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1 vapor pressures of leaf and atmosphere [VPD] increases).
2 ission became spontaneous as steric pressure increased.
3 neutrophilia (HR, 1.06 per 109 neutrophils/L increase; 95% CI, 1.03-1.10).
4 phil counts (hazard ratio [HR], 1.10 per 10% increase; 95% confidence interval [CI], 1.04-1.16), low
5 l activation at baseline was associated with increased Abeta accumulation.
6  individuals with substance addiction showed increased activation in the ventral striatum, whereas in
7  given injections of deoxycholic acid and an increase after they were fed fenofibrate.
8 e anti-inflammatory Th2 subset (CCR3(+)) was increased after DMF treatment.
9  the levels of IL-2 in the serum of AOM rats increased after KJT treatment.
10 01), decreasing scan quality (P < .001), and increasing age (P < .03).
11 ciation between nonfermented milk intake and increased all-cause mortality was recently reported, but
12                             In addition, the increased analytic sensitivity of HTS permitted identifi
13 induction of alphaS inclusion pathology that increased and spread over time.
14 te that this structure is associated with an increased antibiotic activity against bacterial strains
15                 The mutant animals displayed increased anxiety-like behavior in the elevated plus maz
16                                              Increased aortic pressure wave pulsatility and greater d
17 t demonstrates that the extent of fission is increased as the reaction progresses, producing more com
18                              The trend of an increasing association between obesity and disability ha
19  uptake of (99m)Tc-S-HYNIC-28H1 was slightly increased at 9 d after therapy but was not seen macrosco
20 ve contribution of IKur to AP repolarization increases at higher frequencies because of reduced activ
21                Metabolomics analysis reveals increased ATP production and improved energy metabolism
22 n of KCC2 activity in clonal MIN6 beta-cells increases basal and glucose-stimulated insulin secretion
23 hreat memory impairment is also reflected in increased behavioural surprise signals to the conditione
24 esults Although the number of samples tested increased between 2012 and 2014 (2,201 v 2,558 patient c
25                     Thus, ZVI may be used to increase biocathode CH4 production, assist in the start-
26 inhibition of respiratory processes elicited increased biofilm formation.
27 -eight women from 25 to 76 years of age with increased breast cancer risk who underwent CE spectral m
28           During this period, tree mortality increased by an order of magnitude, typically from tens
29 X) started to appear at T 40 K and its value increased by decreasing the temperature.
30 nsion fluctuations in the VEC monolayer were increased by proinflammatory thrombin treatment.
31 r families, representing three- and fourfold increases (+ c. 4 mug excess (13) C) compared with nonsi
32 tures of immune evasion, increased stemness, increased calcium signaling, transformation, and novel E
33 tential factors that alone or in combination increase cancer-associated thrombosis.
34 ngutans more likely to move in directions of increased canopy closure, tall trees, and uniform height
35    In Arabidopsis (Arabidopsis thaliana), OR increases carotenoid levels by posttranscriptionally reg
36                       Exposure to durvalumab increased cediranib area under the curve and maximum pla
37 or clinical outcomes have been attributed to increased cell cycle progression and the development of
38 hRNA expressing KRAS (mt) tumor cells caused increased cell viability by decreasing SMAD2 phosphoryla
39 ay apical membrane chloride permeability and increases ciliary beating.
40 hil recruitment as an essential mechanism to increase colon carcinogenesis.
41 is also induced PC3 cancer cell motility and increased colony size in 2D cultures.
42 tment with the TR antagonists NH-3 and 1-850 increased cone density by 30-40% in the Rpe65(-/-) mouse
43 to minimal wounds in a collective fashion by increased contractility with substantial reach.
44  therapy without trying triple therapy first increases costs while providing minimal incremental bene
45 odd-electron reactivity was circumvented via increased covalency.
46 ons in the eastern floodplain coincided with increased crystallinity of goethite, relative to the oxi
47                                  1,25(OH)2D3 increased CYP27B1 mRNA levels in HCEC, but had no effect
48 tmospheric carbon dioxide concentrations-are increasing demand for N, the element limiting primary pr
49 ed) liver tumorigenesis that correlated with increased DEN-induced hepatocyte apoptosis.
