ライフサイエンスコーパス: inductive signal

1 omously; only later development requires the inductive signal.

2 icating that left coelom is required for the inductive signal.

3 toplasmically localized in the absence of an inductive signal.

4 haryngeal endoderm that is the source of the inductive signal.

5 in proportion to the strength of the floral inductive signal.

6 ession in the mesenchyme is contingent on an inductive signal.

7 petence of the cells to respond to the LIN-3 inductive signal.

8 m of the RAS pathway to regulate response to inductive signal.

9 VPCs reduces the sensitivity of all VPCs to inductive signal.

10 ild-type animals to respond to activation of inductive signal.

11 nsmit and receive a make-ligule-make-auricle inductive signal.

12 ctivation when repression is relieved by the inductive signal.

13 VPC specification EGF signaling is the major inductive signal.

14 iorly derived asymmetrically acting positive inductive signal.

15 progenitors and is a key mediator of the Wnt inductive signal.

16 ed by changes in the spatial distribution of inductive signals.

17 developmental systems patterned by transient inductive signals.

18 meres and does not require micromere or veg2-inductive signals.

19 ty of endodermal intermediates to respond to inductive signals.

20 are still competent to respond to pronephric-inductive signals.

21 and/or serving as one component of multiple inductive signals.

22 ete functional areas in response to specific inductive signals.

23 orrect patterning by later position-specific inductive signals.

24 forms dorsal mesoderm in response to ventral inductive signals.

25 t imprecision of spatial patterning by noisy inductive signals.

26 tion but only as cells that respond to tooth-inductive signals.

27 helial cell migratory responses to lymphatic-inductive signals.

28 endoderm and was mediated by secreted cardio-inductive signals.

29 ation to the underlying cardiac mesoderm via inductive signals.

30 nchymal progenitor population in response to inductive signals.

31 mouse embryonic stem (ES) cells using known inductive signals.

32 t are consistent with having received floral inductive signals.

33 y proteins before myelination in response to inductive signals.

34 s, that are dependent on the level of neural-inductive signaling.

35 ells in the Drosophila eye are determined by inductive signalling.

36 Inductive signals across germ layers are important for t

37 ct cell types is thought to be controlled by inductive signals acting at different concentration thre

38 patterned by a LET-23/EGF receptor-mediated inductive signal and a LIN-12/Notch-mediated lateral sig

39 g the L3 stage by the EGFR-Ras-MAPK-mediated inductive signal and the LIN-12/Notch-mediated lateral s

40 liver progenitors have focused on individual inductive signals and cellular responses.

41 Thus, while somatic inductive signals and chromosome karyotype have overlapp

42 The balance between the inductive signals and endogenous anti-apoptotic mechanis

43 esence of nephrogenic factors can respond to inductive signals and form epithelial structures in vitr

44 These changes are elicited by inductive signals and genetic regulatory factors that ar

45 mbined function of Gli/Zic genes responds to inductive signals and induces patterned neural cell diff

46 ction in Drosophila, various combinations of inductive signals and mesoderm-intrinsic transcription f

47 ink between the competence to receive floral inductive signals and restructuring of the SAM during fl

48 e response of ectodermal cells to endogenous inductive signals and that both of these activities are

49 vertebrates is dependent upon the balance of inductive signals and their specific antagonists.

50 nisms have revealed evolutionarily conserved inductive signals and transcription factor networks that

51 Inductive signals and transcription factors involved in

52 nder favorable conditions, the EGF-mediated "inductive" signal and the LIN-12/Notch-mediated "lateral

53 sent in all VPCs but is not modulated by the inductive signal, and that transcription of lag-2 requir

54 Therefore, the loss of responsiveness to the inductive signal appears not to be associated with the l

55 Inductive signals are also required for Drosophila heart

56 genes such as LEAFY, indicating that floral inductive signals are integrated upstream of LEAFY Here

