ライフサイエンスコーパス: ineffective

1 en generally effective, mixed, and generally ineffective).

2 mutant that was unable to bind pSMAD3 proved ineffective.

3 PEIs with molecular weights below 1.8kDa are ineffective.

4 ng on ED1, whereas betaxolol/ICI-118 551 was ineffective.

5 Re-myelination of CNS nerves after injury is ineffective.

6 where ligand-binding domain antagonists are ineffective.

7 with either glycerol or L. reuteri alone was ineffective.

8 inocyclopropane-1-carboxylic acid (ACC) were ineffective.

9 y is identified or conservative measures are ineffective.

10 time until any such agents will also become ineffective.

11 eas catalytically inactive JD was completely ineffective.

12 arget cell and therefore renders the therapy ineffective.

13 gent, while (+)-dihydrokavain was completely ineffective.

14 lioblastoma in which single agent therapy is ineffective.

15 s in cases where a purely neural approach is ineffective.

16 ns, such as systemic chemotherapy, are often ineffective.

17 and citric acid components of the juice, was ineffective.

18 proach, but heterozygous call sequences were ineffective.

19 from IRI, with standard IPC approaches being ineffective.

20 gies against lung cancer have proved largely ineffective.

21 e, yet many current methodologies are highly ineffective.

22 cern for which pharmacotherapies are largely ineffective.

23 orn blood spot screening (NBS) education are ineffective.

24 for which conventional therapies have proved ineffective.

25 ates too high to be perceived are completely ineffective.

26 evaluations, tRES and HESP individually were ineffective.

27 ing skin vasoconstriction, and labetalol was ineffective.

28 ffective than information provision-which is ineffective.

29 lpha-converting enzyme) inhibitor GM6001 was ineffective.

30 ere additionally tested and also found to be ineffective.

31 ch first-generation RAF inhibitors have been ineffective.

32 ng treatments that are ultimately clinically ineffective.

33 zing that single interventions are generally ineffective.

34 Moreover, adaptation without stimulation was ineffective.

35 howed mixed effectiveness, or were generally ineffective.

36 ell carcinoma (ESCC), but may become quickly ineffective.

37 is substantial risk that the surgery will be ineffective.

38 a precatalyst, and other Pd(II) sources are ineffective.

39 ression, radioactive iodide (RAI) therapy is ineffective.

40 urrent treatments continue to be limited and ineffective.

41 ies against localized and metastatic HCC are ineffective.

42 phosphorylation of focal adhesion kinase was ineffective.

43 arasite renders the adaptive immune response ineffective.

44 y voice, 2) open communication is unsafe and ineffective, 3) embedded expectations of nurse behavior

45 of persistent infection have suggested that ineffective adaptive immune responses are necessary for

46 inst vaccinia virus and other poxviruses but ineffective against a range of other DNA and RNA viruses

47 point blockade (anti-CTLA-4 + anti-PD-1) was ineffective against BRAFi-resistant melanomas, the addit

48 reat hepatitis viruses but has proven rather ineffective against HIV in comparison to triple therapy

49 Indeed, BVM was found to be ineffective against HIV-1 clade C molecular clones teste

50 hese results, PD-1-targeting antibodies were ineffective against Lkb1-deficient tumors.

51 l, the mechanisms by which they are rendered ineffective against M2S31N are unclear.

52 Antimicrobial treatment was totally ineffective against strong biofilm producers, whose elec

53 the hCA IX and XII isoforms, while they were ineffective against the cytosolic enzymes hCAs I and II.

54 troyed CD276-positive cancer cells, but were ineffective against tumor vasculature.

55 is study, 60% were treated with at least one ineffective agent from their therapy combination regimen

56 /protein kinase A pathway have so far proven ineffective, alternative strategies for modulating aquap

57 the live attenuated vaccine was found to be ineffective among children in a year with substantial in

58 tions, therefore rendering natural selection ineffective and allowing new mutations to accrue in the

59 rophores; rendering these labels potentially ineffective and misleading to the field.