50                        Tomo-1 overexpression increased dendritic spine density, whereas Tomo-1 knockd
51 put following a stressor was associated with increased depression severity and reduced amygdala react
52 tolerance, and these genes are sufficient to increase desiccation tolerance when expressed in heterol
53 ted by operator, a multivariate model showed increased differences with decreasing RNFL thickness (P
54 skin identified a larger number of psoriasis-increased differentially expressed genes (DEGs), but ana
55 rough both hypertrophy of existing cells and increased differentiation of adipocyte precursors (hyper
56                                              Increased difficulty of females finding mates as male de
57 ost memory lymphocyte subsets more gradually increased during the first 4 years of life.
58 patients shocked within 2 minutes of arrival increased during the SAED protocol for initial shockable
59 lunch.Compared with 3 meals/d, meal skipping increased energy expenditure.
60  (OCN) is an osteoblast-derived hormone that increases energy expenditure, insulin sensitivity, insul
61                                              Increasing evidence suggests a crucial role of inflammat
62                                              Increased excitability of layer II/III pyramidal neurons
63 ollection of exposed bees improved less with increasing experience than that of unexposed bees, with
64  rounds, the dimension of the strategy space increases exponentially.
65                                Intriguingly, increased expression of Arf in tumor stromal cells, as i
66 3H in tumorigenesis have been interested and increased expression of FAM83H and MYC in hepatocellular
67 ased phosphorylation of STAT3 on Ser727, and increased expression of PML, a STAT3 transcriptional tar
68                      Here we determined that increased expression of XRN2 induced EMT and promoted me
69                  Constitutive Akt signalling increases expression of EC morphogenesis genes, includin
70                                     In turn, increased ferritin protein levels promote the expression
71 rodents, we discovered that a new experience increased firing of active dentate granule neurons rapid
72        Stimulus-related neural responses are increased for the attended stimulus.
73 f this dynamical and photochemical system to increased forcing of the climate by increasing levels of
74                           The speed of sound increased from 1514 to 1532 m/s over the first 24 h, aft
75                             Alimentary cases increased from 21% to 26%.
76 thma in this study's primary care population increased from 48% to 54%.
77 al connectivity in frontal brain regions and increased functional connectivity in posterior brain reg
78 t levels of CRC; however, the addition of CM increases gingival thickness.
79 imize the negative impact of heat stress and increase global food productivity, benefiting from [CO2]
80 own of amino acids in the liver, mediated by increased glucagon, without preventing muscle wasting.
81 in the United States and are associated with increased health care costs.
82 nts like cocaine and methamphetamine greatly increase HS content and sulfation levels in the lateral
83 e system and seal the defect site because of increased hydraulic drag through damage site during filt
84 ing chronic urticaria which is associated by increased IL-31 serum levels.
85            Expression of XBP1 by hepatocytes increased immediately after PH (priming phase of liver r
86 uperhydrophobic tube shows up to 5,000 times increase in acceleration of a sliding droplet compared t
87  attenuates cutaneous vasodilatation and the increase in cardiac output during passive heating.
88           Retrotransposons (RTs) can rapidly increase in copy number due to periodic bursts of transp
89                                          The increase in disability near the time of the event was gr
90 polysaccharide complex resulted in a greater increase in hemoglobin concentration at 12 weeks.
91 ubs in January was identified by a transient increase in HR and activity.
92 riched basal/myoepithelial population and an increase in in vitro stem cell activity.
93 n LERKO mice than in Controls, suggesting an increase in lipid oxidation.
94        Taurocholate induced a time-dependent increase in LPC proliferation and expression of genes as
95                Promoter analysis revealed an increase in luciferase activity under HG, which was redu
96 dependent PGC-SCZ2 subsamples, and showed an increase in magnitude for traits assessed during later a
97 creasing TTA was associated with longer LOS (increase in mean LOS for each additional hour of TTA, 0.
98  8.5% (95% CI, 1.5%-15.0%) for a 1 degrees C increase in monthly MIT at <15, 15-64, and >/=65 years o
99    The association of a greater longitudinal increase in NMS with lower baseline Abeta1-42 level is a
100                            Although a slight increase in number was observed in ASD patients and fami
101                For all taxonomic groups, the increase in numbers of alien species does not show any s
102 presurgery, the mixed meal induced a greater increase in plasma glucose, insulin, and GIP concentrati
103 a 30-fold longer reaction time and a 40-fold increase in pressure compared to standard PTR-TOF-MS.
