ライフサイエンスコーパス: inducible NO synthase

1 y to express tumor necrosis factor alpha and inducible NO synthase.

2 nuclear factor kappaB-mediated induction of inducible NO synthase.

3 d in the absence of endothelial, neuronal or inducible NO synthase.

4 e expression of an NF-kappaB-dependent gene, inducible NO synthase.

5 ld asphyxia stress, correlating with induced inducible NO synthase.

6 Jak2 and STAT1, a key factor for expressing inducible NO synthase.

7 matory protein-2 (MIP-2), ICAM-1, IL-10, and inducible NO synthase.

8 netically deficient for IL-12, IFN-gamma, or inducible NO synthase.

9 NA expressions for CINC-1, MIP-2, IL-10, and inducible NO synthase.

10 inflammatory cytokines and chemokines and of inducible NO synthase.

11 ble mediators IL-1beta, IL-6, TNF-alpha, and inducible NO synthase.

12 ated mice unable to produce IFN-gamma or the inducible NO synthase.

13 tory blood monocyte-derived DCs that express inducible NO synthase.

14 are largely abolished by genetic deletion of inducible NO synthase.

15 Nitric oxide (NO) generated by inducible NO synthase 2 (NOS2) affects cellular iron hom

16 nts (TBE1 and TBE2) in the promoter of human inducible NO synthase 2 (NOS2).

17 Previous studies suggested that inducible NO synthase 2 (NOS2/iNOS) is required for norm

18 ha, IL-6, and IL-1beta cytokines, as well as inducible NO synthase-2 in bmMPhis, and also impaired th

19 ng protein (MSP), inhibits the expression of inducible NO synthase, a marker of classically activated

20 rginase I activity and inhibited LPS-induced inducible NO synthase activity in LPS-treated macrophage

21 priming were dependent on NO production via inducible NO synthase and activation of protein kinase G

22 myeloid-derived suppressor cells expressing inducible NO synthase and arginase 1 are induced.

23 characterized, in part, by the expression of inducible NO synthase and arginase I (Arg1) in M1 versus

24 gulators of oxidative stress and complement (inducible NO synthase and C3) and downregulation of spec

25 nes like IL-6, IL-12, IL-23, or enzymes like inducible NO synthase and cyclooxygenase 2, was reduced.

26 creased M1 macrophages that highly expressed inducible NO synthase and decreased M2 macrophages that

27 Reverse transcription-PCR revealed that inducible NO synthase and endothelial NOS but not neuron

28 id cells were delayed in their production of inducible NO synthase and had reduced expression of MHC

29 ssion of TGF-beta, IFN-gamma, TNF-alpha, and inducible NO synthase and higher expression of IL-10 in

30 -kappaB DNA-binding activity, and subsequent inducible NO synthase and ICAM-1 expression.

31 PS-induced p65 NF-kappaB phosphorylation and inducible NO synthase and ICAM-1 expression.

32 ppaB activity and decreased transcription of inducible NO synthase and ICAM-1.

33 atory cytokine that suppresses expression of inducible NO synthase and IFN-gamma, and suppresses Th1

34 er analogous to the regulation of vertebrate inducible NO synthase and malaria parasite (Plasmodium)

35 f cytokine-treated ALR islets to up-regulate inducible NO synthase and produce NO correlated both wit

36 tion of IFN-beta and subsequent synthesis of inducible NO synthase and production of NO.

37 nduced responses, including transcription of inducible NO synthase and secretion of NO.

38 ines CXCL1 and CCL2 as well as expression of inducible NO synthase and such responses required the ki

39 eta1-42 peptides to induce the expression of inducible NO synthase and to stimulate the expression of

40 mediated killing of BCG within p47(phox-/-), inducible NO synthase(-/-), and Nramp(s) cells was unaff

41 due to their down-regulatory effect on iNOS (inducible NO synthase) and COX (cyclooxygenase)-2 gene e

42 1(+) cells express Arg1 (arginase) and Nos2 (inducible NO synthase) and suppress CD4(+) T cell prolif

43 elease of a multifunctional mediator NO (via inducible NO synthase) and the proinflammatory cytokines

44 tly and/or indirectly through TNFR1, ICAM-1, inducible NO synthase, and AMPA-GluR, all of which were

45 through multiple mechanisms, including PGE2, inducible NO synthase, and arginase.

