ライフサイエンスコーパス: induced sputum

1 y biomarkers (eosinophils and neutrophils in induced sputum).

2 and these cytokines were rarely detected in induced sputum.

3 n that can be demonstrated by examination of induced sputum.

4 Secreted mucin was measured in induced sputum.

5 re (CRQ), incremental shuttle walk test, and induced sputum.

6 t tomography, spirometry, and examination of induced sputum.

7 holine, and the percentage of eosinophils in induced sputum.

8 four phenotypes according to cell counts in induced sputum.

9 EPX levels and the eosinophil percentage of induced sputum.

10 on paired NPSs and NPAs; or paired NPSs and induced sputum.

11 ariable most associated with high quality of induced sputum.

12 itive on NPS, and 2 (18.2%) only positive on induced sputum.

13 sis therapy was 2% (1-3) for expectorated or induced sputum.

14 ave been accurately identified in 120 muL of induced sputum.

15 lytA rtPCR was also performed on induced sputum.

16 as percentage change in neutrophil counts in induced sputum 6 h after lipopolysaccharide challenge.

17 Induced sputum allows to measure mediators of asthmatic

18 pared to PCR, culture sensitivity was 60% in induced sputum and 40% in NPSs.

19 hosphate (AMP) (differential) cell counts in induced sputum and blood and corticosteroid treatment re

20 ere identified through the use of culture of induced sputum and blood, urinary antigen detection, pol

21 Indeed, high levels of IL-17 are found in induced sputum and bronchial biopsies obtained from pati

22 Outcomes included inflammatory cells in induced sputum and bronchial biopsies, and methacholine

23 e, we compare the utility of lytA rtPCR from induced sputum and from NP swabs.

24 Induced sputum and peripheral blood were obtained at bas

25 Induced sputum and plasma were collected prospectively f

26 itutions have little diagnostic success with induced sputum, and BAL is invasive and expensive.

27 etry the CCR4-expressing T cells from blood, induced sputum, and biopsy samples of patients with asth

28 onses to experimental RV infection in blood, induced sputum, and bronchial lavage in 10 asthmatic and

29 in samples of bronchoalveolar-lavage fluid, induced sputum, and bronchial-biopsy specimens obtained

30 y, by radiography, by pulmonary function, by induced sputum, and by histological analysis.

31 erall, lytA rtPCR performs similarly well on induced sputum as on NP swabs for most patients but perf

32 Both groups underwent spirometry and induced sputum at baseline and at 1, 3, and 6 wk.

33 e percentage of columnar epithelial cells in induced sputum at baseline was associated with the sever

34 ul in all children who had no eosinophils in induced sputum before the attempted reduction.

35 opharyngeal/oropharyngeal (NP/OP) swabs, and induced sputum by culture and PCR.

36 Bacterial detection in induced sputum by PCR decreased 7% for exposed compared

37 d nasopharyngeal and oropharyngeal swabs and induced sputum (cases only) for Bordetella pertussis pol

38 Induced sputum CC16 and SPD were significantly higher in

39 According to induced sputum cell count, four different asthma phenoty

40 Effects on induced sputum cell counts and differentials, eosinophil

41 Participants had induced sputum cell counts measured and blood analysed f

42 Exhaled nitric oxide (eNO), induced sputum cell counts, and responsiveness to methac

43 In induced sputum cell pellets from 37 asthmatic patients a

44 tion of various proinflammatory mediators in induced sputum cell-free supernatant in eight patients w

45 Induced sputum cells and fractional exhaled nitric oxide

46 ion, we investigated FPR2/ALXR expression in induced sputum cells obtained from the study groups.

47 FPR2/ALXR expression was reduced in induced sputum cells of children with SA compared with t

48 parable in each group, whereas the amount of induced sputum collected from the CF producers was over

49 ch to October 2015, 320 infants had NPSs and induced sputum collected, and 11 (3.4%) pertussis cases

50 lowed by methacholine challenge (day 7), and induced sputum collection and fractional exhaled nitric

51 adrupole time-of-flight mass spectrometry in induced sputum comparing smokers with and without COPD,

52 We conclude that induced sputum contains high concentrations of eicosanoi

53 nd approximately 20% reduction in yield from induced sputum culture.

54 ected South African adults if blood culture, induced-sputum culture or Gram stain, urine antigen test

55 These results provide direct evidence that induced sputum derives from the central airways with lit

56 Indirect evidence suggests that induced sputum derives from the surfaces of the bronchia

57 nophilic airway inflammation was assessed by induced sputum differential eosinophil count.

58 An induced sputum differential inflammatory cell count sugg

59 Induced sputum differentials were obtained.

60 essment and immunological sampling of blood, induced sputum, endobronchial biopsy, and bronchoalveola

61 nt detailed clinical assessment and provided induced sputum, endobronchial biopsy, bronchoalveolar la

62 Serum and induced sputum endotoxin and cytokine concentrations wer

63 management group) or by normalisation of the induced sputum eosinophil count and reduction of symptom

64 stically significant attenuation of allergen-induced sputum eosinophil count on Day 4 following GSK21

65 nt strategy directed at normalisation of the induced sputum eosinophil count reduces asthma exacerbat

66 ol of eosinophilic inflammation, measured by induced sputum eosinophil count.