57 A series of inductive signals are necessary to subdivide the mesoder

58 The initial floral inductive signals are perceived in the leaves and transm

59 In mice, neural inductive signals are thought to reside in an area of vi

60 The inductive signals at the neural plate border region are

61 osynthesis and transport of the lateral root-inductive signal auxin through local regulation of trypt

62 We propose that subsequent inductive signaling between amnioserosa and dorsal ectod

63 s such as mesenchymal-epithelial transition, inductive signaling, branching morphogenesis, and segmen

64 pression is dependent upon the nature of the inductive signal, but independent of the amplitude of ER

65 se at the neural plate border in response to inductive signals, but much remains to be learned about

66 t, like BMP4, FGF8 constitutes an epithelial inductive signal capable of inducing the expression of d

67 hick embryo is dependent on a medial-lateral inductive signaling cascade moving sequentially from the

68 le of Blimp1 in promoting the dermal papilla inductive signaling cascade that initiates HF growth.

69 from iNOS can be distinct and depend on the inductive signal cascades.

70 Inductive signals cause conversion of mesenchyme into ep

71 During this developmental transition, floral inductive signals cause the vegetative meristem to under

72 SOP recruitment is reiterative because the inductive signal comes from previously recruited SOPs.

73 by apoptosis and decreased responsiveness to inductive signals (competence).

74 ral neurogenesis is mediated in the leech by inductive signals conveyed retrogradely to each hemigang

75 of the dorsal neural tube to respond to this inductive signal declined after stage 10.

76 Hedgehog, a secreted protein, is an inductive signal delivered by retinal axons for the init

77 array of neurons is generated in response to inductive signals derived from localized organizing cent

78 Hedgehog genes have been implicated in inductive signaling during development in a variety of o

79 system for studying the role of Msx genes in inductive signaling during organogenesis.

80 ergo an alkalinization in response to planar inductive signals during neural induction in explants.

81 in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud.

82 inherited determinants (preformation) or by inductive signals (epigenesis).

83 l in which differential reception of cardiac inductive signals establishes chamber proportion.

84 led quantitative picture of an ERK-dependent inductive signaling event in the early Drosophila embryo

85 porally and spatially integrated programs of inductive signaling events.

86 s indicate that Eya1 controls critical early inductive signalling events involved in ear and kidney f

87 es these cells to be competent to respond to inductive signals, expanding the equivalence group.

88 backgrounds as well as timed ablation of the inductive signal favor one geometric model and suffice t

89 LIN-3 is the inductive signal for hermaphrodite vulval differentiatio

90 dings argue that FGF-3 is not required as an inductive signal for invagination of the otic placode to

91 al activation of beta-catenin is the primary inductive signal for taste placode formation, followed b

92 n through its inhibition of p63 and a strong inductive signal for terminal differentiation through it

93 ct of an axon with a dendrite is a necessary inductive signal for the assembly of functional presynap

94 in (MAP) kinase pathway signaling acts as an inductive signal for the CD4 lineage.

95 epidermal growth factor receptor provides an inductive signal for the specification of a large subset

96 ulating hormone (TSH; ie, thyrotropin) as an inductive signal for tumor necrosis factor-alpha (TNF-al

97 te, a region that also serves as a source of inductive signals for mDN specification such as Sonic He

98 ovide metabolic sustenance, but also provide inductive signals for organ development.

99 Although inductive signals for otic placode formation have been c

100 pears to act as a permissive, rather than an inductive, signal for slow MyHC expression in myoblasts.

101 MAP Kinase signaling cascade transduces the inductive signal from 3D and specifies cell fate among t

102 ue of their lineage or their proximity to an inductive signal from another cell.

103 activation of the Ras pathway by an EGF-like inductive signal from the AC.

104 the otic placode is believed to depend on an inductive signal from the adjacent hindbrain.

105 an individual ommatidium is regulated by an inductive signal from the adjacent R7 cell.

106 val precursor cells (VPCs) to respond to the inductive signal from the anchor cell of the somatic gon

107 degrees ) fate in response to a Ras-mediated inductive signal from the gonad.

