ライフサイエンスコーパス: indirect mechanism

1 appears to be regulated by Nkx2.2 through an indirect mechanism.

2 ted by AvrPphB, a bacterial protease, via an indirect mechanism.

3 direct phospho donor or functions through an indirect mechanism.

4 f1 could induce Runx2 degradation through an indirect mechanism.

5 ing of guanidinoacetate, possibly through an indirect mechanism.

6 s by CD137 costimulation through a direct or indirect mechanism.

7 ations in RT may also be in part due to this indirect mechanism.

8 or binding and neuraminidase activity via an indirect mechanism.

9 by ACh (but not carbachol), also through an indirect mechanism.

10 e expression at high levels of glucose by an indirect mechanism.

11 ting DLP1 to peroxisome membranes through an indirect mechanism.

12 ivation by c-Jun appears to occur through an indirect mechanism.

13 ultured endothelial cells, which suggests an indirect mechanism.

14 oss-linking and is activated by Z through an indirect mechanism.

15 mation induced by v-Jun may occur through an indirect mechanism.

16 , but further investigation suggested a more indirect mechanism.

17 l promoter element induced by activin via an indirect mechanism.

18 ion with the Cdc2 complex, rather than by an indirect mechanism.

19 vation of CD4+ Th cells, possibly through an indirect mechanism.

20 ng that the effects of IL-12 occurred via an indirect mechanism.

21 3 protein but, rather, cooperates through an indirect mechanism.

22 double-negative (DN) T cell death through an indirect mechanism.

23 s bone formation in vivo, perhaps through an indirect mechanism.

24 ne, lysine, and methionine) are sensed by an indirect mechanism.

25 st which may function through a Fur-mediated indirect mechanism.

26 decrease in BzGSLs and SnGSLs via an unknown indirect mechanism.

27 timulates phosphorylation on S453/3/5 via an indirect mechanism.

28 ed the carbon catabolite protein CcpA via an indirect mechanism.

29 tations ("classics") are cited mainly by the indirect mechanism.

30 nces expression of these genes by direct and indirect mechanisms.

31 ed FOXP3, CD39, CD73, IL-10, and TGF-beta by indirect mechanisms.

32 sequent repression by Rep through direct and indirect mechanisms.

33 hormone-stimulated lipolysis via direct and indirect mechanisms.

34 e dissociation of corepressors by direct and indirect mechanisms.

35 cts on hepatic glucose fluxes via direct and indirect mechanisms.

36 CR4 promotes tumor progression by direct and indirect mechanisms.

37 8 through direct DNA binding, as well as via indirect mechanisms.

38 cient to cause neuronal damage via direct or indirect mechanisms.

39 ous monoclonal antibodies by both direct and indirect mechanisms.

40 urea denatures proteins via both direct and indirect mechanisms.

41 ves, an effect that involves both direct and indirect mechanisms.

42 As promote beta cell expansion by direct and indirect mechanisms.

43 l intercellular junctions through direct and indirect mechanisms.

44 te viral replication through both direct and indirect mechanisms.

45 ntrol DNA replication by multiple direct and indirect mechanisms.

46 e mechanism is shown to be quite general for indirect mechanisms.

47 vitro, indicating that these inducers act by indirect mechanisms.

48 gh direct interactions with the PPARs or via indirect mechanisms.

49 ytoplasmic dynein activity through direct or indirect mechanisms.

50 es are activated most commonly in disease by indirect mechanisms.

51 ray of cellular processes by both direct and indirect mechanisms.

52 ion of proinflammatory factors via direct or indirect mechanisms.

53 f gene transcription through both direct and indirect mechanisms.

54 which dually regulate AS through direct and indirect mechanisms.

55 s both through direct binding of ligands and indirect mechanisms.

56 sor of transcription through both direct and indirect mechanisms.

57 y influence BamA function by both direct and indirect mechanisms.

58 target genes by employing several direct and indirect mechanisms.

59 normally mediated via an extrahepatic (i.e., indirect) mechanism.