60 r on in the disease these microglia could be ineffective and produce proinflammatory cytokines leadin

61 g, suggesting that sequential monotherapy is ineffective and selects for a progressively higher BRAF

62 es to food security interventions are likely ineffective, and place-specific interventions considerin

63 nuclear bodies containing Sp100 and Daxx is ineffective, and that HSV-1 replicates equally well in p

64 Using previously ineffective antiarrhythmic drugs and reablation procedur

65 ith an effective antiparasitic drug, without ineffective antibiotics.

66 range of antimicrobials, and treatment with ineffective antimicrobials may result in case fatality r

67 By comparing cost-effective and ineffective architectures, we found that cost per protei

68 the order of 10(-6) s(-1) making Rev-erbbeta ineffective as a sensor of Fe(3+)-heme.

69 he Hanle effect, but these approaches become ineffective as the spin lifetime in the semiconductor de

70 covered that CI stimulation was surprisingly ineffective at activating many neurons in auditory corte

71 e, clinical inspection alone was found to be ineffective at blocking transmission.

72 ng tumor cells from blood, these devices are ineffective at capturing CTC clusters, incapable of sepa

73 not well understood, and current methods are ineffective at capturing these details.

74 The Hsp93[P-] construct was ineffective at complementing the pale-yellow phenotype o

75 rnational epidemic, rendering these measures ineffective at curbing the epidemic.

76 A formulations) reduced E. coli CFU but were ineffective at disrupting preformed biofilms or decreasi

77 rs and minimize normal tissue damage, but is ineffective at eliminating metastases.

78 Most vaccine candidates to date have been ineffective at generating Abs that neutralize T/F or ear

79 in betaHP, while also aggregating poorly, is ineffective at inhibiting amyloid formation in trans.

80 inhibit full-length tau aggregation and are ineffective at inhibiting seeding by full-length fibrils

81 nt ephrinB1 construct (Delta327-334) that is ineffective at interacting with RhoGDI1.

82 costly, damaging to non-target species, and ineffective at low population densities.

83 ilation (NIV) with a face mask is relatively ineffective at preventing endotracheal intubation in pat

84 f TopoIIalpha, etoposide and merbarone, were ineffective at preventing TopoIIalpha-dependent TCF tran

85 muscle susceptible to MH that dantrolene was ineffective at reducing halothane-induced repetitive Ca(

86 ce of Th(IV), changes in ionic strength were ineffective at releasing colloids while in the presence

87 On this basis, RanGTP is ineffective at releasing standalone Kapbeta1 from NPCs.

88 This indicates ion-exchange would be ineffective at removing NSAIDs and other negatively char

89 r this paradox is that current therapies are ineffective at targeting immune responses already presen

90 kappa-opioid receptor (kappa-OR), but it is ineffective at the nociceptin receptor.

91 e antagonist for P2X7Rs (IC50 of 10 nM) and ineffective at the P2X1R (at 10 muM).

92 odel complexity by not considering a largely ineffective ban on below-tax alcohol sales, special duty

93 This grand challenge has mostly proved ineffective because of catalytic mechanism constraints a

94 ibitor imatinib, but this drug often becomes ineffective because of secondary mutations in the Kit ki

95 ucts to encourage healthier purchases may be ineffective because other factors may be more important

96 ence interval [CI]: -55%, 32%) and similarly ineffective between age groups; increased risk of infect

97 the embryo, Trunk and Torso-like alone were ineffective but acted synergistically to stimulate Torso

98 Intermittent stimulation was rendered ineffective by either nicotinic or muscarinic receptor a

99 known resistance mechanisms, can be rendered ineffective by unrecognised adaptations in the bacterial

100 The most-cited basis of this ineffective cardiac regeneration in mammals is the low p

101 he homogeneous analogue (t)Bu(L-PdTFA) is an ineffective catalyst owing to decomposition under the ca

102 beta chain genes from one effective and two ineffective CD8(+) T-cell clones from an elite controlle

103 ineating the responsiveness of effective and ineffective CD8(+) T-cell clones recognizing the identic

104 Effective and ineffective CD8(+) T-cell clones segregated based on res

105 ained cytokine and chemokine secretion than "ineffective" CD8(+) T-cell clones.

106 h multiple electron-rich groups is caused by ineffective charge shielding during ion pairing.

