ライフサイエンスコーパス: inducible expression

1 vel protein-DNA complex responsible for TCDD-inducible expression.

2 of coactivators tend to have more resilient-inducible expression.

3 the u-PAR gene required for constitutive and inducible expression.

4 are especially important for ABA- and stress-inducible expression.

5 l were integrated into a single FRT site for inducible expression.

6 samples as well as an experimental model of inducible expression.

7 hich was required for its basal and butyrate-inducible expression.

8 ble, at least in part, for cell specific and inducible expression.

9 ce also show decrease in both basal and xeno-inducible expression and activity of a subset of hepatic

10 flammatory ligand, lymphotoxin that exhibits inducible expression and competes with HSV glycoprotein

11 ily ligand LIGHT (lymphotoxin-like, exhibits inducible expression and competes with HSV glycoprotein

12 discrepancy, we studied the consequences of inducible expression and depletion of MYC in human cells

13 Using cell lines for inducible expression and knockdown of KLF8, we demonstra

14 (p27kip1) in adult mice through doxycycline-inducible expression and show this results in reduced ce

15 We propose that inducible expression and/or suppression of the genes tha

16 rived from homologous to lymphotoxins, shows inducible expression, and competes with herpes simplex v

17 member homologous to lymphotoxins, exhibits inducible expression, and competes with HSV glycoprotein

18 LIGHT (homologous to lymphotoxins, exhibits inducible expression, and competes with HSV glycoprotein

19 nown as homologous to lymphotoxins, exhibits inducible expression, and competes with HSV glycoprotein

20 LIGHT [homologous to lymphotoxins, exhibits inducible expression, and competes with HSV glycoprotein

21 n ligands homologous to lymphotoxin, showing inducible expression, and competing with herpes simplex

22 s ligand, homologous to lymphotoxin, showing inducible expression, and competing with HSV glycoprotei

23 betaR.Fc (homologous to lymphotoxin, showing inducible expression, and competing with HSV glycoprotei

24 t4 gene is not only subject to Pi-starvation-inducible expression, but that transcript levels may be

25 requently used modules like constitutive and inducible expression cassettes, endogenous gene silencin

26 Here, using an inducible expression cell model developed from a human n

27 wed that homologous to lymphotoxin, exhibits inducible expression, competes with herpesvirus glycopro

28 ligand, homologous to lymphotoxin, exhibits inducible expression, competes with herpesvirus glycopro

29 Regardless of their constitutive or inducible expression, decreased H3K9Ac levels after trea

30 lts in Zea mays mesophyll protoplasts on ABA-inducible expression effects on the Late Embryogenesis A

31 Transient transfection and inducible expression experiments showed that FOXO3a repr

32 fate outcomes, we conducted Ascl1- and Ngn2-inducible expression fate mapping using the CreER/LoxP s

33 Indeed, CRTC2 rescued cAMP-inducible expression for certain genes in CBP/p300 null

34 We observed stable inducible expression for over 1 month, with uniform expr

35 number of studies have reported short-term, inducible expression from helper virus-containing HSV-1

36 goal of this study was to obtain long-term, inducible expression from helper virus-free HSV-1 vector

37 n of transcription factor needed to regulate inducible expression from the circuit.

38 Ni(2)(+)-inducible expression from the CYC6 promoter remained a u

39 However, long-term, inducible expression has not been reported using HSV-1 v

40 ology to study gene function by facilitating inducible expression in a timed and reversible manner.

41 ive expression in epithelial appendages, and inducible expression in additional epithelia, when subje

42 ts showed that both vector designs supported inducible expression in cultured fibroblast or neuronal

43 ansgenic approach that enables selective and inducible expression in mice of FLAG-epitope-tagged, dih

44 keratin 17 (Krt17) shows highly dynamic and inducible expression in skin physiology and pathology.

45 press tet-off supported long-term (2 months) inducible expression in striatal neurons.

46 vated calcineurin and NFATc4, which revealed inducible expression in the heart.

47 expression of ID proteins in the former and inducible expression in the latter.