108 results show that evolutionary changes in an inductive signal from the lens are involved in cave fish

109 These findings show that GDF7 is an inductive signal from the roof plate required for the sp

110 n of Pax2 and Gdnf, which in turn elicits an inductive signal from the ureteric bud.

111 intained later in development as a result of inductive signaling from one embryonic cell type to anot

112 by acting within the mesoderm and partly by inductive signaling from the ectoderm.

113 les), indicating that they are the target of inductive signaling from the ureteric bud, and that rena

114 sis involves epithelial growth controlled by inductive signalling from specialised mesenchymal subset

115 Inductive signals from adjacent tissues initiate differe

116 Inductive signals from extrinsic elements such as growth

117 ential keratin expression does not depend on inductive signals from hematopoietic cells.

118 al segments in its lack of dependence on Hox-inductive signals from local tissues, including paraxial

119 h the patterning of the paraxial mesoderm by inductive signals from midline tissues [1, 2].

120 specific cells in early embryogenesis, or by inductive signals from neighboring cells to germ cell pr

121 ormation in multicellular organisms requires inductive signals from neighboring cells.

122 o form anterior neural tissue in response to inductive signals from normal dorsal mesoderm.

123 To test whether inductive signals from one tissue can compensate for los

124 However, Pax-3 inductive signals from posterior nonaxial mesoderm are W

125 m an ectodermal placode that is specified by inductive signals from the adjacent neurectoderm and und

126 rocess that requires at least two sequential inductive signals from the diencephalon.

127 rm at the neural plate border in response to inductive signals from the ectoderm.

128 controls ovo-B expression in the absence of inductive signals from the female soma.

129 ing that the leaf vascular system depends on inductive signals from the margin of the leaf.

130 rm must occur quite late, and as a result of inductive signals from the mesoderm.

131 m the WD or the ureter stalk by antagonizing inductive signals from the metanephric mesenchyme to the

132 Inductive signals from the neural tube, notochord, and o

133 ysis of somite development in the absence of inductive signals from the notochord and floor plate.

134 domains that have different responses to the inductive signals from the prechordal plate, Sonic Hedge

135 Nonautonomous inductive signals from the soma and autonomous signals d

136 Genetic analysis clearly indicates that inductive signals from the soma are not required for ovo

137 Data suggest that inductive signals from the tailbud are primarily respons

138 m the metanephric mesenchyme after receiving inductive signals from the ureteric bud and from the ren

139 is response of the metanephric mesenchyme to inductive signals from the ureteric bud.

140 iption factors expressed in the pouch and by inductive signals from the ventral diencephalon/infundib

141 ents show that vMP2 fate is specified by an "inductive" signal from outside the MP2 lineage.

142 f the developing vertebrate limb responds to inductive signals, giving rise to skeletal elements that

143 N-12 stability or translation in response to inductive signalling helps impose a bias on lateral sign

144 ure of leaves to become permanent sources of inductive signal in addition to the lack of meristem com

145 cap assays and also respond to the embryonic inductive signal in Nieuwkoop recombinants.

146 tted along the retinal axons to serve as the inductive signal in the brain.

147 This could reflect the absence of an inductive signal in the environment of the dorsal telenc

148 sponse of single VPCs to controlled doses of inductive signal in wild-type and in mab-5 mutant animal

149 ble dominant-negative mutant disrupted early inductive signaling in affected tissues, indicating that

150 genitor cells (O-2As) to examine the role of inductive signals in astroglial lineage commitment.

151 nism to provide the competence to respond to inductive signals in different ways, ultimately generati

152 turn regulates the reciprocal expression of inductive signals in the mesenchyme which then act back

153 When exposed to inductive signals in vitro, only those progenitors that

154 ers Arabidopsis plants incompetent to floral inductive signals, including long-day (LD) photoperiod.

155 cell fates appears to depend on a cascade of inductive signals initiated by cells of the epidermal ec

156 nitor cells, and is activated in response to inductive signals involved in lineage specification.

