ライフサイエンスコーパス: induced mutation

1 ites of Pol II stalling is predictive of AID-induced mutation.

2 easel is a novel N-ethyl-N-nitrosourea (ENU)-induced mutation.

3 homologs in other bacteria are required for induced mutation.

4 osinase gene had been deleted by a radiation-induced mutation.

5 sensitive to spontaneously arising and X-ray-induced mutation.

6 gene PTEN was sequenced and analyzed for UV-induced mutations.

7 activation-induced cytidine deaminase (AID)-induced mutations.

8 ic strategy for the discovery and mapping of induced mutations.

9 erivatives for the frequency and kinds of UV-induced mutations.

10 lecular weight between bases to identify any induced mutations.

11 o allows wheat to tolerate high densities of induced mutations.

12 onstrating efficient transmission of the ZFN-induced mutations.

13 ess was accelerated by N-ethyl-N-nitrosourea-induced mutations.

14 amplifications occur as apparent starvation-induced mutations.

15 levated rate of both sporadic and DNA damage-induced mutations.

16 permit the efficient recovery of chemically induced mutations.

17 pathway can greatly reduce the frequency of induced mutations.

18 eated new opportunities for rapid mapping of induced mutations.

19 974 data on dominance of spontaneous and EMS-induced mutations.

20 the occurrence and randomness of chemically induced mutations.

21 at G/C pairs were the predominant type of Cr-induced mutations.

22 t reveal any significant epistasis among the induced mutations.

23 f the skin in which p53 is inactivated by UV-induced mutations.

24 epatocarcinogenesis is associated with MeIQx-induced mutations.

25 genes, including Ty retrotransposons and Ty-induced mutations.

26 in mice carrying N-ethyl-N-nitrosourea (ENU)-induced mutations.

27 f the skin in which p53 is inactivated by UV-induced mutations.

28 s to involve an enhanced expression of MeIQx-induced mutations.

29 rces available for comprehensive analysis of induced mutations.

30 efficient germ-line transmission of the Cas9-induced mutations.

31 om mice carrying N-ethyl-N-nitrosourea (ENU)-induced mutations.

32 ng mice homozygous for N-ethyl-N-nitrosourea-induced mutations.

33 often due to low tumor purity and treatment-induced mutations.

34 ive trait locus (QTL) mapping and mapping of induced mutations.

35 have previously characterized two transgene-induced mutations, 94-A and 94-K, which are allelic with

36 -deficient cells exhibited reduced cisplatin-induced mutation, a process that has been implicated in

37 ra of spontaneous and ethyl methanesulfonate-induced mutations across the Saccharomyces cerevisiae ge

38 Moreover, a recurrent UV-induced mutation activating RAC1 has recently been detec

39 cular lesion responsible for a recessive EMS-induced mutation affecting egg shell morphology by using

40 A screen for N-ethyl-N-nitrosourea (ENU)-induced mutations affecting early development in the asc

41 nt lines revealed >1.8 million canonical EMS-induced mutations, affecting >95% of genes in the sorghu

42 rto unidentified N-ethyl-N-nitrosourea (ENU)-induced mutation affects dorsal root ganglia (DRG) forma

43 analyze mtDNA integrity, damage repair, and induced mutations after exposure of human adult retinal

44 obust mitochondrial damage responses repress induced mutations after mutagen exposure.

45 development either directly or by screening induced mutations against a deletion.

46 oops) generate DNA ends that underlie stress-induced mutation and amplification.

47 We also examined induced mutation and found that either the inability to

48 e D' (3d), a recessive N-ethyl-N-nitrosourea-induced mutation and phenotype in which no signaling occ

49 translesional DNA synthesis in chemotherapy-induced mutation and resistance to front-line chemothera

50 We sequenced 182 UVC (254 nm UV)-induced mutations and 170 mutations induced by a solar U

51 substitutions comprised 86% of the N-OH-AABP-induced mutations and 74% of the spontaneous cII mutatio

52 bryonic fibroblast cells against methylation-induced mutations and characterize the effect of a parti

53 We found that the frequencies of induced mutations and chromosomal changes in populations

54 test this hypothesis, we measured genotoxin-induced mutations and chromosome damage in p27-deficient

55 s II and IV are responsible for misalignment induced mutations and compete with DNA polymerase V whic

56 egies: phenotypic screens for spontaneous or induced mutations and genotypic analysis using homologou

57 enesis by demonstrating that all three drugs induced mutations and led to an increase in the generati

58 lar layer that shapes the specificity of AID-induced mutations and may provide new insights into the

59 ied heteroduplexes derived from a variety of induced mutations and naturally occurring polymorphisms.

