ライフサイエンスコーパス: indispensable

1 bined interpretation of topology and flow is indispensable.

2 hase stabilization of the alumina lattice is indispensable.

3 t 21% of the proteins in the PPI network are indispensable.

4 , and the proximity changes are functionally indispensable.

5 ied or deleted in nine different cancers are indispensable.

6 to spatial autocorrelation becomes even more indispensable.

7 ewiring may render certain outside nutrients indispensable.

8 integration make transposon-based approaches indispensable.

9 ng computational identification of enhancers indispensable.

10 ding the pillars of noninferiority design is indispensable.

11 erefore, validation of the global results is indispensable.

12 , e.g. H2O2, which oxidize the catalytically indispensable active-site cysteine.

13 Indispensable amino acid (IAA) contents (mg IAA/g protei

14 The average Digestible Indispensable Amino Acid Score of red lentils (0.54) was

15 Digestible indispensable amino acid scores (DIAAS) was calculated u

16 howed a lower concentration in the plasma of indispensable amino acids (P < 0.01), a lower entry rate

17 lian autophagy protein that is embryonically indispensable and has been presumed to suppress oncogene

18 relaxation and extraction mechanisms play an indispensable and intriguing role in their photo-electro

19 ents and reinforce the concept that PTPs are indispensable and specific modulators of cellular signal

20 R analysis showed that the intact D ring was indispensable and unsaturated D ring played vital role.

21 A domain where such claims are indispensable are human social engagements.

22 isk of breast cancer-related lymphoedema are indispensable aspects of clinical care, yet remain unsub

23 omains (CTDs) of catalytic subunits bound to indispensable B-subunits, which serve as scaffolds that

24 Here we identify a new indispensable bacterial replication origin element compo

25 , we consider such a minimal model to be the indispensable baseline.

26 or (18)F-labeled radiopharmaceuticals are an indispensable but often overlooked prerequisite to succe

27 growth factor receptor 1 (TGFbetaR1) has an indispensable, cell intrinsic role in the development of

28 e production, thereby reallocating Mg(2+) to indispensable cellular processes.

29 ings identified the eye-localized Cry2 as an indispensable component and a likely photoreceptor of th

30 Inhibition of p22phox, an indispensable component of the NADPH oxidase (NOX) compl

31 RPE65 is an indispensable component of the retinoid visual cycle in

32 ogether, these findings show that CAH1 is an indispensable component of what may be a simple but effe

33 evolution, indicating melanization is not an indispensable component of wound healing in arthropods.

34 most abundant anion in the human body, is an indispensable constituent of the myeloperoxidase (MPO)-H

35 onent, C4, and the second component, C2, are indispensable constituents of the C3 convertase complex,

36 Our results identify SorCS2 as an indispensable coreceptor for p75(NTR) and TrkB in hippoc

37 btained from this study suggest that INTU is indispensable during BCC tumorigenesis and that its aber

38 Coronary guidewires are indispensable during percutaneous coronary interventions

39 ound that glutamine and glucose also fuel an indispensable dynamic regulation of intracellular protei

40 Our data identify the LH GLP-1R as an indispensable element of normal food reinforcement, food

41 FRET is an indispensable experimental tool for studying membrane pr

42 Although chronic inflammation is an indispensable feature of the pathogenesis and progressio

43 anisms processing spatiotopic information is indispensable for a successful interaction with the exte

44 Symbiosis receptor kinase (SYMRK) is indispensable for activation of root nodule symbiosis (R

45 indicating that this non-coding sequence is indispensable for ALAS2 expression in vivo Further analy

46 on in astrocytes and that GFAP activation is indispensable for astrocyte-mediated Tat neurotoxicity.

47 f26b functions in MT stabilization, which is indispensable for asymmetrical cell structure reorganiza

48 lysis reveals a trans-arginine finger, R158, indispensable for ATP hydrolysis; (iii) the location of

49 s the only member of the PIAS family that is indispensable for ATR activation.

50 However, although Oxtr is not indispensable for Avp action in inhibiting osteoblastoge

51 2 integrin cytoplasmic domain, thereby being indispensable for beta2 integrin activation and neutroph

52 This interaction is indispensable for both ciliogenesis and ciliary function

53 conclude that the conserved N1584 residue is indispensable for BTX actions, probably functioning as a

54 It is indispensable for cell differentiation as well as tissue

55 Mur enzymes are indispensable for cell integrity and their lack of count

56 ly are actin-based molecular motors that are indispensable for cellular homeostasis.