46 erized by increased expression of TNF-alpha, inducible NO synthase, and CCR2, CD11b(+)/Ly6C(lo) macro

47 ally proinflammatory proteins such as TNFR1, inducible NO synthase, and ICAM-1 were up-regulated in b

48 reus biofilms revealed increased arginase-1, inducible NO synthase, and IL-10 expression, key mediato

49 -kappaB activity and expression of TNFalpha, inducible NO synthase, and IL-1beta, with enhanced mucop

50 kines, including TNF-alpha and IL-1beta, and inducible NO synthase, and increases in brain-derived ne

51 TLR4, inducible NO synthase, and inflammatory cytokine inducti

52 IL-17, IL-33, thymic stromal lymphopoietin, inducible NO synthase, and MUC5ac in lung tissues.

53 enced by increased levels of IL-1beta, IL-6, inducible NO synthase, and multiple neutrophil/monokine-

54 o the infected lymph node expressed abundant inducible NO synthase, and several Y. pestis homologs of

55 for example, IL-1beta, IL-6, TNF-alpha, and inducible NO synthase, and this effect is antagonized by

56 esion molecules, activation markers, and the inducible NO synthase are up-regulated following the int

57 gamma, produced by activated iNKT cells, and inducible NO synthase, arginase-1, and IL-10 produced by

58 ated tyrosine kinase 3 ligand, c-kit ligand, inducible NO synthase, arginase-1, TNF-alpha, cyclo-oxyg

59 terium, and that expression of TNF-alpha and inducible NO synthase by infected macrophages was depend

60 actor, platelet-derived growth factor B, and inducible NO synthase by the vGPCR-expressing cells.

61 ted mouse macrophages that were deficient in inducible NO synthase caused rapid death of the intracel

62 By increasing both superoxide and inducible NO synthase, CRP resulted in increased nitrati

63 rpose of this study was to determine whether inducible NO synthase deficiency (iNOS(-/-)) affects liv

64 inhibitor, or if the APCs were obtained from inducible NO synthase-deficient mice.

65 2-TLR6 heterodimer, induces IL-12-dependent, inducible NO synthase-dependent, T-reg-sensitive antilei

66 Blocking arginase and inducible NO synthase did not restore B lymphopoiesis, i

67 lar parasite Leishmania major, expression of inducible NO synthase does not confer a cell-intrinsic a

68 including TNF-alpha and IL-1beta, as well as inducible NO synthase, each regulated by NF-kappaB.

69 aled a transient increase in endothelial and inducible NO synthase (eNOS and iNOS, respectively) mRNA

70 infection, NO, produced by the host via the inducible NO synthase, exerts critical antibacterial eff

71 n endotoxin (LPS)-mediated states of sepsis, inducible NO synthase expression and NO production are a

72 Ag-specific Abs (IgG and IgM) and to require inducible NO synthase expression and NO production.

73 y Th-1-activated killer DCs was dependent on inducible NO synthase expression and NO production.

74 holipase A(2) (iPLA(2)) in the regulation of inducible NO synthase expression by macrophages in respo

75 e fails to prevent dsRNA- or EMCV-stimulated inducible NO synthase expression by macrophages.

76 cidal phenotype as evidenced by decreases in inducible NO synthase expression concomitant with robust

77 on also induced a marked increase in hepatic inducible NO synthase expression in C56BL/6 mice, but no

78 B activation and required down-regulation of inducible NO synthase expression to exert its protective

79 LPS-stimulated inducible NO synthase expression was 3- to 6-fold higher

80 - were increased, endothelial NO synthase or inducible NO synthase expression was similar in the tumo

81 TNF-alpha, IL-6, NO, and inducible NO synthase expression were inhibited by SAHA.

82 crosis factor alpha and interleukin-6, lower inducible NO synthase expression, and fewer I/R-associat

83 associated with significantly reduced aortic inducible NO synthase expression, decreased plasma and a

84 concomitant with a markedly increased aortic inducible NO synthase expression, significantly elevated

85 vels of ERK-1/2 and p65/RelA (NF-kappaB) and inducible NO synthase expression, suggesting that AnxA1

86 steopontin (OPN), a potent transrepressor of inducible NO synthase expression.