157 Thus, inductive signals involved in normal pathways of neuroge

158 al steps in cerebellar development depend on inductive signaling involving FGF and Wnt proteins produ

159 ich mediates repression in all VPCs when the inductive signal is absent, and another promoter element

160 each side of a ganglion, indicating that the inductive signal is both highly localized and conveyed t

161 This inductive signal is overridden in the dorsal midline cel

162 ptional control of the lateral signal by the inductive signal is part of the mechanism by which these

163 Here, we provide evidence that the inductive signal is spatially graded and initially activ

164 ack reproductive structures, suggesting that inductive signaling is involved in planarian germ cell s

165 Inductive signaling is of pivotal importance for develop

166 Since inductive signalling is common in many organisms and its

167 efined in stereotypic domains in response to inductive signals is unknown.

168 Inductive signaling leads to the coactivation of regulat

169 precursor cells might bind and sequester the inductive signal LIN-3 EGF, thereby preventing diffusion

170 zebrafish indicate that the source of these inductive signals may be the extra-embryonic yolk syncyt

171 orms the mature bony labyrinth and regulates inductive signaling mechanisms in the otic mesenchyme.

172 but adopt different fates as a result of an inductive signal mediated by the Ras pathway and a later

173 ed competency of mesothelium and a localized inductive signal might play a role in restricting the in

174 e in developing tissues under instruction of inductive signal (morphogen) gradients, which specify di

175 a morphologically normal node to provide the inductive signals necessary for their expression.

176 actors have been identified that provide the inductive signals necessary to transform the simple otic

177 However, it is not clear whether the inductive signal of Wnt arises intradermally or intraepi

178 bsence of a pathogen is a paradoxically weak inductive signal, often requiring concentrations of 0.5

179 to adopt vulval cell fates in response to an inductive signal, only three of these cells are induced

180 ism of control has evolved because different inductive signals operate in each population of muscle p

181 septum transversum mesenchyme, and receives inductive signaling originating from both the septum tra

182 mitogen-activated protein kinase (EGFR-MAPK) inductive signaling pathway, which specifies the 1 degre

183 caused by mutations in several genes of the inductive signaling pathway.

184 ressors, leaving unresolved the link between inductive signaling pathways and transcriptional activat

185 target and a mediator of key dermal papilla inductive signaling pathways including transforming grow

186 it also provides novel targets to study the inductive signaling pathways that direct somite patterni

187 However, we also show that female inductive signals positively regulate ovo-B transcriptio

188 iew, we describe how a limited repertoire of inductive signals-principally FGFs, Wnts and BMPs-set up

189 entral midline of the CNS is dependent on an inductive signaling process mediated by the secreted pro

190 cation program and for the expression of two inductive signals produced by micromeres.

191 First, the coupling between the long-range inductive signals produced by the proneural Hh signaling

192 eloping vertebrate nervous system depends on inductive signals provided by local cell groups that act

193 vertebrate central nervous system depends on inductive signals provided by local organizing cell grou

194 cellular types are generated in response to inductive signals provided by specialized cellular group

195 he generation of dorsal interneurons through inductive signals provided by the roof plate.

196 ng blocks are related to the distribution of inductive signals, provided by the highly conserved epid

197 l ages retain the memory of an area-specific inductive signal received in vivo, even though they may

198 In addition to the inductive signals regulating cardiac specification, thes

199 , but the molecular nature of the endogenous inductive signals remains unknown.

200 of the cardiac mesoderm, both by inhibiting inductive signals required for the development of noncar

201 Competence to respond to the inductive signal requires that the VPCs do not fuse to t

202 and morphogenesis gleaned through studies on inductive signals, responding stem cells, and the extrac

203 of metanephric mesenchyme is triggered by an inductive signal(s) from the epithelial ureteric bud.

204 The mode of action of these inductive signal(s) remains unresolved, since various or

205 te heart develops from mesoderm and requires inductive signals secreted from early endoderm.