60 a 25-fold higher than normal frequency of UV-induced mutations and very unusual kinds (spectrum), mai

61 w to conserve energy, minimize transcription-induced mutation, and permit regulation over the widest

62 te of DNA photoproduct removal, decreases UV-induced mutations, and reduces photocarcinogenesis in UV

63 In addition, how natural variations, induced mutations, and the advanced genome-editing techn

64 e high frequency and abnormal spectrum of UV-induced mutations, and ultimately their malignant transf

65 Natural variation and induced mutations are important resources for gene disco

66 east cells with ultraviolet (UV) light, most induced mutations are inherited by both daughter cells,

67 Recombination-induced mutations are largely independent of mismatch re

68 e, we found in this study that transcription-induced mutations are not limited to specific genes, all

69 Phenotypes associated with these P-induced mutations are similar to those resulting from de

70 In both barley and B. oleracea stable Cas9-induced mutations are transmitted to T2 plants independe

71 The Drosophila transposon P-element-induced mutations are very useful for directly connectin

72 Expression of p48 suppressed UV-induced mutations arising from the nontranscribed strand

73 s suggest genetic reversion due to cisplatin-induced mutations as a distinct mechanism for developing

74 The induced mutations as well as damaged cells would occur t

75 with spontaneous, genetically engineered and induced mutations, as well as 100s of inbred strains and

76 ar to those found in previous studies of EMS-induced mutations, as well as 2.4% indels (insertions an

77 revious work showed that about 85% of stress-induced mutations associated with DNA double-strand brea

78 ides, were then correlated to cell toxicity, induced mutation at the TK (thymidine kinase) and HPRT l

79 wed an increased level of ionizing radiation-induced mutation at the TK and HPRT loci, impaired phosp

80 Our data also indicate that MMS-induced mutations at adenine nucleotides are significant

81 ucts directed by PNAs conjugated to psoralen-induced mutations at frequencies in the range of 0.46%,

82 ase.' Additionally, the frequency of nickase-induced mutations at the I-AniI site was at least 150-fo

83 ow to very low DR, the overall dependence of induced mutations being parabolically related to DR, wit

84 We demonstrate that most break-repair-induced mutations (BRIMs) are point mutations and have a

85 RAD6, and RAD18 did not have any cross-link-induced mutations but showed increased levels of recombi

86 gulated Myc sensitizes B cells to chemically induced mutations, but does not cause, on its own, mutat

87 equencing of mutant chromosomes, to identify induced mutations by comparison to parental chromosomes.

88 iciency revealed by an N-ethyl-N-nitrosourea-induced mutation called elektra.

89 evealed by a recessive N-ethyl-N-nitrosourea-induced mutation called warmflash (wmfl).

90 We have characterized an induced mutation, called embryonic ectoderm development

91 The characterization of ENU-induced mutations can build on the resources provided by

92 doubleridge is a transgene-induced mutation characterized by polydactyly and syndac

93 Of 106 ZFN-induced mutations characterized, 83 (78%) were simple de

94 ees C show much higher frequencies of CRISPR-induced mutations compared to plants grown continuously

95 inst an eGFP transgene in Xenopus tropicalis induced mutations consistent with nonhomologous end join

96 new alleles affected expression of the gypsy-induced mutation ct(6) and found that it was unaltered i

97 cal translocation with LG 2 in one gamma-ray induced mutation, cyc(b213).

98 Furthermore, the kinds of UV-induced mutations differ very significantly from normal.

99 ta indicate that DSB-repair-dependent stress-induced mutation, driven by spontaneous DNA breaks, is a

100 describe a novel N-ethyl-N-nitrosourea (ENU)-induced mutation, early doors (Edo), in the PER-ARNT-SIM

101 train that carries a nitrosoguanidine (MNNG)-induced mutation enabling it to accept DNA from Escheric

102 Spontaneous and induced mutation experiments indicated these patterns of

103 gulation of the tricarboxylic acid cycle and induced mutation facilitate S. aureus persistence and ev

104 We determined non-B DNA-induced mutation frequencies and spectra in human U2OS o

105 rmation and other steps for analyzing damage-induced mutation frequencies and spectra.