87 LR9 expression, higher IL-12 production, and inducible NO synthase expression.

88 enhanced CD40-induced p38MAPK activation and inducible NO synthase expression.

89 lactone prevents dsRNA- and EMCV-stimulated inducible NO synthase expression; however, bromoenol lac

90 o attenuated morphine-induced p53 as well as inducible NO synthase expression; in contrast, N(G)-nitr

91 The inducible NO synthase gene (iNOS) plays a role in a numb

92 genetic polymorphisms in the promoter of the inducible NO synthase gene (NOS2) could modulate product

93 HIF-alpha isoform-specific regulation of the inducible NO synthase gene by HIF-1alpha, and the argina

94 d to the promoter of the NF-kappaB-regulated inducible NO synthase gene in cells from estrogen-treate

95 Macrophages were obtained from p47(phox) and inducible NO synthase gene-disrupted mice (which are una

96 mRNA expression levels of the arginase-1 and inducible NO synthase genes, which characterize MDSCs, w

97 ther BALB/c nor STAT6-deficient MSCs produce inducible NO synthase; however, both produce arginase an

98 ulates several NF-kappaB-regulated proteins (inducible NO synthase, IFN-gamma, and MCP-1).

99 the classical macrophage activation markers, inducible NO synthase, IL-12, and TNF-alpha, as well as

100 uce LPS- and IFN-gamma-induced expression of inducible NO synthase, IL-1beta, and TNF-alpha in vivo i

101 xpression as assessed by measuring levels of inducible NO synthase, IL-6, and IL-8.

102 levels of IFN-gamma, associated with reduced inducible NO synthase immunoreactivity, and lymph node T

103 ed when mice were treated with inhibitors of inducible NO synthase, implicating the NO pathway in par

104 arly, RNS60 also inhibited the expression of inducible NO synthase in activated astroglia.

105 n of nitric oxide (NO) and the expression of inducible NO synthase in activated microglia.

106 ginase 1, with concomitant downregulation of inducible NO synthase in APCs in vitro and in vivo.

107 N-gamma, previously shown to strongly induce inducible NO synthase in human primary astrocytes, induc

108 ombined cytokines up-regulated the NF-kappaB inducible NO synthase in NOD-Rag and C3H/HeJ islets but

109 thase isoforms and absence of Ca-independent inducible NO synthase in PBL.

110 f proinflammatory genes (IL-6, IL-1beta) and inducible NO synthase in response to H. pylori.

111 ddition, expression of interferon- gamma and inducible NO synthase in the heart, which are associated

112 vely cleared despite high level induction of inducible NO synthase in the lesion, and despite their s

113 ation as evidenced by enhanced expression of inducible NO synthase in the lungs of H99gamma-immunized

114 flammatory factors IFN-gamma, TNF-alpha, and inducible NO synthase in the TME merely 4 d postinfectio

115 lecules (reactive oxygen species, TNF-alpha, inducible NO synthase) in 1) M phi propagated from obstr

116 explained by a similar defect in a conserved inducible NO synthase-independent mechanism of innate im

117 ation to the lungs, but rather controlled an inducible NO synthase-independent mechanism of innate im

118 KCa3.1 blocker; and (iii) two inhibitors of inducible NO synthase, indicating that KCa3.1 activity a

119 that inhibiting superoxide production during inducible NO synthase induction would suppress oxidative

120 m that limits IFN-gamma production and local inducible NO synthase induction.

121 feron (IFN-gamma) is an important inducer of inducible NO synthase, infected IL-4(-/-) mice were trea

122 Transfection with inducible NO synthase inhibited etoposide-induced apopto

123 acetyl cysteine, extracellular catalase, and inducible NO synthase inhibitors inhibited ICAM-1 and IL

124 Inducible NO synthase (iNOS) activity is induced upon pa

125 Only microglia, but not OLs, expressed inducible NO synthase (iNOS) after LPS challenge; microg

126 macrophage phagocyte NADPH oxidase (phox) or inducible NO synthase (iNOS) alone or, surprisingly, in

127 that in macrophages, H. pylori up-regulates inducible NO synthase (iNOS) and antimicrobial NO produc

128 inflammatory and antiviral genes, including inducible NO synthase (iNOS) and cyclooxygenase (COX)-2.

