ライフサイエンスコーパス: index case

1 on the spleen and brain of the donor to the index case.

2 al coregulator, HCFC1, was identified in the index case.

3 eening radius around each passively detected index case.

4 cluding fatal intracranial hemorrhage in the index case.

5 1, 2 and 3 of phospholipase C-beta 1 in the index case.

6 mial transmission of infection from a single index case.

7 investigations in response to reports of an index case.

8 3) and duration of exposure (p=0.007) to the index case.

9 in a UK school resulted from one infectious index case.

10 with the degree of exposure to an infectious index case.

11 le in development of the LPD observed in the index case.

12 equent cases occurring within 2 weeks of the index case.

13 22 (73%) occurred 14 or fewer days after the index case.

14 cases between 8 and 28 d after onset of the index case.

15 e genes are known for fewer than 40% of PCLD index cases.

16 n of eleven different CDHR1 variants in nine index cases.

17 infection occurred in household contacts of index cases.

18 3804 were diagnosed with CRC and defined the index cases.

19 ence in high-incidence areas, and sex of the index cases.

20 was traced to single clinical contacts with index cases.

21 tations were identified in 56 PCG and 7 ndJG index cases.

22 s (>6%) only occurs from approximately 5% of index cases.

23 = .049) and a mutation frequency of 1.03% in index cases.

24 h the greatest reported risk to relatives of index cases.

25 , and there have been no deficiencies in RRC index cases.

26 nd prophylactic surgery for the relatives of index cases.

27 segregation analysis in the families of the index cases.

28 sis of the illness and speed the response to index cases.

29 osegregation analysis in the families of the index cases.

30 ne cohorts of individuals exposed to cholera index cases.

31 ndary analysis with typing data were assumed index cases.

32 us POLR3A mutations in approximately 3.1% of index cases.

33 2 household contacts of 487 drug-susceptible index cases.

34 berculosis in adult contacts of tuberculosis index cases.

35 a-like illness than contacts of HIV-negative index cases.

36 Index cases (12404 children) from all children younger t

37 ions (14 novel) were identified in 34 of 183 index cases (19%).

38 health care personnel (HCP) contacts of the index case, 22 (20%) had known unprotected exposures and

39 Among 5,020 contacts of 1,023 index cases, 25 prevalent secondary cases were identifie

40 Two of seven index cases (28%) harbored the reciprocal RNA chimeras i

41 had a parent or sibling with CAD among these index cases, 30 asymptomatic subjects with comparable co

42 hythmogenic right ventricular cardiomyopathy index cases, 44 patients received secondary prevention i

43 a study conducted in 277 households with 298 index cases (62% with laboratory-confirmed influenza) an

44 total of 2047 well-characterized familial BC index cases, 628 OC cases, and 2187 geographically match

45 , 2047 well-characterized familial female BC index cases, 628 OC cases, and 2187 geographically match

46 ews were available for 1728 individuals (641 index cases, 800 siblings, 287 controls) with lifetime d

47 DSM-III-R criteria was highly stable in the index cases (90.5% women, 94.7% men) but much less stabl

48 cardiac PET perfusion imaging, including 18 index cases (a subject with CAD documented by PET and ar

49 in 5 bacterial variants originating from the index case A1 with 0-2 mutations per transmission event

50 diatric surgeons receive limited exposure to index cases after training.

51 SIs were shortest for older index cases (age 11-14 years) and for younger infected h

52 the entire household versus decolonizing the index case alone.

53 ividual contacts, compared with treatment of index cases alone.

54 Five of the index cases also had mild thrombocytopenia.

55 business complex were ill; although not the index case, an employee ill shortly before the outbreak

56 Between 55 and 70% of index cases analysed have a candidate von Willebrand fac

57 icians involved in diagnosing anthrax in the index case and alerting authorities, we offer our perspe

58 f these tests with degree of exposure to the index case and BCG vaccination.

59 h of the 12 GLUT5 exons was performed in the index case and confirmed the negative single-strand conf

60 cal, biochemical, and genetic analyses of an index case and her two sons.

