ライフサイエンスコーパス: inefficiency

1 ition, interference, or sequence-derived PCR inefficiency.

2 lp low-affinity sites overcome their kinetic inefficiency.

3 volve multiple steps that introduce bias and inefficiency.

4 ixed-model methods suffer from computational inefficiency.

5 alternative pathways that increase metabolic inefficiency.

6 hondrial proton gradient and cause metabolic inefficiency.

7 o adverse patient consequences, and provider inefficiency.

8 mere-specific DNA single-strand break repair inefficiency.

9 capture only partial information, leading to inefficiency.

10 subjects protection and incurs considerable inefficiency.

11 d noninvasive method to estimate ventilatory inefficiency.

12 against errors from photon loss and detector inefficiency.

13 ells is an important component of metastatic inefficiency.

14 gs is an important determinant of metastatic inefficiency.

15 ected feature of Ho, however, is its extreme inefficiency.

16 ages that compensate for its inherent energy inefficiency.

17 this may lead to patient harm and procedural inefficiency.

18 educing food intake and increasing metabolic inefficiency.

19 hindered by their haematologic toxicity and inefficiency.

20 or production use due to their computational inefficiency.

21 ation commonly considered a measure of brain inefficiency.

22 itions, as well as the first-cycle coulombic inefficiency.

23 h-charge overpotential that results in large inefficiencies.

24 cians, and surgical staff to reduce systemic inefficiencies.

25 vices sector and result in unintended system inefficiencies.

26 lenges, resulting in introduction delays and inefficiencies.

27 , is presented that overcomes these sampling inefficiencies.

28 rocesses, due to their current high cost and inefficiencies.

29 he continuum of care and creates substantial inefficiencies.

30 We show that this leads to considerable inefficiencies.

31 ther IRBs to begin identifying and improving inefficiencies.

32 ence clinical behavior and correct for these inefficiencies?

33 flexibility and motion, which cause packing inefficiencies and greater disorder of the protein layer

34 Inefficiencies and harms can arise if a biomarker hypoth

35 serine and methionyl-threonine CNBr cleavage inefficiencies and have developed a simple methodology t

36 onsense codons that are generated by routine inefficiencies and inaccuracies in RNA metabolism such a

37 create vast quantities of wastewater through inefficiencies and poor management of water systems.

38 to saponification, correcting for extraction inefficiencies and potential MS matrix enhancement or su

39 ctivities are low owing to carbon and energy inefficiencies and slow kinetics.

40 Multidisciplinary teams identified systemic inefficiencies and strategies to improve interdepartment

41 rent methods and projects while avoiding the inefficiencies and time delays associated with resequenc

42 ts reveals a mechanism underlying prefrontal inefficiency and cognitive deficits in schizophrenia, th

43 Metamorphic inefficiency and compositional relationships in the 1.2

44 ons designed to help healthcare staff reduce inefficiency and improve quality, and have been implemen

45 DPD-mediated metabolic inefficiency and improvement of glucose homeostasis were

46 cessful, but the hospital stay was marked by inefficiency and inconveniences, as well as events that

47 water during wet conditions, this is also an inefficiency and is often detrimental to the environment

48 re spending has generated both concern about inefficiency and policy debate about geographic-based pa

49 se of magnetic metals' optical loss, and the inefficiency and resistivity of semiconductor spin-based

50 pts SSM localization, promotes mitochondrial inefficiency and restricts maximal mitochondrial ATP-gen

51 ocedures in general, however, are limited by inefficiency and sequence biases.

52 astic, leading us to hypothesize that origin inefficiency and stochasticity are the result of a diffu

53 oke researchers aimed to identify sources of inefficiency and waste, recommend approaches to increase

54 resources but achieve lower accuracy (i.e., inefficiency) and that other patients with schizophrenia

55 which an estimated 30% is related to waste, inefficiencies, and excessive prices; health disparities

56 ough use of research designs known to reduce inefficiencies, and further research should be done to l

57 l to ameliorating the causes of many errors, inefficiencies, and reliability problems.

58 cental uric acid levels, prevented placental inefficiency, and improved fetal weights and serum trigl

59 er of factors contribute to nuclear transfer inefficiency, and we will review mouse cloning experimen

60 These inherent inefficiencies are attributed to (i) frictional losses r

61 In most other cases, inefficiencies arise due to unconstructive energy or cha

62 n ECL2 provides a potential rationale to its inefficiency as an antagonist of CCR5 coreceptor activit

63 nt meta-analysis identified processing speed inefficiency as the largest single cognitive impairment

64 arbon-hydrogen (C-H) bonds would obviate the inefficiencies associated with generating halide precurs

65 ization must address the significant scaling inefficiencies associated with library handling and dist

66 The inefficiency associated with the refolding of reduced ma

67 initiation or elongation but rather relative inefficiencies at multiple steps.

