ライフサイエンスコーパス: indolizidine

1 trogen-heterocycles such as pyrrolidines and indolizidines.

2 ] cycloaddition/N-alkylation cascade to form indolizidines.

3 for a one-pot, three-component synthesis of indolizidines.

4 routes for the synthesis of polyhydroxylated indolizidines.

5 for the formation of some quinolizidines and indolizidines.

6 lity is demonstrated by a rapid synthesis of indolizidine 167B.

7 The total synthesis of (-)-indolizidine 195B via a general route, which could poten

8 several sites contained a 5,8-disubstituted indolizidine (205A or 235B), representing another class

9 y chiral GC comparison with the exception of indolizidine 209B (I) for which a natural 209B could no

10 was demonstrated by a total synthesis of (-)-indolizidine 209B.

11 ific route to three (+/-)-5, 8-disubstituted indolizidines, (209B (I), 209I (II), 223J (III)) and two

12 four natural and one non-natural alkaloids: indolizidines (+/-)-209I and (+/-)-8-epi-219F in the rac

13 eld was elaborated into indolizidine 5,8-epi-indolizidine 223A via a five-step reaction sequence in 3

14 nal synthetic plans for the natural product, indolizidine 223A, the new stereoselective cyclization s

15 concise enantioselective total synthesis of indolizidine (-)-223A, a 5,6,8-trisubstituted alkaloid i

16 strated here with the total syntheses of (-)-indolizidine 223AB (1) and alkaloid (-)-205B (2).

17 ddition of pyrrolidino enedione 19 to afford indolizidine 24 as the major product and cyclization/lac

18 ries, and enantiocontrolled syntheses of (-)-indolizidine 251N, (-)-quinolizidine 251AA, and (-)-dehy

19 enated dihydroxypyrrolizidines 20 and 27 and indolizidine 28, respectively, by reductive cleavage of

20 dt reaction, producing the known benzo-fused indolizidine 49, which had been transformed by Ito et al

21 ol obtained in 32% yield was elaborated into indolizidine 5,8-epi-indolizidine 223A via a five-step r

22 the key cyclization yielded, in four steps, indolizidine 6,8-epi-223 in 14% yield.

23 Indolizidines (-)-8-epi-swainsonine triacetate and (+)-1

24 Indolizidine alkaloid 223A was isolated from a skin extr

25 his methodology is to synthesize benzo-fused indolizidine alkaloid mimics.

26 o the synthesis of many natural hydroxylated indolizidine alkaloids as demonstrated in the formal syn

27 Natural and unnatural indolizidine alkaloids can be synthesized from simple un

28 e.g. its precursor role in carnitine and in indolizidine alkaloids of physiological interest.

29 h could potentially be used to prepare other indolizidine alkaloids such as (-)-gephyrotoxin 223AB an

30 ide migration in the biosynthetic pathway of indolizidine alkaloids.

31 by examining the reaction of a dideuterated indolizidine, alpha,beta-unsaturated N-acyliminium ion p

32 ations for the synthesis of highly alkylated indolizidine and other related alkaloids.

33 A new approach to the synthesis of indolizidine and pyrrolizidine skeletons is reported.

34 s of allyl and 3-substituted allylsilanes to indolizidine and quinolizidine alpha,beta-unsaturated N-

35 as been developed as an efficient entry into indolizidine and quinolizidine frameworks.

36 pot approach toward the synthesis of various indolizidine and quinolizidine ring systems.

37 A direct approach to the synthesis of indolizidine and quinolizidine scaffolds of iminosugars

38 enyl isocyanates leading to the formation of indolizidine and quinolizidine scaffolds.

39 ive general strategy for the construction of indolizidine and related alkaloids, illustrated here wit

40 A convergent synthesis of stereodefined indolizidines and quinolizidines through chemoselective

41 preparation of the azabicyclic cores of the indolizidines and quinolizidines using a one-pot cascade

42 itrogen 10 atom at the bridgehead, including indolizidines and quinolizidines, can be prepared in fou

43 oor or electron-rich dipolarophiles yielding indolizidines and related 1-aza[m.3.0]bicycloalkane syst

44 is of highly functionalized pyrrolidines and indolizidines and the reluctance of certain kinds of all

45 provides immediate access to arylpiperidine, indolizidine, and quinolizidine scaffolds from the corre

46 the formation of substituted quinolizidines, indolizidines, and pyrrolizidines.

47 Indolizidines are bioactive heterocyclic compounds of gr

48 which PTXs, alloPTXs, and 5,8-disubstituted indolizidines are derived.

49 hat functionalized tetrahydroindolizines and indolizidines can be prepared selectively, at low pressu

50 rically pure 1-(dibenzylamino)-3-substituted indolizidines could be further transformed into the corr

51 and several selective transformations of the indolizidine derivatives reported here may find further

52 The indolizidine framework was obtained by means of oxidatio

53 ons for the inversion of the nitrogen at the indolizidine framework, allowing rapid equilibration bet

54 nation reaction for the synthesis of complex indolizidine frameworks is illustrated by application to

55 gem-diamine intermediate that undergoes the indolizidine --> pyrrolizidine Amadori-type rearrangemen

56 Multisubstituted tropanes and indolizidines have been prepared with high regio- and st

57 Herein, 1-(dialkylamino)-3-substituted indolizidines have been straightforwardly synthesized us

58 iperdines, pyrrolidines, pyrrolizidines, and indolizidines, have the potential to become important th

59 y suggests that immunomodulatory activity of indolizidine iminosugars can be tuned by minor structura

60 New quaternary indolizidine iminosugars, with hydroxymethyl group at th

61 The enzyme is shown to convert indolizidine intermediates into pyrrolizidines through a

62 uoromethylenated dihydroxypyrrolizidines and indolizidines is described.

63 synthesis of mono-, di-, and trihydroxylated indolizidines is presented in four to six steps from Cbz

64 owledge, detection of 5,8-disubstituted (ds) indolizidine iso-217B in T. electrum represents the firs

65 synthetic alkaloid have established that the indolizidine moiety is trans-fused.

66 ve 5,8-disubstituted or 5,6,8-trisubstituted indolizidines; one 1,4-disubstituted quinolizidine; thre

67 n to set up the manno-stereochemistry of the indolizidine precursor.

68 found in well-known natural products (e.g., indolizidine, quinolizidine, and Stemona alkaloids).

69 oyed as the key step to construct the chiral indolizidine ring.

70 n the configuration at the 6-position of the indolizidine ring.

71 A concise entry to functionalized indolizidine scaffolds through a domino 2-aza-Cope-[3 +

72 5))((t)BuN)]LnE(TMS)(2) to the corresponding indolizidine skeleton in good yield and high diastereose

73 as a key step wherein both the rings of the indolizidine skeleton were built up in one pot following

74 3,5-diols in the context of polyhydroxylated indolizidine synthesis is demonstrated by an application

75 cted under mild conditions to afford diverse indolizidine systems as single diastereomers in good ove

76 ethyl-1,2-dihydropyridines affords tricyclic indolizidines that incorporate quaternary carbons and up

77 Indolizidine type alkaloids have been attractive synthet

78 ategy, substituted tetrahydroindolizines and indolizidines were obtained diastereoselectively in high

79 oaddition with unsymmetrical alkynes to give indolizidines with good regio- and stereoselectivity.