ライフサイエンスコーパス: indole alkaloid

1 other members of the Aspidosperma family of indole alkaloids.

2 ernary stereocenters of multiple monoterpene indole alkaloids.

3 esis of secondary metabolites, including the indole alkaloids.

4 aoctane core shared among several prenylated indole alkaloids.

5 indolenines, a common motif in many natural indole alkaloids.

6 ecule library, reminiscent of the polycyclic indole alkaloids.

7 s that produces high amount of monoterpenoid indole alkaloids.

8 rstand the biosynthesis of fungal prenylated indole alkaloids.

9 ts, including approximately 3000 monoterpene indole alkaloids.

10 er acidic conditions during the synthesis of indole alkaloids.

11 ure eliminates all production of monoterpene indole alkaloids, a class of natural products derived fr

12 Monoterpene indole alkaloids, a class of specialized metabolites tha

13 A linear synthesis of the indole alkaloid (+/-)-akuammicine (2) was completed by a

14 Total syntheses of the monoterpenoid indole alkaloids (+/-)-alstoscholarisine B and C were ac

15 iwinkle, synthesizes bioactive monoterpenoid indole alkaloids, among which the anti-cancer drugs vinb

16 l synthesis of notoamide J, a new prenylated indole alkaloid and potential biosynthetic precursor, is

17 nstitutes the first total synthesis of these indole alkaloids and provides the first regiospecific ro

18 nes, a structural motif embedded in numerous indole alkaloids and synthetic indole derivatives.

19 the synthesis of macroline/sarpagine related indole alkaloids and their antipodes for biological scre

20 f natural products, such as the prostanoids, indole alkaloids, and macrolide antibiotics, provide amp

21 Indole alkaloids are a class of structurally diverse nat

22 Indole alkaloids are a diverse class of natural products

23 Prenylated indole alkaloids are a diverse group of fungal secondary

24 The monoterpene indole alkaloids are a large group of plant-derived spec

25 Dimeric indole alkaloids are structurally diverse natural produc

26 o verify the role of this reverse-prenylated indole alkaloid as an intermediate along the biosyntheti

27 nthesis of the perhydroquinoline core of the indole alkaloid aspidophytine (2), starting from commerc

28 ard the concise total syntheses of classical indole alkaloids (-)-aspidospermidine, (-)-tabersonine,

29 Tryprostatin A 1 and B 2 are indole alkaloid-based fungal products that act in the G2

30 c enzymatic chlorination timing in ambiguine indole alkaloid biogenesis led to the discovery and char

31 and is considered a key step in monoterpene indole alkaloid biosynthesis as it links primary and sec

32 requirement of class II CPRs for monoterpene indole alkaloid biosynthesis with a minimal or null role

33 identification of bottlenecks in monoterpene indole alkaloid biosynthesis, and discovery of new pathw

34 ly hydrolyzes 3 alpha(S)-epimer in terpenoid-indole alkaloid biosynthesis, IpeGlu1 lacked stereospeci

35 diversity-generating power of monoterpenoid indole alkaloid biosynthesis.

36 expression profiles similar to known terpene indole alkaloid biosynthetic genes.

37 that produces the anti-cancer monoterpenoid indole alkaloid camptothecin (CPT).

38 We describe herein formal syntheses of the indole alkaloids cis-trikentrin A and herbindole B from

39 62066 (1 microM) and ibogaine (1 microM), an indole alkaloid claimed to be useful in the treatment of

40 Monoterpene indole alkaloids comprise a diverse family of over 2000

41 ral products belong to a group of prenylated indole alkaloids containing a core bicyclo[2.2.2]diazaoc

42 This fungus produced indole alkaloids containing an anti-bicyclo[2.2.2]diazao

43 Novel routes to the naturally occurring indole alkaloid cycloclavine and its unnatural C(5)-epim

44 ymmetric approach to both enantiomers of the indole alkaloid deplancheine from a readily available, n

45 ynthesis of the biologically significant bis-indole alkaloid dragmacidin D (5) has been achieved.

