ライフサイエンスコーパス: indole

1 ellii, have a similar effect as observed for indole.

2 ted by the substituent at the C3-position of indole.

3 at the former has electronic similarities to indole.

4 d, 3-methylindole (skatole), d-limonene, and indole.

5 ent with alkyl migration from B to C2 of the indole.

6 r furan (IMDAF) cycloaddition to install the indole.

7 accessing 5-ring fused benzo[g]indolo[3,2-b]indole.

8 emiaminal of amide, with various substituted indoles.

9 y synthetically elusive cycloheptanone-fused indoles.

10 by rearomatization reaction to provide such indoles.

11 the corresponding pyrrole-ring unsubstituted indoles.

12 he synthetic transformations of indolo[3,2-b]indoles.

13 synthetic utility of the synthesized hydroxy indoles.

14 y relevant moieties, including pyridines and indoles.

15 on a column packed with poly[N-(3-methyl-1H-indole-1-yl)]-2-methacrylamide-co-2-acrylamido-2-methyl-

16 2,6,6-trimethylbicyclo[3.1.1]heptan-3-yl)-1H-indole -2-carboxamide (26), that shows excellent activit

17 ]thiazol-2-ylamine (SKA-31), 6,7-dichloro-1H-indole-2,3-dione 3-oxime (NS309), and 1-ethylbenzimidazo

18 g 1-EBIO, NS309, SKS-11 (6-bromo-5-methyl-1H-indole-2,3-dione-3-oxime) and SKS-14 (7-fluoro-3-(hydrox

19 complished starting from a readily available indole-2-acetic ester and an alpha,beta-unsaturated N-su

20 ahydroisoquinolin-2-yl)ethyl]cyclohexyl]-1H- indole-2-carboxamide (SB269652), a compound supposed to

21 identify (R)-2-amino-3-(4-(2-ethylphenyl)-1H-indole-2-carboxamido)propanoic acid (AICP) as a glycine

22 We previously reported that the indole 230 is a potent human OXE receptor antagonist.

23 In this study, odour thresholds (indole: 24-65microgkg(-1), skatole: 44-89microgkg(-1), a

24 vivo assays, we identified 2,2'-aminophenyl indole (2AI) as a potent synthetic ligand of AhR that pr

25 s the unstable 2,3-diamino-1-(phenylsulfonyl)indole (3), which can be trapped with alpha-dicarbonyl c

26 spiro-oxindole compounds bearing a spiro[3H-indole-3,2'-pyrrolidin]-2(1H)-one scaffold that are not

27 -1,2,3',3'a,4',5',6',6'a-octahydro-1'H-spiro[indole-3,2'-pyrrolo[3,2-b ]pyrrole]-5'-yl]benzoic acid (

28 ization as observed for the initial spiro[3H-indole-3,3'-pyrrolidin]-2(1H)-one scaffold.

29 und that the auxins indole-3-acetic acid and indole-3-acetamide, which were produced by various (micr

30 pivots on the interaction between the AUXIN/INDOLE-3-ACETIC ACID (Aux/IAA) repressor proteins and th

31 using alpha-(2,4-dimethylphenylethyl-2-oxo)-indole-3-acetic acid (auxinole), alpha-(phenylethyl-2-ox

32 The plant hormone indole-3-acetic acid (IAA or auxin) mediates the elongat

33 binding properties of indoxyl sulfate (IS), indole-3-acetic acid (IAA) and hippuric acid (HIPA) and

34 Gretchen Hagen 3.5 (AtGH3.5) conjugates both indole-3-acetic acid (IAA) and salicylic acid (SA) to mo

35 s thaliana, cotyledons and leaves synthesize indole-3-acetic acid (IAA) from tryptophan through indol

36 To date, the role of the auxin indole-3-acetic acid (IAA) in this context is not well u

37 PLC-ESI-MS/MS analysis showed that levels of indole-3-acetic acid (IAA) increased and levels of absci

38 stasis of the major form of auxin in plants, indole-3-acetic acid (IAA), remains unclear.

