ライフサイエンスコーパス: inclusion body

1 beled cell bodies also commonly displayed an inclusion body.

2 are aggregation-prone and form intracellular inclusion bodies.

3 tration of partially misfolded proteins into inclusion bodies.

4 indispensable for the removal of TDP-43Delta inclusion bodies.

5 and familial encephalopathy with neuroserpin inclusion bodies.

6 olubilized, and are usually sequestered into inclusion bodies.

7 red into detergent-insoluble, Hsp42-positive inclusion bodies.

8 ressed in Escherichia coli and refolded from inclusion bodies.

9 the JEV E ectodomain refolded from bacterial inclusion bodies.

10 ted in a punctate pattern characteristic for inclusion bodies.

11 e: the deposition of the culprit proteins in inclusion bodies.

12 peats) after targeted photo-bleaching of the inclusion bodies.

13 ressed in Escherichia coli and refolded from inclusion bodies.

14 e ebolavirus polymerase L, which is found in inclusion bodies.

15 S) formed polar foci that were distinct from inclusion bodies.

16 d then purified and recovered from bacterial inclusion bodies.

17 modify cell shape but produced intracellular inclusion bodies.

18 rotein than infected cells that did not form inclusion bodies.

19 the presence of ubiquitin positive spheroid inclusion bodies.

20 leads to its aggregation and accumulation in inclusion bodies.

21 disease associated with htt aggregation into inclusion bodies.

22 lation of the expressed protein as insoluble inclusion bodies.

23 ecombinant influenza virus "FHA2" protein in inclusion bodies.

24 ormation of nuclear and cytoplasmic ferritin inclusion bodies.

25 ith recombinant eIF4E that was prepared from inclusion bodies.

26 oluble, folded p38alpha can be produced from inclusion bodies.

27 of ubiquitin (Ub) conjugates within neuronal inclusion bodies.

28 nd has a defect in the formation of Htt103QP inclusion bodies.

29 ylation is sufficient for translocation into inclusion bodies.

30 at are improved byl-DOPA, and development of inclusion bodies.

31 n based of crude hydrolyzed ILV-labeled OmpX inclusion bodies.

32 se LRRK2 into more insoluble and homogeneous inclusion bodies.

33 differential accumulation of electron-dense inclusion bodies.

34 cations and usually need to be refolded from inclusion bodies.

35 by immunohistochemistry or visualization of inclusion bodies.

36 h light and electron microscopy (EM) levels, inclusion body accumulation was seen in satellite cells

37 Sso AcP aggregates in vivo to form bacterial inclusion bodies after expression in E. coli.

38 Polar MurG foci are distinct from inclusion body aggregates, and polar MurG can be remobil

39 lar chaperones Hsp70 and Hsp40 colocalize to inclusion bodies and are neuroprotective in HD animal mo

40 r protein aggregates reminiscent of neuronal inclusion bodies and caused more cancer cell death than

41 he mutant protein accumulates in cytoplasmic inclusion bodies and does not reach the membrane.

42 rSj97 was extracted from Escherichia coli inclusion bodies and purified with sequential anion-exch

43 -alpha7 is involved in the formation of EBOV inclusion bodies and replication.

44 that P6-GFP forms highly motile cytoplasmic inclusion bodies and revealed through fluorescence coloc

45 (i.e., formation of very large intracellular inclusion bodies and slow degeneration over a period of

46 granules are distinct from cytoplasmic viral inclusion bodies and that the RNA binding protein HuR, n

47 In addition to inclusion bodies and the diffuse pool of monomers and ol

48 The cells fill with large inclusion bodies and the membrane becomes irregularly sh

49 frequently revealed eosinophilic inclusions (inclusion bodies) and rimmed vacuoles, but was non-speci

50 h alterations in pigmentation, heterogeneous inclusion bodies, and a lower PSI/PSII ratio than the WT

51 concentrated to the aggresome, a perinuclear inclusion body, and subsequently removed by autophagy.

