ライフサイエンスコーパス: increased activity

1 d with digging for winter forage, moderately increased activity.

2 to arginine (K68R), mimicking deacetylation, increased activity.

3 ischemia, hypoxia, neuromodulator action and increased activity.

4 uced enzymatic activity, whereas one (V166L) increased activity.

5 catalytic reduction can be competitive with increased activity.

6 level, and where protein function is known, increased activity.

7 ration a function of higher affinity and not increased activity.

8 activity, whereas switching to IgG2 markedly increased activity.

9 apamycin complex 1 (mTORC1) complex allowing increased activity.

10 lexibility in favor of an extended conformer increased activity.

11 Because of their increased activity against activating mutants, first-gen

12 The compounds showed increased activity against clinical isolates of P. aerug

13 erences, as the majority of analogues showed increased activity against the cancer cell line MDA-MB-2

14 Recent epidemiological studies show increased activity among GI NoVs, with some members show

15 roved consistent micrographia accompanied by increased activity and connectivity in the basal ganglia

16 Increased activity and energy alongside mood change are

17 We show increased activity and O2 tolerance for a protein fusion

18 d Mn bipyridine electrocatalysts in terms of increased activity and reduced overpotential, a bulky bi

19 cantly worse compared to controls suggesting increased activity and risk taking, diminished short ter

20 point mutations H221F and R312L resulted in increased activity and specificity toward poly-ManA and

21 ecruited to accelerate membrane retrieval at increased activity and temperature.

22 ard cytoplasmic ribosome correlates with the increased activity and that the decreased specificity to

23 gh the underlying mechanisms responsible for increased activity are not well understood.

24 However, the mechanisms responsible for the increased activity are unknown.

25 d medial temporal areas, risk-takers instead increased activity as stakes became more costly.

26 we found that almost all ACC neurons showed increased activity before hippocampal ripple activity; m

27 t was mediated not by caloric restriction or increased activity, but by increased energy expenditure,

28 nput through whisker trimming nor moderately increased activity by environmental enrichment affects c

29 us, Arc mediates the homeostatic response to increased activity by translocating to the nucleus, incr

30 of these analogues demonstrate their 6-fold increased activity compared with that of latrunculin B a

31 2 (10 of 17) edible tissue samples exhibited increased activity concentrations of (137)Cs (234-824 mB

32 Fe incorporation and increased activity correlate with an anodic shift in the

33 trast to this task-negative pattern, we show increased activity during a large and demanding switch i

34 Distinct groups of BL neurons displayed increased activity during appetitive (CS-R) versus avers

35 ike activity, mediate cell death and display increased activity during pathogen infections.

36 ction error deficit correlated strongly with increased activity during silence and with reduced volum

37 emporal sulcus, and left premotor cortex, OT increased activity during social judgments and decreased

38 adult prefrontal cortex is characterized by increased activity during the delay period of the task b

39 d by decreased anxiety-related behaviors and increased activity during the light phase, which were at

40 reotypical behavioral changes beginning with increased activity, followed by incoordination, loss of

41 PAM neurons show increased activity following caffeine administration, an

42 the dorsal anterior cingulate cortex, showed increased activity following errors in the impaired grou

43 The dlPFC, but not the hippocampus, showed increased activity for altered images compared with old

44 arting material and that previous reports of increased activity for beta-NiOOH are due to incorporati

45 on 190 was identified that had significantly increased activity for the aldol reaction of erythrose w

46 and pyrrolidinyl substituents that exhibited increased activity for the C-H borylation of unactivated

47 Resting-state brain scans showed increased activity for the meditation group in the anter

48 s greatly altered substrate specificity with increased activity for the oxyimino-cephalosporin, cefta

49 Fourteen hits showed increased activity (improved >4.5-fold in lysate; kcat i

50 Moreover, both TFs are stabilized and show increased activities in a upl3 mutant background.

51 in its LPZ in the first weeks postlesion and increased activities in its periphery from 1 month onwar

52 Significantly increased activities in the CSF of ASM transgenic mice a

53 Sal-Nalb produced significantly increased activity in 60 brain regions and decreased act

54 h HFD, and male High LG offspring displaying increased activity in a novel environment and reduced HF

55 cene construction in P01 was associated with increased activity in a set of brain areas, including me

56 entry and progression, and frequently shows increased activity in a wide spectrum of human tumors.