39 changes in auxin metabolism, mediated by the indole-3-acetic acid (IAA)-amido synthetase Gretchen Hag

40 al root primordia; decreased auxin maxima in indole-3-acetic acid (IAA)-treated root apical meristems

41 logical responses like the endogenous auxin, indole-3-acetic acid (IAA).

42 static regulation of the phytohormone auxin [indole-3-acetic acid (IAA)] is essential to plant growth

43 d an auxin-inhibitor (a-(phenyl ethyl-2-one)-indole-3-acetic acid (PEO-IAA)), together with the MIR17

44 c acid (auxinole), alpha-(phenylethyl-2-oxo)-indole-3-acetic acid (PEO-IAA), and 5-fluoroindole-3-ace

45 he biosynthesis of the main auxin in plants (indole-3-acetic acid [IAA]) has been elucidated recently

46 Finally, it was found that the auxins indole-3-acetic acid and indole-3-acetamide, which were

47 that neither the naturally occurring auxins indole-3-acetic acid and indole-3-butyric acid, nor the

48 fate, while for weakly bound toxins, namely, indole-3-acetic acid and p-cresyl glucuronide, an increa

49 ated tissues and others through signaling of INDOLE-3-ACETIC ACID INDUCIBLE28 (IAA28), CRANE (IAA18),

50 e gut microbiome (e.g., CMPF, phenylsulfate, indole-3-acetic acid).

51 wards small substrates including the natural indole-3-acetic acid, and the synthetic auxin 2,4-dichlo

52 The phytohormone auxin (indole-3-acetic acid, IAA) is a small organic molecule t

53 ling reporter based on the DII domain of the INDOLE-3-ACETIC ACID28 (IAA28, DII) protein from Arabido

54 The increase in the content of indole-3-acetonitrile, especially considerable within th

55 n biosynthesis from indole-3-pyruvic acid to indole-3-acetonitrile.

56 doxyl-3-sulfate, indole-3-propionic acid and indole-3-aldehyde, or the bacterial enzyme tryptophanase

57 ly occurring auxins indole-3-acetic acid and indole-3-butyric acid, nor the synthetic auxin analogs 1

58 All compounds, except Indole-3-butyric acid, repressed the recovery of the PIN

59 We investigated the efficacy of indole-3-carbinol (I3C), a dietary supplement, and AHR p

60 The Tg is driven by the indole-3-carbinol (I3C)-inducible rat cytochrome P450 1A

61 (Ahr) and treatment with the AHR pro-agonist indole-3-carbinol (I3C).

62 Among them, sulforaphane and indole-3-carbinol have attracted a lot of attention, sin

63 multaneous determination of sulforaphane and indole-3-carbinol in broccoli using UPLC-HRMS/MS is desc

64 The content of sulforaphane and indole-3-carbinol varied between 72+/-9-304+/-2mg and 77

65 lforaphane and 0.997, 0.42mg/L, 1.29mg/L for indole-3-carbinol, respectively.

66 e explored using a model TIM barrel protein, indole-3-glycerol phosphate synthase (IGPS).

67 The indole-3-glyoxamide 6 was discovered as an inhibitor of

68 acetic, phenyllactic, 4-OH-phenyllactic and indole-3-lactic were present only in Bio21B breads.

69 ophan metabolites indole, indoxyl-3-sulfate, indole-3-propionic acid and indole-3-aldehyde, or the ba

70 agonist MDL29,951 (2-carboxy-4,6-dichloro-1H-indole-3-propionic acid) decreases myelin basic protein

71 based approach, using an azido derivative of indole-3-propionic acid.

72 -3-acetic acid (IAA) from tryptophan through indole-3-pyruvic acid (3-IPA) in response to vegetationa

73 involve the sequential conversion of Trp to indole-3-pyruvic acid to IAA However, the pathway leadin

74 ated with a shift in auxin biosynthesis from indole-3-pyruvic acid to indole-3-acetonitrile.

75 he most potent agonists being di(5-fluoro-1H-indole-3-yl)methane (38, PSB-15160, EC50 80.0 nM) and di

76 -15160, EC50 80.0 nM) and di(5,7-difluoro-1H-indole-3-yl)methane (57, PSB-16671, EC50 41.3 nM).

