ライフサイエンスコーパス: indiscriminate

1 ly heterogeneous but seem to be functionally indiscriminate.

2 ected to midget ganglion cells are similarly indiscriminate.

3 upt the mRNA selectivity of Upf1, leading to indiscriminate accumulation of NMD complexes on both NMD

4 Most mammals, including humans, are indiscriminate accumulators of carotenoids but inefficie

5 he lesions to the presence of repetitive and indiscriminate acquisition behaviour and impaired discar

6 This indiscriminate activation necessitates the presence of p

7 Moreover, these results suggest that the indiscriminate activation of CaMKII is able to disrupt p

8 nstrained by insulator elements that prevent indiscriminate activation of nearby genes.

9 Adverse effects, due to indiscriminate activation of other muscarinic receptor s

10 ese results are consistent with a remarkably indiscriminate active site and suggest that the rate of

11 the mechanistic basis for this specific yet indiscriminate activity is not known.

12 the Ag-Pt-Fe3O4 heterotrimers initiates with indiscriminate Ag nucleation onto both the Pt and Fe3O4

13 n to form dimers and tetramers as opposed to indiscriminate aggregation.

14 Indiscriminate altruists can invade by random drift, how

15 These findings of heightened and indiscriminate amygdala responses to anticipatory signal

16 Inactivation of these cells results in indiscriminate and excessive intake of all compounds, in

17 r delayed rewards reflects both a relatively indiscriminate and hyper-reactive VS circuitry.

18 Indiscriminate and intense fishing has occurred in many

19 ment, that larval D. speciosa are relatively indiscriminate, and that H. amazonensis en-tomopathogeni

20 Indiscriminate antimicrobial use has plagued medicine si

21 arene substituents, and (3) does not afford indiscriminate attachment.

22 are broadly tuned and uniform, resulting in indiscriminate avoidance of bitter stimuli, or diverse,

23 Notably, BAFF and APRIL did not cause indiscriminate B cell expansion or an increase in total

24 ions imposed by photodamage, scattering, and indiscriminate background encountered in other UV micros

25 during infection but this activity cannot be indiscriminate because of the critical barrier function

26 This T-cell activation was not indiscriminate because we observed only minimal effects

27 Although in vitro experiments showed indiscriminate binding of Hu proteins synthesized in bac

28 The indiscriminate bulk intercellular transport of inhaled p

29 lphur species are generally considered to be indiscriminate catalyst poisons, the reaction rate to th

30 ndicapped by large antigen sinks in vivo and indiscriminate cell binding due to ubiquitous expression

31 play a role in protecting these tissues from indiscriminate complement activation and inflammatory in

32 redominantly between alike individuals, then indiscriminate cooperation can evolve.

33 evels of assortment therefore do not lead to indiscriminate cooperation if tags are available.

34 However, indiscriminate coupling between spectral types could com

35 This indiscriminate coupling blurs the differences between re

36 Ingestion by indiscriminate deposit-feeders has been reported, yet ph

37 ng leukocyte recruitment and the potentially indiscriminate destructive capacity of these cells, we i

38 We postulate that indiscriminate dG addition by telomerase occurs by reite

39 The indiscriminate disposal of plastic to the environment is

40 ing, facilitates dsRNA release, and prevents indiscriminate DNA aggregation, suggesting that this aci

41 nerate sites is increased, likely because of indiscriminate DNA cleavage.

42 pports an emerging model that delineates how indiscriminate DNA-binding patterns translate into a con

43 ctors" than by the preferences of relatively indiscriminate DR15 molecules.

44 ICC-IM in motor neurotransmission have used indiscriminate electric field stimulation of neural elem

45 -186/+28 SP-10 promoter led to premature and indiscriminate expression of a reporter gene in the semi

46 her such regions throughout the genome in an indiscriminate fashion, partly driven by the accessibili

47 g, such that bursts occurred in a temporally indiscriminate fashion.

48 tivation is to produce anxiety manifested as indiscriminate fear of both tone and context.

49 at the amygdala, in part, is associated with indiscriminate friendliness and that there might be a do

50 and strangers and increased parent report of indiscriminate friendliness behaviors.

51 Indiscriminate friendliness was assessed with parental r

52 l deprivation has been associated with both "indiscriminate friendliness" toward non-caregiving adult

53 entiation correlated with greater reports of indiscriminate friendliness.

54 ation was associated with greater reports of indiscriminate friendliness.

55 lationship between institutional rearing and indiscriminate friendliness.

56 ith reduced amygdala discrimination and more indiscriminate friendliness.

57 for epileptiform bursting, which occurs with indiscriminate GABAA blockade.

58 encing at other loci in trans and preventing indiscriminate gene silencing throughout the genome.

59 all thickenings of protoxylem, as opposed to indiscriminate growth to fill the xylem lumen.

60 The new pHLIP version limits indiscriminate healthy tissue binding, and we demonstrat

61 hat would be highly efficient while avoiding indiscriminate IKK/NF-kappaB inhibition in normal cells.

62 trictly on DNA sequence recognition provides indiscriminate immunity both to lytic and lysogenic infe

63 Treatment involves the use of indiscriminate immunosuppression, which results in signi

64 relies upon broad-scale corticosteroids with indiscriminate impact.

65 nlike other transport systems, OME is rather indiscriminate in what OM goods are transferred.

