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1 duces depressive-like behavior by activating indoleamine 2,3 dioxygenase.
2 the presence of H(2)O(2)/ONOO(-) deactivated indoleamine 2,3-dioxygenase.
3 of 2',5'-oligoadenylate synthetase, Mx1, and indoleamine 2,3-dioxygenase.
4 cells through the induction and activity of indoleamine 2,3-dioxygenase.
5 t in vitro (though not in vivo) inhibitor of indoleamine 2,3-dioxygenase.
6 a induces expression of p47 GTPases, but not indoleamine 2,3-dioxygenase.
7 hyl-tryptophan which is also an inhibitor of indoleamine 2,3-dioxygenase.
8 eam target, the tryptophan-catalyzing enzyme indoleamine 2,3-dioxygenase.
9 eries of substituted tryptophan analogues by indoleamine 2,3-dioxygenase.
10 were evaluated for their ability to inhibit indoleamine 2,3-dioxygenase.
11 xpression of the tryptophan-degrading enzyme indoleamine-2,3-dioxygenase.
12 ited T-cell reactivity through regulation of indoleamine-2,3-dioxygenase.
13 ulatory molecules including IL-10, CD25, and indoleamine-2,3-dioxygenase.
14 tryptophan via the IFN-gamma-induced enzyme indoleamine 2, 3-dioxygenase.
15 was not mediated via induction of the enzyme indoleamine 2, 3-dioxygenase.
16 endent on the tryptophan catabolizing enzyme indoleamine 2,3 dioxygenase 1 (IDO1) in splenic macropha
19 ses of two antiretroviral ISGs indicate that indoleamine 2,3-dioxygenase 1 (IDO1) can inhibit retrovi
20 as driven by IFN-gamma-mediated induction of indoleamine 2,3-dioxygenase 1 (IDO1) enzyme activity wit
25 tion, a host tryptophan-catabolizing enzyme, indoleamine 2,3-dioxygenase 1 (IDO1), is induced specifi
29 hermore, treatment of NKp44(+) NK cells with indoleamine 2,3-dioxygenase 1 catabolites in vitro ablat
34 munodeficiency virus (HIV) infection-induced indoleamine 2,3-dioxygenase-1 (IDO) expression in activa
37 ols, whereas level of messenger RNA encoding indoleamine 2,3-dioxygenase-1 was significantly increase
38 , the SE inhibited the enzymatic activity of indoleamine 2,3 dioxygenase, a key enzyme in immune tole
39 n-gamma-induced degradation of tryptophan by indoleamine 2,3-dioxygenase, activates the previously or
41 cts of gamma interferon (IFN-gamma)-mediated indoleamine 2,3-dioxygenase activity on C. pneumoniae pe
43 cells, possibly via stimulation of host cell indoleamine-2,3-dioxygenase activity, in a dose-dependen
44 e, is similar to that of the large domain of indoleamine 2,3-dioxygenase, an enzyme that catalyzes th
45 lls express high levels of CD163, CD206, and indoleamine 2,3-dioxygenase and secrete immunosuppressiv
46 grafts and increased expression of mRNAs for indoleamine 2,3-dioxygenase and the subunits encoding in
47 is an O2-dependent process and catalyzed by indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygena
48 g induction was mediated by DC expression of indoleamine 2,3-dioxygenase, and was confirmed in IDO-KO
49 of various tumor-promoting genes, including indoleamine 2,3-dioxygenase; and attenuation of these ch
50 ot reverse tolerance, but treatment with the indoleamine-2,3-dioxygenase antagonist 1-methyltryptopha
51 expression of tolerogenic mediators, such as indoleamine-2,3-dioxygenase, arginase, and TGF-beta, and
54 sistent with a common reaction mechanism for indoleamine 2,3-dioxygenase-catalyzed oxidation of trypt
58 physiological importance of human placental indoleamine 2,3-dioxygenase (EC 1.13.11.42), the first a
59 lation of circulating prostaglandin E(2) and indoleamine 2, 3,-dioxygenase enzymatic activity, as wel
63 In human epithelial cells, IFN-gamma induces indoleamine 2,3-dioxygenase expression that inhibits chl
64 feron-gamma, which increases villous explant indoleamine 2,3-dioxygenase expression, has no effect on
66 that inhibition of enzyme activity in human indoleamine 2,3-dioxygenase (hIDO) and a number of site-
69 han 2,3 dioxygenase (hTDO), and the other is indoleamine 2,3-dioxygenase (hIDO), both of which cataly
70 nt in heme-based dioxygenases, such as human indoleamine 2,3-dioxygenase (hIDO), was not recognized u
73 proved SB transposon encoding the human gene indoleamine-2,3-dioxygenase (hIDO), an enzyme that posse
74 HS suppressed mRNA and protein expression of indoleamine 2, 3-dioxygenase (IDO) and its activity upon
76 recently shown that expression of the enzyme indoleamine 2, 3-dioxygenase (IDO) during murine pregnan
78 y modulating the expression of PD-L1; Tim-3; indoleamine 2, 3-dioxygenase (IDO); and interleukin 10.
