ライフサイエンスコーパス: incurable

1 and prolong life, the metastatic PCa remains incurable.

2 of metastatic disease, which remains largely incurable.

3 progressively damage sight, and is currently incurable.

4 te lymphoblastic leukemia (ALL) is currently incurable.

5 Mantle-cell lymphoma is generally incurable.

6 ances, multiple myeloma (MM) remains largely incurable.

7 mmon, chronic skin disease that is currently incurable.

8 ary brain tumor in adults and is essentially incurable.

9 vances in cancer research it is still mostly incurable.

10 plasia in Western societies and is currently incurable.

11 and patients with bone metastases are deemed incurable.

12 atic ductal adenocarcinoma (PDAC) is usually incurable.

13 r ischemic optic neuropathy (NAION) is still incurable.

14 -1) infection is chronic and presently still incurable.

15 h, once a cancer metastasizes to bone, it is incurable.

16 ing to tumor recurrence, which is ultimately incurable.

17 tasis and once established, it is frequently incurable.

18 espite recent treatment advances, it remains incurable.

19 e form of primary brain cancer and virtually incurable.

20 ost common motor neuron disease and is still incurable.

21 , the metastatic lesions from this tumor are incurable.

22 therapeutic strategies, the disease remains incurable.

23 castration-resistant prostate cancer remains incurable.

24 resistance to multiple treatments and become incurable.

25 ability is a prevalent disorder that remains incurable.

26 omas are childhood tumors that remain mostly incurable.

27 ost common primary brain tumor, is generally incurable.

28 are malignant gliomas, which are essentially incurable.

29 ients with non-Hodgkin lymphoma (NHL) remain incurable.

30 GBM) is extremely aggressive and essentially incurable.

31 ategies, multiple myeloma remains at present incurable.

32 Bone metastases are incurable.

33 r metastatic head and neck cancer is usually incurable.

34 en and the metastatic form of the disease is incurable.

35 Multiple myeloma remains treatable but incurable.

36 Mantle-cell lymphoma is generally incurable.

37 this common B cell malignancy still remains incurable.

38 otherapy and temozolomide, it is essentially incurable.

39 gliomas eventually recur and are ultimately incurable.

40 and in its aggressive forms remains largely incurable.

41 the last 2 decades and which to date remains incurable.

42 prostate cancer (mCRPC), which is currently incurable.

43 r metastatic head and neck cancer is usually incurable.

44 Although still incurable, a revolution in the treatment of MM is curren

45 ein aggregation for the treatment of the yet incurable alpha-synucleinopathies.

46 Metastatic colorectal cancer remains largely incurable, although in a subset of patients, survival is

47 static renal cell carcinoma (mRCC) is nearly incurable and accounts for most of the mortality associa

48 tanding of the genetic underpinnings of this incurable and clinically heterogeneous disease, whole-ex

49 ic lateral sclerosis (ALS) is a progressive, incurable and fatal neurodegenerative disease.

50 gnancies, which in their advanced stages are incurable and have poor prognosis.

51 However, the disease remains incurable and is characterized by high rates of drug res

52 KS, PEL, and MCD are largely incurable and poorly understood diseases most common in

53 such as Creutzfeldt-Jakob disease (CJD) are incurable and rapidly fatal neurodegenerative diseases.

54 physicians communicated that the disease was incurable and that no treatment and/or palliative care w

55 Spinal cord injury is currently incurable and treatment is limited to minimising seconda

56 taneous T-cell lymphomas are rare, generally incurable, and associated with reduced quality of life.

57 pite new therapies, multiple myeloma remains incurable, and patients ultimately develop drug resistan

58 reatment, mantle cell lymphoma (MCL) remains incurable, and we are still unable to identify patients

59 ngenital blindness was generally regarded as incurable, as noted in both medical and lay publications

60 tion of prostate cancer to bone is a common, incurable aspect of advanced disease.