61 associated with increased infectivity of the index case and highlights the importance of considering

62 rs and siblings, 19 babies had more than one index case and in 21 families there was one index for mo

63 Platelets from the index case and relatives carrying the K174E defect chang

64 ar irrespective of the sex of the sibling or index case and were particularly strong in siblings of h

65 among 1,055 household contacts of 213 MDRTB index cases and 2,362 household contacts of 487 drug-sus

66 ients were informative and revealed that the index cases and all available affected siblings were com

67 Family and medical history was obtained from index cases and family members.

68 screening high-risk groups (i.e. siblings of index cases and first degree relatives, patients with Ty

69 coding region of the FANCM gene in familial index cases and geographically matched controls is pendi

70 th VWF gene sequencing was performed for all index cases and healthy control subjects in a central la

71 ed autosomal-recessive mutations in the four index cases and in 12 patients with sporadic IIH.

72 coverage amongst individuals located near to index cases and in areas where spraying has not been con

73 nce with ARVC/D was dominated by symptomatic index cases and sudden cardiac death victims-the overt o

74 tations are responsible for only 20% of FEVR index cases and suggests that the other FEVR loci may ac

75 e and other characteristics of 251 pediatric index cases and their 315 infected household contacts on

76 recorded occurrence of that ST in that herd (index case) and all persistent infections with that PTE

77 ndrial cybrids established from the proband (index case) and offspring, the marked respiratory defici

78 d to (1) event pigs, (2) other pigs, (3) the index case, and (4) persons without pig or index case ex

79 10 (33%) occurred 2 or fewer days after the index case, and 22 (73%) occurred 14 or fewer days after

80 actly concordant if CHD was identical to the index case, and concordant for the group if belonging to

81 pulation, the reproduction number of cluster index cases, and cluster sizes to characterise the dynam

82 n cohort, we identified 2017 contacts of 715 index cases, and median follow-up was 10.7 years (IQR 9.

83 uberculosis infection, the HIV serostatus of index cases, and other variables were performed.

84 Contacts of tuberculosis index cases are at increased risk of developing tubercul

85 ological and genetic data and identified the index case as the major source of the virus, suggesting

86 We also identify the index case as the major source of virus, indicating that

87 , and higher levels of systemic virus in the index case, as measured by plasma RNA viral load, have b

88 Among 14,041 household contacts (of 3,446 index cases) assessed for infection and disease during t

89 The index case at age 10 demonstrated multifocal vitelliform

90 henotype of the pedigree and genotype of the index case at ascertainment.

91 ly produced sputum samples may help identify index cases at high risk of transmission.

92 e, sustained exposure to the index case, the index case being in a male patient, lower community hous

93 ontrols who were individually matched to the index cases by age, gender, neighborhood of residence at

94 ing transitions between stages showed how an index case can escalate into a widespread epidemic in th

95 In CDH1 mutation-negative index cases, candidate mutations were identified in 16 o

96 a Cox proportional hazards model to identify index case, contact, and household risk factors for tube

97 compared using different distances from the index case/control to define the rings and different tim

98 zoonotic hosts or vectors, identifying where index cases could present.

99 An autopsy completed on 1 individual, our index case, demonstrated Lewy bodies in the brainstem an

100 None of the 251 siblings of the index cases developed clinical features of mtDNA disease

101 1,055 (3.3%) household contacts of 213 MDRTB index cases developed tuberculosis disease, while 114/2,

102 adults (>15 yr) with incident pulmonary TB (index cases) diagnosed at 106 public health centers in L

103 ee of heart failure and alive at the time of index case diagnosis and matched on age, year of birth,

104 Cough duration of index cases did not display interaction (P = 0.499 for i

105 Minor CHD in the index case does not exclude more severe disease in recur

106 is independently of tuberculin skin test and index-case drug sensitivity results.

107 tween 8 and 28 d after exposure to a cholera index case during the first 2 y was 91% (95% CI 62%-98%)

108 Number of index cases during the preceding year.

109 2) contribute to the bleeding tendency in 92 index cases enrolled in the European MCMDM-1VWD study.

110 Index cases (exposed to colonoscopy) were colonoscopy pa

111 Of 8 index case-exposed persons and 10 without exposures, non

112 e index case, and (4) persons without pig or index case exposure.

113 The strain from the male index case expressed both glycoforms and exhibited both

114 Aspergillus fumigatus was recovered from the index case, Exserohilum rostratum was the primary pathog

115 Clinical information for each of the index cases, first-degree relatives, and any family memb

116 Mothers and siblings amounted to 71% of the index cases for newborn babies with VUR.

117 thout cholera was randomly selected for each index case from the same population, matched by age grou

118 nd BRCA2 mutation testing was carried out on index cases from 119 families with site-specific epithel

119 the RPS19 gene was directly assessed in DBA index cases from 172 new families.