106 inum adducts by determining cytotoxicity and induced mutation frequencies at the hypoxanthine guanine

107 Primary XP-C cells had increased UV-induced mutation frequencies compared with normal cells,

108 Reported here are the selection protocols, induced mutation frequencies, cytogenetic and extensive

109 sociated with significant increases in break-induced mutation frequencies, deletion lengths and the a

110 sults in a 6- to 14-fold increase in the MMS-induced mutation frequency and in a significant increase

111 ice displayed a higher N-ethyl-N-nitrosourea-induced mutation frequency in the colon than p27(+/+) li

112 c dead strain of Rev1 exhibits a lower 4-NQO-induced mutation frequency than wild type.

113 he episomal shuttle vector, the psoralen-PNA-induced mutation frequency was 0.13%, 3.5-fold higher th

114 to cytotoxicity and an increase in H(2)O(2)-induced mutation frequency; however, mutation frequency

115 tion-altering potential of 10,913 laboratory-induced mutations from 2372 proteins.

116 In rice, we identified approximately 18,000 induced mutations from 72 independent M2 individuals.

117 Comparison of the A3-induced mutations from reporter cells and the patient-de

118 milarity between the spectra of UVA- and UVB-induced mutations further supports similar mechanisms of

119 ization analyses indicate that the transgene-induced mutation has generated a complete deletion of th

120 Our results indicate that transcription-induced mutations have altered the composition of bacter

121 Over 10,000 such laboratory-induced mutations have been reported in the UniProt data

122 Induced mutations have been used to generate novel varia

123 These results suggest that APOBEC3G-induced mutations have contributed to the evolution of a

124 To see if transcription-induced mutations have influenced the evolution of bacte

125 These ENU-induced mutations hold promise in yielding new insights

126 The signature of induced mutations, i.e., T to C transitions and T to A t

127 Finally, genetic profiling of transposon-induced mutations identified significant differences in

128 A P-element-induced mutation in dCtBP exhibits gene-dosage interacti

129 This cell culture-induced mutation in HRV16 VPg moderately increased its u

130 were negative for PFOS, we propose that PFOS-induced mutation in liver tissue of lambda transgenic me

131 Here we identify an ENU-induced mutation in mice that reveals a molecular pathwa

132 ated that mice harboring an ethylnitrosourea-induced mutation in the gene encoding mTOR die at embryo

133 As a result of an N-ethyl-N-nitrosourea-induced mutation in the last alpha helix of DCK, a funct

134 cy does not affect spontaneous and radiation-induced mutation in the mouse germline.

135 efficient heritable transmission of the ZFN-induced mutation in the subsequent generation.

136 e we report that male mice homozygous for an induced mutation in TLS are sterile with a marked increa

137 racea, targeting of BolC.GA4.a leads to Cas9-induced mutations in 10 % of first generation plants scr

138 ion density, we searched 528 individuals for induced mutations in 15 genes for which few or no knocko

139 roximately 1900 ethyl methanesulfonate (EMS)-induced mutations in 192 Arabidopsis thaliana target gen

140 Here we report the identification of EMS-induced mutations in 21 essential loci in the 45D-45F re

141 N-ethyl-N-nitrosourea (ENU)-induced mutations in Adam17 (which is required for AREG

142 lopmental regulator subject to translocation-induced mutations in B cell precursor leukemias, the cur

143 n the context of the organ-specificity of IQ-induced mutations in beta-catenin, being highly prevalen

144 Moreover, CRISPR/Cas9 induced mutations in both male and female monkeys, with

145 e (Cloudmap) optimized for identification of induced mutations in Brachypodium.

146 gous effects of ethylmethane sulfonate (EMS)-induced mutations in Caenorhabditis elegans are compared

147 eas duct cells harbouring oncogenic KRAS and induced mutations in CDKN2A, SMAD4 and TP53 expand in vi

148 ct may be a major progenitor of aflatoxin B1-induced mutations in DNA.

149 We induced mutations in Drosophila melanogaster males by tr

150 We have identified EMS-induced mutations in Drosophila Miro (dMiro), an atypica

151 We found that equitoxic doses of cisplatin induced mutations in fibroblasts lacking polymerase eta

152 isome were invariably repaired, this process induced mutations in flanking DNA at a significantly hig

153 The isolation of chemically induced mutations in forward genetic screens is one of t

154 from three independent N-ethyl-N-nitrosourea-induced mutations in host cell factor C2 (Hcfc2).