61 rm of non-Hodgkin lymphoma that is generally incurable at more advanced stages with systemic involvem

62 Because mitochondrial diseases are incurable, attention has focused on limiting the inherit

63 Systemic lupus erythematosus (SLE) is an incurable autoimmune disease characterized by autoantibo

64 Follicular lymphoma is an incurable B cell malignancy characterized by the t(14;18

65 Follicular lymphoma (FL) is an indolent, yet incurable B cell malignancy.

66 onment of human follicular lymphoma (FL), an incurable B cell non-Hodgkin's lymphoma, is thought to p

67 Multiple myeloma (MM) is an incurable B-cell malignancy in which the marrow microenv

68 HIV is incurable because infected individuals harbor cells wher

69 ses of the retina in patients with currently incurable blinding conditions.

70 on is a cause of irreversible vision loss in incurable blinding retinal diseases including retinitis

71 ic epidermolysis bullosa (RDEB), a currently incurable blistering genodermatosis caused by loss-of-fu

72 s the efficacy of therapeutic strategies for incurable bone metastatic prostate cancer is an urgent n

73 Chordoma is a malignant, often incurable bone tumour showing notochordal differentiatio

74 Glioblastoma remains an incurable brain cancer.

75 als with Creutzfeldt-Jakob disease (CJD), an incurable brain disorder caused by alterations in prion

76 High-grade gliomas (HGGs) are incurable brain tumors that are characterized by the pre

77 Multiple sclerosis is incurable, but stem-cell therapy might offer valuable th

78 Advanced stage follicular lymphoma (FL) is incurable by conventional therapies.

79 So far, HTLV-1-associated ATL is incurable by presently known therapies.

80 Multiple myeloma is incurable by standard approaches because of inevitable r

81 iated, myxoid/round cell, or pleomorphic LPS incurable by surgery or radiotherapy were included.

82 Heritable mutations in ABCC6 underlie the incurable calcification disorder pseudoxanthoma elasticu

83 atment: Metastatic melanoma, once considered incurable, can now be treated with potentially curative

84 of a Middle Eastern adolescent patient with incurable cancer and conducted an ethical analysis incor

85 le-blind trials in patients with advanced or incurable cancer and weight loss of 5% or more.

86 study drug response in multiple myeloma, an incurable cancer of the bone marrow.

87 110 patients with advanced, incurable cancer participated.

88 support program for patients with advanced, incurable cancer to assist them in discussing prognosis

89 Conclusion Patients with incurable cancer who received EIPC showed increased use

90 Glioblastoma is a fatal and incurable cancer with the hyper-activated mTOR pathway.

91 aldenstrom macroglobulinemia remains a rare, incurable cancer, with a heterogeneous disease course.

92 , and mood in patients with newly diagnosed, incurable cancer.

93 of-the-art palliative care for patients with incurable cancer.

94 care planning happen early for patients with incurable cancer.

95 a (MPM) is a highly aggressive and generally incurable cancer.

96 uld increase ER stress beyond repair in this incurable cancer.

97 L and mood in patients with newly diagnosed, incurable cancer; however, the use of certain coping str

98 Many patients receiving chemotherapy for incurable cancers may not understand that chemotherapy i

99 Conclusion For patients with newly diagnosed incurable cancers, early integrated PC improved QOL and

100 e, palliate symptoms, and control disease in incurable cancers.

101 ntial for treating many classes of currently incurable cancers.

102 cer patient care, especially in advanced and incurable cancers.

103 Glioblastomas are among the most incurable cancers.

104 rogression from localized prostate cancer to incurable castrate-resistant prostate cancer (CRPC) is d

105 rs, a significant number of patients develop incurable castration-resistant disease.

106 ment, although initially effective, leads to incurable castration-resistant prostate cancer (CRPC) vi

107 tually all patients will relapse and develop incurable castration-resistant prostate cancer (CRPC).

108 r, patients receiving ADT eventually develop incurable castration-resistant prostate cancer (CRPC).

109 n (AD) therapy failure leads to terminal and incurable castration-resistant prostate cancer (CRPC).