57 ned, leading to the conclusion that kif3a is indispensable for ciliogenesis in all cells, including p

58 GTPase ARL-3 in cilia, a regulatory process indispensable for ciliogenesis.

59 lathrin-associated sorting proteins that are indispensable for clathrin-mediated endocytosis, but the

60 N3 of the adenine-6 at the cleavage site are indispensable for cleavage.

61 tif (RXWV) in the TlyA interdomain linker as indispensable for co-substrate binding.

62 anner, hence indicating that beta-catenin is indispensable for Cyp1b1 but not for Cyp1a1 expression.

63 Molecular imaging is indispensable for determining the fate and persistence o

64 nd reproduction of macromolecular models and indispensable for development of structural biology proc

65 Here we show that macrophage FAS is indispensable for diet-induced inflammation.

66 lthough the aspartate at position Asp-50 was indispensable for divalent cation-dependent gating of Cx

67 hosphorylated Syk, a tyrosine kinase that is indispensable for downstream FcvarepsilonRI signalosome

68 gnals after ligand binding and are therefore indispensable for downstream signaling, relatively littl

69 Here, we determined that miR-23a is indispensable for effector CD4(+) T cell expansion, part

70 ignaling, peripheral kisspeptin signaling is indispensable for endometrial adenogenesis and function,

71 r genes (DENND3, NCLN, NUP98, and TBATA) are indispensable for ENS development in zebrafish, and thes

72 nistic studies in mice showed that PD-L2 was indispensable for establishing effective CD4(+) T cell i

73 sms of tolerance initiated in the thymus are indispensable for establishing immune homeostasis, but t

74 al four amino acids of FOS, which we show is indispensable for fast, ubiquitin-independent FOS degrad

75 st, here we show that VMHvl(Esr1+) cells are indispensable for female aggression.

76 ominant expression in the male germline, are indispensable for fertilization [1, 2].

77 IZUMO1 and JUNO proteins are indispensable for fertilization, as constitutive knockdo

78 i-lysine ER retention motif of AnkB-Paris is indispensable for function; most likely as an ER retenti

79 e become a promising critical building block indispensable for future integrated nanophotonic network

80 and apoptosis, which indicated that Ape1 is indispensable for GAPDH-dependent protective effects.

81 -knockdown macrophages revealed that PKD1 is indispensable for GBS-mediated activation of MAPKs and N

82 310 in mice) within the N-terminal domain is indispensable for GC-induced evolutionary conserved inve

83 vo cerebellar slices indicate that ZNHIT3 is indispensable for granule neuron survival and migration,

84 tamins give rise to vital coenzymes that are indispensable for growth and development but their inher

85 for neutrophils in acute peritonitis that is indispensable for host defence against early systemic ba

86 bitor of E protein transcription factors, is indispensable for ILC differentiation.

87 t Vbeta8.1 functioned as an Ir gene that was indispensable for immune reactivity against the malaria

88 h temperatures beyond historic variation are indispensable for improving predictions of future change

89 edicting protein subcellular localization is indispensable for inferring protein functions.

90 on relationship and protein modification are indispensable for inferring signalling pathways from PPI

91 of gD with a cognate entry receptor remains indispensable for initiating membrane fusion of syncytia

92 leukin-1 receptor, TNFR/IL-1R in mammals) is indispensable for intestinal immunity against invading b

93 M promoter following LPS stimulation and was indispensable for IRAK-M transcriptional activation.

94 ular niche represents a constitutive pathway indispensable for iron homeostasis in vivo that is nonre

95 rldwide, and histopathological assessment is indispensable for its diagnosis.

96 In this study, we demonstrate that Rab7 is indispensable for LD breakdown ("lipophagy") in hepatocy

97 rgan-specific vascular competence, which are indispensable for liver development.