46 the total synthesis of the sarpagine-related indole alkaloids (-)-(E)16-epiaffinisine (1), (+)-(E)16-

47 involved in the biosynthesis of monoterpene indole alkaloids either through multiple isomers of stri

48 iosynthetic intermediate for all monoterpene indole alkaloid enzymatic pathways.

49 The total synthesis of the indole alkaloid ervincidine (3) is reported.

50 of the small class of unusual monoterpenoid indole alkaloids exemplified by alstilobanines A (3) and

51 hesis of congeners in the reverse-prenylated indole alkaloid family related to stephacidin A by takin

52 Ibogaine (Endabuse) is a psychoactive indole alkaloid found in the shrub, Tabernanthe iboga, w

53 Ibogaine (Endabuse) is a psychoactive indole alkaloid found in the West African shrub, Taberna

54 dy we have identified new halogenated prenyl-indole alkaloids from an invertebrate-derived Malbranche

55 Bis(indole) alkaloids from Arundo donax were synthesized usi

56 etic precursor of a variety of monoterpenoid indole alkaloids, from d-tryptophan (19) was performed a

57 toward other substrates, including terpenoid-indole alkaloid glucosides.

58 s the reverse prenylation of the tetracyclic indole alkaloid hapalindole U at its C-2 position.

59 members of the vinca and tacaman classes of indole alkaloids has been accomplished.

60 Ibogaine, a hallucinogenic indole alkaloid, has been proposed as a treatment for ad

61 ng the proposed structure of the tetracyclic indole alkaloid ht-13-B is presented.

62 med in good yields and can be converted into indole alkaloids in only a few steps.

63 leton of the apparicine class of monoterpene indole alkaloids in only four steps in 80% overall yield

64 iwinkle, synthesizes bioactive monoterpenoid indole alkaloids, including the anti-cancer drugs vinbla

65 is the source of several medicinal terpenoid indole alkaloids, including the low-level anticancer vin

66 reas phorbol 12-myristate 13-acetate and the indole alkaloids indolactam and octylindolactam were sel

67 n of these prenylated and reverse-prenylated indole alkaloids is bioinspired, and may also inform the

68 Malbrancheamide is a dichlorinated fungal indole alkaloid isolated from both Malbranchea aurantiac

69 Mattogrossine is an indole alkaloid isolated from Strychnos mattogrossensis

70 The okaramines are a class of complex indole alkaloids isolated from Penicillium and Aspergill

71 The communesins are a prominent class of indole alkaloids isolated from Penicillium species.

72 yntheses of the Strychnos-Strychnos-type bis-indole alkaloids (-)-leucoridine A (1) and C (2) were ac

73 sis of the chlorinated [2.2.2]-diazabicyclic indole alkaloid (+)-malbrancheamide B is reported.

74 han, which is then shuttled into monoterpene indole alkaloid metabolism to yield chlorinated alkaloid

75 s of biologically active monoterpene-derived indole alkaloid (MIA) metabolites and is the sole source

76 ristine are condensed from the monoterpenoid indole alkaloid (MIA) precursors catharanthine and vindo

77 Camptothecin is a monoterpene indole alkaloid (MIA) used to produce semisynthetic anti

78 kle), the unique source of the monoterpenoid indole alkaloid (MIA)-type anticancer drugs vincristine

79 The pharmaceutically valuable monoterpene indole alkaloids (MIAs) in Catharanthus roseus are deriv

80 mily produce a large number of monoterpenoid indole alkaloids (MIAs) with different substitution patt

81 of structural expansion in the monoterpenoid indole alkaloids (MIAs) yielding thousands of unique mol

82 biosynthesis of many different monoterpenoid indole alkaloids (MIAs), many of which have powerful bio

83 es more than a hundred different monoterpene indole alkaloids (MIAs).

84 oschizol (4) as well as the opioid agonistic indole alkaloid mitragynine (1).