60 t this regulation in mouse occurs through an indirect mechanism, 1,25-(OH)2D3 acting on a gene geneti

61 ction of brain cells by HIV, suggesting that indirect mechanisms account for neuropathogenesis in the

62 the creation of double-stranded breaks by an indirect mechanism after quinolone treatment.

63 d serve to distinguish unambiguously between indirect mechanisms and direct binding mechanisms of ane

64 sulfur cluster biogenesis through direct and indirect mechanisms and have distinguishable target spec

65 rved is the likely result of both direct and indirect mechanisms and probably involves multiple recep

66 e: it contributes to maintaining latency via indirect mechanisms, and it may also synergize with Z an

67 et fully resolved, involving both direct and indirect mechanisms, and positive and negative effects.

68 HIV-1 RNase H may occur by either direct or indirect mechanisms, and they provide a framework for id

69 el findings demonstrate that a direct and an indirect mechanism are involved in TLR5-driven RA inflam

70 s for transactivation of target genes, while indirect mechanisms are also implicated in RTA transacti

71 utations affecting intersubunit geometry via indirect mechanisms are as important as interface sequen

72 Indirect mechanisms are implicated in the pathogenesis o

73 Indirect mechanisms are involved, because only a fractio

74 indicate that ADARs, through both direct and indirect mechanisms, are important for maintaining wild-

75 sin mediates sister chromatid cohesion by an indirect mechanism as well as one involving entrapment o

76 ycoprotein affects melanin synthesis through indirect mechanisms as well.

77 This compensation probably occurs through an indirect mechanism, as the binding affinity of proteins

78 enic neuropeptide Y (NPY) neurons through an indirect mechanism based on enhancing GABA-mediated inhi

79 nal end bud regression in virgin animals via indirect mechanisms, but acts directly on the mammary ep

80 These patterns could reflect direct and/or indirect mechanisms, but imply that individual variation

81 investigated the importance of the exogenous indirect mechanism by conducting photoinactivation exper

82 possible to ameliorate this immunopathologic indirect mechanism by developing therapies that target K

83 FV-short inhibits coagulation through an indirect mechanism by forming a complex with tissue fact

84 nhibit activation of tryptic KLKs through an indirect mechanism by inhibition of matrix metalloprotei

85 Here we report an indirect mechanism by which c-Jun can regulate transcrip

86 We have previously reported an indirect mechanism by which c-Jun is able to regulate tr

87 d (RA) on KGF expression in vitro provide an indirect mechanism by which RA may regulate the growth a

88 Ocn transcription by TGFbeta, confirming an indirect mechanism by which TGFbeta acts through vimenti

89 200 inhibits angiogenesis through direct and indirect mechanisms by targeting interleukin-8 and CXCL1

90 These data identify direct and indirect mechanisms by which BCR engagement facilitates

91 We propose two possible indirect mechanisms by which CTLA-4 may function in the

92 In addition, we identify both direct and indirect mechanisms by which miR-27a can regulate both M

93 lts strongly suggest that through direct and indirect mechanisms, CD8(+) T cells in some ES control H

94 s direct, endogenous indirect, and exogenous indirect mechanisms contribute to bacterial photoinactiv

95 It has been proposed that direct and indirect mechanisms contribute to the unresolved issue o

96 Indirect mechanisms derive from inflammation related to

97 ent in the promoter region of miR-98, and an indirect mechanism, down-regulating LIN-28 expression.

98 appear not to be infected, and the possible indirect mechanisms driving the neuronal toxicity have r

99 echanism (vasoconstriction) as well as by an indirect mechanism (e.g., inhibition of exocytosis from

100 s block the coagulation cascade either by an indirect mechanism (e.g., vitamin K antagonists) or by a

101 entation) or whether activation occurs by an indirect mechanism, e.g., via effects on CD4+ cells.

102 Some infections cause intraocular damage by indirect mechanisms (eg, HIV-mediated immunosuppression)

103 n tumor-promoting M2 macrophages may form an indirect mechanism for chemoresistance.