104          Patients in the BL group had a mean increase in quality of life score compared with the plac
105   Gonococcal infection induced a significant increase in secreted MMP-9 and an accumulation of cytopl
106 iple seipin mutants, but there is a striking increase in seed dormancy levels.
107 e confirmed, the radiocarbon data suggest an increase in the efficiency of the biological carbon pump
108  in ET injection compared to IV and a slight increase in the mean number of detected cells in irradia
109 ears of age, respectively, while the average increase in the monthly influenza cases was 14.6% (95% C
110 c arrhythmia and is associated with a 5-fold increase in the risk for stroke.
111  claim that supplementation leads to a large increase in the risk of advanced AMD in some genotype su
112 anied by suppression of MYC signaling and an increase in the T cell chemoattractant CCL5.
113 Despite these limitations, there has been an increase in the understanding of pathophysiology and imp
114 ral unit in the pyranoanthocyanins led to an increase in their interaction with aPRPs.
115 ), and 9.2% (95% CI, 1.4%-16.9%) for a 1-hPa increase in vapor pressure.
116                                      Each 1% increase in volume was associated with 73% increased odd
117 ography (CT) for evaluation of kidney stones increased in 2015-2016 compared with that in 2011-2012,
118 nexin V+ (C4d+/AVB+) microvesicles were also increased in AMR patients compared with no AMR and healt
119  confirmed that Hh-mediated transcription is increased in B-lineage cells from Gli3-deficient FL and
120                                  Differences increased in eyes with a thinner RNFL thickness, older a
121  T-helper (Th) 17 cell pathway molecules are increased in inflamed intestinal tissues of patients wit
122 ting, as well as 2'-O-ribose-methylation, is increased in murine muscle tissue during postischemic ne
123 levels of OEA and PEA (P < 0.001-0.001) were increased in response to inflammatory mediators.
124 y anatomic imaging may show that a tumor has increased in size, but this could represent pseudoprogre
125 er controlling for environmental covariates, increases in biomass with biodiversity are stronger in n
126  changes in optical aerosol characteristics, increases in dried aerosol mass were rarely observed (<1
127      The stimulation protocol often produced increases in global network excitability or depression o
128        We evaluated the potential for abrupt increases in inorganic N sources to induce cascading eff
129 rnal state, whereas MIA produced significant increases in proinflammatory cytokines and chemokines.
130 se coupled to a 2-butanone up-regulation and increases in Ruminococcus and Dorea were identified as g
131                                The projected increases in sea levels are expected to affect coastal e
132                                Corresponding increases in survival, quality-adjusted life years (QALY
133 y sign of saturation and most taxa even show increases in the rate of first records over time.
134 oth obesity and atrial fibrillation (AF) are increasing in epidemic proportions, and both increase th
135 crobials in subtherapeutic concentrations is increasing in response to the rising demand for food ani
136                       DOX treatment not only increases interleukin (IL)-33 released from breast tumor
137 of patients with IBD in mucosal healing have increased intestinal permeability.
138 owel syndrome (SBS) with intestinal failure, increasing intestinal wet weight absorption and reducing
139                       Children with STRA had increased intraepithelial neutrophils, which positively
140 ary rate of the outbreak strain and may have increased its adaptability, as many mutations in protein
141                                              Increased level of proinflammatory cytokine interleukin
142                                              Increased levels of leukocytes, platelets, and tissue fa
143 proximation protocols which allow to achieve increasing levels of accuracy, it is relatively simple t
144 ystem to increased forcing of the climate by increasing levels of CO2 and CH4.
145 rated, total n-3 and n-6 fatty acid contents increased linearly (p<0.05) by raising the substitution
146 acking GIRK channels in DA neurons exhibited increased locomotor activation in response to acute coca
147 sought to assess (1) factors associated with increased longer-term cardiovascular mortality and (2) i
148 ntrols, patients with recent STEMI exhibited increased LV wall active tension when normalized by SBP.
149    In addition, Gatm(c/c) colonocytes showed increased metabolic stress in response to DSS with highe
150 ristae density as a regulatory mechanism for increasing metabolic power in human skeletal muscle.