129 tric oxide (NO) production and expression of inducible NO synthase (iNOS) and cyclooxygenase 2 (COX-2

130 on, cyclooxygenase-2 (COX-2) expression, and inducible NO synthase (iNOS) and cytokine production; wi

131 We find that the induction of inducible NO synthase (iNOS) and cytokines is suppressed

132 trite, nitric oxide (NO) and superoxide, and inducible NO synthase (iNOS) and gp91(phox) protein expr

133 Inducible NO synthase (iNOS) and intercellular adhesion

134 However, translation of inducible NO synthase (iNOS) and NO generation by H pylo

135 paB signaling is essential for Con A-induced inducible NO synthase (iNOS) and NO in murine splenocyte

136 Here, we show that inducible NO synthase (iNOS) and PGHS-1 co-localize in a

137 fibrozil inhibited LPS-induced expression of inducible NO synthase (iNOS) and proinflammatory cytokin

138 ion in WT macrophages suppressed LPS-induced inducible NO synthase (iNOS) and promoted M2 polarizatio

139 ction of inflammatory response genes such as inducible NO synthase (iNOS) and TNF (TNF-alpha) in a PP

140 ibute to the overexpression of NO, including inducible NO synthase (iNOS) and transcription factors S

141 activation and the subsequent expression of inducible NO synthase (iNOS) and vascular cell adhesion

142 tosolic proteins that may be involved, using inducible NO synthase (iNOS) as a model target.

143 NO derived from inducible NO synthase (iNOS) can activate macrophage apo

144 Inducible NO synthase (iNOS) contains an amino-terminal

145 NO produced by inducible NO synthase (iNOS) contributes to ischemic bra

146 e role of nitric oxide (NO) generated by the inducible NO synthase (iNOS) during myocardial ischemia

147 n allergens disrupt the Arginase1 (Arg1) and inducible NO synthase (iNOS) dynamic in monocytes/macrop

148 Inducible NO synthase (iNOS) expression and production o

149 d CD4(+) IL-10(+) T lymphocytes that inhibit inducible NO synthase (iNOS) expression and protect intr

150 demonstrate IL-4-induced down-regulation of inducible NO synthase (iNOS) expression and survival of

151 nitric oxide (NO) through the inhibition of inducible NO synthase (iNOS) expression in endothelial c

152 f type I IFNs was exerted through inhibiting inducible NO synthase (iNOS) expression in IFNgamma and

153 role of CXCL1 in LTB(4), NADPH oxidase, and inducible NO synthase (iNOS) expression in lungs and neu

154 ic monophosphate interfered with LPS-induced inducible NO synthase (iNOS) expression in RAW264.7 macr

155 Inducible NO synthase (iNOS) expression was restricted t

156 ative stress), cyclooxygenase-2 (COX-2), and inducible NO synthase (iNOS) expression were significant

157 Hepatocytes are capable of repeated inducible NO synthase (iNOS) expression, which occurs un

158 itric oxide (NO) levels but not with reduced inducible NO synthase (iNOS) expression.

159 t and triptolide on the production of NO and inducible NO synthase (iNOS) gene expression and transcr

160 d previously that gene transfer of the human inducible NO synthase (iNOS) gene into tumor cells and t

161 Given that inducible NO synthase (iNOS) has been implicated in IP,

162 Overproduction of NO by inducible NO synthase (iNOS) has been implicated in the

163 Overproduction of nitric oxide (NO) by inducible NO synthase (iNOS) has been implicated in the

164 NO produced by inducible NO synthase (iNOS) has been implicated in vari

165 ulation of both cyclooxygenase-2 (COX-2) and inducible NO synthase (iNOS) has been shown to be essent

166 Since nitric oxide (NO) released from inducible NO synthase (iNOS) has been shown to possess i

167 of the inducible cyclooxygenase (COX-2) and inducible NO synthase (iNOS) in activated brain macropha

168 The role of inducible NO synthase (iNOS) in allergic airway inflamma

169 by decreased levels of nitric oxide (NO) and inducible NO synthase (iNOS) in cell culture as well as

170 The importance of NO. produced by inducible NO synthase (iNOS) in controlling murine leish

171 Nitric oxide (NO) that is produced by inducible NO synthase (iNOS) in glial cells is thought t

172 achomatis led to downregulated expression of inducible NO synthase (iNOS) in human mesenchymal stem c

173 Inducible NO synthase (iNOS) in human T cells is implica

174 hanges in transcription of key genes such as inducible NO synthase (iNOS) in hypoxic/ischemic environ

175 Enhanced levels of inducible NO synthase (iNOS) in infected lungs are obser

176 shown to down-regulate IFN-gamma-stimulated inducible NO synthase (iNOS) in macrophages.