98 roteasome system (UPS) and autophagy, appear indispensable for longevity in many long-lived invertebr

99 Mast cells are indispensable for LPS-induced septic hypothermia, in whi

100 Recent studies demonstrate that hENT3 is indispensable for lysosomal homeostasis, and that mutati

101 Mitochondria are organelles indispensable for maintenance of cellular energy homeost

102 Here we show that DNMT1 is indispensable for MaSC maintenance.

103 Complete annotation of the human genome is indispensable for medical research.

104 Moreover, DHBPS is shown to be indispensable for Mycobacterium, Salmonella, and Helicob

105 We conclude that actin polymerization is indispensable for neurite elongation.

106 MRT/NCoR1-HDAC3 repressing complex, which is indispensable for NF-kappaB/AP1-mediated GC-induced teth

107 ontrol physiological IL-7 production that is indispensable for normal B-cell lymphopoiesis and is mai

108 equently associated with CHARGE syndrome, is indispensable for normal cerebellar development.

109 acrophage in situ phenotypic shift, which is indispensable for normal muscle tissue repair dynamics.

110 PLA1 function is conserved among mammals and indispensable for normal skin physiology.

111 me-mapping experiments revealed that BRG1 is indispensable for nucleosome remodeling at the Nanog enh

112 nding to HS chains decorating syndecan-1 are indispensable for optimal stimulation of Wnt signaling i

113 pling site for STIM1, the Orai N terminus is indispensable for Orai channel gating.

114 Primary cilia are sensory organelles indispensable for organogenesis and tissue pattern forma

115 age, factors such as RUNX2 and PPARgamma are indispensable for osteogenesis and adipogenesis, respect

116 al homeobox 1 (PDX1), a transcription factor indispensable for pancreas development, in the progressi

117 T-box transcription factor 5 (Tbx5), a gene indispensable for pectoral appendage initiation and deve

118 ant genes, GRCD4 and GRCD5, were found to be indispensable for petal development.

119 f the essential nutrients for plants, and is indispensable for plant growth and development.

120 unction during the early postnatal period is indispensable for preventing the development of murine c

121 Cac2 is indispensable for productive histone binding, while dele

122 MYRF-2 are the first genes identified to be indispensable for promoting synaptic rewiring in C. eleg

123 st immune system and also are believed to be indispensable for proper folding of gp120 and for viral

124 a chloroplast-localized RNA helicase that is indispensable for proper plant development.

125 data demonstrate that the miR-142 family is indispensable for protection against S. aureus infection

126 the Ras and Src families, palmitoylation is indispensable for protein function.

127 We provide evidence that BRCA1 and BARD1 are indispensable for RAD51 stimulation.

128 A properly mounted immune response is indispensable for recognizing and eliminating danger ari

129 cellular columns, Bungner's bands, which are indispensable for regeneration.

130 e import by MntH and MntABCD was found to be indispensable for replication of M. tuberculosis in macr

131 dependent mechanism, and these processes are indispensable for restitution and function after severe

132 Whereas systemic Pip elevations are indispensable for SAR and necessary for virtually the wh

133 PALE HYPOCOTYL (LPH) gene whose activity is indispensable for spatiotemporally correct expression of

134 ble for the STAT3-Smad3 interaction and also indispensable for STAT3-mediated inhibition of TGF-beta

135 t in this particular hair type, NF-kappaB is indispensable for stem cell activation, maintenance, and

136 Proton NMR spectra are indispensable for structural characterization even in co

137 Simulation of biomolecular networks is now indispensable for studying biological systems, from smal

138 involved in substrate recognition and nearly indispensable for substrate methylation.

139 iption factor paired box-protein-7 (PAX7) is indispensable for supplementing the reservoir of satelli

140 ecent evidence suggests that these cells are indispensable for survival and growth of epithelial stem

141 Donor chimerism was indispensable for sustained tolerance, as evidenced by a

142 Whereas Gp2 is indispensable for T7 growth in E. coli, we show that Gp5

143 atc1), a master transcription factor that is indispensable for terminal OC differentiation.