68 to be derived from A1 and FX, indicating an inefficiency at the FX --> FA/FB electron transfer step.

69 dings indicate that AIE increases behavioral inefficiency, but not punishment-mediated risk-taking, i

70 In lean mice, DPD promoted metabolic inefficiency by increasing carbohydrate and fat oxidatio

71 This inefficiency can be overcome by increasing the amount of

72 pecific subsets of people, and the metabolic inefficiencies caused by these SNPs should be examined f

73 luster genes partially rescues reprogramming inefficiency caused by Snai1 depletion.

74 mples lend themselves to the TDT despite its inefficiency compared with cases and unrelated normal co

75 Maturation inefficiency could potentially reflect an evolutionary a

76 ion induced dissociation (CID) fragmentation inefficiency, developing sensitive liquid chromatography

77 ibraries in Escherichia coli, in particular, inefficiencies during digestion and ligation steps.

78 sertions, suggesting a significant degree of inefficiency during the integration process.

79 ternal fructose consumption led to placental inefficiency, fetal growth restriction, elevated fetal s

80 Both are common sources of failure and inefficiencies for these simulators.

81 Thus ERAD inefficiency for distinct aggregation-prone proteins can

82 features of Ang that underlie its catalytic inefficiency: Gln-117 blocks the space corresponding to

83 of folding energy landscapes causes sampling inefficiencies however, particularly at low, physiologic

84 is a means by which the HGE agent overcomes inefficiencies in acquisition of infection by ticks and

85 uplication (ITD), remains challenging due to inefficiencies in alignment of ITD-containing reads to t

86 There are inefficiencies in current approaches to monitoring patie

87 Addressing inefficiencies in diagnostic testing could minimize pote

88 cell level are poorly documented leading to inefficiencies in differentiation and concerns regarding

89 mind wandering in humans is characterized by inefficiencies in executive control (task-monitoring) pr

90 g TAC reduced anaplerotic flux, ameliorating inefficiencies in glucose oxidation, with energetic and

91 nt evidence of unacceptable inequalities and inefficiencies in health care.

92 ved as an essential component for addressing inefficiencies in healthcare.

93 Inefficiencies in high-risk infants later classified wit

94 n in agriculture and industry, and pervasive inefficiencies in its use.

95 ent myogenic cell lineages was confounded by inefficiencies in lineage marking and ablation.

96 the destruction of particles by weathering, inefficiencies in magnetic collection or separation tech

97 e in the Protein Data Bank, largely owing to inefficiencies in protein production.

98 ined solid + fluid volume is reduced and the inefficiencies in space filling by the interpenetrated p

99 device as well as inform the mechanisms for inefficiencies in SWNTs and carbon based solar cells.

100 Accordingly, decades-long standing inefficiencies in targeted nuclear gene editing broadly

101 and temporal functions, probably reflecting inefficiencies in the adaptive interpretation of sensory

102 poorly cited articles and journals suggests inefficiencies in the cardiovascular research enterprise

103 For example, apparent inefficiencies in the cleavage of wood-specific H-bonds,

104 he current study maps the emergence of these inefficiencies in the first year of life.

105 t these gene products normally contribute to inefficiencies in the killing pathway.

106 ust be performed, which may actually lead to inefficiencies in the laboratory.

107 alleles that are diabetes prone, because of inefficiencies in the peptide-MHC structural interaction

108 ead to inaccuracies of study information and inefficiencies in the process.

109 drug susceptibility testing, high costs and inefficiencies in the supply of second-line drugs, and i

110 ting signals, certain stresses, or intrinsic inefficiencies in their translocation.

111 We also demonstrate inefficiencies in transcription initiation and elongatio

112 Inefficiencies in triaging, off-hour presentation, intra

113 ng to strong compensatory dietary responses, inefficiency in absorption of the energy they contain, a

114 d mice demonstrated a less mature phenotype, inefficiency in Ag uptake, and impaired migration in vit

115 with preschool asthma suggests its potential inefficiency in asthma studies at this age range.

116 Inefficiency in brain circuitry, defects in white matter

117 rol the overall type I error) induces a core inefficiency in clinical trial productivity by reducing

118 importance of population size and selection inefficiency in creating an evolutionary niche to promot

119 oid duplication of effort, slow adoption and inefficiency in development, those developing biological

120 esults indicate that spillover, a measure of inefficiency in dietary fat storage, is inversely associ

121 l is an important source of FFA and reflects inefficiency in dietary fat storage.