57 wer memories, slower mnemonic decisions, and increased activity in anterior cingulate cortex.

58 Furthermore, increased activity in bilateral caudate nucleus and hipp

59 In experiment 2, emotional voices evoked increased activity in both the auditory cortex and the i

60 advantageous to be in a habitat, we observed increased activity in brain regions that underlie prepar

61 Increased activity in brainstem autonomic regulatory nuc

62 ta suggested that asynchronous delays led to increased activity in Broca's area and its right homolog

63 However, mechanisms underlying GLI1-increased activity in DLBCL are poorly characterized.

64 ntrast, relative to controls, acute nicotine increased activity in dorsal striatum for anticipated ma

65 active GSSG efflux mechanism, showed 2-fold increased activity in EOMA compared with MAE cells.

66 Previous fMRI studies have found increased activity in frontoparietal cortex when task sw

67 We found that increased load not only increased activity in frontoparietal network, but also h

68 episodic memory encoding is associated with increased activity in hippocampus and lateral prefrontal

69 However, the TPJ showed increased activity in IED on escitalopram compared with

70 specificity was supported by the presence of increased activity in lateral caudate in sIL-2Ralpha tre

71 vid remembering is typically associated with increased activity in lateral parietal cortex (LPC)--"re

72 rtantly, place preference is associated with increased activity in midbrain dopaminergic neurons and

73 leus, the zona incerta (ZI), and concomitant increased activity in one of its main targets, the poste

74 ure to a pup was selectively associated with increased activity in oxytocin and vasopressin neurons a

75 luenza virus polymerase for human cells also increased activity in pig cells.

76 r-related metabolic network characterized by increased activity in pons, thalamus, medial frontal and

77 Synchronous speech was associated with increased activity in posterior and anterior auditory fi

78 ce activity was reduced in visual cortex but increased activity in precuneus, frontopolar, and premot

79 3, both L290P and L290V mutants have greatly increased activity in promoting cancer cell migration an

80 esonance imaging in a rodent model, we found increased activity in regions known to depress cortical

81 ing of neuronal activity after flow revealed increased activity in serotonergic neurons of the dorsal

82 bital cortex, and, like noxious stimulation, increased activity in temporal cortex, insula, pulvinar,

83 lphavbeta6 integrin causes androgen receptor-increased activity in the absence of androgen and conseq

84 ng and connectivity, which is accompanied by increased activity in the BLA in response to social stim

85 ventional moral reasoning is associated with increased activity in the brain's frontostriatal system,

86 ncreased tinnitus loudness is represented by increased activity in the cochlear nucleus (CN) and IC a

87 Patients with tremor-dominant PD had increased activity in the contralateral dorsolateral pre

88 eral distinct neural processes, most notably increased activity in the default mode network (DMN), su

89 Challenges to political beliefs produced increased activity in the default mode network-a set of

90 dant personality disorder patients exhibited increased activity in the dorsal anterior cingulate cort

91 ng the appraisal condition, allopregnanolone increased activity in the dorsal medial prefrontal corte

92 Antidepressants increased activity in the dorsolateral prefrontal (dlPFC

93 sed fMRI activity in the parahippocampus and increased activity in the hippocampus and other brain re

94 The network was associated with increased activity in the lateral cerebellum, dorsal pre

95 tion and optogenetic studies have shown that increased activity in the lateral hypothalamus (LH) prom

96 amygdala bilaterally revealed significantly increased activity in the left amygdala in paranoid pati

97 ingulate gyrus, right PrCS and right PPC and increased activity in the left PFC and left insular (INS

98 of auditory stimuli and was associated with increased activity in the left superior temporal sulcus

99 Hypoglycemia is associated with increased activity in the low-frequency bands in the ele

100 hyperactivity in the hippocampus that drives increased activity in the midbrain and basal ganglia.