77 rbonyl compounds to afford 5H-pyrazino[2,3-b]indoles 7-10.

78 5-b]pyridine (PhIP), 2-amino-9H-pyrido[2,3-b]indole (AalphaC), 2-amino-3,8-dimethylimidazo[4,5-f]quin

79 Elevated amounts of indole acetic acid, active cytokinins, active gibberelli

80 We showed that auxin (indole acetic acid, IAA) repressed the expression of key

81 lear AUXIN RESPONSE FACTOR7 (ARF7)/ARF19 and INDOLE ACETIC ACID7 pathway ensures correct nuclear plac

82 auxin response elements, and treatment with indole-acetic acid strongly induces MtLAX2 expression in

83 ile fatty acids (VFAs), two phenols, and two indoles) against three metal-organic frameworks (MOFs),

84 nthesis of the perhydroquinoline core of the indole alkaloid aspidophytine (2), starting from commerc

85 c enzymatic chlorination timing in ambiguine indole alkaloid biogenesis led to the discovery and char

86 requirement of class II CPRs for monoterpene indole alkaloid biosynthesis with a minimal or null role

87 hesis of congeners in the reverse-prenylated indole alkaloid family related to stephacidin A by takin

88 s the reverse prenylation of the tetracyclic indole alkaloid hapalindole U at its C-2 position.

89 Malbrancheamide is a dichlorinated fungal indole alkaloid isolated from both Malbranchea aurantiac

90 Mattogrossine is an indole alkaloid isolated from Strychnos mattogrossensis

91 Jerantinine A (JA) is a novel indole alkaloid which displays potent anti-proliferative

92 Total syntheses of the monoterpenoid indole alkaloids (+/-)-alstoscholarisine B and C were ac

93 ard the concise total syntheses of classical indole alkaloids (-)-aspidospermidine, (-)-tabersonine,

94 The pharmaceutically valuable monoterpene indole alkaloids (MIAs) in Catharanthus roseus are deriv

95 mily produce a large number of monoterpenoid indole alkaloids (MIAs) with different substitution patt

96 of structural expansion in the monoterpenoid indole alkaloids (MIAs) yielding thousands of unique mol

97 es more than a hundred different monoterpene indole alkaloids (MIAs).

98 aranthus roseus produces bioactive terpenoid indole alkaloids (TIAs), including the chemotherapeutics

99 armaceutically valuable, bioactive terpenoid indole alkaloids (TIAs).

100 Indole alkaloids are a diverse class of natural products

101 Dimeric indole alkaloids are structurally diverse natural produc

102 We describe herein formal syntheses of the indole alkaloids cis-trikentrin A and herbindole B from

103 Monoterpene indole alkaloids comprise a diverse family of over 2000

104 This fungus produced indole alkaloids containing an anti-bicyclo[2.2.2]diazao

105 involved in the biosynthesis of monoterpene indole alkaloids either through multiple isomers of stri

106 n of these prenylated and reverse-prenylated indole alkaloids is bioinspired, and may also inform the

107 The okaramines are a class of complex indole alkaloids isolated from Penicillium and Aspergill

108 ne and communesin F are structurally related indole alkaloids with an intriguing polycyclic core cont

109 Monoterpene indole alkaloids, a class of specialized metabolites tha

110 e of CPRs in the biosynthesis of monoterpene indole alkaloids, we provide compelling evidence of an o

111 ernary stereocenters of multiple monoterpene indole alkaloids.

112 esis of secondary metabolites, including the indole alkaloids.

113 aoctane core shared among several prenylated indole alkaloids.

114 a indicate that some IP bacteria, or perhaps indole alone, can influence the ability of Cryptosporidi

115 Hydrogen bonding at the indole amine most likely stabilizes the radical-like sta

116 ctly from serine (Ser) and the corresponding indole analogue.

117 ed biocatalyst also reacts with a variety of indole analogues and thiophenol for diastereoselective C

118 7-positions, using Ser and readily available indole analogues as starting materials.