48 cribe an improved Ca(2+) sensor, GCaMP2, its inducible expression in the mouse heart, and its use to

49 ature characterized by early and late stress-inducible expression in tolerant and intolerant genotype

50 Heterogeneity of tet-inducible expression is generally attributed to the inst

51 f FUS may give insight into how its stimulus inducible expression may be associated with neurological

52 This was tested using islets with an inducible-expression mutation which renders defined numb

53 sogenic motor neuronal NSC34 cell model with inducible expression of a (G4C2)102 repeat, to investiga

54 1/2 (ERK1/2) MAPK signaling is activated by inducible expression of a BRAF(V600E) oncogene.

55 Inducible expression of a constitutively active form of

56 In contrast, inducible expression of a dominant inhibitor of NF-kappa

57 ere combined with mice that have doxycycline-inducible expression of a dominant-negative (DN) BMPR2.

58 Down-regulation of FRH by inducible expression of a hairpin RNA leads to low level

59 nerated a novel glioma mouse model driven by inducible expression of a mutant EGFR (EGFR*).

60 m has been used in transgenic mice to enable inducible expression of a mutant, constitutively active

61 Inducible expression of a mutated K-ras gene under the c

62 Inducible expression of a PP1 interaction-defective form

63 e a transgenic mouse that has tamoxifen (Tm)-inducible expression of a subgenomic segment of DA RNA i

64 sh orthotopic ovarian tumors, and found that inducible expression of a UBC-targeting shRNA led to tum

65 Here, we analyze the effect of the inducible expression of AIP1 RNAi in Arabidopsis plants

66 However, tolerized DCs demonstrated a novel inducible expression of aldehyde dehydrogenase 1/2 and p

67 constituted transcription system and that RA-inducible expression of all RARbeta isoforms is abrogate

68 Inducible expression of all three RAP2s conferred tolera

69 erated cardiac-specific transgenic mice with inducible expression of alpha1G, which generates Cav3.1

70 The inducible expression of ampC is controlled by the global

71 Here we generated transgenic mice with inducible expression of an active TAK1 mutant (TAK1Delta

72 Inducible expression of an Atcdc48A Walker A ATPase muta

73 ered a transgenic zebrafish with temperature-inducible expression of an EGFP-labeled single-chain hum

74 t expression of essential genes based on the inducible expression of an enzymatically inactive Cas9 p

75 /-) mice, as well as in transgenic mice with inducible expression of an ERK1/2-inactivating phosphata

76 omyocytes, we generated transgenic mice with inducible expression of an N-terminal FLAG epitope-tagge

77 We generated mice with endothelial-specific, inducible expression of an RAF1 gene with a gain-of-func

78 s study, we used double transgenic mice with inducible expression of angiopoietin-2 (Ang2) to investi

79 Although the basal and inducible expression of anti-apoptotic proteins in TRAF2

80 ic-dependent ribosome stalling that controls inducible expression of antibiotic resistance genes in b

81 cartilage constructs capable of tunable and inducible expression of antiinflammatory molecules, spec

82 The inducible expression of antimicrobial peptide genes in D

83 e immune response in Drosophila involves the inducible expression of antimicrobial peptide genes medi

84 Furthermore, we found that the inducible expression of any of three dominant interferin

85 , we demonstrate that ROP represses methanol-inducible expression of AOXI when P. pastoris is culture

86 ofile transcriptional changes in response to inducible expression of Arabidopsis (Arabidopsis thalian

87 sis and perturbing the ARF6 GTP/GDP cycle by inducible expression of ARF6 mutants defective in GTP bi

88 odocyte-specific genetic ablation of XBP1 or inducible expression of ATF6 in mice aggravates DN.

89 Inducible expression of AtMCP1b and AtMCP2b significantl

90 In catecholamine-secreting PC12 cells, inducible expression of B'beta decreased both N-terminal

91 We report here that constitutive or inducible expression of B7-H1, a B7 family molecule wide

92 eared to be a local effect, and regulated by inducible expression of B7-H1, an inhibitory molecule of

93 mopoietic cell line, TonB210, engineered for inducible expression of Bcr-Abl.

94 gen synthase kinase 3 inhibitors followed by inducible expression of beta-catenin shRNA or chemical i

95 hondrial-targeted bKu binds to ori5 and that inducible expression of bKu triggers petite formation pr

96 Using tetracycline-inducible expression of brain-derived neurotrophic facto

97 These findings document inducible expression of Brk in normal T lymphocytes and

98 Mechanistic studies showed that inducible expression of CD82 in highly metastatic melano

99 e knockout mice were devoid of the basal and inducible expression of certain phase 2 detoxification e

100 acting motif mediates the nitrosative stress-inducible expression of cgb.