85 esis of the 9-methoxy-substituted Corynanthe indole alkaloids mitragynine (1), 9-methoxygeissoschizol

86 synthesis of the ring-A oxygenated sarpagine indole alkaloids (+)-N(a)-methylsarpagine (8), (+)-majvi

87 aloids are a diverse class of fungal-derived indole alkaloid natural products with potent pharmacolog

88 as the key step in concise syntheses of the indole alkaloids norfluorocurarine and strychnine.

89 olled strategy to the Aspidosperma family of indole alkaloids, one that is readily adapted to the asy

90 idea that Trp biosynthesis and the secondary indole alkaloid pathway are coordinately regulated.

91 es cerevisiae host from 14 known monoterpene indole alkaloid pathway genes, along with an additional

92 anticancer drug produced by the monoterpene indole alkaloid pathway in Camptotheca acuminata.

93 s of the architecturally complex tremorgenic indole alkaloid (-)-penitrem D (4) has been achieved.

94 There are approximately 3,000 monoterpene indole alkaloids produced by thousands of plant species

95 provides Trp for both protein synthesis and indole alkaloid production and therefore represents a ju

96 Dimeric indole alkaloids represent a structurally unique class o

97 N-N-linked dimeric indole alkaloids represent an unexplored class of natura

98 nalyte electrochemistry was tested using the indole alkaloid reserpine, which is often used to test t

99 zophenanthridine alkaloids and monoterpenoid indole alkaloids, respectively, in response to microbial

100 The indole-alkaloid scytonemin is the most common and widesp

101 , the first total synthesis of the monomeric indole alkaloids (+)-spegatrine (2), (+)-10-methoxyvello

102 apply this strategy to the synthesis of the indole alkaloid spegazzinidine, it was necessary to addr

103 e early steps for creation of the prenylated indole alkaloid structure and suggest a scheme for the b

104 the 19th century to the present, the complex indole alkaloid strychnine has engaged the chemical comm

105 l synthesis of the bridge-fused Aspidosperma indole alkaloid (+/-)-subincanadine F has been accomplis

106 Scytonemin is a heterocyclic indole-alkaloid sunscreen, the synthesis of which is ind

107 ontribute to the regulation of monoterpenoid indole alkaloid synthesis in this species.

108 corynantheol and the formal syntheses of the indole alkaloids tacamonine, rhynchophylline, and hirsut

109 Seven new prenylated indole alkaloids, taichunamides A-G, were isolated from

110 Ibogaine, an indole alkaloid that causes hallucinations, tremor, and

111 Ibogaine (IBO) is an indole alkaloid that is reported to facilitate drug abst

112 tural products--specifically the monoterpene indole alkaloids, the benzylisoquinoline alkaloids and t

113 s roseus produces a large array of terpenoid indole alkaloids (TIAs) that are an important source of

114 e to the interest in their dimeric terpenoid indole alkaloids (TIAs) vinblastine and vincristine, whi

115 aranthus roseus produces bioactive terpenoid indole alkaloids (TIAs), including the chemotherapeutics

116 armaceutically valuable, bioactive terpenoid indole alkaloids (TIAs).

117 rived from the dimerization of the terpenoid indole alkaloids vindoline and catharanthine.

118 e of CPRs in the biosynthesis of monoterpene indole alkaloids, we provide compelling evidence of an o

119 uld permit entry into many ring-A oxygenated indole alkaloids when coupled with the asymmetric Pictet

120 Jerantinine A (JA) is a novel indole alkaloid which displays potent anti-proliferative

121 Tremorgenic mycotoxins are a group of indole alkaloids which include the quinazoline-containin

122 ed Zincke aldehyde cycloaddition approach to indole alkaloids, which permitted the gram-scale synthes

123 Actinophyllic acid is a biologically active indole alkaloid with a unique structural framework that

124 ne and communesin F are structurally related indole alkaloids with an intriguing polycyclic core cont

125 a general entry into C-6 hydroxy-substituted indole alkaloids with either an alpha or a beta configur

126 Hapalindoles are bioactive indole alkaloids with fascinating polycyclic ring system