104 To test the indirect mechanism for FGF1 stimulation of PI 3-kinase a

105 pathway and provide further support for the indirect mechanism for FGF1 stimulation of PI 3-kinase i

106 racts with Bcl-XL but not BAX, suggesting an indirect mechanism for promoting Bax translocation to th

107 craniofacial skeletogenesis, and suggest an indirect mechanism for secondary cleft palate in Nog mut

108 tions of the TnC molecule, which provides an indirect mechanism for their pathogenic properties.

109 We identify a number of potential direct and indirect mechanisms for these responses, including the i

110 The indirect mechanism gives a power-law tail.

111 (111) and (100) facets, we predict that the indirect mechanism has a higher onset potential than the

112 Here, we show that the indirect mechanism has properties that are distinct from

113 d Au(111) are the cases where the direct and indirect mechanisms have the same onset potential.

114 to partially repress their expression by an indirect mechanism in the presumptive retina region in w

115 hat MOT1 might activate transcription via an indirect mechanism in which limiting TBP can be liberate

116 etation is possible within the context of an indirect mechanism in which solubilization of an anesthe

117 dylinositol (PI) 3-kinase are mediated by an indirect mechanism in which the docking protein fibrobla

118 The activation proceeded by an indirect mechanism in which thrombin cleaved components

119 Our data implicate indirect mechanisms in CXCL10 and CXCL11 repression by E

120 hat ATM may activate Chk1 by both direct and indirect mechanisms in mammalian cells.

121 cause Ad virions activate complement through indirect mechanisms in vivo.

122 id and occurs up to 70,000 times faster than indirect mechanisms in which heme is released into the s

123 ibitory effect on CYP7A1 transcription by an indirect mechanism, in contrast to the stimulation and b

124 We also show that the indirect mechanism, in which urea acts as a chaotrope, i

125 ough endothelial barriers by both direct and indirect mechanisms, including through a mechanism invol

126 ng the potential contribution of alternative indirect mechanisms/interactions between the Ag-SPs and

127 homocysteine is likely to be incorporated by indirect mechanisms into proteins in living organisms.

128 The indirect mechanism involves local ACh release, is potent

129 influence Jak-STAT signaling through a novel indirect mechanism involving a wt p53-dependent gene pro

130 Our results favor an indirect mechanism involving acid sphingomyelinase activ

131 our types this appears to be achieved via an indirect mechanism involving inappropriate expression of

132 es NFAT-dependent gene expression through an indirect mechanism involving induction of cardiac AP-1 a

133 147 expression influences Abeta levels by an indirect mechanism involving MMPs that can degrade extra

134 of III-AC by direct phosphorylation or by an indirect mechanism involving phosphorylation of a protei

135 e regulatory protein or were activated by an indirect mechanism involving Spo0A-mediated relief of re

136 ain why elotuzumab eliminates MM cells by an indirect mechanism involving the activation of NK cells.

137 transcriptional function in part through an indirect mechanism involving the suppression of TBP expr

138 f MHCI expression on immature thymocytes via indirect mechanisms involving IL-10.

139 transport in Aqp1-null mice, suggesting that indirect mechanisms involving other channels or transpor

140 egulates cell migration and adhesion through indirect mechanisms involving posttranscriptional contro

141 combination of both physical interaction and indirect mechanisms involving the activation of a second

142 This transcriptional repression can occur by indirect mechanisms involving the time-dependent assembl

143 y mimic BH4 in its inhibition of GTPCH by an indirect mechanism, involving interaction with a recentl

144 central effects of cocaine may occur, via an indirect mechanism, involving peripheral neural elements

145 hat this stimulation was mediated through an indirect mechanism, involving tumor necrosis factor alph

146 The indirect mechanism is found to contribute about one-half

147 Operation of the indirect mechanism is not exclusive of the direct mechan

148 chondrocytes, downstream of FGFRs and via an indirect mechanism, is required for normal extension and

