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1 harbour organized sarcomeres but are fusion-incompetent.
2 Their loss renders neutrophils functionally incompetent.
3 s II presentation pathway in this population incompetent.
4 t of their mating (a/alpha), which is mating-incompetent.
5 tive and -negative Rho GTPase are comparably incompetent.
6 oocytes are ovulated, they are fertilization incompetent.
7 framework that is initially cargo transport incompetent.
8 Hence, the neck is limb-incompetent.
9 both arms of the palindrome were replication incompetent.
10 feration, rendering the T cells functionally incompetent.
11 ife-sustaining treatments should they become incompetent.
12 pleted from endosomes, rendering them fusion-incompetent.
13 ies formation, whereas the presence of redox-incompetent 7,8-dihydrobiopterin demonstrates little que
14 Upon transfection of MEFs with replication-incompetent 8OG constructs, we observed a marked increas
16 ples both C-binding competent (inactive) and incompetent (active) conformations within a nearly degen
17 one in lungs of mice, by using a replication-incompetent adeno-associated virus vector, results in tu
19 ortions of HA from a recombinant replication-incompetent adenoviral vector, achieving vaccine product
20 on, three structurally different replication-incompetent adenoviral vectors were engineered that expr
23 hanced expression of AEG-1 via a replication-incompetent adenovirus (Ad.AEG-1) in HeLa cells markedly
24 ression of hPNPase(old-35) via a replication-incompetent adenovirus (Ad.hPNPase(old-35)) in human mel
25 ectopic expression of MDA-5 via replication-incompetent adenovirus (Ad.Mda-5) initiates multiple sig
26 al development, we constructed a replication-incompetent adenovirus (AdlacZalpha4AS) that expresses a
27 ostates or prostatic tumors as a replication-incompetent adenovirus (AdTSTA-sr39tk) and imaged using
29 da-9/syntenin expression using a replication-incompetent adenovirus expressing either sense or antise
30 tigens expressed by recombinant, replication-incompetent adenovirus serotype 26 vectors markedly augm
31 nogens expressed by recombinant, replication-incompetent adenovirus serotype 26 vectors to process an
32 prophylactic efficacy of DNA and replication-incompetent adenovirus serotype 5 (Ad5) vaccine vectors
33 fficacies of several multivalent replication-incompetent adenovirus serotype 5 (Ad5) vaccines were ex
35 the FGF-4 transgene carried by a replication incompetent adenovirus type 5, Ad5FGF-4, was developed o
36 pproaches have demonstrated that replication-incompetent adenovirus vectors are an effective means fo
37 when administered by means of a replication-incompetent adenovirus, Ad.mda-7, several colorectal car
38 L-24, administered by means of a replication-incompetent adenovirus, as a gene therapy for cancer has
39 oreskin fibroblasts, infected by replication-incompetent adenoviruses carrying EGFP gene, as the test
44 ter attack on the thioester (Glu(161)) by an incompetent analog (Gln(161)) gave a UGDH variant (E161Q
45 ures indicate that mutant desmin is assembly-incompetent and able to disrupt a pre-existing filamento
46 14 in human CD4-TLR4 rendered them signaling-incompetent and blocked TLR4 tyrosine phosphorylation.
47 rho(0)] cells) are oxidative phosphorylation incompetent and displayed loss of the Mcl-1 protein unde
50 ells to PK1 cells, they gradually became R33 incompetent and swa sensitive, unless the transfer was i
51 virus strains in reservoirs are replication incompetent, and (iii) rebounding virus after CD8(+) cel
52 could promote immune tolerance by acting as incompetent antigen-presenting cells (APC), as well as a
53 NMDAR GluN2B subunit that is CaMKII binding-incompetent, any tatCN21 effects that are specific to th
54 g either catalytically inactive or packaging-incompetent APO3G variants suggest that wild-type APO3G
59 xpressing CaMKII phosphorylation- or binding-incompetent beta(2a) subunits were incapable of entering
60 toward conformers that are substrate-binding incompetent (BI), while TMAO shifts the ensemble toward
64 aracterized by ischemia, neovascularization, incompetent blood-retinal barrier, and vascular occlusio
66 he R753Q polymorphism renders TLR2 signaling-incompetent by impairing its tyrosine phosphorylation, d
67 d with cells rendered G(i)-protein signaling incompetent by pertussis toxin treatment, supporting an
68 her retention of SP might render CA assembly incompetent by testing the ability of Rous sarcoma virus
70 tive astrocytes have been proposed to become incompetent bystanders in epilepsy as a result of cellul
71 served between binding-competent and binding-incompetent can be explained by changes in solvation and
72 r define a novel population of proliferation-incompetent CD4+ T cells that are generated in the prese
74 ion kinetics are greater in interferon (IFN)-incompetent cells and that the virus is unable to suppre
76 rofiles of clearance-competent and clearance-incompetent cells revealed that mesenchymal genes are en
77 arvations (in both respiratory competent and incompetent cells) to show that successful starvation re
79 istant mutations thus may arise from binding-incompetent changes in the conformational equilibrium.