151 aphorin/Plexin repellents to combinatorially increase Mical-mediated F-actin disassembly, cellular re
152 coupled with an increased pool of free NADH, increased mitochondrial biogenesis, triggering of the mi
153 contribute to asthma severity by transiently increasing MMP activation, airway smooth muscle growth,
154 dity score was independently associated with increased mortality (P = 0.003; odds ratio, 1.254; 95% c
155    Diabetes mellitus (DM) is associated with increased mortality after transplantation, but the effec
156     Influenza viral infections often lead to increased mortality in older people.
157  contractions that have been associated with increased motor neuron excitability and decreased inhibi
158 in-1, IL-6, IL-1beta, and is associated with increased MyoD expression, suggesting that Hmox1(-/-) SC
159 initiate a signaling pathway that ultimately increases nuclear CREB phosphorylation and, in most case
160 ated mutant variants of RabA2 resulted in an increased number of abortive infection events, including
161                                  However, an increasing number of reports suggest the ubiquity of ple
162 a dynamic view of RNA structure changes with increased numbers of 2-5-linkages in the same duplex.
163 isole) react at the air-water interface with increasing O3(g) during tauc approximately 1 mus contact
164 ing of amphibian malformations, suggest that increased observations of abnormal amphibians are associ
165                       A threefold to 32-fold increase occurred within 15 minutes after initiation of
166 % increase in volume was associated with 73% increased odds of improving SMR over time [odds ratio (O
167 azard ratio, 2.18; 95% CI, 1.90-2.51) but no increased odds of mortality (odd ratio, 1.07; 95% CI, .6
168 -2.9 mm Hg in aortic valve mean gradient, an increase of 0.028 in Doppler velocity index, and an incr
169 e of 0.028 in Doppler velocity index, and an increase of 0.09 cm2 in effective orifice area.
170     Purified LLMs invaded erythrocytes by an increase of 10-300 fold compared to wild-type (WT) meroz
171 .13 BMI z-score (95% CI: 0.01, 0.25) per log increase of p,p'-DDE).
172 io=2.33; 95% CI: 1.06-5.13); with a one unit increase on this subscale, the incidence of the NPs serv
173 d osteoclast-progenitor survival, leading to increased osteoclastogenesis.
174 /SS, CD33CD11bHLA-DR MDSCs were dramatically increased out to 28 days (P < 0.05).
175 s across single- and multi-site cohorts, and increased over 1 year in Parkinson's disease but not in
176  negative trend in survival was observed for increasing pack-years of smoking ( Ptrend = .008), with
177  who underwent autologous reconstruction had increased pain interference (difference, 2.0; P = .006).
178 anastomotic leaks in favor of LC but with an increased perineal wound breakdown rate.
179 ocused ultrasound tumor treatment, and these increases persisted for 3 hours.
180 ed regulation of NFkappaB and IL6 secretion, increased phosphorylation of STAT3 on Ser727, and increa
181 cate that the inability of Chl reductions to increase photosynthesis arises primarily from the connec
182 diaphragm muscle activity is associated with increased phrenic motoneuron expression of glutamatergic
183 ans as well; E2D induces postural avoidance, increases physiological arousal, and enhances visual per
184 re variable water availability, for instance increasing plant P uptake more with a pulsed water suppl
185                      This is coupled with an increased pool of free NADH, increased mitochondrial bio
186 s of this 21st century are changing with the increased power and speed of computers, with the "big da
187                               The RV-GDT has increased power by efficiently incorporating information
188 ional false discovery rate analysis provides increased power to discover genetic variants and could e
189 ller alterations in current tobacco smokers, increased production of antioxidants in individuals with
190                                              Increased production of leukotrienes has been associated
191  (b) had prior negative biopsy findings with increased prostate-specific antigen (PSA) level, or (c)
192 ranules and associates with polyribosomes to increase protein synthesis in a CAP-independent manner.
193  had a prior history of prostate cancer with increasing PSA level.
194 rosis stage; in overweight patients, surgery increased QALYs for all patients regardless of fibrosis
195                                              Increased Rac1 activity caused by OGD/ischemia contribut
196       We fed rats an HFM and showed that HFM increases rat fecal Gram-negative bacteria, elevates lip
197 to-noise ratio(SNR), stent-lumen attenuation increase ratio (SAIR), and subjective image quality scor
198 ic extrusion of mitochondrial DNA along with increased reactive oxygen species and reduced superoxide
199 h a linear range 100ng to 1microg due to the increased reactive sites and distance.