149 With respect to indirect mechanisms, it will be important to determine w

150 Moreover, either by direct or indirect mechanisms, KIS counteracts the inhibitory acti

151 We suggest that an indirect mechanism linking Rho GTPases and formins via R

152 This finding suggests that a second indirect mechanism may be responsible for the destructio

153 on bile acid receptors, and other potential indirect mechanisms, may also contribute to the observed

154 ished during development, suggesting that an indirect mechanism mediated by plant water relations cou

155 that regulatory T cells, by either direct or indirect mechanisms, modulate B cell development and ane

156 This implies an indirect mechanism of action for Bk via the non-neuronal

157 nity chromatography experiments implicate an indirect mechanism of action involving direct binding of

158 The indirect mechanism of action rationalizes the persistenc

159 irectly interact with the APE, suggesting an indirect mechanism of activation through this site.

160 This latter interaction represents an indirect mechanism of agonist activity elicited by sIL-1

161 Taken together, these findings support an indirect mechanism of AHR activation, indicating that AH

162 These results suggest a novel indirect mechanism of androgen action on FHL2 expression

163 transferred to infected mice, suggesting an indirect mechanism of antibody function.

164 These results provide an indirect mechanism of cross-inhibition of TLRs and delin

165 hell, but also support the involvement of an indirect mechanism of dopamine control, through a concom

166 close to the P-site is very favorable for an indirect mechanism of eIF1's action by influencing the c

167 Favoring this indirect mechanism of GAPDH inhibition, the neuroprotect

168 ndings suggest that we initially observed an indirect mechanism of genetic complementation.

169 om the polymerase active site, suggesting an indirect mechanism of inhibition.

170 y the hepatocytes themselves, arguing for an indirect mechanism of liver damage.

171 re of the cells to the ligand, suggesting an indirect mechanism of phosphorylation.

172 ssion of p16 in human pituitary tumors as an indirect mechanism of Rb inactivation.

173 eins, suggesting the possibility of a novel, indirect mechanism of recruitment involving DNA target-s

174 tured mouse myotubes were refractory to this indirect mechanism of S-phase re-entry.

175 eatic acinar cells is likely regulated by an indirect mechanism of stimulation of afferent neurons.

176 rminal transactivation domain, suggesting an indirect mechanism of transcriptional inhibition involvi

177 e in lesions from these mice, implicating an indirect mechanism of tumorigenesis.

178 ed involvement of virion surface proteins in indirect mechanisms of HIV-1 pathogenesis.

179 cellular models suggest that both direct and indirect mechanisms of protein aggregation are probably

180 ior by decreasing spines selectively, via an indirect mechanism, on a subset of VMH neurons that proj

181 -induced Quin production in MOs occurs by an indirect mechanism, perhaps via cytokines produced by th

182 y deactivation of a negative regulator; this indirect mechanism, pervasive in Akt signaling, has yet

183 proinflammatory responses through direct and indirect mechanisms, pinpointing SQSTM1 as a key mediato

184 a suggest a model in which G-CSF, through an indirect mechanism, potently inhibits osteoblast activit

185 tion in vivo; however, this effect is due to indirect mechanisms rather than to direct infection of C

186 to the bone marrow niche by both direct and indirect mechanisms, rather than directly altering HSC f

187 postsynaptic neurons, but rather through an indirect mechanism: reduction of endocannabinoid-mediate

188 Both direct cell killing and indirect mechanisms related to immune activation have be

189 ) inhibits pituitary prolactin release by an indirect mechanism requiring stimulation of dopamine for

190 of recovery from desensitization through an indirect mechanism; responses activated with either chol

191 pidermal barrier function through direct and indirect mechanisms result in susceptibility to skin com

192 on results in diminished proliferation by an indirect mechanism, resulting from defective receptor ex

193 ation of peribronchial mast cells in vivo by indirect mechanism(s), which include inhibiting the lung

194 4 cells mediate antitumor effects through an indirect mechanism similar to the delayed hypersensitivi

195 may be due to direct antioxidant effects, or indirect mechanisms such as affecting signal transductio

196 hrough both direct viral infection and virus indirect mechanisms, such as immune activation.