110 Primary sclerosing cholangitis (PSC) is an incurable cholangiopathy of unknown etiopathogenesis.

111 Genital herpes is an incurable, chronic disease that affects millions of peop

112 PURPOSE Cancer-related lymphedema (LE) is an incurable condition associated with lymph-involved cance

113 rn opens up new therapeutic avenues for this incurable condition.

114 lammatory bowel disease (IBD), a chronic and incurable condition.

115 tive and targeted interventions against this incurable condition.

116 reat these highly debilitating and currently incurable conditions.

117 Light-chain (AL) amyloidosis remains incurable despite recent therapeutic advances.

118 and aggressive primary brain malignancy, is incurable despite the best combination of current cancer

119 Multiple myeloma is largely incurable, despite development of therapies that target

120 Alzheimer's dementia is a devastating and incurable disease afflicting over 35 million people worl

121 Recurrent breast cancer is typically an incurable disease and, as such, is disproportionately re

122 ystrophic epidermolysis bullosa (RDEB) is an incurable disease caused by mutations in the gene encodi

123 Chronic lymphocytic leukemia (CLL) is an incurable disease characterized by accumulation of clona

124 HIV-1 causes a chronic, incurable disease due to its persistence in CD4+ T cells

125 Furthermore, CLL is still an incurable disease due to the persistence of residual leu

126 ioblastoma multiforme (GBM) remains a mainly incurable disease in desperate need of more effective tr

127 y arterial hypertension (PAH) is a medically incurable disease resulting in death from right ventricu

128 study point to new drug targets in CRPC, an incurable disease state which remains the chief therapeu

129 minal illness acknowledgment, recognition of incurable disease status, knowledge of the advanced stag

130 Although SMA remains an incurable disease to date, recent advances in the field

131 Adult T-cell leukemia/lymphoma (ATLL) is an incurable disease where most patients succumb within the

132 thought to represent cures in this otherwise incurable disease with conventional modalities.

133 However MCL remains a largely incurable disease, and following relapse, it can be a ch

134 t time, AML remains a devastating and mostly incurable disease, but the combination of optimized chem

135 HIV/AIDS remains a chronic and incurable disease, in spite of the notable successes of

136 ose and patients often present with advanced incurable disease.

137 o the development of an indolent and largely incurable disease.

138 er (SCLC) at advanced stage is considered an incurable disease.

139 therapeutic target for the treatment of this incurable disease.

140 utes a potential therapeutic target for this incurable disease.

141 r therapeutic intervention in this otherwise incurable disease.

142 us cell cancer (ESCC) present with advanced, incurable disease.

143 rly drug development trials in children with incurable disease.

144 Metastatic melanoma remains a mostly incurable disease.

145 radiotherapy, making radioresistant CRPC an incurable disease.

146 vival time, myeloma continues to be a mostly incurable disease.

147 ise as a therapeutic strategy to combat this incurable disease.

148 potential opportunity for treatment of this incurable disease.

149 novel therapeutic target for this currently incurable disease.

150 hronic lymphocytic leukemia (CLL) remains an incurable disease.

151 Ataxia Type 3 (SCA3), one of nine inherited, incurable diseases caused by similar mutations.

152 re toxic, causing or contributing to severe, incurable diseases including Alzheimer's and prion disea

153 mation of amyloid fibrils is associated with incurable diseases including Alzheimer's, Parkinson's, a

154 ting peripheral neuropathies are progressive incurable diseases without effective treatment.

155 ic and induced) for regenerative medicine of incurable diseases, immunotherapy and blood transfusions

156 sfolded proteins are the hallmark of several incurable diseases, including Alzheimer's disease, type-

157 o offer unproven procedures to patients with incurable diseases.

158 peutic alternative for many debilitating and incurable diseases.

159 s to vaccination, implantation, and treating incurable diseases.

160 ous potential for clinical treatment of many incurable diseases.