101 The constitutive and inducible expression of chemokines and their receptors b

102 Inducible expression of chromosomal AmpC beta-lactamase

103 report that both constitutive and IFN-gamma-inducible expression of CIITA in mouse bone marrow-deriv

104 Darby canine kidney (MDCK II) cell line with inducible expression of claudin-8, a tight junction prot

105 Inducible expression of CNS-derived CXCL1 resulted in in

106 TLR-inducible expression of co-stimulatory signals is one of

107 However, it is unclear whether or how the inducible expression of co-stimulatory signals would dis

108 the gene expression profiles resulting from inducible expression of comparable levels of either wild

109 Here, we report that inducible expression of constitutively active MEK1 fails

110 erminal kinase phosphorylation; furthermore, inducible expression of constitutively active MEK1/2 or

111 used cre-lox technology to test whether the inducible expression of Cre minimize the deleterious eff

112 ed to produce mice with forebrain-restricted inducible expression of CRH.

113 Moreover, inducible expression of DACH1 augmented DATS-mediated in

114 of resistance; this can be achieved through inducible expression of defense genes or by the concentr

115 x2-interactome in ESC, we engineered ESC for inducible expression of different combinations of epitop

116 cells in transgenic mice, using doxycycline-inducible expression of diphtheria toxin, triggers a sig

117 LNCaP and PC3 prostate cancer cell lines and inducible expression of Dkk-3 reduced LNCaP cell prolife

118 ole of ligand-mediated Wnt signaling through inducible expression of Dkk1, an endogenous secreted inh

119 Although inducible expression of dual-specificity phosphatase 6 i

120 8 gene-deleted mice and transgenic mice with inducible expression of DUSP8 in the heart were used her

121 Inducible expression of each candidate open reading fram

122 Inducible expression of either CFTR or the calcium-activ

123 Inducible expression of either KD IKK alpha or WT PTEN s

124 l overexpression of Smad3 potently repressed inducible expression of endogenous iNOS and IL-6.

125 l overexpression of Smad3 potently repressed inducible expression of endogenous MCP-1.

126 We first observed efficient inducible expression of enhanced green fluorescent prote

127 The inducible expression of EWS-FLI1 in embryoid bodies, or

128 unction in vivo, we engineered mice with Cre-inducible expression of EWS/FLI-1 from the ubiquitous Ro

129 haracterized in Ba/F3 cells with doxycycline-inducible expression of F/P and in EOL-1 cells.

130 to have impaired migration but rescued with inducible expression of FAK.

131 rexpression of PGC-1alpha also prevented the inducible expression of Fn14 in denervated skeletal musc

132 We utilized transgenic and inducible expression of four transcription factors (Oct4

133 tion of ATF2 abrogates both constitutive and inducible expression of FoxP3 in normal epithelial cells

134 Inducible expression of FXYD2 in INS 832/13 cells produc

135 Inducible expression of Galpha12 or constitutively activ

136 Loss of SERF1 impairs the salt-inducible expression of genes encoding members of a mito

137 The heat-inducible expression of genes that encode BiP2, an endop

138 titative proteomics pipeline that allows for inducible expression of GFP-tagged SMAD proteins followe

139 Inducible expression of GNC demonstrates that GNC-mediat

140 Nevertheless, inducible expression of gneY alleviated all the defects

141 Constitutive and FN-f-inducible expression of GRO-alpha and GRO-gamma were als

142 addition, in transgenic Arabidopsis plants, inducible expression of groEL activated PTI marker gene

143 The inducible expression of Ha-Ras(V12) increased the produc

144 developed two transgenic mouse lineages with inducible expression of HCV structural proteins and cons

145 not the Refseq Hdac7 (Hdac7-s), promoted LPS-inducible expression of Hdac-dependent genes (Edn1, Il-1

146 of human tissue culture cells prevented the inducible expression of heat shock genes, shown by suppr

147 scription factors (Hsfs) activate the stress-inducible expression of heat shock proteins (Hsps) and o

148 mammary epithelial-specific and doxycycline-inducible expression of HEXIM1.

