators demonstrated that wild-type

301 ing in the formation of a single fused lower incisor within the hypoplastic fused mandible.