107 Here, by comparison of effective and ineffective chloride treatments, we show the main role o

108 t current may be achieved through use of the ineffective chlorides, or indeed simple air annealing, v

109 n-dependent kinase inhibitors Ink4a/b, while ineffective chondrocyte hypertrophy is due to the suppre

110 have adverse consequences-consequences which ineffective clinical interventions can at best only miti

111 TCRs cloned from an effective and one of two ineffective clones conferred upon primary CD8(+) T cells

112 th lentivirus expressing TCR from one of the ineffective clones exhibited a level of activation by co

113 nlytic cytokine and chemokine secretion than ineffective clones.

114 he present results identifying smoking as an ineffective coping mechanism and the likely role of inac

115 le iron salts, leading to non-compliance and ineffective correction of iron-deficiency anaemia.

116 cessful development of OA treatment includes ineffective delivery of therapeutic agents to the reside

117 l dose of androstenedione to physiologically ineffective doses of letrozole and oxidative stress bypr

118 Ultimately this could reduce the quantity of ineffective drugs taken and facilitate early switching t

119 edly, simple alkyl ester-based prodrugs were ineffective due to chemical instability cyclizing to for

120 rate existing antibiotics that are currently ineffective due to efflux mechanisms.

121 r-associated peptide antigens, are typically ineffective due to poor immunogenicity.

122 her conventional non-destructive methods are ineffective due to sample opacity.

123 Current therapies for OM are ineffective due to the emergence of antibiotic-resistant

124 stablishment, but in B-ALL, TRC105 alone was ineffective due to the shedding of soluble CD105.

125 AR antagonists are ineffective due to their inability to repress the expres

126 aberrant IN multimerization but are largely ineffective during the early steps of viral replication.

127 ing neurally adjusted ventilatory assist and ineffective efforts appeared only in pressure support.

128 n excess of free alpha-globin chains causing ineffective erythropoiesis and hemolysis.

129 nder high iron conditions that might promote ineffective erythropoiesis and iron-loading anemia.

130 s that were accompanied by an alleviation of ineffective erythropoiesis in Th3/(+) mice.

131 be beneficial in ameliorating the anemia and ineffective erythropoiesis in thalassemias.

132 repletion completely reversed ID anemia and ineffective erythropoiesis of Hri(-/-) , eAA, and Atf4(-

133 er underproduction (a regenerative anemia or ineffective erythropoiesis) or increased destruction, an

134 that address the underlying chain imbalance, ineffective erythropoiesis, and iron dysregulation, with

135 d beta-thalassemia, minihepcidin ameliorates ineffective erythropoiesis, anemia, and iron overload.

136 alance in the alpha/beta-globin chain ratio, ineffective erythropoiesis, chronic haemolytic anaemia,

137 However, persistent increased and ineffective erythropoiesis, for example in thalassemia,

138 thways, eIF2alphaP and mTORC1, to circumvent ineffective erythropoiesis, highlighting heme and transl

139 beta-Thalassemia is characterized by ineffective erythropoiesis, reduced production of erythr

140 optotic destruction of erythroblasts causing ineffective erythropoiesis.

141 elodysplastic syndromes are characterised by ineffective erythropoiesis.

142 ogenic role in the development of anemia and ineffective erythropoiesis.

143 esence of covalently closed circular DNA and ineffective/exhaustive immune system.

144 tion by ELT when combined with the otherwise ineffective extracellular hydroxypyridinone chelator, CP

145 ation with impaired laminin organization and ineffective fibronectin degradation at the MTJ.

146 New evidence suggests that acetaminophen is ineffective for acute low back pain, and duloxetine is a

147 New evidence found that acetaminophen was ineffective for acute low back pain, nonsteroidal anti-i

148 a number of problems that have rendered ECA ineffective for biosensing applications.

149 ave factory default settings are potentially ineffective for certain types of medical waste and highl

150 ally ineffective results) and were generally ineffective for clinical outcomes (18 reviews with 6 mix

151 eld with internal polarization, rendering it ineffective for conventional ferroelectric applications

152 ight be effective for weight but is probably ineffective for height, cognition, and attendance.

153 reconstruction, rendering these experiments ineffective for high-throughput applications.