119 o microbiota-derived AhR ligands tryptamine, indole and 1,4-dihydroxy-2-naphthoic acid (DHNA).

120 ed to parasitism with localized elevation of indole and aliphatic glucosinolates.

121 coupling that joins an allylic acetate, and indole and an organo-B(pin) species to provide substitut

122 data suggest that small molecules related to indole and derived from commensal microbiota act in dive

123 All six tryptophan indole and eight glycine backbone (15)N-(1)H NMR signals

124 Indole and indene compounds were engineered for high hCB

125 ded to examine the association between fecal indole and indole-producing (IP) gut microbiota on the o

126 in Catharanthus roseus are derived from the indole and iridoid pathways that respond to jasmonate (J

127 YC2 and BIS1/BIS2, are known to regulate the indole and iridoid pathways, respectively.

128 The enantioselective N-alkylation of indole and its derivatives with aldimines is efficiently

129 Also, both indole and pyridone cores are constructed during the cou

130 ferently substituted (mainly on phenyl ring) indoles and 1-benzothiophenes from the reaction of 3-alk

131 ulation method to produce highly substituted indoles and 1-benzothiophenes via sequential acid-cataly

132 le-based unsymmetrical triarylmethanes using indoles and aldehydes is challenging because the signifi

133 C3-substituted indoles and carbazoles react with alpha-aryl-alpha-diazo

134 l alcohols with indoles to form 3-benzylated indoles and H2O that is catalyzed, for the first time, b

135 organo-B(pin) species to provide substituted indoles and indolines with high enantio-, regio-, and di

136 of the enynols generates dihydrocyclohepta[b]indoles and indolotropones.

137 We evaluated tryptophan, indole, and IFN-gamma levels in cervicovaginal lavages f

138 nal catalysis furnish tetrahydrocyclohepta[b]indoles, and a one-pot quadruple reaction sequence of th

139 hree reaction partners comprising aldehydes, indoles, and arylboronic acids.

140 partners, including pyridines, pyrimidines, indoles, and piperidines.

141 rroles, thieno[3,2-b]pyrroles, pyrrolo[2,3-b]indoles, and pyrrolo[2,3-b]pyridines in good yields.

142 Here, we describe (4 + 3) and (3 + 2) indole annulation strategies that quickly generate compl

143 The derivatives of 7-amino indole are synthetically useful for accessing a variety

144 reactions of trans-beta-nitorostyrenes with indoles are examined, and good yields and enantioselecti

145 A variety of alkyne-tethered indoles are suitable for this process.

146 rates, including bulky or electron-deficient indoles, are poorly accepted.

147 ing a Cu-vinylidene complex, and 3-styryl-1H-indole as probable intermediates.

148 ifluoromethyltrimethylsilane and substituted indoles as nucleophiles.

149 This method tolerates a wide array of indoles, as well as pyrrole and carbazole, to afford the

150 Direct carbonylative coupling of indoles at the third position has also been accomplished

151 IC50 values (2 muM) ever observed among all indole-based compounds we have evaluated.

152 t the design and synthesis of a new class of indole-based conjugated trimers.

153 d 11 with respect to our previously reported indole-based fluorescent probe.

154 ibacterial agents, and recently we described indole-based inhibitor candidates.

155 Here we report a new library of indole-based perenosins and their anion transport proper

156 transport efficiency when compared to other indole-based transporters, due to favourable encapsulati

157 n of medicinally and synthetically important indole-based unsymmetrical triarylmethanes using indoles

158 bazoles through the functionalization of two indole C(sp(2))-H and one C(sp(3))-H bond of the active

159 Strategic bromination at the indole C3 position greatly improved the allylic alkylati

160 tephacidin A by taking advantage of a direct indole C6 halogenation of the related ketopremalbranchea

161 unds including naphtols, phenols, pyridines, indoles, carbazoles, and thiophenes in combination with

162 a structural mimic of the fused tetracyclic indole compound IDC16 that targets SRSF1, it did not aff

163 hat in vitro cultures of A. bisporus release indole compounds in conditions simulating the human dige

164 Fecal indole concentrations (FICs) of 50 subjects and 19 taxa

165 e designed and synthesized 9H-pyrimido[4,5-b]indole-containing compounds to obtain potent and orally

166 The resulting indole-containing inhibitor was 100-fold more potent tha

167 ynthesis of the 2,3-dihydro-1H-pyrrolo[1,2-a]indole core of the putative structure of yuremamine is r

168 te the selective direct C-H-amination of the indole core of various tryptamines.