67 utum eosinophil peroxidase (EPX) levels with induced sputum eosinophil percentage in 10 adults with p

68 al EPX and pharyngeal EPX levels compared to induced sputum eosinophil percentage were 0.81 (P = 0.00

69 was associated with attenuation of allergen-induced sputum eosinophilia and with lower levels of try

70 and 75 mug significantly attenuated allergen-induced sputum eosinophilia by 63 and 61% at 7 hours, re

71 Budesonide did not reduce allergen-induced sputum eosinophilia versus placebo.

72 The level of induced sputum eosinophilic cationic protein mug/l, was

73 Test), spirometry, exhaled nitric oxide and induced sputum evaluation.

74 ry and present the clinical, radiologic, and induced sputum features.

75 andin (PG)D2 (PGDM) and leukotriene (LT)E4 , induced sputum fluid LTB4 , LTE4 , PGD2 , and PGE2 , pla

76 We collected blood for culture, induced sputum for culture and multiplex polymerase chai

77 Analysis of induced sputum from a subset of SARP subjects showed 4 s

78 onally, OSM protein levels were increased in induced sputum from asthmatic patients compared with tha

79 IL-32 is detectable in induced sputum from asthmatic patients.

80 y of SECs may be a useful quality measure of induced sputum from young children with pneumonia.

81 We evaluated induced sputum Gram stain smears and cultures from hospi

82 Compared with control, induced sputum greatly enhanced clearance after central

83 Induced sputum has been used to study airway inflammatio

84 Induced sputum has provided considerable information abo

85 tion, such as exhaled nitric oxide (eNO) and induced sputum, has been shown to improve asthma monitor

86 (NPSs), nasopharyngeal aspirates (NPAs), and induced sputum, have been used for B. pertussis detectio

87 o characterize and compare the microbiome of induced sputum in asthmatic and nonasthmatic adults.

88 Protocols for induced sputum in children were collated from published

89 chest radiograph interpretation, utility of induced sputum in children, measurement of pathogen dens

90 n and the reproducibility of measurements in induced sputum in multicenter studies is unknown.

91 Induced sputum inflammatory cells, neutrophils, interleu

92 philic airway inflammation measured by using induced sputum is an important treatment stratification

93 at measurement of markers of inflammation in induced sputum is as reproducible as methacholine PC(20)

94 Induced sputum is occasionally used to investigate lower

95 uberculosis/rifampicin) automated testing on induced sputum (IS) is possible, but the capacity for pe

96 Induced sputum (IS) may provide diagnostic information a

97 The incremental value of a repeated induced sputum (IS) sample, compared with a single IS or

98 ction of respiratory viruses and bacteria in induced sputum (IS) specimens from children hospitalized

99 o hundred thirty-two clinical specimens (120 induced-sputum [IS] and 112 bronchoalveolar lavage [BAL]

100 the relationship of efferocytosis by airway (induced sputum) macrophages and blood monocytes to marke

101 We conclude that markers in induced sputum may be useful, noninvasive outcome measur

102 We evaluated the diagnostic utility of induced sputum microscopy and culture in patients enroll

103 Induced sputum microscopy and culture results were not a

104 Plasma PIIINP correlated with induced sputum MMP-1 concentrations and radiological sco

105 cts, smokers and never smokers), we measured induced sputum MMP-12 concentrations (ELISA) and enzyme

106 ng function and computed tomography (CT) and induced sputum MMP-12 concentrations and activity in pat

107 In patients with TB, induced sputum MT1-MMP mRNA levels were increased 5.1-fo

108 ed TB who provided expectorated (n = 438) or induced sputum (n = 128), tracheal aspirates (n = 71), b

109 expression was assessed on the total RNA of induced sputum (n = 83), nasal brushings (n = 41), and e

110 tudy generated gene expression profiles from induced sputum of 47 asthmatic patients.

111 soluble IL-6 receptor (sIL-6R) expression in induced sputum of asthmatic patients was correlated with

112 l propeptide (PIIINP) was 3.8-fold higher in induced sputum of HIV-uninfected tuberculosis patients c

113 coinfection decreased MMP concentrations in induced sputum of patients with TB.

114 inflammatory processes and biomarkers using induced sputum or bronchial biopsies.

115 ly involve invasive sampling methods such as induced sputum or bronchoalveolar lavage that are uncomf

116 agnosed by direct microscopic examination of induced sputum or by bronchoalveolar lavage (BAL).

117 n separate occasions followed immediately by induced sputum or no sputum (control), while seated in f

118 using multicopy gene targets, together with induced sputum or oral wash samples.