80 , depletion of Gr1(+) cells or inhibition of indoleamine 2,3 dioxygenase (IDO) activity abrogates gra
82 amino acid TRP, cells expressing the enzyme indoleamine 2,3 dioxygenase (IDO) can mediate potent loc
85 d expression of the immune regulatory enzyme indoleamine 2,3 dioxygenase (IDO) in local lymph nodes.
87 xpression of the tryptophan-degrading enzyme indoleamine 2,3 dioxygenase (IDO) is selectively induced
88 ha(-/-) mice was likely because of a lack of indoleamine 2,3 dioxygenase (IDO), a critical regulator
89 local draining lymph nodes (dLNs) to express indoleamine 2,3 dioxygenase (IDO), which confers T cell
90 aneously, pDCs up-regulate the expression of indoleamine 2,3 dioxygenase (IDO), which is essential fo
95 ther gamma interferon (IFN-gamma) can induce indoleamine 2,3-dioxygenase (IDO) activity in aortic smo
96 higher levels of gamma interferon-inducible indoleamine 2,3-dioxygenase (IDO) activity than endothel
97 ike receptor (TLR) 4 signaling, can regulate indoleamine 2,3-dioxygenase (IDO) activity, favoring TH2
100 describe a subset of human APCs that express indoleamine 2,3-dioxygenase (IDO) and inhibit T cell pro
101 h a focus on the tryptophan catabolic enzyme indoleamine 2,3-dioxygenase (IDO) and its recently disco
102 inhibitory effect was primarily mediated by indoleamine 2,3-dioxygenase (IDO) and prostaglandin E2 (
103 omotes immune suppression through the enzyme indoleamine 2,3-dioxygenase (IDO) and subsequent product
104 tivated inflammatory macrophages can express indoleamine 2,3-dioxygenase (IDO) and thus actively depl
106 ortage of tryptophan caused by expression of indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dio
107 eprogramming was suppressed by tumor-induced indoleamine 2,3-dioxygenase (IDO) and vaccination failed
112 aneous efficacy of serum and urine biomarker indoleamine 2,3-dioxygenase (IDO) enzyme activity and pe
113 CR analysis revealed a 5-fold enhancement of indoleamine 2,3-dioxygenase (IDO) expression in the tumo
116 vation of the tryptophan catabolizing enzyme indoleamine 2,3-dioxygenase (IDO) in cancer cells facili
117 ously shown that an immunomodulatory enzyme, indoleamine 2,3-dioxygenase (IDO) in dermal fibroblasts
118 rucial role for the immunosuppressive enzyme indoleamine 2,3-dioxygenase (IDO) in GVHD regulation.
