ライフサイエンスコーパス: indirubin

1 h 4-OBzl-indole was neither an indigo nor an indirubin.

2 xyl, isatin) that couple to yield indigo and indirubin.

3 irubin, which was > or =10x more active than indirubin.

4 ve affinity for certain compounds, including indirubin [(2Z)-2,3-biindole-2,3 (1'H,1'H)-dione and que

5 Here, we report the synthesis of new indirubin 3'- and 5'-derivatives in the search of water-

6 We showed previously that the small molecule indirubin-3'-monoxime (I3MO) prevents vascular smooth mu

7 no previously known antiangiogenic activity, indirubin-3'-monoxime (IRO), was identified.

8 glycogen synthase kinase 3 (GSK3) inhibitor indirubin-3'-monoxime and GSK3beta short interfering RNA

9 vity, and incubation with the GSK3 inhibitor indirubin-3'-monoxime protected against this decrease in

10 Lapatinib and indirubin-3'-monoxime showed moderate hCOX-1 activity (1

11 patinib, SB-202190, RO-316233, GW786460X and indirubin-3'-monoxime were tested against human COX-1.

12 we present the indirubin derivative 6-bromo-indirubin-3'-oxime (6BIO) as a promising antimetastatic

13 supplements, the GSK3beta inhibitor 6-bromo-indirubin-3'-oxime (BIO) and the PPARgamma inhibitor GW9

14 abrogated by a small molecule CDK inhibitor, indirubin-3'-oxime (IO), but not a kinase-inactive deriv

15 Indirubin also suppressed cytokine-induced cellular inva

16 Indirubin also suppressed the NF-kappaB activation induc

17 of these indigoids were the monosubstituted indirubins and 5,5'-dimethoxyindirubin, which was > or =

18 the di(5-methoxy) derivatives of indigo and indirubin, and both of the possible mono 5-methoxy deriv

19 lmaleimide I, bisindolylmaleimide IX, U0126, indirubin, and indigo, inhibited three diverse non-kinas

20 Together, we present indirubins as novel chemotypes for the development of 5-

21 s and identify 6ha as a potent water-soluble indirubin-based IGF-1R inhibitor.

22 Further studies showed that indirubin blocked the phosphorylation and degradation of

23 In addition, indirubins blocked migration of endothelial cells, sugge

24 nducing kinase, and IKKbeta was inhibited by indirubin but not that induced by p65 transfection.

25 '-derivatives in the search of water-soluble indirubins by introducing basic centers.

26 y, suggesting that the antitumor activity of indirubin compounds is at least partially due to inhibit

27 In this study, we present the indirubin derivative 6-bromo-indirubin-3'-oxime (6BIO) a

28 Here, we show that the indirubin derivatives E564, E728, and E804 potently bloc

29 Evaluation of substituted indirubin derivatives led to the identification of (3Z)-

30 arget genes of Stat3, were down-regulated by indirubin derivatives, followed by induction of apoptosi

31 Here we show that GSK-3 inhibitors of the indirubin family reduce invasion of glioma cells and gli

32 Indirubins have been identified as potent ATP-competitiv

33 Indirubins improved survival in glioma-bearing mice in w

34 We also found that indirubin inhibited the expression of NF-kappaB-regulate

35 Overall, our findings suggest that indirubin inhibition of GSK-3 offers a novel treatment p

36 These observations suggest that indirubin is a potent hAHR ligand that is able to select

37 Although indirubin is known to exhibit anti-cancer and anti-infla

38 flammatory activities previously assigned to indirubin may be mediated in part through the suppressio

39 In this study, we investigated whether indirubin mediates its effects through interference with

40 We identify 7-bromoindirubin-3'-oxime, an indirubin oxime derivative that induces necrosis, as a p

41 We made use of the bisindole core of indirubin, present in GSK-3 inhibitors, to innovatively

42 tryptophan, kynurenine, or synthetic agonist indirubin reduced mycobacterial viability.

43 the DNA binding of NF-kappaB, we found that indirubin suppressed tumor necrosis factor (TNF)-induced

44 Indirubin, the active component of a traditional Chinese

45 These indigoids included indigo, indirubin, the di(5-methoxy) derivatives of indigo and i

46 Three active components, indirubin, tryptanthrin and isorhamnetin, were successfu

47 Indirubin was also a more potent inducer of Cyp1a1 expre

48 phoretic mobility shift assays revealed that indirubin was more efficient at transforming the hAHR co

49 d from 5-OBzl-indole was mainly 5,5'-di-OBzl-indirubin, whereas the dominant blue dye isolated upon i

50 f the possible mono 5-methoxy derivatives of indirubin, which were all identified by visible, mass, a