52 Inclusion bodies are a characteristic feature of ebolavi

53 Ubiquitin-containing inclusion bodies are characteristic features of numerous

54 ntingtin in these mice demonstrated that the inclusion bodies are composed largely of a much smaller

55 ectron microscopic studies indicate that the inclusion bodies are consistent with aggregates of viral

56 ch as stress granules and processing bodies, inclusion bodies are exclusively present in infected cel

57 Live-cell imaging further showed that inclusion bodies are highly dynamic structures and that

58 nert aggregates of nucleocapsids, ebolavirus inclusion bodies are in fact complex and dynamic structu

59 t RNAs using click technology we showed that inclusion bodies are indeed the site of viral RNA synthe

60 Inclusion bodies are insoluble aggregates that are forme

61 of expression, Sso AcP is incorporated into inclusion bodies as a native-like protein, still exhibit

62 uses to understand the mechanisms regulating inclusion body assembly.

63 observed in connection with the cylindrical inclusion bodies at structurally modified PDs in cells c

64 ul, ambient conditions, creating non-amyloid inclusion bodies at the nuclear-vacuolar junction, and i

65 Here we report a rapid method for refolding inclusion-body-based, recombinant cell surface receptors

66 olubilizing and refolding these fusions from inclusion bodies, both EGFP fragments are cleaved from i

67 t viral RNA predominantly localized to viral inclusion bodies but a small percentage also interacted

68 ld be extracted, refolded, and purified from inclusion bodies, but when subjected to analytical gel f

69 st expression levels and for the presence of inclusion bodies containing aggregated protein.

70 Inclusion bodies containing alpha-synuclein are present

71 LGMD1D muscle has rimmed vacuoles and inclusion bodies containing DNAJB6, Z-disc proteins and

72 (htt) protein, resulting in accumulation of inclusion bodies containing fibrillar deposits of mutant

73 o deposition of cytoplasmic and intranuclear inclusion bodies containing htt.

74 Cytoplasmic inclusion bodies containing mutant SOD1 and a number of

75 Cytoplasmic inclusion bodies containing p62 and ubiquinated proteins

76 We show that mammalian JUNQ inclusion bodies containing soluble misfolded proteins a

77 aracterized by the presence of intracellular inclusion bodies containing the mutant FTL polypeptide a

78 blue staining of SGs demonstrated that these inclusion bodies corresponded to sulfatide accumulation.

79 The refolding of these inclusion bodies could provide a route to soluble protei

80 Boid inclusion body disease (BIDB) is a fatal disease of boid

81 Inclusion body disease (IBD) is an infectious disease or

82 s to demonstrate that reptarenaviruses cause inclusion body disease (IBD), a serious transmissible di

83 nnulated tree boas (Corallus annulatus) with inclusion body disease and is implicated in the disease

84 arenavirus infection produces inclusions and inclusion body disease, although inclusions per se are n

85 The newly discovered boid inclusion body disease-associated arenaviruses (BIBDAV)

86 ions affecting PI(3,5)P(2) can contribute to inclusion body disease.

87 in stress granules, also localized to viral inclusion bodies during infection.

88 This construct readily formed inclusion bodies during overexpression, allowing high le

89 Familial encephalopathy with neuroserpin inclusion bodies (FENIB) is an autosomal dominant dement

90 bserved for several specific residues in the inclusion body FHA2.

91 rmation of large cytoplasmic granules, named inclusion bodies, for genome replication and transcripti

92 of ER protein overload in mutants that cause inclusion body formation and alpha1AT deficiency.

93 ty is saturable, the rate-limiting steps for inclusion body formation and death can be traced to diff

94 ApiCCT1(r) also delays the onset of inclusion body formation as visualized via live imaging.

95 sing this virus, we showed that the onset of inclusion body formation corresponds to the onset of vir

96 Of importance, the defect of inclusion body formation in dsk2 mutants can be rescued

97 imilar changes are important contributors to inclusion body formation in several diseases.

98 Thus, an understanding of inclusion body formation is crucial for the discovery of

99 Though inclusion body formation is nuanced, it corresponds to a

100 Inclusion body formation was consistent with an actin-de

101 errant aggregation of misfolded proteins and inclusion body formation, a hallmark of neurodegenerativ

102 data suggest that the HSR does not mitigate inclusion body formation.

103 but that viral transcription occurs prior to inclusion body formation.

104 unds, but also to investigate the biology of inclusion body formation.

105 ivity in LRRK2-induced neuronal toxicity and inclusion body formation.

106 tive diseases and the therapeutic benefit of inclusion body formation.

107 that the UBL domain of Dsk2 is critical for inclusion body formation.