200 erghei ookinetes and exhibited significantly increased resistance to Plasmodium infections as well as
201 opsis genome annotation with a substantially increased resolution of gene models will not only furthe
202  locomotor sensitization profile, as well as increased responding for and intake of cocaine in an int
203 alized REgimen Selection), may significantly increase response rates for breast cancer patients, espe
204 reasing their regional retention and driving increasing richness.
205 whether similar mechanisms contribute to the increased risk for calcium oxalate stone formation obser
206 surface morphology, and increasing size with increased risk for covert malignancy.
207 -insufficient cystic fibrosis (PI-CF) are at increased risk for developing diabetes.
208             New onset AF was associated with increased risk of all outcomes.
209  days; P < .001) but was not associated with increased risk of any of the other secondary outcomes.
210  (HR = 2.56, P < .0001) were associated with increased risk of DCGF; however, later-onset dysfunction
211                                           An increased risk of definite AST was associated with short
212              The only factor associated with increased risk of IC within 6 months was Roux-en-Y hepat
213              Patients with psoriasis have an increased risk of myocardial infarction, and psoriasis i
214                                              Increasing rotating speed reduces the charge transfer re
215 progresses, producing more compartments with increased self-replication.
216  alterations in substrate metabolism, and an increased sensitivity to ischemic insults.
217  CGNPs showed reduced lactate production and increased SHH-driven proliferation.
218 ater supply compared to a regular supply and increasing shoot N concentration more when lower water a
219                          Vascular tortuosity increased significantly in high-risk lesions, whereas di
220  dose CT for evaluation of kidney stones has increased since 2011-2012, but remains low; variability
221 s classification and surface morphology, and increasing size with increased risk for covert malignanc
222 els after treatment (P = 0.007) demonstrated increased skin expression of the anti-inflammatory media
223 d with idelalisib, but not ibrutinib, showed increased somatic hypermutation in AID off-targets.
224        Instead, decreased peak ICa-L offsets increased SR load such that Ca(2+) release from the SR w
225 ice, exhibited signatures of immune evasion, increased stemness, increased calcium signaling, transfo
226 or use for >/=2 years was associated with an increased subsequent risk of iron deficiency.
227  2006 to 2012 the use of PC in ESLD patients increased substantially; socioeconomic, geographical, an
228 0.024) for a lag of 2 wk; the estimated risk increased successively beyond this SST threshold.
229                       Although beta-blockers increase survival in patients with heart failure (HF), t
230 ment with the KATP channel agonist pinacidil increases survival of bees while decreasing viral replic
231    Accordingly, ROS-high NKT cells exhibited increased susceptibility and apoptotic cell death with o
232                                          The increased susceptibility of phoQ Salmonella to RNS requi
233 ic inflammatory skin disease associated with increased susceptibility to atherosclerosis, provides a
234 he addition of ribavirin was associated with increased SVR rates for certain DAA regimens and patient
235 ide verified the phosphoproteomic results of increased T31 phosphopeptide abundance with decreased MK
236 netic reactivation of ERalpha, which in turn increases TAM-dependent anti-estrogen chemosensitivity i
237 esistance exhibits a monotonic decrease with increasing temperature for all densities, with the impor
238                                              Increasing temperature increased the viscosity of the ex
239                         Surviving DPCs could increase the availability of neurotrophic factors in the
240 y age, sex, and race.A 1-y MMC in 2015 would increase the average national F&V consumption by 7% for
241 hycardia phase to low intensity VNS, but can increase the bradycardia to higher intensity VNS.
242 lioviruses had been eradicated, but it might increase the cost of OPV withdrawal.
243 ut normally nonadhesive blood constituent to increase the efficiency, strength, and stability of bact
244 optical grating substrate, it is possible to increase the grating amplitude due to shadowing effects,
245 increasing in epidemic proportions, and both increase the prevalence of cardiovascular disease events
246                              Furthermore, to increase the quality and reproducibility of published pr
247 inging everybody to at least $2.97 PPP would increase the required mitigation rate by 27%.
248  coupled with prenatal stress is reported to increase the risk for children to develop autism spectru
249                  Longstanding diabetes might increase the risk of acute rejections.
250 n and nuclease treatment did not discernibly increase the sequencing efficiency of PV isolates.