177 endothelial NO synthase (eNOS) in bovine and inducible NO synthase (iNOS) in stimulated human endothe

178 icate the organism, despite up-regulation of inducible NO synthase (iNOS) in the gastric mucosa.

179 lished by the removal of NO by the use of an inducible NO synthase (iNOS) inhibitor or iNOS-deficient

180 Inducible NO synthase (iNOS) is a hallmark of chronic in

181 Inducible NO synthase (iNOS) is involved in the producti

182 nflammatory in either constitutive (eNOS) or inducible NO synthase (iNOS) knockout mice with IL-1beta

183 cies results in expression and activation of inducible NO synthase (iNOS) leading to intracellular pa

184 gamma is associated with increased pulmonary inducible NO synthase (iNOS) levels.

185 Flagellin stimulated an increase in inducible NO synthase (iNOS) mRNA and activation of the

186 effects of doxycycline and erythromycin A on inducible NO synthase (iNOS) NO production as well as iN

187 e tumor in mice in which the gene for either inducible NO synthase (iNOS) or endothelial NOS (eNOS) h

188 Nitric oxide (NO) generated from inducible NO synthase (iNOS) participates in immune and

189 as undertaken to investigate the role of the inducible NO synthase (iNOS) pathway in the pathogenesis

190 Nitric oxide (NO) generated by inducible NO synthase (iNOS) plays crucial roles in infl

191 E1-dependent toxicity, whereas inhibition of inducible NO synthase (iNOS) potentiated toxicity.

192 Exemplifying this, ablation of inducible NO synthase (iNOS) protected effector-memory T

193 The production of nitric oxide (NO) by inducible NO synthase (iNOS) regulates many aspects of p

194 rminate infection by upregulating epithelial inducible NO synthase (iNOS) transcription and NO produc

195 To determine whether p300 is involved in inducible NO synthase (iNOS) transcriptional regulation,

196 on of macrophage arginase II (Arg2) inhibits inducible NO synthase (iNOS) translation, causes apoptos

197 Inducible NO synthase (iNOS) was significantly upregulat

198 Elevated levels of inducible NO synthase (iNOS) were also observed in the d

199 WT), endothelial NO synthase (eNOS)(-/-) and inducible NO synthase (iNOS)(-/-) lymphatic vessels to c

200 ines (IFN-gamma, TNF-alpha, IL-6, IL-17, and inducible NO synthase (iNOS)), cell adhesion molecules,

201 Here we show that cells regulate inducible NO synthase (iNOS), an important host defense

202 unosuppressive factors including IL-10, IDO, inducible NO synthase (iNOS), and cyclooxygenase 2 (COX-

203 ethyl)-lysine hydrochloride, an inhibitor of inducible NO synthase (iNOS), and PTIO, a scavenger of N

204 Arginase is the endogenous inhibitor of inducible NO synthase (iNOS), because both enzymes use t

205 ppaB activation and production of TNF-alpha, inducible NO synthase (iNOS), cyclooxygenase-2, IL-1beta

206 In this study, we show a key role of inducible NO synthase (iNOS), expressed by classically a

207 Inducible NO synthase (iNOS), however, was found to be a

208 tory genes (e.g., inducible protein (IP)-10, inducible NO synthase (iNOS), monocyte chemoattractant p

209 s found to inhibit LPS-induced expression of inducible NO synthase (iNOS), proinflammatory cytokines

210 ntestinal epithelial cells the expression of inducible NO synthase (iNOS), the critical enzyme in the

211 er growth in mice that are unable to produce inducible NO synthase (iNOS), the dominant source of NO

212 ion of tumor necrosis factor (TNF)-alpha and inducible NO synthase (iNOS), these cells have been refe

213 on of IFN-gamma, MIP-2, IL-1beta, TNF-alpha, inducible NO synthase (iNOS), TLR2, TLR4, MyD88, and NF-

214 ndent proteins, cyclooxygenase-2 (COX-2) and inducible NO synthase (iNOS), were lower in bystander rh

215 Inducible NO synthase (iNOS)-dependent production of NO

216 IL-4(+) T cells and enhanced recruitment of inducible NO synthase (iNOS)-producing neutrophils to in

217 s required for control of M. tuberculosis is inducible NO synthase (iNOS).