161 Muscular dystrophies are common, currently incurable diseases.

162 HIV infection is incurable due to a long-lived reservoir of HIV(+)memory

163 is a plasma cell malignancy that is largely incurable due to development of resistance to therapy-el

164 diagnostic and therapeutic tools, AD remains incurable due to its complex and multifactorial nature a

165 e sarcoma and soft-tissue sarcomas (STS) are incurable due to the inability to eradicate chemoresista

166 atic and castration-resistant cancer remains incurable due to the lack of effective therapies.

167 aging hematopoietic system and are currently incurable due to therapy-resistant, disease-reinitiating

168 ia in the western countries and is currently incurable due, in part, to difficulty in eliminating the

169 option for patients suffering from otherwise incurable end-stage pulmonary diseases such as chronic o

170 sure for a clinical trial to treat currently incurable eye diseases severely affecting cone vision de

171 ulmonary fibrosis (IPF) is a progressive and incurable fibroproliferative disorder characterized by u

172 ntinues to increase, and the disease remains incurable for many due to its metastatic nature and high

173 volves blood, bone marrow, and spleen and is incurable for most patients.

174 llicular lymphoma is a very common and still incurable form of lymphoma.

175 for patients with refractory NB, thus far an incurable form of this disease.

176 uired to develop new therapies for currently incurable forms of AMD.

177 Friedreich's ataxia is an incurable genetic disorder caused by a mutant expansion

178 Endometriosis is an incurable gynecological disorder characterized by debili

179 Patients were considered incurable, had measurable disease, and were treated with

180 eoplasm (BPDCN) is an aggressive and largely incurable hematologic malignancy originating from plasma

181 Multiple myeloma (MM) is an incurable hematologic malignancy that often exhibits abn

182 Currently, CTCL is incurable, highlighting the need for new therapeutic mod

183 Light chain (AL) amyloidosis is an incurable human disease characterized by the misfolding,

184 protein ion channels underlie many currently incurable human diseases.

185 Waldenstrom's macroglobulinemia is an incurable, IgM-secreting lymphoplasmacytic lymphoma (LPL

186 Metastatic breast cancer (MBC) remains an incurable illness in the majority of cases, despite majo

187 erative transmissible agents causing several incurable illnesses in humans and animals.

188 ions in 68% of ICCs and that the disease was incurable in 85% of ICCs.

189 Stage III/IV melanoma remains incurable in most cases due to chemotherapeutic resistan

190 While motor neuron diseases are currently incurable, induced pluripotent stem cell research has un

191 , we can expect to see a substantial rise in incurable infection and fatality in both developed and d

192 itis pigmentosa (RP) is the leading cause of incurable inherited blindness in the developed world, wi

193 Herpesviruses, including HCMV, persist in an incurable, latent state that has profound implications f

194 -cell chronic lymphocytic leukemia (CLL), an incurable leukemia, is characterized by defective apopto

195 Sezary syndrome (SS) is an incurable leukemic variant of cutaneous T-cell lymphoma

196 ve historical controls who began therapy for incurable lung cancer at least 1 year before the start o

197 Although patients receiving RT for incurable lung cancer believe it will help them, most do

198 and January 2011, 102 eligible patients with incurable lung cancer were approached, and 100 agreed to

199 tient expectations about the goals of RT for incurable lung cancers.

200 iety and Depression Scale) within 8 weeks of incurable lung or GI cancer diagnosis.

201 data from 350 patients with newly diagnosed incurable lung or GI cancer.

202 domly assigned patients with newly diagnosed incurable lung or noncolorectal GI cancer to receive eit

203 record remain low, even among patients with incurable malignancies.

204 PEL is an incurable malignancy and has extremely poor prognosis wh

205 Multiple myeloma (MM) remains an incurable malignancy due, in part, to the influence of t

206 lear cell renal cell carcinoma (CCRCC) is an incurable malignancy in advanced stages and needs newer

207 r systemic treatment of multiple myeloma, an incurable malignancy of antibody-secreting plasma cells

208 Primary effusion lymphoma (PEL) is a largely incurable malignancy of B cell origin with plasmacytic d

209 Multiple myeloma is an incurable malignancy of plasma cells, and its pathogenes

210 Multiple myeloma (MM) is a nearly always incurable malignancy of plasma cells, so new approaches

211 Follicular lymphoma is an incurable malignancy, with transformation to an aggressi

212 er gene in chordoma.Chordoma is a rare often incurable malignant bone tumour.