154 Current diagnostic tests are ineffective for identifying the etiological pathogen in

155 to abate addiction and relapse are currently ineffective for mitigating this growing global epidemic.

156 the current distribution of CASTNET sites is ineffective for monitoring the influence of Marcellus we

157 , we reveal that voltage clamp is completely ineffective for most excitatory synapses due to spine el

158 Oxacillin was ineffective for MSSA colonization in approximately 30% o

159 s for size distribution characterization are ineffective for nonmonodisperse samples, and further the

160 photosensitisers used clinically for PDT are ineffective for photochemical internalisation owing to t

161 for primary biliary cholangitis, is largely ineffective for pruritus.

162 fective for rheumatoid arthritis, are either ineffective for psoriasis or can induce new-onset psoria

163 onic low back pain, and benzodiazepines were ineffective for radiculopathy.

164 thiol-ene Michael addition were found to be ineffective for the synthesis of the desired products.

165 rametric excitation of a classical system is ineffective from the ground state, we show that in our e

166 me (MDS) is clonal disorder characterized by ineffective hematopoiesis and a tendency to evolve into

167 rosis in the bone marrow that contributes to ineffective hematopoiesis.

168 ating factor with myeloid cell dysplasia and ineffective hematopoiesis.

169 share features of cytological dysplasia and ineffective hematopoiesis.

170 ee DNA levels in MDS patients as a result of ineffective hematopoiesis.

171 Most patients with ineffective hemostasis with PCCs had ICH (n = 16; 61.5%)

172 e standard cluster analysis approaches to be ineffective: (i) the data take the form of a list of poi

173 Whereas ineffective IFN-alpha2 therapy was associated with CD8(+

174 slow chronic fashion eliciting a strong but ineffective immune response, mainly characterized by NK

175 fe long-term therapy (i.e., <7.5 mg/day) are ineffective, implying that immunosuppression should be p

176 ssed as effective in 58 (69.1%) patients and ineffective in 26 (30.9%) patients.

177 nother JAK inhibitor, ruxolitinib (RUX), was ineffective in 8 of 10 FED-responsive samples.

178 nt therapy with systemic vasoconstrictors is ineffective in a substantial proportion of patients and

179 treatment given 2 d postinfection is mostly ineffective in accelerating plasma VL loss in macaques.

180 HP was ineffective in amp1 and elevated the protein levels of P

181 In summary, CNTO3157 was ineffective in attenuating the effect of HRV-16 challeng

182 y for Bevacizumab, causing Bevacizumab to be ineffective in blocking MV-dependent VEGF receptor activ

183 radigms suggest that such approaches will be ineffective in cancers with few nonsynonymous mutations.

184 ns, binds MKK4, but not MKK7 or JNK3, and is ineffective in cells at enhancing activation of JNK3.

185 o C. jejuni in chicken and shows antibody is ineffective in clearing C. jejuni from the ceca within t

186 es from 1950s and 1960s have been relatively ineffective in combating recent epidemics.

187 ent is available, and therapeutics are often ineffective in controlling AS-associated seizures.

188 and programmed death receptor 1 (PD-1) were ineffective in controlling tumor growth.

189 achieved in progenitor cells, whereas it was ineffective in differentiated oligodendrocytes.

190 Standard methods were ineffective in disentangling the two selection pressures

191 tive thinking as to why recombinant Envs are ineffective in eliciting bNAbs and has led to the "germl

192 pe call sequences were randomized, they were ineffective in eliciting vigorous maternal approach beha

193 HP-I mutant males were ineffective in enforcing paternity when a second male wa

194 ments with antibiotics or biocides are often ineffective in eradicating biofilms.

195 c2 reversed this effect, and treatments were ineffective in Fpr2/3 knockout mice, which displayed an

196 subset of HPV types are available, they are ineffective in HPV-infected individuals.

197 ing it possible to use antibodies previously ineffective in immunochromatography.

198 gfb2-/- NPCs transplanted into EAE mice were ineffective in impairing MC accumulation within the CNS

199 Antibiotic therapy has been largely ineffective in improving clinical outcomes following Sal

200 asures often taken after the first event are ineffective in improving the visual outcome of a second

201 bi)(-/-) (ie, IL-27-incompetent) DC-RAs were ineffective in inducing food allergen tolerance.