108 s induced for a short time before noticeable inclusion body formation.

109 clearance of misfolded proteins by promoting inclusion body formation.

110 Hsp70.3 significantly increased the size of inclusion bodies formed by mutant htt exon 1, but surpri

111 ateral sclerosis (ALS), are characterized by inclusion bodies formed by polyubiquitinated and hyperph

112 known to be a major component of cytoplasmic inclusion bodies formed during CaMV infection.

113 However, when the inclusion body forms after a long Htt103QP induction, Ds

114 nd biochemical similarities between ferritin inclusion bodies found in transgenic mice and in individ

115 ay influence the formation of aggregates and inclusion bodies generated by mutant SOD1.

116 inuclear compartment consists of cytoplasmic inclusion bodies generated in response to the accumulati

117 athogenesis (11 weeks of age), whereas large inclusion bodies have not been observed in the brains of

118 degeneration (FTLD) with ubiquitin-positive inclusion bodies-have been linked to familial forms of b

119 mine (polyQ) and expanded huntingtin and its inclusion bodies (IB) in both autophagy-proficient and a

120 fection induces the formation of cytoplasmic inclusion bodies (IB), comprised mainly of viral nucleop

121 A5 and MAVS were observed within large viral inclusion bodies (IB).

122 mHtt) proteins, rendering them prone to form inclusion bodies (IB).

123 ntington disease, mutant huntingtin leads to inclusion body (IB) formation and neuronal toxicity.

124 ntingtin (htt) induces self-aggregation into inclusion bodies (IBs) and causes Huntington's disease (

125 Inclusion bodies (IBs) containing aggregated disease-ass

126 infected with HMPV revealed the formation of inclusion bodies (IBs) from early times postinfection.

127 tory syncytial virus (RSV) forms cytoplasmic inclusion bodies (IBs) that are thought to be sites of n

128 roteins within and at the perimeter of viral inclusion bodies (IBs), respectively.

129 s ectopically expressing mutant LRRK2 formed inclusion bodies (IBs), retracted neurites, accumulated

130 s (CaMV) is responsible for the formation of inclusion bodies (IBs), which are the sites for viral ge

131 tected in viral replication factories termed inclusion bodies (IBs).

132 ation of insoluble protein aggregates called inclusion bodies (IBs).

133 ine TDP-43 and with human recombinant TDP-43 inclusion bodies (IBs).

134 Intracytoplasmic inclusion bodies (ICI) have been identified in ciliated

135 The identification of cytoplasmic inclusion bodies in acute Kawasaki disease ciliated bron

136 These antibodies identify intracytoplasmic inclusion bodies in acute KD tissues.

137 Mcoln1(-/-) mice present with numerous dense inclusion bodies in all cell types in brain and particul

138 e concentration threshold at which HTT forms inclusion bodies in cells expressing aggregation-prone,

139 CMV colitis was diagnosed as having positive inclusion bodies in colonic tissue.

140 portance of protein aggregate trafficking to inclusion bodies in degenerative diseases and the therap

141 rostriatal dopamine neurons, the presence of inclusion bodies in dopamine neurons, and motor impairme

142 antly nuclear RNA-binding protein that forms inclusion bodies in frontotemporal lobar degeneration (F

143 presence of nuclear and cytoplasmic ferritin inclusion bodies in glia and neurons throughout the CNS

144 uced precipitation and formation of ferritin inclusion bodies in hereditary ferritinopathy.

145 Electron microscopy showed inclusion bodies in neuronal processes and degenerating

146 Recombinant EnvD was recovered from inclusion bodies in soluble form from an Escherichia col

147 We show that SRPK1 is sequestered into E4 inclusion bodies in terminally differentiated cells with

148 cp-A/1), form intracellular and intranuclear inclusion bodies in the brains of patients with Huntingt

149 ing loss correlated with the accumulation of inclusion bodies in the satellite cells and their subseq

150 These results suggest that inclusion bodies in various forms of ALS result from a s

151 tructures containing microvilli (microvillus inclusion bodies) in epithelial enterocytes, a phenotype

152 lein showed increased aggregation into large inclusions bodies, increased accumulation of high molecu

153 gtin (Htt) is known to accumulate in compact inclusion bodies inside neurons, this is widely thought