101 h the same task on clear speech demonstrated increased activity in the midline frontal cortex in the

102 -hoc tests showed that there was significant increased activity in the mPFC/ACC in CCRT but not TAU g

103 COX4i2 is about twice as active (88 and 102% increased activity in the presence of allosteric activat

104 ministration were positively associated with increased activity in the right amygdala and orbitofront

105 IFG suppressed activity in the left pIFG and increased activity in the right pIFG during pseudoword v

106 OT increased activity in the striatum, the middle frontal g

107 This social value signal was associated with increased activity in the ventral striatum and medial pr

108 veying negative affective valuations and the increased activity in this region among depressed people

109 s to Galphao-R243H, an oncogenic mutant with increased activity in vitro and in cells due to rapid nu

110 dulated by absolute reward value, exhibiting increased activity, increased gamma-band power and decre

111 st or both helices resulted also in strongly increased activity indicating that the N-terminal domain

112 hat mimics homeostatic scaling up induced by increased activity, indicating that activation of this p

113 o "filling-in" of the target location due to increased activity induced by the flankers.

114 Increased activity is a consequence of both a larger fra

115 based on cued attention conditions revealed increased activity mainly in somatosensory and cerebella

116 ower outputs, decreased food availability or increased activity may render some populations energetic

117 textualizes the independent origins of their increased activity metabolism.

118 as present in bilateral anterior PT, with no increased activity observed in posterior PT or parietal

119 ases, these effects were such that there was increased activity occurring during recall relative to w

120 liver tissue, tumors from all 3 strains had increased activities of Akt, mTORC1, and mitogen-activat

121 tants or inhibition of GSK3 in psrA(-) cells increased activities of both PKBR1 and PKBA, but only th

122 agent combination strongly activated Bax and increased activities of cytochrome c and caspase-9 and -

123 N-end-rule-insensitive Delta13RAP2.12 led to increased activities of fermentative enzymes and increas

124 ated sirtuin 1 inhibition was accompanied by increased activities of two vital inflammatory regulator

125 Increased activity of 5-aminolevulinate synthase 2 (ALAS

126 Moreover, treatment increased activity of a 2-kb NOTCH2 promoter.

127 messenger, cyclic diguanylate (c-di-GMP), by increased activity of a c-di-GMP specific phosphodiester

128 cul-6, suggesting that pals-22 mutants have increased activity of a CUL-6/cullin-containing ubiquiti

129 ifts in diel nitrogen fixation patterns, and increased activity of a potentially regulatory DNA methy

130 influx across an unstable sarcolemma due to increased activity of a STIM1-Orai1 complex is a disease

131 ed their mean heart rate and cardiac output, increased activity of aconitase and reversed abnormal mi

132 counteracted by actin cortical contraction, increased activity of actin-severing proteins could rele

133 We found increased activity of androgen receptor (AR) signaling i

134 ent in the production of osmoprotectants and increased activity of antioxidant enzymes.

135 allele confers cancer susceptibility through increased activity of APOBEC-dependent mutational proces

136 These findings also imply that the increased activity of APOBEC3B may contribute to PyV-med

137 in tonoplast CsHMA5.2 is consistent with the increased activity of ATP-dependent copper transport int

138 epetitive spiking is maintained, through the increased activity of barium-sensitive potassium channel

139 to specifically identify a mechanism linking increased activity of BLA glutamatergic neurons to aberr

140 e neurohormonal derangements may act through increased activity of both NHE1 and NHE3.

141 This is secondary to increased activity of calpain 1, the primary enzyme resp

142 se pathological phenotypes correlate with an increased activity of cAMP-mediated PKA and ERK1/2 signa

143 We demonstrated that increased activity of casein kinase 2 (CK2) observed in

144 masome as demonstrated by the processing and increased activity of caspase-1 and secretion of IL-1bet

145 s and apoptosis and decreased the HI-induced increased activity of caspase-3.