155 ntrations of vitamin C can prevent oxidation-induced mutations in human cells.

156 study of spontaneous and ionizing radiation-induced mutations in kidney epithelia and ear fibroblast

157 Fitness effects of induced mutations in lines of Caenorhabditis elegans wer

158 To study double-strand break (DSB)-induced mutations in mammalian chromosomes, we stably tr

159 To study double-strand break (DSB)-induced mutations in mammalian chromosomes, we transfect

160 During a screen for ethylnitrosourea-induced mutations in mice affecting blood natural killer

161 goal is the identification of experimentally induced mutations in multiple isogenic samples.

162 mutation frequency, it greatly enhanced BPDE-induced mutations in nucleotide excision repair (NER)-pr

163 ns, but in many cases was associated with UV-induced mutations in p53.

164 Finally, UV-induced mutations in PL-fed-mice were decreased by appro

165 n, we determined the spectra of UVA- and UVB-induced mutations in primary human fibroblasts.

166 e transcriptase (RT) active against the drug-induced mutations in RT continues to be a very important

167 ple recent studies to find unique, treatment induced mutations in sets of isogenic samples with very

168 The ENU-induced mutations in several families were mapped using

169 orrelated this information with peroxidation-induced mutations in several human fibroblast cell lines

170 the frequency and specificity of dG-N(2)-AAF-induced mutations in simian kidney (COS-7) cells.

171 equency and specificity of dG-AAF- and dG-AF-induced mutations in simian kidney (COS-7) cells.

172 the mouse, we have identified recessive ENU-induced mutations in six genes that prevent normal speci

173 The density of ROS-induced mutations in ssDNA is lower, compared to that ca

174 iver allelic series of ethylmethanesulfonate-induced mutations in target 1-kb loci requested by the i

175 the feasibility of screening for chemically induced mutations in target sequences in Arabidopsis tha

176 and cytological characterization of four EMS-induced mutations in teflon (tef), a gene involved in th

177 Experimentally-induced mutations in the C3HC4 RING finger domain of the

178 The induced mutations in the D310 region were predominantly

179 Here we analyze a set of EMS-induced mutations in the egg gene, identify the molecula

180 target two copies of HvPM19 and observe Cas9-induced mutations in the first generation of 23 % and 10

181 termined whether chronic H. pylori infection induced mutations in the gastric mucosa of male and fema

182 Long-term exposure of HIV-1 to KRAB-PBS2 induced mutations in the HIV-1 PBS that reduced the effe

183 The pattern of IR-induced mutations in the MMR-deficient animals was notab

184 itrate permeases, a collection of chemically induced mutations in the nrtA gene encoding a 12-transme

185 s was obtained in a collection of chemically induced mutations in the spoIIR locus of Bacillus subtil

186 The frequency of UV radiation-induced mutations in the XP variant cells is significant

187 The absence of drug induced mutations in these sera collected several years

188 regulate leukotriene production, natural or induced mutations in this bipartite nuclear localization

189 are responsible for at least 80% of the UVB-induced mutations in this mammalian cell model.

190 Although induced mutations in traditional laboratory animals have

191 populations were evaluated by screening for induced mutations in two genes of interest and the induc

192 It is unclear if APOBEC3-induced mutations in vivo are always lethal or can occur

193 hese results suggest that ionizing radiation-induced mutations in vivo can result from both direct an

194 uency and striking difference in kinds of UV-induced mutations in XPV cells strongly suggest that, in

195 e high frequency and abnormal spectrum of UV-induced mutations in XPV cells, we identified an unlimit

196 Here we show that transposon-induced mutations in Zmiz1 drive expression of a truncat

197 Cisplatin-induced mutations, including short insertions and deleti

198 Introduction of danoprevir and BILN 2061-induced mutations into the original clones by site-direc

199 The formation of MNNG-induced mutations is almost abolished in the rad30Delta

200 demonstrate that the incidence of radi-ation-induced mutations is dependent on the genetic background

201 ycle block in Os and in the 94-A/K transgene-induced mutations is due to disruption of the Anapc10 (A

202 curacy of computational tools for laboratory-induced mutations is much lower than that observed for t