80 tudy of a new malaria vaccine, a replication-incompetent chimpanzee adenovirus 63 (ChAd63) encoding t
81 synergistically to switch these regeneration-incompetent CNS neurons into a regeneration-competent ph
82 tment to report all instances of impaired or incompetent colleagues in their medical practice to a re
83 ed that physicians should report impaired or incompetent colleagues to relevant authorities, 45% of r
91 nding locks TmCorA in a symmetric, transport-incompetent conformation and loss of intracellular Mg(2+
95 y "conformationally trapping" CA in assembly-incompetent conformational states induced by H-site bind
98 beta subunit of IL-27 (Ebi)(-/-) (ie, IL-27-incompetent) DC-RAs were ineffective in inducing food al
99 IAP3 knockdown caused accumulation of fusion-incompetent DCVs in BON neuroendocrine cells and lysosom
100 e co-expressed different types of signalling-incompetent DDR1 mutants ('receiver') with functional DD
101 1,3-glucan phagosomes expressing a signaling incompetent Dectin-1 failed to mature as demonstrated by
102 ing COS1 cells engrafted into a regeneration-incompetent digit amputation wound resulted in a locally
105 nes rendered both Fas incompetent and ICAM-1 incompetent displayed significantly higher numbers of tu
108 velope glycoprotein allow relatively viremia-incompetent, enzootic subtype ID strains to adapt for eq
111 We also demonstrate that a catalytically incompetent EST2 protein can suppress such overhang accu
112 +CD4+ T cells were found to be proliferation incompetent, even after strong mitogen stimulation.
113 ic evidence that de novo synthesized RNA4 is incompetent for autonomous assembly whereas prior packag
114 its (Rpt1-4) with ATP binding mutations were incompetent for cellular assembly into 26 S proteasome.
115 thyroglobulin devoid of the ChEL domain was incompetent for cellular export; however, a recombinant
116 reorganization renders IA afferent synapses incompetent for efficient motoneuron synaptic depolariza
118 lexes (C1-Zr2, Zr2, and Zr1) are found to be incompetent for ethylene-styrene copolymerization, yield
119 st that activated mutated B-Raf proteins are incompetent for folding in the absence of Hsp90, thus su
120 embrane domain (A14L and W22A), rendering it incompetent for interaction with human BST-2, was able t
123 inactive conformation that is catalytically incompetent for phosphotransfer from small molecule phos
124 ile the ccm knockout mutants were completely incompetent for photosynthesis, the Cu-unresponsive muta
127 h may decay into a more stable catalytically incompetent form (O) in the absence of electron donors.
128 lly slow equilibrium between a catalytically incompetent form of enzyme and an active species that ca
129 TcpB also does not affect a mutant, signal-incompetent form of MAL that cannot be phosphorylated.
134 41L, F359L, F368L) and generated RNA-binding-incompetent FUS mutants with and without ALS-causing mut
136 The ABP-PEG-HCBP1-conjugated replication incompetent GFP-expressing ad, (Ad/GFP)-ABP-PEG-HCBP1, s
141 CE1-containing intermediates, while assembly-incompetent HIV-1 GagZip proteins harboring mutations in
142 pe of the hrpJ mutant expressing a secretion incompetent HrpJ derivative and were reduced in their im
143 ementation of the hrpJ mutant with secretion incompetent HrpJ derivatives restores the secretion of H
145 ith coaching]?" P009), worry about appearing incompetent ("I think it would be perceived as either a
146 not express the Vif protein are replication incompetent in 'nonpermissive' cells, such as primary T
150 ted recombinant MVA, ADS-MVA, is replication incompetent in mammalian cells and highly immunogenic in
152 raditional search-based optimization methods incompetent in terms of both searching efficiency and re
156 subunit cytochrome b, which are respiratory incompetent, increase ROS levels and stabilize the HIF-1
157 d reverse genetics to generate a replication-incompetent influenza virus carrying the sequence for th
158 is strategy, which is based on a replication-incompetent influenza virus possessing the antigenic reg
159 t of bivalent vaccines, based on replication-incompetent influenza virus, against pathogens that caus
160 ly, we demonstrated that several replication-incompetent influenza viruses efficiently elicit IgG in
162 strate-binding pocket encode a catalytically incompetent kinase, thereby preventing emergence of resi
163 potential for select retrotranspositionally-incompetent L1 loci to generate genomic instability.