213 e within 10 years and eventually progress to incurable metastatic disease.

214 d malignancy, not infrequently presenting as incurable metastatic disease.

215 al muscular dystrophy (FSHD) is a prevalent, incurable myopathy, linked to hypomethylation of D4Z4 re

216 lin-mutant mouse models of the inherited and incurable nerve disorder, Charcot-Marie-Tooth (CMT) neur

217 Retinitis pigmentosa (RP) is an incurable neurodegenerative condition featuring photorec

218 Spinocerebellar ataxia type 1 (SCA1) is an incurable neurodegenerative disease caused by a pathogen

219 This incurable neurodegenerative disease is the most prevalen

220 Sporadic Alzheimer's disease (AD) is an incurable neurodegenerative disease with clear pathologi

221 Parkinson's disease (PD) is an insidious and incurable neurodegenerative disease, and represents a si

222 lateral sclerosis (ALS) is a devastating and incurable neurodegenerative disease, characterised by pr

223 nted promise for the treatment of this still incurable neurodegenerative disease.

224 lyQ) tracts beyond a certain threshold cause incurable neurodegenerative diseases.

225 Parkinson disease is a debilitating and incurable neurodegenerative disorder affecting approxima

226 Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disorder affecting motoneuro

227 Huntington's disease is an inherited and incurable neurodegenerative disorder caused by an abnorm

228 Huntington's disease is an incurable neurodegenerative disorder caused by expansion

229 Alzheimer's disease (AD) is an incurable neurodegenerative disorder clinically characte

230 To find new keys to this incurable neurodegenerative disorder we focused on the p

231 he pathological role of TMEM106B in FTLD, an incurable neurodegenerative disorder.

232 the mainstay of symptomatic therapy for this incurable neurodegenerative disorder.

233 isease (AD) and similar dementias are common incurable neurodegenerative disorders in the aging popul

234 scinoses (NCLs) are a group of inherited and incurable neurodegenerative disorders primarily afflicti

235 fidence in legitimate stem cell research for incurable neurological diseases such as multiple scleros

236 Huntington's disease (HD) is an incurable neurological disorder caused by an abnormal gl

237 ) protein causes Huntington disease (HD), an incurable neurological disorder.

238 enne muscular dystrophy is a progressive and incurable neuromuscular disease caused by genetic and bi

239 Cutaneous T-cell lymphoma (CTCL) is an incurable non-Hodgkin lymphoma of the skin-homing T cell

240 lief of malignant dysphagia in patients with incurable oesophageal cancer.

241 Multiple myeloma is incurable once osteolytic lesions have seeded at skeleta

242 veral tuberculosis-endemic countries to drug-incurable or programmatically incurable tuberculosis (to

243 f low-risk PC and, conversely, lower risk of incurable PC and lower PC mortality.

244 roups and novel therapeutic targets for this incurable pediatric cancer.

245 These incurable peripheral nerve tumors result from loss of NF

246 Multiple myeloma is an incurable plasma cell cancer selectively localized in th

247 ulin light-chain (AL) amyloidosis is a rare, incurable plasma cell disorder.

248 Multiple myeloma (MM) is an incurable plasma cell malignancy of the bone marrow.

249 Multiple myeloma is an incurable plasma cell malignancy with a complex and inco

250 Multiple myeloma (MM) is an incurable plasma-cell neoplasm for which most treatments

251 otoreceptor degenerations (IPDs), a group of incurable progressive blinding diseases, are caused by m

252 s an early inflammatory phase followed by an incurable progressive phase with subdued inflammation an

253 sheep, small ruminant lentiviruses cause an incurable, progressive, lymphoproliferative disease that

254 Light chain amyloidosis is an incurable protein misfolding disease where monoclonal im

255 s a promising therapeutic strategy for these incurable Ras-driven tumors and highlight the utility of

256 Diastrophic dysplasia (DTD) is an incurable recessive chondrodysplasia caused by mutations

257 uffering from breast cancer often succumb to incurable recurrent disease resulting from therapy-resis

258 ctasia (AT) is a rare genetic disease, still incurable, resulting from biallelic mutations in the ata

259 nown as retinal degeneration slow/RDS) cause incurable retinal degeneration with a high degree of phe

260 involvement (4 [6.7%]), or other (8 [13.3%]) incurable sites.