203 Because the frequency of damage-induced mutations is strongly dependent on the repairabi

204 two forms of Pol iota, whose frequency of UV-induced mutations is twice that of XPV cells expressing

205 In contrast, most of the retrotransposon-induced mutations isolated in maize are caused by the in

206 lthough uracil DNA glycosylases limit APOBEC-induced mutation, it is unknown if subsequent base excis

207 The P-element-induced mutation, l(3)01544, affects the steady-state le

208 Here, we characterize the ENU-induced mutation lazy mesoderm (lzme), which disrupts th

209 Here we describe an ENU-induced mutation, limulus (lulu), which disrupts gastrul

210 The radiation-induced mutation minute (Mnt) in the mouse leads to intr

211 -CMdA nor N4-CMdC blocked DNA replication or induced mutations, N3-CMdT, O4-CMdT and O6-CMdG moderate

212 clease-induced DSBs strongly activate stress-induced mutations near the DSB, but not globally.

213 One hypothesis is that UV-induced mutations occur only after deamination of the cy

214 Instead, we discover that the laboratory-induced mutations occur predominately at the highly cons

215 ' sites, and in both yeast and human DNA, UV-induced mutations occur primarily by 3' C to T transitio

216 e analysis revealed that the majority of MDA-induced mutations occurred at GC base pairs.

217 xon 3, where a total of 23 (27%) of all PhIP-induced mutations occurred.

218 , we demonstrate loss of mature B cells upon induced mutation of a signaling module of the BCR, not p

219 l cavity could promote tooth development, we induced mutation of epithelial beta-catenin to a stabili

220 ents latency shortening by methylating agent-induced mutation of K-ras.

221 al histology associated with spontaneous and induced mutations of both embryonic and adult mice inclu

222 MCH was chosen to test because induced mutations of the MCH gene in mice cause hypophag

223 Here we show that TALEN of dmrt1 efficiently induced mutations of this gene.

224 The radiation-induced mutation Oligosyndactylism (Os) is associated wi

225 ethal mutation uncovered in a screen for ENU-induced mutations on mouse chromosome 5.

226 heterozygotes (who are at risk for treatment-induced mutation or loss of the remaining wild-type alle

227 The immunovariant N-ethyl-N-nitrosourea-induced mutations Pococurante (Poc) and Lackadaisical we

228 The characteristic PUVA-induced mutations predominate in the p53 mutational spec

229 Next, we show that two EMS-induced mutations, previously shown to interact genetica

230 t IGHV3-23*01 in Ramos cells accumulates AID-induced mutations primarily in the AGCT in CDR2, which w

231 Males homozygous for the repro32 ENU-induced mutation produced by the Reproductive Genomics p

232 avirus integration and ultraviolet-radiation-induced mutations, providing rationale for treatment wit

233 Ac-induced mutations range from small footprints of host se

234 DRC) in cultured human cells and decrease UV-induced mutation rate and photocarcinogenesis in mouse s

235 Recessive N-ethyl-N-nitrosourea (ENU)-induced mutations recovered at the fitness-1 (fit1) locu

236 provide a method for developing large-scale induced mutation resources with relatively small investm

237 , through positional cloning of a chemically induced mutation responsible for a neurobehavioral pheno

238 panel to map two N-ethyl-N-nitrosourea (ENU)-induced mutations responsible for visible phenotypes in

239 The induced mutations showed intrinsic features of Ig V(D)J

240 Genome-wide analysis of these crosslinking-induced mutation sites (CIMS) in HITS-CLIP data for Nova

241 n data analysis take advantage of cross-link-induced mutation sites (CIMS) to refine RNA-binding maps

242 Analysis of the UV-induced mutation spectra revealed that > 90% were point

243 the control (p < 0.008), as well as a unique induced mutation spectrum as established by DNA sequence

244 This difference in the Z-DNA-induced mutation spectrum between mammals and bacteria m

245 nt human cells significantly altered the ICL-induced mutation spectrum from predominantly T-->A to T-

246 The cisplatin-induced mutation spectrum shows good correlation with ca

247 r substitutions in 5'-d(CG) sites in the MDA-induced mutation spectrum.

248 ectra were similar to those reported for *OH-induced mutations, suggesting that *OH generated from po

249 agm Vif inhibited the accumulation of hApo3G-induced mutations, suggesting that SIVagm Vif is indeed

250 The results support efforts to achieve drug-induced mutation suppression of stop codons.

251 Surprisingly, induced mutations temporally lagged behind high levels o

252 rly than late reproductive output, since EMS-induced mutations tend to cause delayed reproduction.