120 edigrees with inherited neuropathies and 163 index cases from Australian, European, and Korean distal

121 tion in 150 PTD patients, either sporadic or index cases from small PTD families.

122 for association with type 2 diabetes in 786 index cases from type 2 diabetic families and 619 normal

123 Thirty-three of these 43 index cases had a "Schwartz" score (> or =4) suggesting

124 Approximately 11% (43 of 388) of the index cases had a positive swimming phenotype.

125 in first-degree relatives was higher if the index cases had an unprovoked compared with a provoked V

126 All index cases had mild to borderline ID combined with beha

127 household contacts of HIV-infected influenza index cases had twice the risk of developing secondary i

128 by the time of identification of symptomatic index cases, half of transmission had already occurred,

129 Similar to index cases, Hashimoto thyroiditis, psoriasis, and infla

130 Although most index cases have a positive family history of VHL, some

131 usness of HIV-seropositive and -seronegative index cases have been performed in sub-Saharan Africa.

132 hich a mutation has not been identified, the index cases have had 125 children, of whom only 29 are a

133 ous right coronary artery despite 2 of the 5 index cases having anomalous left coronary artery.

134 fection causing severe viral pneumonia, with index cases having resided in or recently travelled to t

135 tly transmitted network with probably single index case, high frequency of primary drug resistance an

136 ong household contacts within 1 month of the index case highlights a potential role for antibiotic pr

137 affect the likelihood of being an influenza index case, household contacts of HIV-infected influenza

138 , and VWF mutation analysis performed in all index cases (ICs).

139 rst analysis, individuals living around each index case identified during the 5-y period were assembl

140 on ancestor which was closely related to the index case identified in wild boar.

141 f ITP, implemented after presentation of the index case, identified all 5 subsequent cases before ser

142 tered) M. tuberculosis genotypes and cluster index cases (ie, the first tuberculosis case in a cluste

143 sing a consecutive sample of 33 cases plus 1 index case in an academic medical center.

144 er for siblings who immediately followed the index case in birth order compared with those later in b

145 he number of secondary cases generated by an index case in the absence of control interventions R0.

146 nvestigation should include HIV-seropositive index cases in high disease burden settings.

147 We show how in these EVD outbreaks the index cases in humans (i.e. spillover from wildlife rese

148 The difference between confirmed and assumed index cases in VUR prediction was not significant.

149 Index cases included 284 098 ambulatory surgical procedu

150 d in each woman it was derived from a single index case, indicating that diversity was most likely to

151 eichoic acid (LTA) was abolished only in the index case individual, the only family member lacking LT

152 ed exome sequencing on germline DNA of eight index-case individuals from eight unrelated kindreds wit

153 Accurate diagnosis of the index case is essential for reliable counseling on patte

154 al therapy (ART) provided to an HIV-infected index case led to greatly reduced transmission of HIV to

155 HIV-infected influenza index cases may facilitate transmission of influenza wit

156 ldren who had no identified MDR-tuberculosis index case (median delay, 123 vs 58 days; P < .001).

157 CDH1 germline mutations was performed on 183 index cases meeting clinical criteria for HDGC.

158 The index case occurred in a healthy child who had been vacc

159 ntact patients, after a mean exposure to the index case of 4.3 days.

160 The bacterial metalloregulator MerR is the index case of an eponymous family of regulatory proteins

161 crosomal cytochrome P450c17, and because the index case of apparent isolated 17,20-lyase deficiency h

162 The index case of Family A had bulbar ALS and frontemporal d

163 The index case of Family B developed spinal ALS without FTD

164 rs of northern California households with an index case of gastroenteritis were interviewed regarding

165 nvestigation prompted by an unusually severe index case of infectious pulmonary tuberculosis.

166 frameshift mutation in the ABC1 gene of the index case of Tangier disease.

167 importantly, once a mutation is found in an index case of the family, relatives can be tested for th

168 ular, we identified the cocirculation in the index case of two viral strains showing a different inse

169 ha-synuclein gene were amplified by PCR from index cases of 30 European and American Caucasian kindre

170 Among the subjects with index cases of laboratory-confirmed influenza, the media

171 results of a screen of 230 European familial index cases of Parkinson's disease for the recently desc

172 Families (n=340) of index cases of sudden cardiac deaths who underwent postm

173 f 13 shared the same country of birth as the index case, of whom ten did not share a strain type or d

174 investigated the influence of the sex of the index case on disease penetrance within families.