144 actions of His122 and Tyr125 with Trp159 are indispensable for tertiary structural intactness through

145 , a membrane-bound O-acyltransferase that is indispensable for the activity and secretion of all vert

146 transcriptional target(s) of FOXE3 that are indispensable for the anterior segment development, we e

147 Here we show that cGAS is indispensable for the antitumor effect of immune checkpo

148 ult mice, which shows that neuroplastins are indispensable for the availability of previously acquire

149 The transcription factor GATA-3 is indispensable for the development of all innate lymphoid

150 operties of the microtubule cytoskeleton are indispensable for the development of the mammalian brain

151 ox genes and enhancers in zebrafish that are indispensable for the development of the wrists and digi

152 PHLPP is indispensable for the differentiation of induced Treg ce

153 containing receptor-like kinase 3 (LYK3) are indispensable for the establishment of root nodule symbi

154 The adipocyte GR is indispensable for the feeding-fasting transition but als

155 Group II chaperonins are ATP-ases indispensable for the folding of many proteins that play

156 ions and that the integrity of this helix is indispensable for the function of the complex.

157 NX1 (Runt-related transcription factor 1) is indispensable for the generation of hemogenic endotheliu

158 romal cells, we show that Notch signaling is indispensable for the homeostasis of three tissue-restri

159 led that activation of ERK, p38, and CREB is indispensable for the induction of IL-10 production, whe

160 beyond the CD27 single-positive stage and is indispensable for the maintenance of liver-resident NK c

161 cate that the chloroplast-targeted HCF222 is indispensable for the maturation and/or assembly of the

162 port that the essential amino acid valine is indispensable for the proliferation and maintenance of H

163 Moreover, endogenous PINK1 or parkin is indispensable for the proper autophagic removal of damag

164 tion of the isoprenoid metabolic pathways is indispensable for the rational design of plant and micro

165 phatidylinositol 4-kinase IIIbeta (PI4KB) is indispensable for the replication of various positive-se

166 Furthermore, TA and LAP1 were indispensable for the retrograde flow of dorsal perinucl

167 Finally, dimerization was indispensable for the strong, dominant negative effect o

168 Bacteria are indispensable for the study of fundamental molecular bio

169 e proteins, proline-mediated helix kinks are indispensable for the tight packing of transmembrane (TM

170 (NS5A) is a hepatitis C virus (HCV) protein indispensable for the viral life cycle.

171 nsferase activity of HopZ1a in vitro and are indispensable for the virulence function of HopZ1a in Ar

172 racts with Sox2 in adult NeuPCs, where it is indispensable for their maintenance and controls neurona

173 their proliferation and adipogenesis, but is indispensable for their myogenesis.

174 ranslation machinery to produce polypeptides indispensable for their reproduction is most conspicuous

175 ptively transferred CD8(+) effectors that is indispensable for therapeutic efficacy.

176 and we find that its accessory protein 5b is indispensable for this function.

177 etes and squids), minerals are thought to be indispensable for tooth-hardening and durability.

178 RasGRP1 is indispensable for transduction of weak signals.

179 on-native Hh precursor autoprocessing and is indispensable for transesterification with cholesterol.

180 ncodes a putative mRNA export factor that is indispensable for transgene silencing and the production

181 hormone (TSH) and TSH receptor (TSHR) and is indispensable for TSH/TSHR-mediated proliferation of thy

182 curately recapitulate clinical pathology are indispensable for understanding molecular mechanisms and

183 We showed that only myosin VIIa is indispensable for USH2 complex assembly at ankle links,

184 n that targeting of ARF10/16/17 by miR160 is indispensable for various aspects of development, but it

185 suggest that high mobility materials will be indispensable for various future applications such as hi

186 and functionally resemble pericytes and are indispensable for vascular stabilization and sustained t

187 While T cells are indispensable for viral clearance, they also contribute

188 e found that NLS2 is also monopartite and is indispensable for viral infection.

189 Genes with indispensable functions are identified as essential; how

190 sures to escape immune recognition, maintain indispensable functions, and mask vulnerabilities have s

191 e here the first microbe in which htrA is an indispensable gene, a situation unique in the bacterial

192 RAD51 is an indispensable homologous recombination protein, necessar

193 titative trait loci (QTL) model involves two indispensable hypothesis tests: the test of whether or n

194 Such selectivity has become indispensable in biology, enabling biomolecules to be de

195 s, with the exception of coelacanths, and is indispensable in both innate and adaptive immunity.