253 tor-induced, but not ionizing radiation (IR)-induced, mutations than similarly treated wild-type cell

254 re, we report a novel, N-ethyl-N-nitrosourea-induced mutation that causes a gain of function in adeno

255 d the zebrafish tortuga (tor) gene by an ENU-induced mutation that disrupts the presomitic mesoderm (

256 receptors, and we describe here a chemically-induced mutation that impairs this response in macrophag

257 cted a forward genetic screen for chemically induced mutations that cause Caenorhabditis elegans to b

258 contractions are regulated, we isolated EMS-induced mutations that cause males to execute prolonged

259 time identification of N-ethyl-N-nitrosourea-induced mutations that cause phenotypes in mice.

260 Moreover, ethyl methanesulfonate-induced mutations that change amino acids within the MBC

261 The three original NTG-induced mutations that defined the whiK/bldM locus each

262 are very successful in diagnosing laboratory-induced mutations that elicit significant functional cha

263 -wide screen for novel N-ethyl-N-nitrosourea-induced mutations that give rise to eye and vision abnor

264 ndependent, recessive, N-ethyl-N-nitrosourea-induced mutations that map to a approximately 1- to 2-cM

265 ntly fail in correctly annotating laboratory-induced mutations that show no functional impact in the

266 es this loss-of-function phenotype using EMS-induced mutations that specifically alter the nau gene,

267 By screening for chemically induced mutations that suppress the bushy, determinate g

268 We selected for transposon-induced mutations that upregulate P(Y) transcription in

269 nt study, we utilized TALEN- and CRISPR/Cas9-induced mutations to analyze the promoter of the barley

270 The key data supposedly linking smoke-induced mutations to lung cancer were obtained from the

271 00-fold increase in the frequency of nitrite-induced mutations to streptomycin resistance, which are

272 rent screening strategies target CRISPR-Cas9-induced mutations to the 5' exons of candidate genes, bu

273 In cancers due to chemically induced mutations, viral infections, somatic and inherit

274 In particular, PFOS-induced mutation was characterized by +1 frameshift muta

275 We present the first study in which an ENU-induced mutation was identified by massively parallel DN

276 In two other families, the ENU-induced mutation was identified--Sema3CL605P was associa

277 N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced mutations was determined in human lymphoblastoid

278 Evidence of APOBEC3-induced mutations was found in gag sequences derived fro

279 Overall, through the recovery of an ENU-induced mutation, we uncovered Megf8 as an essential reg

280 involvement of 5-methylcytosine in sunlight-induced mutations, we have analyzed the cII transgene in

281 contribution of 5-methylcytosine to sunlight-induced mutations, we have used mouse fibroblasts contai

282 The most frequently induced mutations were A to T transversions, which were

283 However, 24% of the solar light-induced mutations were at dipyrimidines that contain 5-m

284 UVA-induced mutations were characterized by statistically si

285 the presence or absence of HR, and the Z-DNA-induced mutations were characterized.

286 MDA-induced mutations were completely abolished when the add

287 Both site-directed and chemically induced mutations were constructed within mrkD1P, and th

288 Most of the induced mutations were deletions and single-base-pair su

289 The vast majority (97.5%) of the induced mutations were distinct from natural variations.

290 n the lacI gene, 68% (75 of 111) of the BPDE-induced mutations were G-to-T events, and 58 of 75 (77%)

291 quences in vivo, 83 of 147 (56%) of the BPDE-induced mutations were G-to-T transversions, and 58% (48

292 DMY-nanos3UTR-TALENs induced mutations were passed through the germline to F1

293 Like normal adaptive mutations, gIIp-induced mutations were recA(+) and ruvC(+) dependent and

294 re than 95% of the UVC and solar irradiation-induced mutations were targeted to dipyrimidine sites, t

295 Adduct-induced mutations were targeted toward G:C base pairs wi

296 The induced mutations were typically insertions or deletions

297 d mutations in two genes of interest and the induced mutations were validated by sequence analysis.

298 1 replicon and virus systems identified drug-induced mutations within the N-terminal region of NS5A.

299 Ethyl methanesulfonate-induced mutations within the second B-box caused up-regu

300 rapidly, as well as to map novel chemically-induced mutations within these complexes, will facilitat