218 reversed by anti-IFN-gamma or inhibitors of inducible NO synthase (iNOS).

219 ults in increased production and activity of inducible NO synthase (iNOS).

220 of mice with cardiac-specific expression of inducible NO synthase (iNOS).

221 roduced in large amounts by up-regulation of inducible NO synthase (iNOS).

222 amma and LPS by inhibiting the expression of inducible NO synthase (iNOS).

223 levels in asthma are suggested to be through inducible NO synthase (iNOS).

224 lla strains regain virulence in mice lacking inducible NO synthase (iNOS).

225 levels in asthma are suggested to be through inducible NO synthase (iNOS).

226 chanism is the production of NO derived from inducible NO synthase (iNOS).

227 ous ceramide treatment induced biogenesis of inducible NO synthase (iNOS)/NO and apoptosis through an

228 acrophages, IFN-gamma-mediated expression of inducible NO synthase (iNOS)/TNF-alpha and NO/TNF-alpha

229 : (i) the effect of O(2) on NO production by inducible NO synthase (iNOS); (ii) the effect of NO on N

230 or necrosis factor-alpha, interleukin-1) and inducible NO synthase (iNOS); the former is dependent on

231 Indeed, throughout the course of infection, inducible NO synthase (iNOS, NOS2) mRNA or enzyme activi

232 NO, which is due to increased expression of inducible NO synthase, is responsible for apoptosis of I

233 rs (protein kinase Cepsilon, endothelial and inducible NO synthase isoforms, and heat shock protein 7

234 Inducible NO synthase knockout mice exhibited significan

235 +) T cells from BCG-infected DR5, TNFR1, and inducible NO synthase knockout mice had impaired caspase

236 +)FoxP3(+) or CD4(+)Foxp3(+) phenotypes from inducible NO synthase knockout mice.

237 ion studies in myoglobin and endothelial and inducible NO synthase knockout models suggest that only

238 into the cerebellum and brainstem, increased inducible NO synthase levels in the cerebellum and brain

239 Microbicidal NO production is reliant on inducible NO synthase-mediated L-arginine metabolism in

240 production is associated with inhibition of inducible NO synthase mRNA and protein expression.

241 py, as suggested by decreased IL-23 mRNA and inducible NO synthase mRNA and protein.

242 tly decreased cytokine-induced activation of inducible NO synthase mRNA expression and NO production

243 Trichinella spiralis infection inhibits host inducible NO synthase (NOS-2) expression.

244 and passive Ab efficacy in mice deficient in inducible NO synthase (NOS2(-/-)) and the parental strai

245 Mice deficient in inducible NO synthase (NOS2(-/-)) exhibited reduced morb

246 y increased mRNA synthesis for IFN-gamma and inducible NO synthase (NOS2) and by NOS2 protein synthes

247 ion have been done in mouse models, in which inducible NO synthase (NOS2) and NO are important compon

248 NO produced by inducible NO synthase (NOS2) is important for the contro

249 ures of EIM include differential patterns of inducible NO synthase (NOS2) mRNA induction in the left

250 Inhibiting inducible NO synthase (NOS2), but not neuronal NOS (NOS1

251 O production by decreasing expression of the inducible NO synthase (NOS2).

252 d: 1) decreased lung neutrophil and monocyte inducible NO synthase (NOSII) expression, and 2) decreas

253 ulting in formation of NO in the presence of inducible NO synthase or conversion to ornithine in the

254 rease the expression of type II NO synthase (inducible NO synthase, or iNOS) decreased PKG expression

255 e M1 genes IL-1beta, IL-6, IL-12, IL-23, and inducible NO synthase owing to enhanced transcriptional

256 Both TGF-beta and inducible NO synthase play an important role in morphine

257 to the tumor killing because an inhibitor of inducible NO synthase prevents IL-12-induced tumor suppr

258 stead, monocyte-derived innate TNF-alpha and inducible NO synthase-producing DCs dominated the antiba

259 e, like MCP-1(-/-) mice, have fewer TNF- and inducible NO synthase-producing dendritic cells (Tip-DCs

260 hat physiologically produced NO from TNF and inducible NO synthase-producing dendritic cells can cont

261 synthase (products of inflammatory TNF- and inducible NO synthase-producing dendritic cells), CD83,

262 immune cells, as evidenced by the absence of inducible NO synthase production in infectious foci.