146 ation and activity of the phosphatase SHP-1, increased activity of caspases 8 and 3, and accelerated

147 parallel with apoCcp1 export, cells exhibit increased activity of catalase A (Cta1), the mitochondri

148 -coenzyme A and dihydroxy LCB substrates but increased activity of class II ceramide synthases that u

149 ent with these observations, I/R but not LPS increased activity of cognate kinases (Erk1/2, Msk1/2 an

150 The results showed increased activity of cytotoxic T cells and natural kill

151 sphorylation of Replication Protein A due to increased activity of DNA2 and WRN at the DNA interstran

152 hat activation of the reward system involves increased activity of dopaminergic (DA) neurons in the v

153 In RB family mutant TECs, increased activity of E2F transcription factors drives i

154 Increased activity of efflux transporters, e.g., P-glyco

155 Additionally, obesity is associated with increased activity of endocannabinoid system (eCB).

156 erature, impairment in biofilm formation and increased activity of enzymes detoxifying reactive oxyge

157 on follows decreased activity of ERalpha and increased activity of ERbeta.

158 Nerve injury increased activity of euchromatic histone-lysine N-methy

159 Thus, increased activity of excitatory DH interneurons coupled

160 The increased activity of Fur under anaerobic conditions led

161 during anesthesia is attributed primarily to increased activity of gamma-aminobutyric acid type A rec

162 n of learned fear responses and suggest that increased activity of GluN2C receptors may underlie the

163 nal mechanisms of steroid resistance include increased activity of GR phosphorylating kinases which m

164 common finding in human cancer and leads to increased activity of hypoxia-inducible factors (HIFs),

165 s by a dual mechanism that involves both the increased activity of individual cells and the recruitme

166 suggesting that its removal would result in increased activity of inflammatory responses.

167 el and GATA family transcription factors and increased activity of interferon response factors and th

168 Increased activity of Kir channels results in the genera

169 11), infections (six), mucositis (four), and increased activity of liver enzymes (three).

170 before and during movement, owing in part to increased activity of local parvalbumin-positive interne

171 In addition, the increased activity of macrophages, osteoclasts, and mega

172 These changes in gene expression result from increased activity of MEKK3, a mitogen-activated protein

173 d beta-tubulin isotypes are, in part, due to increased activity of miR-200c.

174 of SLC7A5 to Salmonella-containing vacuoles, increased activity of mTORC1, and increased survival of

175 As a result of increased activity of mutant ryanodine receptor type 2 c

176 enhanced actin dynamics, characterized by an increased activity of n-cofilin and profilin 1, leading

177 we used figure-ground modulation (FGM), the increased activity of neurons representing figures compa

178 induction of CD44 by DLX4 was attributed to increased activity of NF-kappaB that was stimulated by t

179 sm or normal levels of aldosterone exhibited increased activity of NLRP3 inflammasome, suggesting tha

180 lastomic strains overexpressing NDA2 show an increased activity of nonphotochemical reduction of plas

181 opamine signaling and elevated in flies with increased activity of octopaminergic neurons.

182 owed increased phosphooccupancy, pointing to increased activity of one or more MAP kinases in PKA kno

183 accompanied by crystal decomposition and by increased activity of oxalate oxidase that converts oxal

184 These findings suggest that increased activity of P-gp could be responsible for incr

185 in the presence of hydrogen peroxide showed increased activity of p53 at Serine 15.

186 tivity of (20S)-Rg3 directly correlated with increased activity of phosphatidylinositol 4-kinase IIal

187 atidylinositol 4-kinase IIIbeta and PKC; the increased activity of phosphatidylinositol 4-phosphate 5

188 Here, we demonstrate that gossypol rapidly increased activity of phospholipase A2 (PLA2), which led

189 reased stability of PDCD4 protein as well as increased activity of PRMT5 toward PDCD4.

190 tion factor binding motif analysis showed an increased activity of pro-inflammatory upstream signalin

191 resulting in altered input organization and increased activity of proopiomelanocortin (POMC) neurons

192 Increased activity of protein clearance pathways in the

193 Increased activity of protein kinase CK2 is associated w

194 ontributes a developmental mechanism for the increased activity of Pten-depleted neurons.

195 suppression of excitatory mPFC networks via increased activity of PV+ FSIs may enhance reward-relate

196 Merlin loss-of-function is associated with increased activity of Rac and p21-activated kinases (PAK

197 r mice revealed more dendrite extensions and increased activity of renal DCs in real time.

198 e of hexoses also contributes to sustain the increased activity of respiratory metabolism to fuel pla

199 eased ratio of p-eNOS/eNOS and p-AKT/AKT and increased activity of RhoK in SMA.