154 R analysis suggested that the coalescence of inclusion bodies is a strategy to efficiently replicate

155 The structure of the protein in inclusion bodies is poorly understood but it has been hy

156 e protein tau aggregates and forms insoluble inclusion bodies known as neurofibrillary tangles in the

157 of the RNA was sequestered in characteristic inclusion bodies known as viral replication complexes (V

158 At later times, the Sso AcP molecules in the inclusion bodies lose their native-like properties and c

159 Mammalian IPOD-like inclusion bodies, meanwhile, are not always inherited by

160 oduce similar structures have suggested that inclusion bodies might be involved in genome replication

161 d a shorter life span, formation of ferritin inclusion bodies, misregulation of iron metabolism, accu

162 ular HD mouse models, including intranuclear inclusion bodies, motor impairment, and changes in stria

163 pathological features, including hereditary inclusion body myopathy (hIBM) and limb-girdle muscular

164 nNAc) kinase (GNE/MNK), result in hereditary inclusion body myopathy (HIBM), an adult-onset, progress

165 ns in valosin-containing protein (VCP) cause inclusion body myopathy (IBM) associated with Paget's di

166 ns in valosin-containing protein (VCP) cause inclusion body myopathy (IBM), Paget's disease of the bo

167 Inclusion body myopathy 3 (IBM-3) is an autosomal domina

168 in MEFs harboring a p97 mutation that causes inclusion body myopathy and neurodegeneration, and damag

169 rontotemporal lobar degeneration (FTLD) with inclusion body myopathy and Paget disease of bone is a r

170 Hereditary inclusion body myopathy associated with early-onset Page

171 se a rare, autosomal dominant disease called inclusion body myopathy associated with Paget disease of

172 Here we have tested ten major inclusion body myopathy associated with Paget disease of

173 In the p97-associated human disease inclusion body myopathy associated with Paget disease of

174 d cause a multisystem degenerative disorder, inclusion body myopathy associated with Paget disease of

175 linical multiple-disorder condition known as inclusion body myopathy associated with Paget's disease

176 ety of cellular activities) chaperone, cause inclusion body myopathy associated with Paget's disease

177 Inclusion body myopathy associated with Paget's disease

178 Inclusion body myopathy associated with Paget's disease

179 Inclusion body myopathy associated with Paget's disease

180 n of muscle shows classic characteristics of inclusion body myopathy including rimmed vacuoles and TD

181 n disease: amyotrophic lateral sclerosis and inclusion body myopathy with early-onset Paget disease a

182 sin-containing protein (VCP) mutations cause inclusion body myopathy with Paget disease and frontotem

183 Inclusion body myopathy with Paget disease of the bone a

184 nt for a spectrum of phenotypes that include inclusion body myopathy with Paget's disease of the bone

185 clerosis, frontotemporal lobar degeneration, inclusion body myopathy, and multisystem proteinopathy,

186 ons in p97/VCP cause the multisystem disease inclusion body myopathy, Paget disease of the bone and f

187 cause an autosomal dominant disease known as inclusion body myopathy, Paget disease with frontotempor

188 previously been identified in families with Inclusion Body Myopathy, Paget disease, and Frontotempor

189 also lead to TDP-43 deposition, resulting in Inclusion Body Myopathy, Paget disease, and Frontotempor

190 rmore, we show that a p97 mutant that causes inclusion body myopathy, Paget's disease of bone, and fr

191 VCP mutations are the cause of inclusion body myopathy, Paget's disease of the bone, an

192 e human GNE-opathies sialuria and hereditary inclusion body myopathy.

193 histologically distinct patient populations, inclusion body myositis (IBM) and anti-Jo-1-associated m

194 inst a 43 kDa muscle autoantigen in sporadic inclusion body myositis (IBM) and demonstrated the feasi

195 Historically, the diagnosis of sporadic inclusion body myositis (IBM) has required the demonstra

196 Inclusion body myositis (IBM) is a poorly understood aut

197 PURPOSE OF REVIEW: Inclusion body myositis (IBM) is a poorly understood pro

198 Inclusion body myositis (IBM) is an inflammatory muscle

199 Inclusion body myositis (IBM), a degenerative and inflam

200 To examine new developments in sporadic inclusion body myositis (IBM), including updated clinica

201 Inclusion body myositis (IBM), the most common muscle di

202 reatment and serum and imaging biomarkers of inclusion body myositis (IBM).