197 Fs normally influences axon diameter through indirect mechanisms, such as the slowing of NF transport

198 quired to stabilize the ZNF2 mRNA through an indirect mechanism suggesting that Znf2 and Pum1 each po

199 tion, have an unusually powerful CD4(+) cell indirect mechanism that can cause rejection of both isle

200 tein titration curves is predicted, using an indirect mechanism that couples solute-induced changes i

201 ve, MHC class II-negative cancer cells by an indirect mechanism that depends on IFN-gamma.

202 ode of Na(+)/Ca(2+) exchange, probably by an indirect mechanism that does not involve phosphorylation

203 cumbens (NAc) and caudate-putamen through an indirect mechanism that involves striatal cholinergic in

204 hat Rac1 induces STAT3 activation through an indirect mechanism that involves the autocrine productio

205 affect the sphingolipid organization via an indirect mechanism that involves the cytoskeleton.

206 Sestrins inhibit mTORC1 activity through an indirect mechanism that is still unclear.

207 (IR), by directing attenuating SOD3 or by an indirect mechanism that limited TNFa production, thereby

208 rA activates Eda synthesis, apparently by an indirect mechanism that may be involved in the modest ch

209 on by DAHP in phosphate buffer occurs via an indirect mechanism that requires the presence of GTPCH f

210 pression of Kos1 inhibits Ras activity in an indirect mechanism that results in the downregulation of

211 ent throughout all forms of life, as well as indirect mechanisms that appear to have originated in eu

212 ed leukocytes to kill tumor cells in situ by indirect mechanisms that are dependent upon IFN-gamma.

213 NE deficiency may reduce APL penetrance via indirect mechanisms that are still NE dependent.

214 c beta-cell function through both direct and indirect mechanisms that converge on reduced EP3 signali

215 oes not accurately reflect the importance of indirect mechanisms that have previously been reported i

216 ssay, and their destruction likely occurs by indirect mechanisms that have yet to be determined.

217 ls by acting on them directly, or may act by indirect mechanisms that involve alterations of the host

218 In the indirect mechanism, the author of a new paper finds an o

219 lation observed in CS cells are caused by an indirect mechanism: these cells shut down transcription

220 ly by KLF8 binding to the GT box A and by an indirect mechanism through its repression of a potential

221 bile toxin, the repression of nlpA may be an indirect mechanism through which the virulence regulator

222 ndrite, NMDARs must signal to the axon by an indirect mechanism to alter release.

223 modulating the contribution of the exogenous indirect mechanism to the overall bacterial photoinactiv

224 Tumors use a complex set of direct and indirect mechanisms to evade the immune system.

225 H(2) receptor subtypes, utilizes direct and indirect mechanisms to excite septohippocampal GABA-type

226 Oncogenic viruses have evolved direct and indirect mechanisms to overcome the tumour suppressor p5

227 therefore alter colonic epithelial cells via indirect mechanisms to promote neoplasia.

228 ating basal transcriptional machinery) or an indirect mechanism (via regulation of other genes) is un

229 3K9 methylation at the MCAM promoter, and an indirect mechanism, via the Ets1 transcription factor.

230 To distinguish among direct and indirect mechanisms, we developed fluorescent human CD1b

231 id binding to the transcription factor or by indirect mechanisms where fatty acids regulate signaling

232 nitiation and progression of the plaques and indirect mechanisms where inflammation at nonvascular si

233 utations RT(Val108Ile) appears to act via an indirect mechanism which in this case is through alterat

234 n of the other IE protein, BZLF1, through an indirect mechanism which we previously showed to require

235 iciency of rRNA synthesis by both direct and indirect mechanisms, with resulting effects on transcrip

236 LHX8 regulated p57(Kip2) via both direct and indirect mechanisms, with the latter mediated by Forkhea

237 cell injury and apoptosis through direct and indirect mechanisms without affecting NO levels.

238 positively regulated FOXP3 expression via an indirect mechanism yet to be identified.

239 With comparable parameters, the indirect mechanism yields a broader range of sensitivity