66 ings suggest that STN-DBS does not act as an indiscriminate informational lesion but rather as a filt

67 nes is a promising therapeutic strategy, but indiscriminate inhibition of both the mutant and wild-ty

68 ay initiate an unpredictable reaction to the indiscriminate inhibition or activation of a single comp

69 These findings suggest that DAHP is not an indiscriminate inhibitor of GTPCH in biological systems;

70 n for myelination results from excessive and indiscriminate initiation of wrapping followed by refine

71 We proposed that indiscriminate insertion of dAMP opposite the 3'-T of ea

72 gridless configuration substantially reduces indiscriminate ion losses.

73 iotics tend to be broad spectrum, leading to indiscriminate killing of commensal bacteria and acceler

74 he back-to-back kinetochore geometry and the indiscriminate kinetochore-MT turnover provide strong er

75 man granulocyte migration have been based on indiscriminate labeling of total granulocyte populations

76 nic radicals generated during photolysis are indiscriminate, leading to a large mixture of photoprodu

77 ndom gathering of the genome into domains of indiscriminate length but rather that the genome is gath

78 an ancestral RLN3-like gene that encodes an indiscriminate ligand for LGR7 (RXFP1) and LGR8.

79 t small solutes within the CC are subject to indiscriminate long-distance transport via the transloca

80 We also show the focal and indiscriminate loss of calbindin(+), calretinin(+), parv

81 During viral CNS infections, however, an indiscriminate maintenance of CNS immune privilege throu

82 and that the promoter alone functions in an indiscriminate manner.

83 ction of apoptosis in C2C12 cells results in indiscriminate miRNA release.

84 several steps; by specific selection from an indiscriminate mixture, by concentration from dilute sol

85 This exogenous Env is an indiscriminate molecular "bridge" between Env-specific A

86 Unlike the indiscriminate multiorgan autoimmune phenotype of the co

87 ied product, with a high frequency of nearly indiscriminate mutations, are produced.

88 ination and suggest a model in which broadly indiscriminate myelination is tailored by inhibitory sig

89 This indiscriminate nature provides one of its main weaknesse

90 Thus, ozone is not an indiscriminate neuronal activator, but rather it potentl

91 Although peroxynitrite caused a fairly indiscriminate nitration of tyrosine residues, reversibl

92 The 2Cys-peroxiredoxin assembly may prevent indiscriminate oligomerisation, localise ten peroxidase

93 The effects of peroxynitrite were indiscriminate on RyR1 and RyR2.

94 ather than opposition combatants, suggesting indiscriminate or targeted warfare contrary to internati

95 patients at low risk for cardiac events, and indiscriminate perioperative therapy with beta-blockers

96 It deserves neither condemnation nor indiscriminate praise but instead a commitment to help i

97 lyadenylation in prokaryotes is a relatively indiscriminate process that can occur at all mRNA's 3'-e

98 e resulting population demonstrates that the indiscriminate properties of interchromosomal interactio

99 r poorer surgical outcomes in the setting of indiscriminate prophylactic vancomycin use, measures to

100 pression in normal colon did not result from indiscriminate protein or RNA degradation.

101 The indiscriminate rapid bulk transport of brain homogenate

102 in drug discovery because of their presumed indiscriminate reactivity.

103 mitochondria, and endosomes, consistent with indiscriminate sampling of intracellular membranes from

104 beta1 Integrin-null acinar cells displayed indiscriminate secretion to all membrane surfaces, consi

105 the subject exhibits internal flexibility or indiscriminate self-association.

106 cision?" First, Precision Oncology relies on indiscriminate sequencing of genomes in biopsies that ba

107 -->Ala by alkylsulfonates is apparently more indiscriminate, since methane-, ethane-, or propane-sulf

108 to four selected domains of psychopathology (indiscriminate social behavior, posttraumatic stress dis

109 s 2'-deoxy precursor reveal the surprisingly indiscriminate specificity of this transferase.

110 ial resolution of current devices results in indiscriminate stimulation of interleaved cells of diffe

111 We propose that this selectivity limits indiscriminate target selection by E. coli Hfq and enfor

112 sY pre-organized into the Stable mode led to indiscriminate targeting in vitro and disrupted FtsY fun

113 Therapeutically, the indiscriminate targeting of wild-type and point-mutated

114 This regulation minimizes the indiscriminate transmission of mRNAs from mother to daug

115 disseminate intracellular signals and avert indiscriminate transmission of these responses throughou

116 sease, most patients are limited to generic, indiscriminate treatment options: cytotoxic chemotherapy

117 For example, indiscriminate treatment with 0.45% saline cannot be rec

118 dications and utilization, it is likely that indiscriminate use is cost-ineffective, but that judicio

119 The absence of such data promotes indiscriminate use of antibiotics and delays implementat

120 This difficulty results in the indiscriminate use of antibiotics, which are expensive a

121 ings provide a further rationale against the indiscriminate use of antibiotics.

122 Indiscriminate use of balloons larger than the angiograp

123 mate change adaptation policies based on the indiscriminate use of climate envelope methods irrespect

124 ty and tumors in animals caution against the indiscriminate use of demethylating agents, such as 5-az

125 imental model, should raise concerns for the indiscriminate use of G-CSF in the clinic.

126 The indiscriminate use of mineral supplements can adversely

127 hways, these data also raise concern for the indiscriminate use of Rluc and aequorin as reporters in

128 The indiscriminate use of the cumulative exposure metric (th

129 Indiscriminate use of the terms dehydration and volume d

130 or phosphatidylglycerol, caused by itself an indiscriminate vesiculation of uncoated Golgi membranes

131 C areas (1.0 = perfect discrimination, 0.5 = indiscriminate) were minor VSD 0.92 +/- 0.02 and major/i

132 rval relative to pre-odor baseline, but were indiscriminate with regard to sample odor identity.

133 data, micronutrient supplementation is often indiscriminate without regard to nutrient status.