202 uced nTreg cell-mediated enhancement, it was ineffective in iTreg cell-mediated enhancement; converse

203 s and humans indicate that norepinephrine is ineffective in modulating mnemonic processes in the abse

204 tant for viral clearance, and although often ineffective in neonates they can be protective when adeq

205 non-Hodgkin lymphomas have, however, proved ineffective in patients treated with rituximab and chemo

206 Multivariate functional diversity was ineffective in predicting ecosystem function due to the

207 xa5 is ineffective in preventing disease by strains containing

208 rmobaric 17% O2 or intermittent hypoxia, are ineffective in preventing neuropathology.

209 Current therapies are ineffective in preventing the development of cardiac phe

210 s in patients with Crohn's disease are often ineffective in producing long-term healing.

211 mitigation strategies used to date have been ineffective in protecting bats.

212 Antibiotic treatment is ineffective in reducing S. aureus colonization in the lo

213 trast to WT mice, supplemental glutamine was ineffective in reducing the rate of HSV-1 reactivation i

214 share machinery when a canonical pathway is ineffective in removing a difficult lesion.

215 VEGFR2 phosphorylation, VEGF, or VEGFR2 are ineffective in shutting down signaling to ERK1/2.

216 of sequential endocrine-based therapy may be ineffective in some settings of acquired CDK4/6 resistan

217 fy donor-specific antibodies are limited and ineffective in the most highly HLA-sensitized patients.

218 ent induced by Rho kinase inhibition but was ineffective in the presence of Rap-1 GTPase inhibitors.

219 ox potential set-point value, appeared to be ineffective in the presence of thiols.

220 dose steroids and calcineurin inhibitors are ineffective in the treatment of GVHD after LT.

221 dministered chemotherapeutic drugs are often ineffective in the treatment of invasive brain tumors du

222 inal and internal limiting membrane peel was ineffective in the treatment of microcystoid macular cha

223 However, EGFR inhibitors are ineffective in these patients, and tumor level of EGFR d

224 3) Are behavioral interventions that ineffective in this population?

225 nnium suggests that such institutions become ineffective in times of societal upscaling.

226 er, pig CD47 has previously been shown to be ineffective in transducing signals through primate signa

227 owdered dentine and was therefore considered ineffective in triggering a growth factor-mediated respo

228 subcellular localization and was relatively ineffective in triggering autophagy.

229 m, seizures, rather than the disease and are ineffective in up to 30% of patients.

230 doses/week was 75%-90% effective in men but ineffective in women.

231 (NS), but have serious side effects and are ineffective in ~20-50% of patients.

232 Expressing the pHO-lncRNA in trans is ineffective, indicating that transcription in cis is req

233 The ineffective inflammatory response associated with tissue

234 RS) cells are surrounded by an extensive but ineffective inflammatory/immune cell infiltrate.

235 Reed-Sternberg cells within an extensive but ineffective inflammatory/immune cell infiltrate.

236 As a result of ineffective initial control efforts, an Ebola outbreak o

237 ostatic activity during treatment, but it is ineffective long-term in asymptomatic T. cruzi carriers.

238 Coadministration of ineffective lorcaserin (0.1 mg/kg per day) and pimavanse

239 venting further resources being wasted on an ineffective model.

240 to quickly identify those therapies that are ineffective, modify or change therapy, and avoid disease

241 e main carbon sources within the nodules; in ineffective (nifH) nodules, particularly low levels of s

242 eoA or feoB deletion strains elicited small, ineffective nodules on soybean roots, containing few bac

243 control symptoms and/or using omalizumab is ineffective, not practical or unfunded.

244 y in patients with both AD and VCID would be ineffective on cognitive outcomes.

245 Importantly, the compound is ineffective on healthy breast cells, and exogenous overe

246 ion, the belief that thrombolytic therapy is ineffective once a patient has already arrested, the dif

247 years or older, in whom other treatments are ineffective or are contraindicated, and as an additional

248 have unintended consequences, rendering them ineffective or even detrimental.

249 suggests that right hemisphere engagement is ineffective or even maladaptive.