149 Inducible expression of Hst3p in G1 or G2 triggers deace

150 ionally significant differences in basal and inducible expression of human and murine P-selectin in v

151 ntire human SELP gene recapitulate basal and inducible expression of human P-selectin and reveal huma

152 Inducible expression of human SLUG in the dividing MDA-M

153 Inducible expression of hypoxia-inducible factor 1alpha

154 s into the nuclear genome of tobacco through inducible expression of I-SceI, and showed experimentall

155 ct was attributable to loss of basal and LPS-inducible expression of IFN-beta, which maintains Stat1

156 Inducible expression of IL-1alpha mRNA and protein were

157 vate the insulin pathway and alter basal and inducible expression of immunity-related genes in intest

158 2(V617F) knock-in mice with constitutive and inducible expression of JAK2(V617F) in hematopoietic cel

159 LXRs regulate basal and inducible expression of key cholesterol homeostatic gene

160 Tetracycline-inducible expression of KLF4 in B-cell progenitors of tr

161 In addition, inducible expression of KLF4 in the HL60 human acute mye

162 In this study, we showed that the inducible expression of kRasV12 in nontransformed intest

163 le 2HG was associated with repression of the inducible expression of lineage-specific differentiation

164 We describe a system for inducible expression of LPG, applying a novel protein-ba

165 Finally, the DeltaPsi-inducible expression of lrgAB was shown to be dependent

166 formation of NIH3T3 fibroblasts and that the inducible expression of LRIG1 in PC3 prostate tumor cell

167 Inducible expression of mCREB did not affect baseline se

168 Loss of Nrf2 function blocks the basal and inducible expression of microsomal epoxide hydrolase, a

169 MIR21 inhibitors, and stable cell lines with inducible expression of MIR21.

170 paB site that was also critical for IL-1beta-inducible expression of mouse TSLP.

171 Inducible expression of MtrR was found to repress rpoH e

172 NtMYC2a, b, c are required components of JA-inducible expression of multiple genes in the nicotine b

173 IFN-gamma-inducible expression of multiple genes, including IFN re

174 signaling pathways by using cell lines with inducible expression of mutant alpha1AT as well as liver

175 ver from transgenic mice with liver-specific inducible expression of mutant alpha1AT.

176 we generated a mouse model of selective and inducible expression of mutant DISC1 in astrocytes, the

177 Interestingly, inducible expression of mutant PIK3CA resulted in a robu

178 s of transcription 1 (STAT1), we showed that inducible expression of mutant Ras markedly decreased bo

179 e defect was associated with lower basal and inducible expression of MyD88 and reflected impaired act

180 We propose that this process allows pathogen-inducible expression of NBS-LRR proteins and that it con

181 Conversely, the inducible expression of NIPP1 switched the directional r

182 ed both the basal and tert-butylhydroquinone-inducible expression of NQO1, a prototypical Nrf2 target

183 rf2 x Maf to ARE controls both the basal and inducible expression of Nqo1.

184 engineered transgenic mice with doxycycline-inducible expression of Nup88.

185 Here, we show that inducible expression of OCT4 (iOCT4) supports long-term

186 Inducible expression of oncogenic Kras(V12) in hepatocyt

187 sactivation, which is directly implicated in inducible expression of OSM.

188 in the degree of endoreduplication, whereas inducible expression of p21(Waf1/Cip1) in p53-negative N

189 This is further confirmed by the inducible expression of p27(kip1) phosphorylation site m

190 enerated a novel transgenic mouse model with inducible expression of p52 in Clara cell secretory prot

191 We have therefore optimized galactose-inducible expression of PfCRT in S. cerevisiae yeast.

192 Conversely, inducible expression of PGC-1beta in white adipose tissu

193 Regulation of constitutive and inducible expression of pglyrp2 is important for systemi

194 he native pilin, PilE, but supplemented with inducible expression of PilA1 and PilA2 of C. perfringen

195 receptor (ADRB2) antagonist ICI118,551 or by inducible expression of PKA inhibitor (PKI) or of BCL2-a