119 tent to express the T-cell regulatory enzyme indoleamine 2,3-dioxygenase (IDO) in mice treated with T
120 upregulated both the immunoregulatory enzyme indoleamine 2,3-dioxygenase (IDO) in plasmacytoid DCs an
121 critical role for the immune escape mediator indoleamine 2,3-dioxygenase (IDO) in supporting inflamma
122 Elevation of the immunomodulatory enzyme indoleamine 2,3-dioxygenase (IDO) in tumor cells can fac
123 n 4 (CTLA-4) blockade and treatment with the indoleamine 2,3-dioxygenase (IDO) inhibitor 1-methyl-D-t
124 n a prodrug conjugate of PEG with NLG919, an indoleamine 2,3-dioxygenase (IDO) inhibitor currently us
125 nt and include chemotherapeutics, radiation, indoleamine 2,3-dioxygenase (IDO) inhibitors, inhibitors
133 bolism of the amino acid tryptophan (Trp) by indoleamine 2,3-dioxygenase (IDO) is considered an impor
138 y, expression of the immunoregulatory enzyme indoleamine 2,3-dioxygenase (IDO) is induced following i
144 Here, we examine the inhibitory role of indoleamine 2,3-dioxygenase (IDO) on the antitumor effic
148 ors of the tryptophan (Trp) catabolic enzyme indoleamine 2,3-dioxygenase (IDO) represent a vanguard o
150 s study, we investigated the relationship of indoleamine 2,3-dioxygenase (IDO) systemic activity on c
153 In contrast, we found that the induction of indoleamine 2,3-dioxygenase (IDO) was required for the a
154 the tolerogenic tryptophan-degrading enzyme indoleamine 2,3-dioxygenase (IDO) were analyzed using fl
155 ithelial infection by inducing expression of indoleamine 2,3-dioxygenase (IDO), a host enzyme with pr
156 sed antitumor response through inhibition of indoleamine 2,3-dioxygenase (IDO), a key tolerogenic enz
158 duct brassinin to be a moderate inhibitor of indoleamine 2,3-dioxygenase (IDO), a new cancer immunosu
160 Br-brassinin) are bioavailable inhibitors of indoleamine 2,3-dioxygenase (IDO), a pro-toleragenic enz
161 s to HDAC inhibitors increased expression of indoleamine 2,3-dioxygenase (IDO), a suppressor of DC fu
162 through pathogen-specific local induction of indoleamine 2,3-dioxygenase (IDO), a tryptophan cataboli
163 re treated with a pharmacologic inhibitor of indoleamine 2,3-dioxygenase (IDO), a tryptophan-cataboli
164 ad7-deficient DCs expressed higher levels of indoleamine 2,3-dioxygenase (IDO), an enzyme associated
165 at M. tuberculosis induced the expression of indoleamine 2,3-dioxygenase (IDO), an enzyme involved in
166 blot analysis, which indicated induction of indoleamine 2,3-dioxygenase (IDO), an enzyme that conver
168 Similar to CTLA-4 and FoxP3, expression of indoleamine 2,3-dioxygenase (IDO), an immunosuppressive
170 sing T cells (CARTs) through the activity of indoleamine 2,3-dioxygenase (IDO), an intracellular enzy
171 l-molecule immunotherapy agent that inhibits indoleamine 2,3-dioxygenase (IDO), encapsulated in the n
172 yptophan catabolism, initiated by the enzyme indoleamine 2,3-dioxygenase (IDO), is a critical partici
173 Although the tryptophan-degrading enzyme, indoleamine 2,3-dioxygenase (IDO), is a pivotal mediator
174 ted reduced toxicity as reflected by induced indoleamine 2,3-dioxygenase (IDO), suggesting discreet a
176 induce an IFNgamma-driven induction of host indoleamine 2,3-dioxygenase (IDO), the first and rate-li
178 n of innate immunity, induces high levels of indoleamine 2,3-dioxygenase (IDO), the rate-limiting enz
179 f expressing the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase (IDO), which allows them to
181 C production of the immunosuppressive enzyme indoleamine 2,3-dioxygenase (IDO), which depletes local
182 ations of RV-PV dysfunction with circulating indoleamine 2,3-dioxygenase (IDO)-dependent tryptophan m
183 ptophan oxidation products produced from the indoleamine 2,3-dioxygenase (IDO)-mediated kynurenine pa