169 a quinoline moiety to the 9H-pyrimido[4,5-b]indole core, we identified a series of small molecules s

170 of alkynes is achieved for the synthesis of indole-cyclic urea fused derivatives through a double cy

171 Indoles decreased the induction of IL-17 but promoted IL

172 ray-based transcriptomics demonstrating that indole decreases the expression of genes involved in ene

173 uted boronium [L2PhBCN]BF4 5 and a 2-boranyl-indole derivative 6, depending on the substituent R.

174 n of a novel series of 3-(piperazinylmethyl) indole derivatives as 5-hydroxytryptamine-6 receptor (5-

175 he way for synthesizing a variety of 7-amino indole derivatives in excellent yields at ambient reacti

176 under mild conditions to afford N-alkylated indole derivatives in good yield (up to 86 %) and excell

177 11 out of 41 indole derivatives inhibited the TNF-alpha effect.

178 f original strategies for the preparation of indole derivatives is a major goal in drug design.

179 R, T cell receptor) repertoire but generated indole derivatives of tryptophan that activated the aryl

180 P, BAZ2B, and BRPF1b) in complex with acetyl indole derivatives reveal the influence of the gatekeepe

181 Novel indole derivatives with inhibitory activity towards acet

182 NF-alpha activity in the compound library of indole derivatives.

183 to facilitate the rapid synthesis of several indole derivatives.

184 d all of these pathways are inhibited by bis-indole-derived NR4A1 antagonists that inhibit nuclear ex

185 Tubingensin B is an indole diterpenoid that bears a daunting chemical struct

186 inhibitor, epacadostat, and/or an effector, indole ethanol (IDE).

187 palladium-catalyzed amination and oxidative indole formation.

188 rein, we report the first straight access to indoles from anilines and ethylene glycol by heterogeneo

189 ficient catalyst-free synthesis of 6-hydroxy indoles from carboxymethyl cyclohexadienones and primary

190 We show that indoles from commensal microbiota extend healthspan of d

191 hod for the synthesis of dihydropyrido[1,2-a]indoles from mixtures of nitrones and allenoates has bee

192 n alkyl or amide group at the C3-position of indole furnishes the 3-azidooxindole product.

193 Indole furthermore inhibited the three-channel quorum se

194 dipeptide has been developed to prepare new indole-fused aminoacetals.

195 A straightforward synthetic route toward indole-fused heteroacenes was developed.

196 ticulum (ER) body formation and induction of indole glucosinolate (IGs) metabolism selectively, via t

197 hrome P450 monooxygenases and IGMTs encoding indole glucosinolate O-methyltransferases have been iden

198 of plants that synthesize phytoalexins from indole glucosinolate.

199 se in A. thaliana root ER bodies, hydrolyzes indole glucosinolates (IGs) in addition to the previousl

200 s enhanced on cyp79B2 cyp79B3 hosts (without indole glucosinolates) but inhibited on atr1D hosts (wit

201 but inhibited on atr1D hosts (with elevated indole glucosinolates) relative to wild-type hosts, whic

202 we observe side chain losses, including the indole group from tryptophan, and immonium ions.

203 racy (RPD=1.36, 1.65, 1.63, 1.11) while, for indole-GSLs, glucosinigrin, glucoiberin, glucobrassicin

204 An efficient route to multisubstituted indoles has been developed through intramolecular oxidat

205 route to nonracemic tetrahydropyrrolo[2,3-b]indoles has been developed via SN2-type ring opening of

206 Hexahydropyrrolo[2,3-b]indoles have been detosylated in the same pot to afford

207 obable mechanisms for the formation of these indoles have been suggested.