164 gest that a subset of retrotranspositionally-incompetent L1s, previously considered to be harmless to
165 is required for sumoylation, and sumoylation-incompetent La(K41R) shows only anterograde transport, w
166 l-length H chains and Dmu, whereas secretion-incompetent lambda1 L chains could only do so with full-
170 vac2, as shown by coinfections of interferon-incompetent lymphatic cells with viruses expressing diff
172 n of wild-type mBMSCs but not of mutant, GJC-incompetent mBMSCs or mBMSCs with dysfunctional mitochon
173 these mutations render the virus replication-incompetent, MCV is not a "passenger virus" that seconda
174 Generation of the E1 homotrimer on fusion-incompetent membranes identified an intermediate conform
176 geometry holds the enzyme as a catalytically incompetent metal complex and may represent a previously
177 highly susceptible 129/SvEv mice and immune incompetent mice (IFN-gamma-/-, SCID) were resistant to
178 able tolerant chimeras onto syngeneic immune-incompetent mice, graft-infiltrating T cells migrated fr
179 s grafted under the kidney capsule of immune-incompetent mice, which allowed the development of human
182 owed generation of suppressor-competent and -incompetent molecules and uncoupling of the VSR and part
183 inducers, tau protein behaved as an assembly-incompetent monomer with little tertiary structure.
184 n mutations are located in the enzymatically incompetent monomer, suggesting a "dominant" or regulato
185 of mouse bone marrow cells with replication-incompetent murine stem cell virus (MSCV) expressing onl
188 n macrophages expressing Lps(d), a signaling-incompetent mutant form of TLR4, suggesting that the enh
192 Fas ligand, and BAD protein) or replication-incompetent mutants (e.g., the d120 mutant lacking both
196 tion velocity of mice expressing KSP phospho-incompetent NF-M were also indistinguishable from wild-t
197 ed region of the tailpiece binds to assembly-incompetent NMII-C fragments, inducing filament assembly
198 ysteine residues also formed a catalytically incompetent octanoyl adduct, indicating the presence of
199 In conclusion, we found that mitotically incompetent ocular tissue cells contain adult NCDPs that
200 plexes, there are always PSII subpopulations incompetent of oxygen evolution, but are in the process
201 e formation of other off-pathway and amyloid-incompetent oligomers that are isomeric with amyloid-com
202 d PKA constructs we show that in meiotically incompetent oocytes PKA is distributed throughout the cy
204 oes not render the viral episome replication incompetent: our model predicts that concurrent delivery
206 We show that expression of transactivation-incompetent p53 inhibits DNA synthesis in ALT cell lines
208 ad as the result of either a developmentally incompetent paternal pronucleus or asynchrony between th
209 ct, providing no demonstrable benefit to the incompetent patient and complicating the psychological p
210 not clearly reflect the prior values of the incompetent patient and is likely to intensify rather th
211 withholding life-prolonging treatment for an incompetent patient who had left no advance directive or
212 ng treatment is withdrawn or withheld for an incompetent patient who has indicated no prior wishes re
214 ENGWEGMIDG, and its two point-mutant, fusion-incompetent peptides G1E and G13L, in mixtures with hydr
215 and less than 20% of these cells show import-incompetent, peroxisome-like structures (peroxisome remn
216 p alteration that underlies the inflamed and incompetent polarization of neutrophils leading to sever
218 esistant/R33-competent and swa-sensitive/R33-incompetent prions had different conformational stabilit
219 converts ERBB3 into a passive and signaling incompetent probe of its immediate receptor environment.
220 thin this domain also produced translocation incompetent proteins and the conversion of MF to a trans
221 ze of the reservoir by detecting replication-incompetent proviruses; however, viral outgrowth assays
222 default cyclization/release route for redox-incompetent R* domains embedded in NRPS assembly lines.