119 Sputum, induced sputum, or bronchial specimens are all suitable

120 pneumonia" (nasopharyngeal/oropharyngeal or induced sputum PCR-positive without confirmed/suspected

121 ryngeal swabs, nasopharyngeal aspirates, and induced sputum performed similarly for the detection of

122 (PERCH) study, we reviewed the literature on induced sputum procedures.

123 with >/=2 TB-related symptoms, obtained one induced sputum sample for smear microscopy (AFB) and myc

124 One induced sputum sample was available for analysis from 37

125 ificantly more radioactivity recovered in an induced sputum sample, and greater airways clearance of

126 ), respectively, with use of expectorated or induced sputum samples and 66% (51-81) and 98% (96-99),

127 Furthermore, induced sputum samples are similar to spontaneously expe

128 llenge from patients with mild asthma and in induced sputum samples collected from patients with mild

129 he direct detection of CFP32 by ELISA in the induced sputum samples from 56% of pulmonary TB patients

130 tion analysis on cells from nasal lavage and induced sputum samples from all subjects after RV16 inoc

131 Comparisons were made between induced sputum samples from hospitalized children with r

132 ed reduced chemotaxis (approximately 30%) to induced sputum samples obtained during theophylline trea

133 atric asthma using flow cytometry to analyse induced sputum samples obtained from healthy and asthmat

134 IL-32 was determined in serum and induced sputum samples of asthmatic patients and healthy

135 t surprisingly, the microbiome data from the induced sputum samples we collected revealed a significa

136 Induced sputum samples were analysed using 7-colour flow

137 Induced sputum samples were obtained from 10 nonasthmati

138 r the detection of pulmonary tuberculosis on induced sputum samples, using mycobacterial cultures as

139 Results show that sphingolipid expression in induced sputum significantly differs between smokers wit

140 ercentage of neutrophils in sputum (%PMN) in induced sputum similarly and significantly increased in

141 sis of B. pertussis culture was performed on induced sputum specimens and in a subset of NPSs.

142 valence of potential pathogens cultured from induced sputum specimens and quantity of oropharyngeal f

143 of this study do not support the culture of induced sputum specimens as a diagnostic tool for pneumo

144 The microbial composition of induced sputum specimens collected from adult patients s

145 Only 26.3% of 99 induced sputum specimens collected were determined to be

146 These same indices in the induced sputum specimens from CF producers were signific

147 uality ratings have never been evaluated for induced sputum specimens from children with suspected pn

148 Of 3772 induced sputum specimens, 2608 (69%) had <10 SECs per lo

149 Induced sputum supernatant and plasma was obtained befor

150 We have measured induced sputum supernatant LTC(4)/D(4)/E(4) concentratio

151 ous proinflammatory and tussive mediators in induced sputum supernatants from 20 patients with cough

152 We examined LXA4 and LTB4 concentrations in induced sputum supernatants from children with intermitt

153 Chemotaxis experiments were performed using induced sputum supernatants from subjects with and witho

154 ith SA have decreased LXA4 concentrations in induced sputum supernatants in comparison with children

155 175 oral washes, each paired with either an induced sputum that was positive for Pneumocystis or a B

156 iratory specimen types (expectorated sputum, induced sputum, tracheal aspirates, bronchoalveolar lava

157 on of candidate SNPs with mRNA expression in induced sputum was also elucidated.

158 Induced sputum was analyzed for eosinophilic inflammatio

159 Induced sputum was assayed for bacterial density, cell c

160 Induced sputum was assessed for neutrophils 4 hours afte

161 Induced sputum was collected at baseline before rhinovir

162 Induced sputum was collected before and following bronch

163 Induced sputum was collected before and repeatedly after

164 d to control for inhaled corticosteroid use, induced sputum was collected.

165 ncreased integrin beta3 mRNA accumulation in induced sputum was detected, to our knowledge, for the f

166 de-induced inflammatory cell infiltration in induced sputum was investigated in 21 healthy men.

167 Induced sputum was obtained before and 48h after a whole

168 Induced sputum was obtained for simultaneous enrichment

169 Induced sputum was obtained from nonsmoking patients wit

170 Induced sputum was obtained, and airway hyperresponsiven

171 Induced sputum was sampled 24 hours after exposure.

172 Induced sputum was used to measure mast cell mediators a

173 Induced sputum weights were comparable in each group, wh

174 her markers of infection and inflammation in induced sputum were a useful and safe outcome measure in

175 , baseline FEV(1) and percent eosinophils in induced sputum were not significantly associated with LA

176 biopsy specimens, epithelial brushings, and induced sputum were obtained from asthmatic patients wit

177 Nasal secretions and induced sputum were repeatedly sampled over the next 14

178 Bronchial biopsies and induced sputum were taken from 140 current and former sm

179 n 149 (67.1%) of 222 patients with available induced sputum, whereas the results of either Gram stain

180 t in asthmatic airway secretions (sampled as induced sputum), which possess chemotactic activity for

181 eproducibility of markers of inflammation in induced sputum with the reproducibility of the FEV(1) an

182 acterial density and inflammatory content of induced sputum would decrease after antibiotic therapy.