122 ogenous Wnt signalling underlies much of the inefficiency in directing hESCs towards specific cell ty

123 en analyzing a large number of genes and the inefficiency in exploiting prior knowledge, such as the

124 coming of nonlive vaccines is their relative inefficiency in generating T cell responses, thus limiti

125 ause there is considerable inconsistency and inefficiency in identifying those who would benefit from

126 -ND may partially compensate for the cardiac inefficiency in impaired beta-adrenergic signaling.

127 The lack of photoresolution was traced to inefficiency in intramolecular, through-bond triplet ene

128 th developmental dyslexia is how to separate inefficiency in learning on the one hand from exposure t

129 n-proteasome system function and only modest inefficiency in macroautophagy late in disease.

130 tive cardiolipin remodeling and bioenergetic inefficiency in myocardium rendered diabetic by streptoz

131 s, we suggest that ASD is associated with an inefficiency in optimizing network connections to achiev

132 e connections between neighboring areas, and inefficiency in pathways for emotions, and may help expl

133 ell receptor (TCR) signaling strength due to inefficiency in promiscuous expression of self-antigens

134 doplasmic reticulum (ER), we reveal a slight inefficiency in PrP signal sequence function that genera

135 nfluence to reduce other causes of waste and inefficiency in research.

136 ts application is limited by low potency and inefficiency in systemic delivery, especially failure to

137 Whether this reflects inefficiency in the ability of yeast actin to activate m

138 idely discussed illustration, are a cause of inefficiency in the allocation of resources across space

139 This increases inefficiency in the allocation system.

140 es in longer studies) can assist in reducing inefficiency in the current paradigm, which is still hea

141 l resources in private sectors might produce inefficiency in the health care system and inequity in a

142 p I (NifS/IscS-like) paralogues results from inefficiency in the nucleophilic attack step associated

143 ty and specificity, thereby causing a severe inefficiency in the underlying multiple testing problem.

144 policy gives the greatest equity but causes inefficiency in unit bed-flow (0.5033 days).

145 a feedback cycle of electron transport chain inefficiency, increased reactive oxygen species producti

146 ules (e.g., ATP) but also triggers energetic inefficiency inside the cell.

147 k (i.e., Gibbs free energy of mixing) due to inefficiencies intrinsic to the process.

148 Such inefficiency is apparently due to competition between a

149 In part, the inefficiency is due to an absence of the coxsackie B and

150 c induction in the ferrocene system, and its inefficiency is explained by intramolecular coordination

151 concentrations in vivo and suggest that drug inefficiency is likely related to proteomic heterogeneit

152 metabolically inefficient, the source of the inefficiency is not from a primary function in thermogen

153 The intracellular source of inefficiency is postulated to be an increase in the ATP

154 A consequence of this inefficiency is that small numbers of transmitted founde

155 , this "female-specific crossover maturation inefficiency" is inferred to make major contributions to

156 te that the polymerase ribozyme, despite its inefficiency, is partially processive.

157 these tumor cells, often termed "metastatic inefficiency," is poorly understood.

158 This inefficiency leads to an increase in H3K9me2 at its targ

159 conform to established locales of prefrontal inefficiency linked to genetic risk for schizophrenia.

160 However, due to its computational inefficiencies, long run-time and complexity of various

161 , increased risk aversion) and/or allocation inefficiencies may have played a role.

162 by rs10748842, which does not fit the simple inefficiency model of risk association in DLPFC and sugg

163 Data were inconsistent with the neural inefficiency model.

164 Agricultural biotechnology is limited by the inefficiencies of conventional random mutagenesis and tr

165 Because of the inefficiencies of current formulation methods, materials

166 s (HCV) persistence in the host results from inefficiencies of innate and adaptive immune responses.

