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1 Owing to this complexity, an Independent Data and Safety Monitoring Board (DSMB) is best suited to deal with s
2 The trial was suspended by the sponsor and the independent data and safety monitoring board because of both a lack of efficacy a
3 Thirteen months after enrollment, the independent data and safety monitoring board detected an unanticipated imbalance
4 The study was terminated early after the independent data and safety monitoring board noted an increased annualised relaps
6 ects randomized to warfarin (14 warfarin versus 3 placebo deaths; P = 0.005) an independent Data and Safety Monitoring Board recommended stopping the study after
7 included 1135 primary end-point events (71% of the projected total number), the independent data and safety monitoring board recommended termination of the trial
8 At a prespecified interim analysis, including 212 primary end point events, the independent data and safety monitoring board recommended termination of the trial
9 A scheduled interim review by an independent data and safety monitoring board showed significant differences in vi
10 ence of physiological or clinical benefit for combination therapy, prompted the independent data and safety monitoring board to recommend termination of the comb
11 The study was terminated early by an independent data and safety monitoring board when statistically significant resul
12 The study was terminated early, on the recommendation of an independent data and safety monitoring board, after the interim analysis showed e
13 After review of the interim analysis by an independent data and safety monitoring board, crossover from dacarbazine to vemur
14 After a recommendation by an independent data and safety monitoring board, randomisation was stopped and immed
15 Following the first planned interim monitoring conducted by an independent data and safety monitoring board, study enrollment was terminated.
16 A preplanned interim analysis was performed by an independent data and safety monitoring committee after 359 progression-free survi
17 The study was terminated based on the recommendation of an independent data and safety monitoring committee after the second of three planne
18 Trial recruitment stopped early at the recommendation of the independent data and safety monitoring committee because of a significant differe
21 or and the steering committee terminated the trial on the recommendation of the independent data and safety monitoring committee; the median follow-up was 9 mont
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