175 -resistant variants were detected in treated index cases or contacts.

176 Within households, younger age of either index cases or susceptible contacts elevated the odds of

177 fections acquired the infections mostly from index cases outside the study population, such as retrea

178 indoor-outdoor location at the time of each index case participant's homicide.

179 Providing care for the index case patient and watching television with the inde

180 The estimate was significantly higher if the index case patient was a sibling (SIR, 5.01 [CI, 3.30 to

181 ase patient and watching television with the index case patient were risk factors among parents and s

182 xposed cohort) with a first-degree relative (index case patient) previously hospitalized with S aureu

183 The index case patient, nursed in source isolation, develope

184 Older children were index case patients for 11 (73%) of the within-household

185 Index case patients underwent a standard evaluation, and

186 the highest rates in individuals exposed to index case patients with non-hospital-acquired infection

187 One index case (PD onset age 33) inherited a GIGYF2 mutation

188 g by first-degree relatives of two groups of index cases: people homozygous for the C282Y mutation as

189 hom two or more first-degree relatives, i.e. index case plus one extra have been affected.

190 uitability maps were used to define stage 1, index-case potential, which assesses populations at risk

191 unrelated consanguineous families, where the index cases presented with classical DC or the more seve

192 patients revealed 20 sequence variants in 17 index cases presenting with homozygous or compound heter

193 ubset of these uncharacterized families, the index case presents with severe disease previously defin

194 members of 73 Hispanic families in which an index case (proband) had hypertension.

195 n a cross-sectional analysis, we studied 139 index cases (probands and unrelated individuals) with FE

196 When combined with the treatment of index cases, prophylactic treatment of family members wi

197 d among smear-positive versus smear-negative index cases (ratio of odds ratios = 5.45, 95% CI: 3.43,

198 course stabilized and improved, although the index case recently died from bronchopneumonia.

199 We selected 1008 index cases, regardless of family history of cancer, and

200 46 (26%) index cases reported at least one coexisting autoimmune

201 imens positive for SIV within 2 weeks of the index case's illness.

202 ependence varied among the subject groups of index cases, siblings, and community-based controls.

203 tus, contact age, socio-economic status, and index case sputum smear grade, the hazard ratio for tube

204 onsiveness, chronic bronchitis symptoms, and index case status.

205 ncoding the metalloprotease neprilysin in 19 index case subjects diagnosed with axonal polyneuropathi

206 We initially genotyped 134 SNPs on 786 index case subjects from type 2 diabetes families and 61

207 unaffected spouses and offspring of FUSION 1 index case subjects or their affected siblings, and 223

208 The index case subjects were two brothers, individuals 1 and

209 lotype, or haplogenotype frequencies between index case subjects with diabetes and the elderly and sp

210 We screened 51 index case subjects with late-onset CMT2 for mutations b

211 IDDM Genetics [FUSION] 1) and 255 (FUSION 2) index case subjects with type 2 diabetes, 185 and 414 un

212 Characteristics of the index case, such as age and stage at diagnosis, subsite

213 The findings in these index cases support a model in which early development o

214 siblings (1.5 [1.2-1.9], p<0.0001) of female index cases than among those of male cases.

215 From this index case the virus was spread by human-to-human contac

216 for atypical mycobacterial infection of the index case, the affected individuals did not have notabl

217 As with the index case, the anemia did not improve until 12 to 15 we

218 tuberculosis, age, sustained exposure to the index case, the index case being in a male patient, lowe

219 cted data on the smear and culture status of index cases, the age and bacillus Calmette-Guerin vaccin

220 s enabled confirmatory clinical diagnosis in index cases through exclusion of phenocopies and provide

221 th and without a microbiologically confirmed index case to estimate the age-specific risk of infectio

222 h the risk of transmission of infection from index cases to contacts and compared this with sputum mi

223 ay allow campaign strategies that respond to index cases to successfully target subpatent infections

224 Eleven of 25 index cases underwent ICD implantation.

225 idate gene haplotypes within pedigrees of 14 index cases, using a covariance components model for mul

226 All index cases versus none of the historical IHPS cases had

227 Of clinical strains from the index cases, veterinary and environmental HEV strains we

228 r of sexual partners medically evaluated per index case was 5.9.

229 The index case was a 72-year-old woman who suffered progress

230 Our index case was a patient with common variable immunodefi

231 fter vaccination and was similar whether the index case was a young child (<5 y) or was older.