167 sidies, hostility to foreign investment, and inefficiencies of its state-planned economy underlie Ira

168 ic uncertainties of random mutations and the inefficiencies of nuclear transfer we directed our effor

169 ystem overcomes the small flow rates and the inefficiencies of previously described microfluidic and

170 Unfortunately, the workload and inefficiencies of primary care practice present barriers

171 te Carlo (ABC-SMC) help address the inherent inefficiencies of rejection sampling, such approaches ar

172 se they seemingly rid themselves of the many inefficiencies of sexual reproduction-the so-called cost

173 The catalytic inefficiencies of the CO2-fixing enzyme ribulose-1,5-bis

174 These data suggest that the natural inefficiencies of transcription termination by the NS1 a

175 We conclude that the inefficiencies of unnatural AA-tRNA incorporations were

176 However, the inefficiency of adenovirus-mediated gene transfer could

177 electrical functional defect, reflecting the inefficiency of AdV-mediated gene transfer to the epithe

178 is physiological mechanism could explain the inefficiency of antitumor T cells in the tumor microenvi

179 Thus, the energy inefficiency of ATP production, despite high energy subs

180 ficient mice and further corroborated by the inefficiency of carbachol to increase IPSC frequency in

181 The targeting inefficiency of CAT-ANL could be ameliorated when K was

182 These results draw attention to the inefficiency of catechin to prevent actin oxidation, in

183 The complexity and inefficiency of chromatin immunoprecipitation strategies

184 ments, which could lead to marked failure or inefficiency of control strategies.

185 large part to the technical problems and/or inefficiency of conventional DNA transfer methods, as we

186 experience more frequent drought and flood, inefficiency of cropping systems water use will also inc

187 C) enzyme/prodrug strategy is limited by the inefficiency of cytosine deaminase (CD)-catalyzed conver

188 polbeta-knockout cell extracts is not due to inefficiency of damage incision but rather to deficiency

189 lopment of protein-based therapeutics is the inefficiency of delivery of protein cargo across the mam

190 ut limited by technical hurdles and profound inefficiency of direct gene transfer to the pancreas in

191 rect presentation, we show unequivocally the inefficiency of direct presentation and the essential re

192 The inefficiency of electron transfer in the TA sequence is

193 The inefficiency of gene transfer has greatly hindered gene

194 es from Ogt to investigate the basis for the inefficiency of hAGT in repair of m(4)T.

195 tor has been defined, in part because of the inefficiency of Histoplasma reverse genetics.

196 The inefficiency of HIV breast-milk transmission may be caus

197 itory receptors, which may contribute to the inefficiency of HIV-specific antibody responses.

198 ts by reverse genetics is constrained by the inefficiency of homologous recombination and by the diff

199 However, due to the relative inefficiency of homologous recombination in cultured hum

200 eted mutational analyses are hampered by the inefficiency of homologous recombination.

201 Despite the success of multiple groups, the inefficiency of in vitro reprogramming has made it chall

202 The inefficiency of internalization of chemokine receptors i

203 However, in contrast to the inefficiency of KSHV maturation following reactivation f

204 The inefficiency of lytic reactivation in various in vitro s

205 One of the main reasons for the inefficiency of multicenter randomized clinical trials (

206 consequence of geographic isolation and the inefficiency of natural selection to eliminate harmful v

207 and practicability of viral vectors and the inefficiency of nonviral transfection techniques.

208 Inefficiency of oxidative phosphorylation can result fro

209 Our results suggest that the inherent inefficiency of primer strand loop repair is not simply

210 ribution to conserving biodiversity, and the inefficiency of protected area systems is widely acknowl

211 often hampered by short ex vivo shelf life, inefficiency of recruitment to sites of inflammation, an

212 ly in tissue culture, in part because of the inefficiency of replication in cells.

213 has been underappreciated as a result of the inefficiency of ROS scavengers to control ROS bursts aft

214 To explain the inefficiency of salivary gland clearance we hypothesized

215 to investigate possible transport defects or inefficiency of SMN associated RNPs in motor neuron axon

216 lem of animal genome engineering, namely the inefficiency of targeted DNA cassette insertion.

217 Thus, the inefficiency of TFIID binding to a promoter may be partl

218 The inefficiency of the anaerobic pathway is compensated by

219 The immunological basis for the inefficiency of the cellular immune response in chronica

220 The relative inefficiency of the complement-independent killing mecha

221 osis has been limited in part because of the inefficiency of the delivery systems.

222 Additionally, our results expose an inefficiency of the enzyme in processing its radical int

223 lex virus-thymidine kinase assay support the inefficiency of the exonuclease as a "proofreading" acti

224 By reversing the energetic inefficiency of the failing heart, pharmacological XO in

225 ctive triphosphates is often hampered by the inefficiency of the first kinase-mediated step.

226 asculitic T cells expressed PD-1, suggesting inefficiency of the immunoprotective PD-1/PD-L1 immune c

227 equally large obstacle was presented by the inefficiency of the integration event when using traditi

228 at the introduction of the COMT overcame the inefficiency of the native pine methyltransferases for s

229 onally nonequivalent in vivo, with intrinsic inefficiency of the native PrP signal being required for

230 Yet the inefficiency of the ON cell is compensated by its presyn

231 cloning experiments, however, is the overall inefficiency of the process, typically 0-4%.