208 pe ring opening of activated aziridines with indoles having substitutions at 3- and other positions f

209 ion strategies that quickly generate complex indole heterocycle libraries that contain novel cyclohep

210 successfully addresses this problem for the indole heterocycle.

211 o stem from the electrostatic dislocation of indole highest occupied molecular orbital (HOMO) charge

212 cresol (o-C), phenol (PhAl), p-cresol (p-C), indole (ID), and skatole (SK)).

213 ate that levels of androstenone, skatole and indole in back fat and meat products tend to correlate s

214 at the C-2 position (via C-H activation) of indole in water in the presense of a hypervalent iodine

215 rd the corresponding tetrahydropyrrolo[2,3-b]indoles in good yields and excellent ee (up to 99%).

216 both symmetric and nonsymmetric indolo[3,2-b]indoles in good yields.

217 es that can be cyclized to 1,2-disubstituted indoles in moderate to high yields (up to 94% over two s

218 nown as kratom, represent diverse scaffolds (indole, indolenine, and spiro pseudoindoxyl) with opioid

219 y oriented one-pot synthesis of cyclohepta[b]indoles, indolotropones, and tetrahydrocarbazoles (THCs)

220 Upon nucleophilic addition of indoles, indolylenamides were obtained with yields of 60

221 plementation with the tryptophan metabolites indole, indoxyl-3-sulfate, indole-3-propionic acid and i

222 In C. elegans, indole induces a gene expression profile in aged animals

223 Moreover, in older animals, indole induces genes associated with oogenesis and, acco

224 Some of the cyclohexadienones gave 6-amino indoles instead of 6-hydroxy indoles using the Re2O7 cat

225 The radical character of the cation-indole interaction is predicted to stem from the electro

226 n accomplished the problematic conversion of indole into 2-indolinone.

227 amino acid metabolism, the data suggest that indole is a starvation signal in V. campbellii.

228 ions show that the formation of the observed indole is most favored energetically, while the potentia

229 vel method for the oxidation of indolines to indoles is described.

230 ester or ketone moiety at the C3-position of indole leads to azidation at the C2-position, whereas a

231 g because the significant nucleophilicity of indole leads to C-C coupling with an azafulvene intermed

232 The reaction of indoles leads to the formation of chiral C-N cross-coupl

233 Thus, preexisting indole levels in the gut join the oocyst dose and immune

234 Elevated indole levels significantly decreased motility, biofilm

235 xes based on the unexplored 7-(azaheteroaryl)indole ligands.

236 ally aromatic in nature and mostly indole or indole-like.

237 The cyclopenta[b]indole motif is present in several natural and synthetic

238 first approach where one can synthesize free indole N-H benzo-fused pyridoindolones.

239 ectivity could be controlled by changing the indole N-protecting group in the reductive cyclization p

240 ps, including an alcohol, aldehyde, epoxide, indole, nitroalkane, and sulfide.

241 ked on the terminal basepair such that their indole nitrogen atoms lie on the major groove side, and

242 econd of which requires deprotonation of the indole nitrogen in Trp during its attack on methylcobala

243 he installation of an amide bond between the indole-nitrogen of tryptophan and an anthranilic acid re

244 phosphate activates both the alkyne and the indole nucleophile in the initial cyclization step throu

245 ol catalyst in the presence of electron-rich indole nucleophiles.

246 A hydrogen bond between the indole of W733 of the TRP helix and the backbone oxygen

247 Effects of indoles on healthspan in worms and flies depend upon the

248 By incorporation of an indole or a quinoline moiety to the 9H-pyrimido[4,5-b]in

249 are generally aromatic in nature and mostly indole or indole-like.

250 ing therapeutics based on microbiota-derived indole or its derivatives to extend healthspan and reduc

251 e C-terminal amide onto either N-peptidoacyl indoles or pyrroles.

252 ly require preformation and alkylation of an indole precursor.