203 fications: dermatomyositis, polymyositis and inclusion body myositis (IBM).

204 eneration in myositis, focusing primarily on inclusion body myositis (IBM).

205 genesis, diagnosis and treatment of sporadic inclusion body myositis (IBM).

206 arget of serum antibodies from patients with inclusion body myositis (IBM).

207 Sporadic inclusion body myositis (sIBM) is a poorly understood im

208 Sporadic inclusion body myositis (sIBM) is an inflammatory myopat

209 the muscle fibers of patients with sporadic inclusion body myositis (sIBM) is unknown.

210 Sporadic inclusion body myositis (sIBM) pathogenesis is unknown;

211 TAR DNA binding protein TDP-43, in sporadic inclusion body myositis (sIBM) sarcoplasm are important

212 of the skeletal muscle pathology in sporadic inclusion body myositis (sIBM), have remained elusive.

213 PM), Necrotizing Myositis (NM), and sporadic Inclusion Body Myositis (sIBM).

214 in the pathogenesis of familial and sporadic inclusion body myositis (sIBM).

215 in scattered muscle fibers occur in sporadic inclusion body myositis and clinically similar disorders

216 Dendritic cells present in inclusion body myositis and polymyositis are primarily m

217 ociated through genetic analyses to sporadic inclusion body myositis and sarcoidosis.

218 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE: Inclusion body myositis and T cell large granular lympho

219 itochondrial pathology (IM-VAMP), which have inclusion body myositis as a pathologic subtype and are

220 , we prospectively screened 38 patients with inclusion body myositis for the presence of expanded lar

221 Ultrasound has the ability to differentiate inclusion body myositis from other myopathies.

222 elated with the lower limb components of the inclusion body myositis functional rating score (rho=-0.

223 Most (22/38; 58%) patients with inclusion body myositis had aberrant populations of larg

224 Although the cause of sporadic inclusion body myositis is unknown, GNE myopathy is asso

225 The extent of CD8+ and CD57+ cells in inclusion body myositis muscle correlated with the size

226 nflammatory responses that resemble sporadic inclusion body myositis pathology.

227 ge granular lymphocytes into muscle in 15/15 inclusion body myositis patients but in only 1/28 patien

228 eta-analysis of the apolipoprotein E gene in inclusion body myositis suggests that this gene does not

229 .3]) and MTR reduced compared with controls (inclusion body myositis thigh -1.5 percentage units [pu;

230 ared with controls (regression coefficients: inclusion body myositis thigh 4.0 ms [SE 0.5], calf 3.5

231 ith either Charcot-Marie-Tooth disease 1A or inclusion body myositis who were attending the inherited

232 forms are polymyositis, dermatomyositis, and inclusion body myositis) are systemic autoimmune disease

233 individual cells from patients with sporadic inclusion body myositis, a late-onset inflammatory myopa

234 Muscle biopsies from patients with sporadic inclusion body myositis, a well defined myopathy with ch

235 cot-Marie-Tooth disease 1A, 20 patients with inclusion body myositis, and 29 healthy controls (alloca

236 In polymyositis and inclusion body myositis, muscle fibers are surrounded an

237 In many patients with inclusion body myositis, the autoimmune T cell expansion

238 In inclusion body myositis, the HLA 8.1 ancestral haplotype

239 ciated with aging and is related to sporadic inclusion body myositis, the most common acquired muscle

240 Inclusion body myositis, the most common muscle disorder

241 genotype confers the highest disease risk in inclusion body myositis.

242 r focus on polymyositis, dermatomyositis and inclusion body myositis.

243 mulate intracellularly in some patients with inclusion body myositis.

244 includes polymyositis, dermatomyositis, and inclusion body myositis.

245 omprising dermatomyositis, polymyositis, and inclusion body myositis.

246 ntotemporal lobar degeneration, and sporadic inclusion body myositis.

247 sent key early events in the pathogenesis of inclusion body myositis.

248 s are potential disease activity sensors for inclusion body myositis.

249 vided into dermatomyositis, polymyositis and inclusion body myositis.

250 ive muscle disease of aging humans, sporadic inclusion body myositis.

251 ulates early in Alzheimer's disease (AD) and inclusion body myositis.