200 In enterocytes of AEG-1KO mice, we observed increased activity of RXR heterodimer partners, liver X

201 rom the combined action of enhanced IICR and increased activity of sarcolemmal Na(+)-Ca(2+) exchange

202 ne kinase 1 (WNK1), which, in turn, leads to increased activity of serum and glucocorticoid-inducible

203 causes accumulation of VEGFR2, resulting in increased activity of signaling pathways downstream of V

204 Increased activity of SIRT3 was evidenced by normalizati

205 ed with phospholipid vesicles can facilitate increased activity of soluble RhoGEFs on vesicle-delimit

206 s of the acclimation to low light consist of increased activity of state 1 and 2 transitions and incr

207 esulted in increased tumoursphere growth and increased activity of stem cell markers such as Aldehyde

208 Increased activity of suppressor of cytokine signaling-1

209 geted by microRNA-21, which in turn leads to increased activity of Syk and Erk in CLL cells.

210 d insulin responsiveness but correlated with increased activity of sympathetic fibers innervating bro

211 Increased activity of T follicular helper (Tfh) cells pl

212 This occurs through increased activity of the 11beta-hydroxysteroid dehydrog

213 We also observed significant increased activity of the Anterior Cingulate Cortex (ACC

214 hibition induces prosurvival signals through increased activity of the autophagy/lysosomal network.

215 sented a remarkable elevation of cGMP and an increased activity of the cGMP-dependent protein kinase

216 t" moiety addressing the DFG motif led to an increased activity of the compounds.

217 y and insulin resistance are associated with increased activity of the endocannabinoid/CB1 receptor (

218 At the mechanistic level, CFA increased activity of the Epac target Rap1 in dorsal roo

219 Increased activity of the epigenetic modifier EZH2 has b

220 bers selectively in hippocampal area CA1 and increased activity of the filamentous actin severing pro

221 taepsilon) tetramers, which may underlie the increased activity of the former.

222 tral carbon metabolic network, as well as an increased activity of the glyoxylate bypass and the 3-hy

223 Our results show that increased activity of the IDOL pathway in the liver can

224 ad decreased plasma ghrelin and demonstrated increased activity of the left anterior cingulate cortex

225 While increased activity of the lysosomal form has been associ

226 n for the p.R384X, supported by the fourfold increased activity of the most probable readthrough-medi

227 ory activation through a mechanism involving increased activity of the NADH-sensitive transcriptional

228 Increased activity of the neurotransmitter glutamate is

229 These traits were associated with increased activity of the noncanonical Wnt/Ras homolog f

230 ncrease in scavenger receptors was caused by increased activity of the nuclear factor (erythroid-deri

231 ted in the absence of HS1BP3, as a result of increased activity of the PA-producing enzyme phospholip

232 We also found that isoflurane increased activity of the parvalbumin interneurons, and

233 Therefore, increased activity of the PI3K/AKT signaling pathway in

234 Here we found that increased activity of the RB cell cycle inhibitor in hum

235 emic hypertension is mainly a consequence of increased activity of the renal Na(+)-Cl(-) cotransporte

236 Hypertension was associated with increased activity of the renin-angiotensin-aldosterone

237 This was associated with increased activity of the repressor of hTERT transcripti

238 Enhanced IICR, however, together with an increased activity of the sodium-calcium exchange mechan

239 Conversely, miR-132 increased activity of the STAT3 and ERK pathways, thereb

240 y microarray analysis of gene expression and increased activity of the SuperTOPFlash luciferase repor

241 Increased activity of the sympathetic nervous system is

242 , suggesting that this effect is mediated by increased activity of the sympathetic nervous system.

243 However, cells within TSC lesions show increased activity of the target of rapamycin complex 1

244 Furthermore, NSP activities unleashed increased activity of the tissue-destructive proteases m

245 Increased activity of the transcription factor CREB in H

246 These mechanical stimuli are associated with increased activity of the transcriptional coactivator YA

247 ossible mechanism for the involvement of the increased activity of the tricarboxylic acid cycle in ca

248 of carbohydrates and fatty acids as well as increased activity of the tricarboxylic acid cycle.