196 Backpropagating action potentials (bAPs) are indispensable in dendritic signaling.

197 mputational and structural studies have been indispensable in investigating the molecular origins of

198 3D ray tracing was indispensable in modeling behavior in the more demanding

199 Polymeric nanoparticles have become indispensable in modern society with a wide array of app

200 g factors of work-home conflict is therefore indispensable in order to avoid it.

201 prior to hair analysis are considered to be indispensable in order to exclude external contamination

202 demonstrated that CCL5 and CCR2 ligands were indispensable in supporting TNFalpha-activated MSCs to p

203 flammatory and immunosuppressive medications indispensable in the clinic.

204 and easily reproducible imaging tool and is indispensable in the diagnosis of CPAM.

205 E) is a flavone, found in cereals and herbs, indispensable in the human diet.

206 between C70-TiO2 hybrid and bacteria is not indispensable in the photocatalytic disinfection process

207 quitous in radar and radio communication and indispensable in the readout chains of superconducting q

208 Persistent free radicals have become indispensable in the synthesis of organic materials thro

209 Calorimetry has proven indispensable in this regard for recording full energeti

210 Genome-scale engineering is indispensable in understanding and engineering microorga

211 s establish the presence of a long-lived and indispensable Krt15+ progenitor cell population that pro

212 arrest in response to cellular stress, is an indispensable mechanism to counter tumorigenesis by halt

213 The N-terminal tail of histone H4 is an indispensable mediator for inter-nucleosome interaction,

214 act signaling axis, become reprogrammed into indispensable mediators of anti-tumor immunity.

215 or Mincle signalling, are reprogrammed into indispensable mediators of anti-tumour immunity in the a

216 e dispensable to outcome in PDA, they became indispensable mediators of tumor protection upon gammade

217 These findings provide an indispensable molecular basis to rationalize the essenti

218 Despite the indispensable need of thorough domain knowledge in ontol

219 D4(+)Foxp3(+) regulatory T cells (Tregs) are indispensable negative regulators of immune responses.

220 Glutamate is an indispensable neurotransmitter, triggering postsynaptic

221 s network allows us to classify proteins as "indispensable," "neutral," or "dispensable," which corre

222 Mitochondria are multifaceted and indispensable organelles required for cell performance.

223 ding-like homologous protein 5 (PfRH5) is an indispensable parasite ligand that binds with its erythr

224 tion to the interferon family, constitute an indispensable part of the innate immune response.

225 any metabolites in a single shot makes it an indispensable platform in metabolomics.

226 ite quantum systems of increasing size is an indispensable prerequisite for scalable quantum computat

227 Interestingly, these indispensable proteins are the primary targets of diseas

228 topoietic stem and progenitor cells, and its indispensable requirement for AML development.

229 RNAi is an indispensable research tool with a substantial therapeut

230 s independent of Hrd3, these studies show an indispensable role for Hrd3 in living cells.

231 Since previous studies showed an indispensable role for Pdx1 in pancreas organogenesis, w

232 Our results reveal an indispensable role for ROCK, yet redundant role for isof

233 for binding site recognition and thus their indispensable role for the binding of KP1019.

234 nesis of BB loop pocket residues revealed an indispensable role for TLR2/1, but not TLR2/6, signaling

235 Here we identified an indispensable role for ZFP36L1 as the regulator of a pos

236 ting that TNFalpha-secreting B cells play an indispensable role in BRAF inhibitor resistance induced

237 ology in humans, which is a testament to its indispensable role in cell biology.

238 fundamental cellular behavior that plays an indispensable role in development and homeostasis, but c

239 te that the phosphorylation of ACF7 plays an indispensable role in focal adhesion dynamics and epider

240 Intestinal epithelial cells (IECs) play an indispensable role in maintaining body fluid balance par

241 e further demonstrate that GSK3beta plays an indispensable role in mediating AKT-induced axon regener

242 water shortages is vital because of water's indispensable role in social-ecological systems.

243 Essential proteins play an indispensable role in the cellular survival and developm

244 on (OER), surface oxygen adsorption plays an indispensable role in the electrocatalysis.