232 mperatures, arising because of the radiative inefficiency of the smallest grains, probably contribute

233 This feature appears to account for the inefficiency of the tRNA(SG)(Ala) promoter since provisi

234 to be both cause and effect of this partial inefficiency of the two-stage system, as confirmed also

235 rfering RNAs (siRNAs) as therapeutics is the inefficiency of their delivery across the plasma and end

236 The root cause of the catalytic inefficiency of TpCS may lie in the lack of protein flex

237 of Chlamydomonas is greatly hampered by the inefficiency of transgene expression from the nuclear ge

238 cost-effective alternative approach, but the inefficiency of transgene integration mandates ex vivo s

239 constraints, orientational effects, and the inefficiency of translational energy in promoting the re

240 These results indicate that inefficiency of type II-C Cas9 enzymes for genome editin

241 In spite of the inefficiency of unreduced pollen in unilateral sexual po

242 nditions (i.e., 0.1% at pH 7.0) explains the inefficiency of VanA in dipeptide synthesis.

243 to account for a substantial fraction of the inefficiency of viral protein synthesis, independent of

244 The results also highlight the general inefficiency of whole-genome bisulphite sequencing, as 7

245 These observations suggest that the relative inefficiency of WT IKBKAP mRNA production from the mutan

246 iation from the 3/4 exponent suggests either inefficiency or compensating physiological mechanisms.

247 gth in the secondary dimension (tuning), the inefficiency or cross correlation between the two dimens

248 odeled as having three additional sources of inefficiency originating in the motor system, calculatio

249 ly if generalists must pay an extra cost, an inefficiency penalty, for their capacity to perform more

250 widely considered to be evidence of program inefficiency, policymakers need to understand how differ

251 elivery of health care is hindered by waste, inefficiencies, poor quality of services, and scarcity a

252 system have resulted in rapid cost increase, inefficiencies, poor quality, unaffordable health care,

253 ddition, within the high-risk infants, these inefficiencies predicted 24-month symptom severity.

254 tical next step is to establish whether this inefficiency predicts transition to stimulant dependence

255 that evolution might have worked around the inefficiency problem by fashioning a system capable of t

256 ical dyssynchrony associated with mechanical inefficiency, regional dysfunction, and RV dilatation is

257 fuel, but land-use requirements and process inefficiencies represent hurdles for large-scale deploym

258 Apart from the case with heterogeneity, inefficiencies result from the presence of strategic int

259 gene is inefficiently transcribed, and this inefficiency results from lack of a specific sequence wi

260 This inefficiency results from two characteristics of Ho.

261 ypes using this approach is often plagued by inefficiency, slow conversion, and an inability to produ

262 dependently from other sources of perceptual inefficiency, such as the ability to filter out external

263 This relative inefficiency suggests a decreased ventilatory reserve an

264 Siblings and patients showed greater DLPFC "inefficiency" than controls.

265 sociated with physician rounding can produce inefficiencies that decrease time for essential activiti

266 sociated with physician rounding can produce inefficiencies that decrease time for essential activiti

267 ment is susceptible to design and procedural inefficiencies that hinder recruitment and to personnel

268 biodiversity, payment schemes must trade-off inefficiencies that result from over-simplified policies

269 ine deficient, probably by causing metabolic inefficiencies that should be detectable even while inge

270 o administer, taps an information processing inefficiency that is a central feature of the cognitive

271 Reduced mechanical inefficiency (the ratio of rate-pressure product to MVO(

272 explanation for the often-observed "frontal inefficiency," the failure to recruit prefrontal system

273 verse TCR repertoire by overcoming Vbeta RSS inefficiency to promote Vbeta recombination and alphabet

274 e serious drawbacks, such as safety hazards, inefficiency under in vivo-like conditions, and expensiv

275 We explored the impact of two potential 'inefficiencies': uneven net distribution among household

276 oxygen consumption decreased and ventilatory inefficiency (VE/VCO2 slope) increased with increasing s

277 text]e/[Formula: see text]co2), ventilatory inefficiency was closely related to PcCO2 (r values from

278 To overcome this inefficiency we constructed a new virus, AdPK, that cont

279 l compensation, capacity limitations, neural inefficiency) were examined in relation to working memor

280 The extreme inefficiency with which infectious HIV-1 is able to infe

281 However, we show here that the inefficiency with which T134K presents intracellular ant

282 flecting limbic interference with and neural inefficiency within the frontoparietal network.