206 We show that LIN-3 is an inductive signal sufficient to promote the P12 fate, and

207 tiated or upregulated in VPCs in response to inductive signaling, suggesting that direct transcriptio

208 anted somites cannot be over-ridden by local inductive signals, suggesting that somitic tissue may be

209 n these results we propose that FGF-10 is an inductive signal that initiates ocular gland morphogenes

210 sponse to activation of EGFR/Ras/MAPK by the inductive signal that initiates vulval development.

211 Hox gene in the gut mesoderm influences the inductive signaling that leads to regionally specific di

212 amic interplay between these progenitors and inductive signals that act in concert to specify brown a

213 combination of external and internal floral inductive signals that are perceived across the whole pl

214 development cell commitment is regulated by inductive signals that are tightly controlled in time an

215 t restrain autophagy, the nature of positive inductive signals that can promote autophagy remain cryp

216 Our data suggest that the inductive signals that control Myf5 expression switch ra

217 ental markers, we tested for the presence of inductive signals that control the differentiation of an

218 morphogenesis is a complex event mediated by inductive signals that establish and maintain the distin

219 ermine whether paraxis might be a target for inductive signals that influence somite patterning, we e

220 space and time, and is under the control of inductive signals that initiate gastrulation movements.

221 FGF4 and BMP4 are inductive signals that participate in the communication

222 the utility of treating ES cells with local, inductive signals that regulate CNS neuronal development

223 about the appropriateness of targets and/or inductive signals that trigger the cascade of events lea

224 responsible for their different responses to inductive signals that use a common receptor.

225 In order to be receptive to the micromere inductive signal the macromeres first must transport bet

226 ulval patterning depends on both a localized inductive signal, the LIN-3 growth factor, and lateral s

227 During kidney development and in response to inductive signals, the metanephric mesenchyme aggregates

228 manner in which they may be established, the inductive signals they produce, and candidate signaling

229 N-3 EGF, thereby preventing diffusion of the inductive signal to distal vulval precursor cells.

230 and it has been suggested that Hh acts as an inductive signal to induce cells to enter a furrow fate

231 uggest that at least two signals, a positive inductive signal to specify the aboral ectoderm and a ne

232 r to play significant roles in conveying the inductive signal to the CNS.

233 ly during vertebrate organogenesis to permit inductive signaling to occur back and forth between tiss

234 has demonstrated that the notochord provides inductive signals to activate myoD and pax1 regulatory g

235 Early in gut development, the endoderm sends inductive signals to the mesoderm.

236 itional identity of prechordal mesendodermal inductive signals to the overlying neuroectoderm.

237 rix of these cells and activation of a novel inductive signal transduction pathway.

238 1 function and suggests dlf1 mediates floral inductive signals transmitted from leaves to the shoot a

239 Here we show that Hedgehog, an initial inductive signal transported along retinal axons from th

240 ial ectoderm is competent to respond to this inductive signal, trunk ectoderm is not.

241 w specific defects in lateral inhibition and inductive signaling, two characteristic processes regula

242 gehog, and distinct anterior-posterior (A-P) inductive signals, two topographically related progenito

243 e posterior marginal zone, which secretes an inductive signal, undergo spatially directed cytokineses

244 is paper, we have analysed the nature of the inductive signal underlying the formation of the epibran

245 umber of second messenger pathways propagate inductive signals via protein-protein interactions that

246 To investigate inductive signaling, we have isolated clusters of epithe

247 s and using specific inhibitors of different inductive signals, we show that the first inductive step

248 functional fibers is coordinated largely by inductive signals which act through discrete intracellul

249 at Jagged1-Notch signaling conveys a lateral inductive signal, which is indispensable for lens progen

250 ed at regulating the overall strength of the inductive signal, which may contribute to the quantitati

251 duced to differentiate and, depending on the inductive signal, will adopt either the osteogenic or ad

252 acts to pattern the response of ectoderm to inductive signals (Wnt-like).