250 ICD therapies when antiarrhythmic drugs are ineffective or not desired.

251 and other diseases where T cell immunity is ineffective or short-lived due to PD-1-mediated signalin

252 armacological treatments for PTSD are either ineffective or temporary with high relapse rates.

253 e been investigated, most have proven either ineffective or toxic.

254 prophylaxis using topical aminoglycoside was ineffective (OR, 1.97; CI, 1.17-3.31).

255 These include ineffective pathways of care, unsuitable environments, i

256 zation toward amyloid deposits, resulting in ineffective plaque encapsulation and reduced plaque comp

257 are based on slow batch synthesis, which is ineffective, poorly controlled, and incapable of simulta

258 prevent fluid backflow and the vessels were ineffective pumps.

259 t to human anemias that are characterized by ineffective red cell production.

260 This is attributed in part to ineffective repression of Tcf1 expression in knockout T

261 In the multivariate analysis, ineffective response to first-line treatment (hazard rat

262 es (27 reviews with 11 mixed and 3 generally ineffective results) and were generally ineffective for

263 mes (18 reviews with 6 mixed and 9 generally ineffective results).

264 re unable to fix nitrogen effectively due to ineffective rhizobial colonization.

265 ygous gene disruptions and rescues otherwise ineffective sgRNAs.

266 efibrillator efficacy (arrhythmic deaths and ineffective shocks), and composite safety end point (the

267 However, ineffective strains can arise, making discrimination ess

268 ur via partner choice, where legumes prevent ineffective strains from entering, or via sanctioning, w

269 To test when and how plants discriminate ineffective strains we developed sets of fixing and non-

270 nservation planning could lead to the use of ineffective strategies and an overly optimistic view of

271 ever, treatment of mature Lep(ob/ob) mice is ineffective, suggesting that the trophic action of lepti

272 In contrast, our pruned enzymes were ineffective sulfatases, and this limited promiscuity may

273 acrophages of HIV/TB patients increases with ineffective T cell-dependent activation of monocytes/mac

274 eukemia (AML) portends a poor prognosis, and ineffective targeting of the leukemic stem cell (LSC) po

275 ious pseudo-high-dilution method, indicating ineffective templation in these cases.

276 Antidepressant drugs are too often ineffective, the exact mechanism of efficacy is still am

277 are less effective (glutamine and serine) or ineffective (threonine, lysine, and arginine).

278 dal neurons is induced at +30 ms, a normally ineffective timing interval for t-LTP induction in salin

279 This approach is ineffective to deal with the noise in the expression dat

280 pathogenesis of allergic diseases entails an ineffective tolerogenic immune response to allergens.

281 geting of hotspots with drug campaigns is an ineffective tool for elimination due to limited sensitiv

282 iption was a correlate of both effective and ineffective training and of treatments not producing mem

283 he block and allowed even a brief, generally ineffective training to produce long-term memory.

284 4, less cytotoxic conventional cisplatin and ineffective transplatin.

285 imarily from the lack of early diagnosis and ineffective treatment for advanced tumors.

286 Its endemicity and ineffective treatment options emphasize its public healt

287 BCID results is suboptimal and can result in ineffective treatment or missed opportunity to narrow th

288 nt has reliably distinguished effective from ineffective treatments.

289 Moreover, ineffective tricarboxylic acid cycle replenishment, dist

290 his impairment was due, at least in part, to ineffective use of negative feedback to guide subsequent

291 Concomitant with ineffective virus clearance, macrophage numbers were inc

292 typically impair memory consolidation become ineffective when animals are given intense training.

293 he retention test restored IA memory but was ineffective when given in the basolateral amygdala (BLA)

294 from a small quantity of recent data, become ineffective when neural recording conditions subsequentl

295 rongly affected by MABr concentration and is ineffective when replacing MABr with methylammonium iodi

296 breast cancer model, adjuvant sunitinib was ineffective, whereas adjuvant CVX-060 delayed the progre

297 We know that this is largely ineffective with resistance arising in most tumors follo

298 of treatment, current bronchodilators become ineffective with worsening asthma severity.

299 r intramuscular needle-syringe injection was ineffective, with only one participant (who received 320

300 ven weekly, while every other week dosing is ineffective, with reductions in Dermatology Life Quality