252 l (3.3%, 1.8-4.9, p=0.0007) in patients with inclusion body myositis.

253 ly definite by MRC criteria was required for inclusion body myositis.

254 myopathy, polymyositis, dermatomyositis, and inclusion body myositis].

255 Sporadic inclusion-body myositis (IBM) is the most common muscle

256 The hallmark pathologies of sporadic inclusion-body myositis (s-IBM) muscle fibers are autoph

257 Sporadic inclusion-body myositis (sIBM) is the most common disabl

258 y provides insights into the pathogenesis of inclusion-body myositis and concludes that in sIBM one s

259 inclusion-body myositis muscle biopsies with inclusion-body myositis experimental models in tissue cu

260 equences, and correlate findings in sporadic inclusion-body myositis muscle biopsies with inclusion-b

261 ent may only slightly contribute to sporadic inclusion-body myositis muscle-fiber damage.

262 Sporadic inclusion-body myositis, the most common muscle disease

263 Inclusion bodies of aggregated mutant huntingtin (htt) f

264 The aggregation and inclusion bodies of alpha-synuclein with ubiquitin are p

265 as the major protein present in the hallmark inclusion bodies of frontotemporal lobar degeneration wi

266 is a rare recessive myopathy associated with inclusion bodies on muscle biopsy.

267 tia familial encephalopathy with neuroserpin inclusion bodies or FENIB.

268 smic replicating viruses produce cytoplasmic inclusion bodies or protein aggregates; however, a hallm

269 concentrated at aggresomes and other related inclusion bodies prevalent in neurodegenerative disease.

270 ed p38alpha derived from natively folded and inclusion body protein.

271 be applicable to structural analysis of many inclusion body proteins and should provide useful inform

272 n proenzyme in Escherichia coli as insoluble inclusion bodies, refolding and activating via proteolyt

273 ral lobar dementia (FTLD) with ubiquitinated inclusion bodies show TDP-43 pathology, the protein enco

274 This excess ferritin L-chain was found in inclusion bodies, some of which were co-localized with l

275 The IF-MoS2 and INT-WS2 reside in vesicles/inclusion bodies, suggestive of endocytic vesicles.

276 on-prone and form a variety of intracellular inclusion bodies that are characteristic of different ne

277 accumulation of alpha-synuclein constitutes inclusion bodies that are considered a characteristic fe

278 -associated antigen localizes to cytoplasmic inclusion bodies that are consistent with aggregates of

279 omitantly accumulating metabolic products in inclusion bodies that are later mobilized as part of a r

280 coli frequently results in the production of inclusion bodies that are subsequently used to produce f

281 essing N586-82Q accumulate large cytoplasmic inclusion bodies that can be visualized with antibodies

282 s, UCH-L1 is also found in the ubiquitinated inclusion bodies that characterize neurodegenerative dis

283 Such proteins formed inclusion bodies that could be resolved by HSF1 activati

284 Carboxysomes are polyhedral inclusion bodies that play a key role in autotrophic met

285 the VICE domain component Hsc70 into nuclear inclusion bodies that resemble VICE domains.

286 gresomes are transient microtubule-dependent inclusion bodies that sequester misfolded proteins and a

287 The recombinant CD formed inclusion bodies that were solubilized with 6 M urea and

288 tein was expressed in E. coli in the form of inclusion bodies, the protein could misfold during expre

289 that ubiquitylated proteins are directed to inclusion bodies under stress conditions, when both chap

290 d double-stranded RNA synthesis within viral inclusion bodies (VIBs).

291 In order to study filovirus inclusion bodies, we fused mCherry to the ebolavirus pol

292 d secretion so that only small quantities of inclusion bodies were detected.

293 Inclusion bodies were not necessary for the toxicity and

294 Large, heterogeneous inclusion bodies were observed in cells of mutants inact

295 The inclusion bodies were studied either in the context of t

296 despread accumulation of the typical storage inclusion bodies were the major histological findings in

297 with a His(6) tag were found exclusively in inclusion bodies when no additives were used in the buff

298 GSAP is expressed in inclusion bodies, which can be solubilized using harsh d

299 ontaining proteins by refolding from E. coli inclusion bodies, which would not normally be amenable t

300 gle-layer capsid contained within polyhedrin inclusion bodies, yet being fully capable of cell entry