245 ther, our results suggest that AnkG plays an indispensable role in the maturation and long-term stabi

246 iously evaluated, we show that ANKZF1 has an indispensable role in the mitochondrial response to cell

247 Dolichol plays an indispensable role in the N-glycosylation of eukaryotic

248 Because of the indispensable role of alternative pathway convertase in

249 These results establish the indispensable role of DNMT1-mediated epigenetic regulati

250 Given the indispensable role of heme, this auxotrophy may be explo

251 Non-coding RNAs play indispensable roles in regulating the activity and stabi

252 nd write computer programs is among the most indispensable skills that a modern researcher can cultiv

253 Host cell invasion is an indispensable step for a successful infection by intrace

254 Myoblast fusion is an indispensable step for skeletal muscle development, post

255 The nuclear import of IAV genome is an indispensable step in establishing virus infection.

256 ntal problem in computational biology, is an indispensable step toward predicting protein structures

257 that a Pip/FMO1 signaling module acts as an indispensable switch for the activation of SAR and assoc

258 With the mixing/ionic substitution, it is indispensable to compute the quality factors precisely.

259 hallmark of cancer because its induction is indispensable to fuel an expanding tumor.

260 commonly as part of the invasion process, is indispensable to identifying and anticipating potential

261 at SPPL2a-mediated processing of CD74 NTF is indispensable to maintain appropriate levels of tonic BC

262 en-sensing, mediating RAP2.12 degradation is indispensable to optimize metabolic performance, plant g

263 talysts provide access to molecules that are indispensable to physicians and researchers in the life

264 Carotenoids are indispensable to plants and critical in human diets.

265 ken together, our results show that CUL4B is indispensable to spermatogenesis, and it functions cell

266 f functions, and its health is pertinent and indispensable to survival.

267 ction between the two thiol redox systems is indispensable to sustain photosynthesis performed by cot

268 ell-defined multichromophoric structures are indispensable to the development of artificial photofunc

269 on of amine functionalized monomer, which is indispensable to the enzyme immobilization, with palladi

270 While macrophages are indispensable to the fibrotic cascade, surprisingly neut

271 Experimental animal models are indispensable to the field of CHIKV research.

272 prion replication and neurotoxicity would be indispensable to the pursuit of intervention strategies.

273 Essential proteins are indispensable to the survival and development process of

274 neuronal angiotensin II type 1 receptors are indispensable to this process.

275 mprehensive catalogs of GxE interactions are indispensable to thoroughly annotate genes and bridge ep

276 Crystal structures of enzymes are indispensable to understanding their mechanisms on a mol

277 RNA sequencing has increasingly become an indispensable tool for biological research.

278 Light microscopy has long been an indispensable tool for cell biology research.

279 oposed filter-optimization method will be an indispensable tool for developing new and improving exis

280 piratory pathogen, molecular detection is an indispensable tool for diagnosis and surveillance.

281 try (MS) for the detection of proteins is an indispensable tool for evaluating the biological process

282 accelerator technologies, which would be an indispensable tool for exploring gamma-ray vortex scienc

283 omenon, clustered mutagenesis also became an indispensable tool for identifying a previously unrecogn

284 Mass spectrometry (MS) has become an indispensable tool for investigating the architectures a

285 Antibodies have become an indispensable tool for many biotechnological and clinica

286 r correlations in molecular scattering is an indispensable tool for mapping out interaction potential

287 Pairwise local alignment is an indispensable tool for molecular biologists.

288 rs for short-lived intermediates provides an indispensable tool for synthetic design.

289 iRegNet3D promises to be an indispensable tool in large-scale sequencing and disease

290 proteomics employing mass spectrometry is an indispensable tool in life science research.

291 EUS is an indispensable tool in making a preoperative diagnosis an

292 med musculoskeletal MR examination and is an indispensable tool in the appropriate management of the

293 gnetic resonance imaging (MRI) has become an indispensable tool in the diagnosis and treatment of man

294 ent of cardiac structure and function, is an indispensable tool in the evaluation and management of p

295 lar magnetic resonance imaging has become an indispensable tool in the evaluation of congenital heart

296 These novel sources promise to become indispensable tools for the investigation of structural

297 Ensemble methods are indispensable tools in science and engineering and have

298 ins including their C-terminal peptide exert indispensable, unknown functions.

299 is information and nowadays is proving to be indispensable when studying dynamic heterogeneous protei

300 st that bioinformatics will become ever more indispensable without necessarily becoming more visible,