253 ine the association between fecal indole and indole-producing (IP) gut microbiota on the outcome of a

254 Both intermediates can lead to the observed indole product, albeit through different mechanisms.

255 angement, which would produce the unobserved indole product, is destabilized by the electron-withdraw

256 Furthermore, the indole products contain a 3-trifluoroacetyl group, which

257 bled approach assembles 2-trifluoromethyl NH-indole products from simple commercially available anili

258 ed coupling of 1,3-dicarbonyl compounds with indole, pyrrole, imidazole, and pyrazole nucleophiles vi

259 action leads to only one of the two possible indole regioisomers, along with minor decomposition prod

260 t contain novel cyclohepta- and cyclopenta[b]indoles, respectively.

261 xploration of substituents introduced to the indole ring of lead compound 1 (MI-136) to identify comp

262 The introduction of chlorine atoms on the indole ring of malbrancheamide differentiates it from ot

263 as well as at the 2- and 3-positions of the indole ring.

264 volve unpaired electron density at C3 of the indole ring.

265 residues at the 5- and/or 7-position of the indole rings displayed the highest activity in cAMP assa

266 ent inhibitor containing a 9H-pyrimido[4,5-b]indole scaffold against the N-terminal domain of the top

267 study, some unexplored modifications on the indole scaffold are proposed.

268 sition en route for synthesizing the 7-amino indole scaffold has been achieved by using dioxazolone,

269 Among NorA inhibitors, the indole scaffold proved particularly effective and suitab

270 ximately 200 compounds containing the acetyl indole scaffold.

271 nent arises due to the local mobility of the indole side chain, whereas the longer rotational-correla

272 double bond isomerization or cyclization to indole side product was not observed.

273 In this study, the impact of indole signalling on the virulence of Vibrio campbellii

274 Further, indole signalling was found to interact with the stress

275 r meat, were developed for quantification of indole, skatole, and androstenone in different meat prod

276 ology for the synthesis of benzothieno[3,2-b]indoles starting from 3-nitrobenzothiophene.

277 Moreover, we showed that all other indole-substituted analogs of Trp undergo methylation at

278 s and the heterologous reconstitution of the indole-sulfur phytoalexin pathway sheds light on an impo

279 inin, demonstrating that the biosynthesis of indole-sulfur phytoalexins can be engineered into noncru

280 ssica crop species are prolific producers of indole-sulfur phytoalexins that are thought to have an i

281 Here, inspired by the Fischer indole synthesis, we report an iridium-catalysed tyrosin

282 llows single-step access to 3-functionalized indoles that usually require preformation and alkylation

283 ]pyrroles, thieno[3,2-b]furans, thieno[3,2-b]indoles, thieno[3,2-b]benzofurans, thieno[3,2-b]pyridine

284 hyl groups as well as heteroarenes including indole, thiophene, pyridine, and isoquinoline.

285 le nucleophilic addition of two molecules of indole to one molecule of alkyne occurs in a tandem mann

286 n, and some Ct strains utilize extracellular indole to restore tryptophan levels.

287 talysts using the Friedel Crafts addition of indole to trans-beta-nitrostyrene.

288 f primary and secondary benzyl alcohols with indoles to form 3-benzylated indoles and H2O that is cat

289 Boronic esters react with 2-lithiated indoles to form boronate intermediates.

290 nessing three indolyne isomers, six isomeric indole trimers are accessible, none of which have been p

291 and control of the wayward reactivity of the indole unit to standard oxidants.

292 Azidation of indoles using iodine and copper bromide as catalysts und

293 es gave 6-amino indoles instead of 6-hydroxy indoles using the Re2O7 catalyst.

294 ]quinazolinones from the suitably fabricated indoles via C-N bond forming cyclization in 28-82% yield

295 ve synthetic route to hexahydropyrrolo[2,3-b]indoles via Lewis acid-catalyzed SN2-type ring opening o

296 Due to its volatility, indole was not measurable in either group.

297 Titration of indole with sodium hydroxide or ammonium hydroxide yield

298 p sequence for the synthesis of cyclopenta[b]indoles with a great structural diversity.

299 recedented transition metal-free coupling of indoles with aryl halides.

300 ndolylmethane derivatives by condensation of indoles with formaldehyde in water under microwave irrad