196 The IFN-inducible expression of PKR, however, was Sp3-independen

197 TBK1-induced RelA phosphorylation results in inducible expression of plasminogen activator inhibitor-

198 Noscapine also abrogated the inducible expression of proteins involved in survival, p

199 We separately generated transgenic mice with inducible expression of proteolytic-resistant alpha1C Pr

200 nnovative bigenic system for the doxycycline-inducible expression of RANKL in the mammary epithelium

201 Tetracycline-inducible expression of REDD1 triggers rapid dephosphory

202 ntroducing a dun1 mutation, thus eliminating inducible expression of ribonucleotide reductase in mec1

203 ted transcription factor that regulates drug-inducible expression of several key cytochrome P450 enzy

204 Notably, the inducible expression of several noncoding transcripts wa

205 and MLL4 is required to suppress doxorubicin-inducible expression of several p53-target genes.

206 sis, we generated cell lines for doxycycline-inducible expression of short hairpin RNAs (shRNAs) targ

207 Mice with inducible expression of shRNAs against Anln mRNA develop

208 The inducible expression of SKD1(E232Q) in Arabidopsis resul

209 We have developed a SMA mouse with inducible expression of SMN to address the temporal requ

210 Inducible expression of SSBP2 causes growth arrest and p

211 Furthermore, inducible expression of SSBP2 in the AML cell line U937

212 Remarkably, inducible expression of SSBP2 is accompanied by downregu

213 mutant Ras markedly decreased both basal and inducible expression of STAT1, a transcription factor wi

214 The ligand-inducible expression of Stat5 in transgenic females medi

215 differentiation of embryonic stem cells and inducible expression of tagged proteins.

216 More significantly, adult-onset inducible expression of TAK1DeltaN protected the myocard

217 Inducible expression of TAp73 led to the recruitment of

218 We recently demonstrated that inducible expression of tau truncated at Asp-421 to mimi

219 Inducible expression of TDP-43 specifically in neurons e

220 Inducible expression of tetracycline responsive element

221 erated a transgenic mouse model that allowed inducible expression of TGF-beta(1) in keratinocytes exp

222 ere we generated mice with podocyte-specific inducible expression of the APOL1 reference allele (term

223 x 1 (PRC1) components with DSBs generated by inducible expression of the AsiSI restriction enzyme in

224 Heat-inducible expression of the AtCK2 transcript was complet

225 Inducible expression of the carboxyl terminus of either

226 We previously showed that inducible expression of the catalytic domain of cGMP-dep

227 deregulation of matriptase and simultaneous inducible expression of the cognate matriptase inhibitor

228 erated a transgenic mouse that had tamoxifen-inducible expression of the DA L-coding region in oligod

229 Inducible expression of the Dominant Negative protein re

230 ansgenic mouse line with tissue-specific and inducible expression of the EGFR ligand epigen, we showe

231 Using inducible expression of the energy acceptor at multiple

232 We further show that inducible expression of the ErbB2DeltaEx16 variant in ma

233 Inducible expression of the erm erythromycin resistance

234 n important transcription factor involved in inducible expression of the gene.

235 In an analysis of U2OS cell lines with inducible expression of the HCV polyprotein or individua

236 stable A549 human epithelial cell line with inducible expression of the hepatitis C virus protease N

237 We show that inducible expression of the homing endonuclease efficien

238 ibe a transgenic zebrafish line that enables inducible expression of the human AML1-ETO oncogene.

239 To understand the constitutive and inducible expression of the IKKi gene we localized the t

240 our earlier studies by both constitutive and inducible expression of the kras(V12) oncogene, hepatoce

241 he factors that control the constitutive and inducible expression of the mEH gene (EPHX1) that is alt

242 Here we demonstrate that inducible expression of the most common HER2 mutant (HER

243 id copy number is achieved through arabinose-inducible expression of the necessary Rep protein, pi, w

244 diated by repressing Notch signaling because inducible expression of the Notch Intracellular Domain (

245 ious work from our laboratory optimized MeOH-inducible expression of the P. falciparum malarial paras

246 We also report successful high level inducible expression of the P. vivax orthologue, PvCRT,

247 ferator-activated receptor gamma (PPARgamma)-inducible expression of the potent angiogenic factors VE

248 Inducible expression of the secreted Wnt antagonist Dick

249 Bypassing the native SPI-1 regulation by inducible expression of the SPI-1 activator, HilA, consi

250 ontrol of the tetracycline response element, inducible expression of the target gene is temporally re

251 however, the molecular mechanisms that drive inducible expression of the TG2 gene (TGM2) require eluc

252 genes, although HIRA is not required for IFN-inducible expression of these genes.