263 o affected dendritic cells, reducing TNF and inducible NO synthase (products of inflammatory TNF- and

264 Abeta1-42 peptides induced the expression of inducible NO synthase, proinflammatory cytokines (TNF-al

265 Analysis of a 1.7-kb region of the murine inducible NO synthase promoter revealed the presence of

266 Using inducible NO synthase promoter-reporter constructs, we f

267 strate a mechanism for reduced production of inducible NO synthase protein and its NO product.

268 The presence of inducible NO synthase protein in a number of inflammator

269 cancer-prone chronic inflammatory disease), inducible NO synthase protein levels were positively cor

270 ted Ms demonstrated comparable expression of inducible NO synthase protein suggesting that NO synthas

271 oxide dismutase, endothelial NO synthase, or inducible NO synthase protein, but HHcy caused a 100% in

272 LPS-induced cyclooxygenase-2 and inducible NO synthase proteins and NO production were ma

273 ow that viable Mtb elicits the expression of inducible NO synthase, RANTES, IFN-inducible protein 10,

274 Viable Mtb also up-regulates inducible NO synthase, RANTES, IFN-inducible protein 10,

275 the combined influence of NO generated from inducible NO synthase, reactive oxygen species, and alte

276 1400W, an inhibitor of NO production by the inducible NO synthase, reduced HMGB1 release stimulated

277 Abrogation of murine-inducible NO. synthase restores virulence to hmp mutant

278 d are adjacent to macrophages that expressed inducible NO synthase, suggesting a potential protective

279 as well as cells expressing MHC class II and inducible NO synthase, suggesting an induction of potent

280 Fas, Fas ligand, FLIP, TNF-alpha, inducible NO synthase, TGF-beta, and IFN-gamma were high

281 Expression of inducible NO synthase, TGFbeta, NADPH oxidase, VEGF, and

282 4)B radical in the oxygenase domain dimer of inducible NO synthase that was trapped by rapid freeze q

283 gamma, MIP-2, IL-1beta, TNF-alpha, IL-6, and inducible NO synthase; TLR signaling molecules, includin

284 ediators, such as IL-1alpha, IL-1beta, IL-6, inducible NO synthase, TNF, and reactive oxygen intermed

285 s during brain abscess development including inducible NO synthase, TNF-alpha, IL-1beta, CXCL2, and C

286 The inducible NO synthase to arginase ratio was lower in the

287 signal transduction via JAK-STAT, escalating inducible NO synthase transcription levels and promoting

288 Within 2 weeks, 69% of the inducible NO synthase-transduced EB displayed spontaneou

289 poptosis was prevented in the presence of an inducible NO synthase type 2 inhibitor.

290 FN-gamma priming was critically required for inducible NO synthase upregulation, NO production, Rac a

291 ssically activated macrophages, that produce inducible NO synthase via an IFN-gamma-dependent mechani

292 eliminate tumor was moderately impaired when inducible NO synthase was inhibited and greatly impaired

293 ction of NO and TNF-alpha, and expression of inducible NO synthase was inhibited by Tau-Cl in activat

294 Under these conditions, inducible NO synthase was not up-regulated and increased

295 Expression of inducible NO synthase was significantly upregulated in P

296 s nonhemopoietic dependent, whereas IL-6 and inducible NO synthase were derived from both cell types.

297 alpha and expression of cyclooxygenase-2 and inducible NO synthase were still inhibited in MyD88-defi

298 of IL-12p40, matrix metalloproteinase 9, and inducible NO synthase, whereas mRNA and protein levels o

299 However, blocking NO either by inhibiting inducible NO synthase with l-N(6)-(1-iminoethyl)-lysine

300 ydrobiopterin and decreases NO production by inducible NO synthase without affecting constitutive NO