195 use tryptophan-catabolizing enzymes such as indoleamine 2,3-dioxygenase (IDO-1) to induce an immunos
196 oring of tryptophan (trp) metabolism through indoleamine 2.3-dioxygenase (IDO) has been previously pr
197 uced inducible nitric oxide synthase (iNOS), indoleamine-2,3-dioxygenase (IDO) and heme oxygenase (HO
201 t levo-1-methyl tryptophan (L-1MT) can block indoleamine-2,3-dioxygenase (IDO) expressed by human den
202 the tumor tissue by the rate-limiting enzyme indoleamine-2,3-dioxygenase (IDO) expressed in tumor cel
203 yptophan pools by gamma interferon-inducible indoleamine-2,3-dioxygenase (IDO) is believed to be the
205 roids augment MSC expression and activity of indoleamine-2,3-dioxygenase (IDO), a primary mediator of
207 m the induction of type I IFN-alpha/beta and indoleamine-2,3-dioxygenase (IDO)-mediated immunosuppres
211 ession of the tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase (IDO1) in human epithelial c
214 he anti-inflammatory and anti-bacterial gene indoleamine 2,3-dioxygenase (IDO1) is dependent on STAT1
215 al burdens than control mice, underexpressed indoleamine-2,3-dioxygenase (Ido1) in lung endothelium a
216 in the promoter region of the gene encoding indoleamine-2,3-dioxygenase (IDO1) was found to be assoc
217 on (IFN)-gamma induces the expression of the indoleamine 2, 3-dioxygenase (INDO) gene in human cells,
221 n (which is a known competitive inhibitor of indoleamine 2,3-dioxygenase) is a competitive inhibitor
222 ed during tryptophan metabolism initiated by indoleamine 2,3-dioxygenase, is known to induce T cell d
223 Abnormal tryptophan metabolism catalyzed by indoleamine 2,3-dioxygenase may play a prominent role in
224 ance of L-tryptophan transport for placental indoleamine 2,3-dioxygenase-mediated degradation of L-tr
225 nts both BCH and 1-methyl-tryptophan inhibit indoleamine 2,3-dioxygenase-mediated L-tryptophan degrad
226 e trophoblast to be a rate-limiting step for indoleamine 2,3-dioxygenase-mediated L-tryptophan degrad
227 his mechanism is dependent both on placental indoleamine 2,3-dioxygenase-mediated tryptophan degradat
228 cyte division was specifically suppressed by indoleamine 2,3-dioxygenase-mediated tryptophan depletio
229 also inhibited PIV3, including IFITM1, IDO (indoleamine 2,3-dioxygenase), PKR (protein kinase, RNA a
230 rs such as TGF-beta, CTLA-4, PD-1, ICOS, and indoleamine 2,3-dioxygenase play an important role in im
232 FN-gamma synthesis by donor T cells inducing indoleamine 2,3-dioxygenase synthesis by donor pDCs limi
233 ane vesicles as part of a study on placental indoleamine 2,3-dioxygenase, the L-tryptophan-catabolisi
234 ending on IFNgamma signaling and mediated by indoleamine 2,3-dioxygenase to a constitutive mechanism
235 ence of interferon-gamma (known to stimulate indoleamine 2,3-dioxygenase) tryptophan but not threonin
238 explants was markedly reduced when placental indoleamine 2,3-dioxygenase was stimulated with interfer
239 a number of suppressive enzymes, among which indoleamine 2,3-dioxygenase was sufficient to inhibit an
240 ic cell accumulation, expression of IL-2 and indoleamine 2,3-dioxygenase were evident in TLR4 compare
241 ly produced by both cell populations, unlike indoleamine 2, 3-dioxygenase which was only produced fol
242 ophan limitation mediated by the host enzyme indoleamine 2,3-dioxygenase, which converts l-tryptophan
243 and primarily dependent on pDC expression of indoleamine 2,3-dioxygenase, which was induced through t
244 tor-kappaB, as well as the metabolic enzyme, indoleamine-2,3-dioxygenase, which breaks down tryptopha
245 uman (hIDO) and Shewanella oneidensis (sIDO) indoleamine 2,3-dioxygenases, Xanthomonas campestris (Xc
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