253 We also developed mice with inducible expression of transgenes encoding small hairpi

254 a critical need for genetic methods for the inducible expression of transgenes in specific cells dur

255 ines were capable of directing efficient and inducible expression of transgenes in the murine trabecu

256 cluding two gain-of-function models with tet-inducible expression of Trask in tumor cells lacking Tra

257 ssue with carnosol inhibited the pervanadate-inducible expression of tyrosine-phosphorylated beta-cat

258 disease, we generated mice with doxycycline-inducible expression of uncoupling protein-1 (UCP1) in t

259 control of cell adhesion and is required for inducible expression of urokinase-type plasminogen activ

260 hysiology on mammalian kidney epithelia with inducible expression of various WNK4 constructs.

261 In vitro, AGI-1096 inhibited the inducible expression of vascular cell adhesion molecule

262 indicate that mTORC2 and Akt facilitate CD40-inducible expression of VEGF in EC, which is of clinical

263 Inducible expression of VHR suppressed directional cell

264 /- mice stably transfected with plasmids for inducible expression of wild-type ARD1 protein (KO-WT),

265 L1(+) pre-B ALL together with a new model of inducible expression of wild-type Ikaros in IKZF1 mutant

266 we generated transgenic fruitflies with GAL4-inducible expression of wild-type or mutant csw, the Dro

267 Thus, stress-inducible expression of xCT is a two-step process: under

268 me inhibitor MG132 and lentiviruses enabling inducible expression or knockdown of c-myb were used to

269 4 target genes display STAT4-dependent IL-12-inducible expression, other genes displayed IL-12-induce

270 s of promoters that share common patterns of inducible expression, p300 recruitment, dependence on se

271 The second phase is defined by A20, whose inducible expression provides for a rheostat function by

272 A (shRNA-mir) cassette with a locus-defined, inducible expression strategy, we developed a system for

273 ctivity, making them particularly useful for inducible expression studies.

274 icted expression, localization, and cytokine-inducible expression suggest a role in the terminal diff

275 ghts the sensitivity and utility of the dual inducible expression system because in previous studies,

276 Using an inducible expression system Dominant Negative protein wa

277 urkat cells by using a tetracycline (Tet-on)-inducible expression system down-regulated CXCR4-mediate

278 In this study, using an inducible expression system for an miRNA target message,

279 Using an inducible expression system for the exosome cargo protei

280 ressed HCV core protein using a tetracycline-inducible expression system in HeLa cell lines.

281 Using an ecdysone-inducible expression system in mammalian dopaminergic ne

282 ination of tissue-specific expression and an inducible expression system in the loss-of-function phyB

283 Induction of IGFBP-3 using an ecdysone-inducible expression system inhibited DNA synthesis in a

284 We found that a 2-part nonviral Tet-KRAB inducible expression system repressed expression of a lu

285 Further analysis using an inducible expression system showed that BAK1 accumulatio

286 We used a lac-based inducible expression system to generate a conditional rr

287 Next, we used an inducible expression system to silence MECP2 in neurobla

288 wild-type APC protein was expressed using an inducible expression system, HT-29 cells became sensitiv

289 Using an inducible expression system, we discovered that age-onse

290 Using an inducible expression system, we examined the effects of

291 Using an inducible expression system, we found that IRF4 directly

292 Using an inducible expression system, we restored Mus81 or Sgs1 t

293 taNp73beta mutants by using the tetracycline-inducible expression system.

294 be easily adapted to other organisms with an inducible expression system.

295 system overcomes the limitations of current inducible expression systems by enabling robust spatial

296 roplasts using both constitutive and ethanol-inducible expression systems.

297 liver in a novel transgenic mouse model with inducible expression to screen for changes in gene expre

298 protein in the U937 cells containing a Zn2+-inducible expression vector coding for this fusion prote

299 cells overexpressing PKC-delta using a Zn2+ inducible expression vector.

300 For temporal regulation, Cre/loxP-mediated inducible expression vectors were used in combination wi