261 confirmed diagnosis of advanced, malignant, incurable solid tumours from University of California at

262 a recommended phase 2 dose in patients with incurable solid tumours, especially those with melanoma

263 Eligible patients had incurable solid tumours, were 18 years or older, and had

264 HSV infections represent an incurable source of morbidity and mortality in humans an

265 ary tumor should be removed in patients with incurable stage IV colorectal disease.

266 , most pancreatic cancers are detected at an incurable stage owing to the absence of disease-specific

267 Does the dogma that multiple myeloma is incurable still hold?.

268 tle cell lymphoma (MCL) is an aggressive and incurable subtype of B-cell non-Hodgkin lymphomas.

269 The chronic form remains incurable, there are no vaccines, and 2 existing drugs f

270 V), and herpes simplex virus (HSV) have been incurable to date because effective antiviral therapies

271 ntries to drug-incurable or programmatically incurable tuberculosis (totally drug-resistant tuberculo

272 203 (74%) had programmatically incurable tuberculosis and unfavourable outcomes (treatm

273 The emergence of programmatically incurable tuberculosis threatens to destabilise control

274 n half of the patients with programmatically incurable tuberculosis were discharged into the communit

275 Glioblastoma is an incurable tumor, and the therapeutic options for patient

276 1-deficient lymphocytes induced rejection of incurable tumors and promoted protection against tumor r

277 to obtain major improvements in survival of incurable urothelial cancer.

278 Follicular lymphoma (FL) is currently incurable using conventional chemotherapy or immunothera

279 rpes simplex virus 1 (HSV-1) infection is an incurable viral infection with the most significant morb

280 cting the macula constitute a major cause of incurable vision loss and exhibit considerable clinical

281 is a leading cause of blindness resulting in incurable visual impairment and drastic reduction in the

282 utations of Crb1 gene cause irreversible and incurable visual impairment in humans.

283 nical management of MM, it remains uniformly incurable with a dismal median survival time post-treatm

284 eatures because these patients are virtually incurable with chemotherapy alone.

285 tients with acute myeloid leukemia (AML) are incurable with chemotherapy and may benefit from novel a

286 ced follicular lymphomas (FL) are considered incurable with conventional chemotherapy and there is no

287 on leukemia in the Western world and remains incurable with conventional chemotherapy treatment appro

288 Follicular lymphoma (FL) is incurable with conventional therapies and has a clinical

289 common in patients aged >/= 60 years and are incurable with conventional therapies.

290 (MCL) has a variable natural history but is incurable with current therapies.

291 Recurrent glioblastoma multiforme (GBM) is incurable with current therapies.

292 midline high-grade astrocytomas (mHGAs) are incurable with few treatment targets identified.

293 in lymphomas, these lymphomas remain largely incurable with standard therapies.

294 However, CLL remains largely incurable, with drug resistance and treatment relapse a

295 are primary brain tumours that are generally incurable, with heterogeneous prognosis and few treatmen

296 This malignancy is considered virtually incurable, with high response rates to therapy but frequ

297 all therapeutic efforts, they remain largely incurable, with the most aggressive forms being lethal w

298 Duchenne muscular dystrophy (DMD) is an incurable X-linked genetic disease that is caused by a m

299 Duchenne muscular dystrophy (DMD) is an incurable X-linked muscle-wasting disease caused by muta

300 sis of luminal breast cancer is frequent and incurable, yet the metastasis mechanisms are poorly unde