249 Increased activity of the tumour suppressor p53 is incom

250 The mechanism was dependent on increased activity of the tyrosine phosphatase CD45 and

251 of medial prefrontal neurons correspond with increased activity of their striosome-predominant striat

252 esis and that this upregulation is caused by increased activity of Torc1.

253 moter-based bioinformatic analyses indicated increased activity of transcription factors involved in

254 Fura-2 experiments demonstrated increased activity of TRPV5 in response to dobutamine, w

255 Obesity is associated with increased activity of two lipid signaling systems (endoc

256 Hence, an increased activity of ventral motor thalamic nuclei nice

257 Bloom decline is also accompanied by increased activity of viruses other than AaV, including

258 ecombinant factor VIIa (FVIIa) variants with increased activity offer the promise to improve the trea

259 Surprisingly, variant p.G214R had increased activity on a small chromogenic peptide substr

260 The findings confirm that including increased activity or energy as part of DSM-5 criterion

261 When the new DSM-5 criterion of increased activity or energy was added as a coprimary sy

262 ritable mood and abnormally and persistently increased activity or energy" as a primary criterion for

263 DSM-IV criteria plus the DSM-5 criterion of increased activity or energy) and those who did not meet

264 DSM-IV criteria plus the DSM-5 criterion of increased activity or energy) and those who did not meet

265 phenotype characterized by elevated mood and increased activity or energy.

266 Infants had increased activity over right dorsal lateral PFC when ru

267 Phospholipid-free FV(MTTS/Y) showed increased activity, particularly a 10-fold increase in a

268 icarbazones can lead to a more than 100-fold increased activity, probably due to interactions with ce

269 mbrane-tethered cytokine had a substantially increased activity profile compared to non-targeted TR3.

270 x raises the interesting question of whether increased activity recruits ATP-independent mechanism(s)

271 g RVF5, we show that Tsc1 KO neurons exhibit increased activity relative to wild-type neurons and add

272 Increased activity requires cleavage of IL-1alpha by cal

273 Paradoxically, the increased activities resulted in serious growth impedime

274 states is consistent with a model where the increased activity results from an increased rate-consta

275 postnatal days of development, we show that increased activity results in exuberant VSN axonal proje

276 ound 27 (MI-538), which showed significantly increased activity, selectivity, polarity, and pharmacok

277 ases activity, while ferrous RsbR results in increased activity, suggesting that the V. brasiliensis

278 such that increased IIV was associated with increased activity, the MAP+ group displayed this relati

279 reas graded cross-link lengthening gradually increased activity, thus defining the conformational con

280 ods, whilst halving the time taken to detect increased activity to 1.3 days.

281 on, we further identified derivatives having increased activities toward Oct3/4 induction.

282 nd D117V mutations resulted in significantly increased activity toward (R)-3-hydroxybutyryl-CoA.

283 contrast, FKBP19, FKBP22, and FKBP65 showed increased activity toward hydroxyproline-containing pept

284 e as a reporter gene, we observed 10-15-fold increased activity under hypoxia and 10-80-fold inductio

285 DRN DA neurons show increased activity upon social contact following isolati

286 alogues with several modifications providing increased activity versus S. aureus and other bacterial

287 acids at the same position showed that this increased activity was not achievable with any of the 20

288 structures were systematically modified, and increased activity was observed for those possessing an

289 y node in the default mode network and shows increased activity when individuals retrieve autobiograp

290 However, connector nodes do exhibit increased activity when more cognitive functions are eng

291 asing daily physical activity, assuming that increased activity will lead to corresponding increases

292 t to examine how an enzyme can evolve toward increased activity with a variety of beta-lactam antibio

293 Apratoxin S9 (1d) exhibited increased activity with subnanomolar potency.

294 PW/R) complexes, which are short episodes of increased activity with superimposed high-frequency osci

295 Increased activity within known reward-processing neuroc

296 no modulation of activity within the SN, but increased activity within the EN.

297 Relative to controls, amputees also showed increased activity within the former cortical sensorimot

298 decreased metastability was associated with increased activity within the frontoparietal control/dor

299 4) if NAT was available and the donor had no increased activity within the window period (P < 0.001).

300 iated signaling in BNST VGAT neurons and saw increased activity within ventral midbrain structures, i