225 gh normal respiration to deliver replication-incompetent recombinant adenoviral vectors expressing ge
226 Despite the widespread use of replication-incompetent recombinant adenovirus (Ad) vectors as candi
228 Delivery of F and G proteins via replication incompetent recombinant vesicular stomatitis viruses (VS
229 hat intramuscular injection of a replication-incompetent, recombinant adeno-associated virus (rAAV) d
230 plore the protective efficacy of replication-incompetent, recombinant adenovirus serotype 35 (rAd35)
232 ell-autonomous manner, we used a replication-incompetent retrovirus encoding Cre recombinase to inact
233 within this zone, we injected a replication-incompetent retrovirus, encoding the enhanced green fluo
234 We report that pseudotyped, replication-incompetent retroviruses can be used in axolotls to perm
235 tions in the early chick retina, replication-incompetent retroviruses were utilized to over-express a
237 In contrast, mice expressing phosphorylation-incompetent RyR2 displayed depressed AM sarcomere shorte
238 s obtained from db/db mice were functionally incompetent secondary to the increased proportion of apo
240 es, pro- and anti-angiogenic genes, and RNAi-incompetent siRNAs all suppressed CNV in mice comparably
242 Salmonella strain expressing a catalytically incompetent SopAC753S mutant had reduced Salmonella-indu
243 ules, leaving the complexes in an elongation-incompetent state and effectively suppressing HIV-1 repl
244 propose that E-cadherin, when in an adhesion-incompetent state at the lateral domain, serves as targe
245 preferentially interacts with the C-binding incompetent state of the adjacent cAMP-binding domain (C
252 conversion between reassembly-competent and -incompetent states corresponds to a cis/trans isomerizat
253 he free RNA, including binding competent and incompetent states that have distinct fluorescence decay
254 establish the X state by permitting lysis of incompetent streptococci, uptake of DNA fragments, and i
255 es of NCR-CD3zeta assemblies: 1) a signaling incompetent structural NKp30-CD3zeta complex and 2) a li
259 S1) could only replicate in interferon (IFN)-incompetent systems, suggesting that the NS1 protein is
260 stration of soluble tubulin into an assembly-incompetent T2S complex (two alpha:beta tubulin dimers p
261 r effects, but its poor water solubility and incompetent targeting property largely limit its clinica
262 n rescues the polymerization of the assembly incompetent tethramethyl rhodamine (TMR)-actin and T203C
263 ished that TMR-actin alone is polymerization incompetent, the impact of its copolymerization with unl
266 scription factors renders Arabidopsis plants incompetent to floral inductive signals, including long-
268 es the intermediate cell mass, callus, to be incompetent to form shoot progenitors, whereas induction
269 phalic cells lacking Foxg1 are intrinsically incompetent to generate the ventral telencephalon has re
270 raditionally, the law has viewed children as incompetent to make medical decisions, and society has a
271 ferent activities, whereas CAP-Gly-1 appears incompetent to mediate either +TIP behavior or MT nuclea
272 l knowledge of a physician colleague who was incompetent to practice medicine in their hospital, grou
273 ing physicians who are impaired or otherwise incompetent to practice, but data suggest that the rate
275 eat and rendering the porphyrins kinetically incompetent to readily perform useful photochemistry.
277 cells at 11.5-19.5 days postcoitum (dpc) are incompetent to support full-term development of cloned m
279 port surveillance factor that retains export-incompetent transcripts near their transcription site.
280 analyses of these replication-competent and -incompetent truncation mutants suggest potential roles f
282 ocE cDNA was incorporated into a replication-incompetent type-5 adenoviral vector with a cytomegalovi
284 ariants of SOD1 is shown to be catalytically incompetent: unable to bind superoxide in a way comparab
285 of wild-type US2 with those of a dislocation-incompetent US2 mutant, and identify signal peptide pept
287 and evaluation of attenuated and replication-incompetent vaccinia strains being tested for variola an
290 complexes, we generated native and signaling-incompetent versions of each receptor by site-directed m
291 We also identified a clearly replication-incompetent viral sequence in multiple memory T cells in
292 tein ICP10PK is delivered by the replication incompetent virus mutant DeltaRR and prevents kainic aci
293 us 1 blocks apoptosis induced by replication-incompetent virus mutants, proapoptotic members of the B
294 nflammation were tested by using replication-incompetent viruses carrying a deletion of the pretermin
297 gellar export apparatuses that are secretion incompetent, we determined that formation of the apparat
299 pregulated mating-associated genes in mating-incompetent white cells without causing G1 arrest or shm
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