251 te transport into the symbiosome space would increase the solubility and availability of Fe(III) for
252      Moreover, this conversion significantly increased the efficacy of anti-PD-1 checkpoint blockade.
253 osal immune responses in CCR7-deficient mice increased the efficiency of bacteria clearance from the
254  fasting period with breakfast skipping also increased the inflammatory potential of peripheral blood
255  we found that the probability of antagonism increased the more metabolically similar the strains wer
256                         Mechanistically, CpG increased the number of circulating B cells, which produ
257           In addition, linagliptin treatment increased the relative GLP-1 vs glucagon production in b
258 ic DOS molecular formulas, solar irradiation increased the similarity due to the removal of photolabi
259                       Increasing temperature increased the viscosity of the extrudates.
260 ed with blended carboxymethyl cellulose film increased the water barrier and the TPC.
261 igation pathway, eradicating extreme poverty increases the effort by 2.8% whereas bringing everybody
262              Further, DNA-bound RecA protein increases the rate of ATP hydrolysis catalysed by RecN d
263                                           By increasing the field strength about iron, odd-electron r
264 Global climate change drives sea-level rise, increasing the frequency of coastal flooding.
265  species expanded over the long-term, slowly increasing their regional retention and driving increasi
266 nd CD4-induced non-nAb epitope exposure, and increase thermal stability while maintaining bnAb antige
267 re human adenovirus (HAdV) infections are an increasing threat for immunosuppressed individuals, part
268 palmitoyl-PC/cholesterol, whereas 16 carbons increase Tmix again.
269  to 6045 ng h/ml (P=0.03), and trough levels increased to 218 ng/ml (P=0.03), above the 90th percenti
270 a under the concentration-time curve further increased to 6045 ng h/ml (P=0.03), and trough levels in
271 silon4 genotype (APOE epsilon4) information, increased to 86% when individuals carried one or two all
272 igher [CO2] responsiveness incorporated with increased tolerance to high temperatures during flowerin
273  partially mediates visual delay, suggesting increased transmission time, whereas grey matter (GM) in
274 d with the EBI2 ligands showed significantly increased transwell migration that was enhanced by primi
275                                   Despite an increased travel burden, patients treated at high-volume
276 fluctuates over the course of the year, with increased travel from rural to urban communities after n
277 x and all the elasticities showed an obvious increasing trend from the upstream to the downstream in
278                                              Increasing TTA was associated with longer LOS (increase
279 tor-alpha (TNFalpha) that contributed to the increased tumor resistance to BRAF inhibitors.
280                  The charge carrier lifetime increased upon reversing the applied bias, thus indicati
281 AIMS: Clinical studies showed teduglutide to increase urine production and reduce need for parenteral
282                                              Increasing use of emergency departments among older pati
283  amount of a protein can also be selectively increased using ASOs designed to hybridize to other tran
284 asing sample size of individuals and with an increasing value of actual relatedness.
285 ratio, 9.08; 95% CI, 4.0-23.7; P < .001) and increased variability of nevus dermoscopic pattern (adju
286 ntagonist tolbutamide decreases survival and increases viral replication.
287                       With advancing age, an increased visibility of perivascular spaces (PVSs) on ma
288 ct the immune system and, with time, lead to increased vulnerability to infectious diseases.
289 riction ("waist formation"), pulsation-which increases waist longitudinal stresses-and transverse rup
290 y of the sample almost always increases with increasing water content, and its T g decreases correspo
291 forations were found in the skin models with increasing water content.
292 tory loop, in which ectopic DNMT1 expression increases, whereas targeted DNMT1 depletion abrogates KI
293           At high doses, staple dissociation increases which causes structural disintegration.
294 ly, the steady-state levels of circular RNAs increased while expression of their associated linear mR
295 ages of the modified estimators are shown to increase with a decreasing sample size of individuals an
296    We hypothesized that litter quality would increase with latitude (despite variation within regions
297 We hypothesized that soil Po would initially increase with paddy management and then would persist un
298                         Fire frequency, too, increased with rainfall.
299 thods do result in samples whose resistivity increases with decreasing temperature, similar to the te
300 lecular mobility of the sample almost always increases with increasing water content, and its T g dec
301 dance decreased as sheep grazing intensities increased, with a significant cumulative effect occurrin

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