232 The affected mother of the index case was an obligatory carrier.

233 The index case was compound heterozygous for p.A195V and a n

234 The male index case was diagnosed with HCM after an out-of-hospit

235 neous, even when the virus population in the index case was genetically diverse.

236 confidence interval [CI], 1.43-3.85), if the index case was younger (OR, 0.97 per year older; 95% CI,

237 e RR for diverticular disease in siblings of index cases was 2.92 (95% confidence interval [CI], 2.50

238 The cause of ESRD in index cases was consistent with hypertension-associated

239 The female/male sex ratio among index cases was more than 4, but among newborn babies wi

240 Purified DNA obtained from the 42 index cases was screened for germ-line p53 mutations in

241 first affected individual in the family (the index case) was a mosaic for a disease-causing mutation.

242 equencing combined with RNA sequencing of an index case, we analyzed a total of six SN-HPCs for mutat

243 ls followed by whole-exome sequencing of the index case, we identified a previously undescribed homoz

244 In a survey of 197 familial ALS index cases, we identified two further missense mutation

245 suggested that household contacts of a DF(+) index case were at greater risk of infection with V. cho

246 detecting a case within the household of the index case were significantly higher than in neighbourin

247 The index cases were 182 alcoholic criminal offenders, throu

248 Patients identified as index cases were contacted by mail and asked to reply on

249 A total of 269 child contacts of 140 index cases were evaluated.

250 The index cases were identified from a wide range of family

251 0-79 years; 46.7% women) identified from 221 index cases were included.

252 Major index cases were largely concentrated with small groups

253 Cluster index cases were significantly more likely than other tu

254 nd 299 paternal half siblings born after ASD index cases were used to calculate recurrence risks.

255 contacts ("contact cases") to active cases ("index cases") were studied.

256 ng Enterobacteriaceae for at least 24 hours (index case) were screened for ESBL carriage by testing o

257 Consecutive patients admitted with CRC (index cases) were prospectively evaluated, and those who

258 hat recurrence risks may well be <50% in the index case when a mutation is not identified in lymphocy

259 lications of our study are illustrated by an index case where deep brain stimulation of estimated pre

260 (or both) of infectious virus present in the index case, which in turn will influence the quantity of

261 Five elderly index cases who had died at the stage of mild cognitive

262 16 received vinblastine; we also include our index case, who began vinblastine following relapse in 1

263 identification of an inferred source (i.e., index case), whose identity was revealed at trial to be

264 seven multiplex kindreds ascertained via an index case with a nonsyndromic solitary kidney or renal

265 After serendipitously identifying an index case with ALMCA, we examined proximal coronary art

266 uary 2004 to December 2013, contacts of each index case with CDI were screened for toxigenic C. diffi

267 Among first-degree relatives of an index case with factor V Leiden or the prothrombin 20210

268 The index case with the presenilin-2 mutation had late-onset

269 idate platelet function disorder genes in 13 index cases with a history of excessive bleeding in asso

270 Analyses restricted to index cases with a young age at onset (< or = 21 years)

271 tested 148 healthy relatives of 70 Romanian index cases with biopsy-proven CD (87% of all first-degr

272 Exome sequencing was performed in three index cases with bone marrow failure and neurological dy

273 We investigated a series of 97 index cases with complex spastic paraplegia referred to

274 nd Palestinian populations, we recruited 220 index cases with cone-dominated diseases, of which 2 car

275 ome-wide rare variant burden analysis of 363 index cases with familial ALS (FALS).

276 Eighty-five of 122 white index cases with FECD (69.7%) harbored the triplet repea

277 Of the 1567 index cases with half-siblings in multiple sclerosis cli

278 encoding matrix metallopeptidase 21) in nine index cases with heterotaxy.

279 RTEL1 identified biallelic mutations in 6/23 index cases with HHS but none in 102 DC or DC-like cases

280 s candidate genes from exome sequencing in 3 index cases with imaging features of brain iron accumula

281 ividuals, 349 sib pairs) ascertained through index cases with neovascular disease or geographic atrop

282 osure prophylaxis (PEP) and treatment of ill index cases with oseltamivir, in an attempt to prevent i

283 recruited contacts aged 15 years or older of index cases with pulmonary tuberculosis who lived in des

284 discussion is the evaluation of siblings of index cases with reflux.

285 ol patients were individually matched to the index cases with respect to multiple clinical and pathol

286 trospective analysis was performed comparing index cases with the rest of the cases in our institutio