ライフサイエンスコーパス: inefficient

1 is and disruption of gene expression and are inefficient.

2 er of graphene render these hybrid catalysts inefficient.

3 ectly to zygotes, these strategies are quite inefficient.

4 anism renders designing a selective catalyst inefficient.

5 dine by ultraviolet irradiation is extremely inefficient.

6 LP assembly is poorly understood and appears inefficient.

7 eward made it worthwhile to be energetically inefficient.

8 wever they are time-consuming, expensive and inefficient.

9 prisingly variable, convoluted, and wantonly inefficient.

10 activity under conditions in which Arch was inefficient.

11 reorganization that occurs is transient and inefficient.

12 ckpoint arrest, indicating that HR repair is inefficient.

13 mical and photochemical conversion processes inefficient.

14 lies that makes most methods inapplicable or inefficient.

15 tion, infection by the enteral route is very inefficient.

16 containing mixed sequences remains slow and inefficient.

17 r screening practice in the United States is inefficient.

18 but the technique thus far has been slow and inefficient.

19 by nonviral, nonintegrating methods remains inefficient.

20 ively, yields universal O-type blood, but is inefficient.

21 blems wherein this paradigm is fundamentally inefficient.

22 kes up a majority of the material, making it inefficient.

23 um and tantalum metals and oxides are energy inefficient.

24 ect is due to hyperactivation of cofilin and inefficient actin polymerization.

25 h RasG in vitro, and psrA(-) cells displayed inefficient activation of multiple Ras species, decrease

26 1 mutations (i) would directly be due to the inefficient actomyosin complex, and (ii) could be restor

27 YAMAT-seq circumvents the issue of inefficient adapter ligation, a characteristic of conven

28 nge, suboptimal management outcomes, and the inefficient allocation of resources for climate adaptati

29 ockouts through NHEJ, editing by HDR remains inefficient and can be corrupted by additional indels, p

30 y, clinically used tocolytics are frequently inefficient and cross the placenta causing fetal side ef

31 ion of NKG2D ligands by HIV-1 Nef from EC is inefficient and leaves infected cells susceptible to ADC

32 ion between spatially orthogonal orbitals is inefficient and limited to field and inductive effects.

33 V particle populations and vector purity are inefficient and low resolution.

34 Furthermore, otherwise inefficient and non-stereoselective transformations with

35 tion is efficient and processive, RNase H is inefficient and periodic.

36 oss the cell's plasma membrane barrier is an inefficient and poorly controlled process, despite its f

37 end is </=150 bp, second-end capture becomes inefficient and repair shifts from GC to break-induced r

38 a large set of highly specific priors may be inefficient and restrict the speed at which expectations

39 However, direct reprogramming strategies are inefficient and slow.

40 l revealed that ER export of procollagen was inefficient and that ER tubules were dilated, faithfully

41 ing, in large part because VLP production is inefficient and the mechanisms underlying particle assem

42 es this alleviation, making mgtL translation inefficient and thereby permitting mgtA transcription.

43 approaches to point mutation correction are inefficient and typically induce an abundance of random

44 Fixed Bandwidth (FB) implementation is both inefficient and unable to deal with sample sets providin

45 ausible sets of factors, an approach that is inefficient and unscalable.

46 Infection in current systems, however, is inefficient and virus fails to spread.

47 ss to such clickable agents is challenged by inefficient and/or poorly defined multistep radiochemica

48 verage by building onto a highly fragmented, inefficient, and costly health system.

49 synthesis of O-PS are technically demanding, inefficient, and expensive.

50 alogues, the process can be relatively slow, inefficient, and frequently low-yielding.

51 nant interferon gamma (IFN-gamma) therapy is inefficient, and hematopoietic stem cell transplantation

52 ic agent of Chagas disease, have been highly inefficient, and no endogenous tagging of genes has been

53 Nuclear reprogramming is relatively inefficient, and the development of the resultant embryo

54 DUX4 polyadenylation signal is surprisingly inefficient, and use this finding to develop an faciosca

55 contentious and is considered by some as an inefficient approach to food production.

56 current underlying action potentials, is an inefficient approach.

57 tination and degradation, and the consequent inefficient assembly of the FA core complex, FANCD2, and

58 fective fusion of Vam7-6A was due in part to inefficient association with its cognate SNAREs and HOPS

59 Epithelial cells are innately inefficient at clustering even in the presence of HSET/K

60 macrophage activation, rendering these cells inefficient at controlling infection.

61 However, in contrast to Pol IV, Pol II is inefficient at disrupting rolling-circle synthesis by th

62 Mn(2+) ions in IR-sensitive cells, which are inefficient at DSB repair, exist largely as low-symmetry

63 ion, whereas the Cx50P59A mutation was found inefficient at forming detectable plaques.

64 n summary, chronic inflammation is extremely inefficient at inducing PC in the presence of TP53.

65 more efficiently than G3*:C pair, but it is inefficient at nucleotide incorporation opposite dG-C8-I

66 In addition, Abeta43 fibrils are very inefficient at seeding Abeta42 amyloid formation, even t

67 trast, E46K alphaS fibrils are intrinsically inefficient at seeding alphaS inclusion pathology.

68 Our data show very inefficient attachment of VSV to the most resistant huma

69 to atheroprone low SS were characterized by inefficient autophagy as a result of mammalian target of

70 sue-specific stresses, such as DNA damage or inefficient autophagy.

71 Severe motoneuron death and inefficient axon regeneration often result in devastatin

72 nous, cloned-gene expression compensated for inefficient B protein binding, as did suppressing mutati

73 at this is because the virus is surprisingly inefficient, barely replicating well enough to spread to

74 This is inefficient because deviation in chemical shifts associa

75 able energy; however, hydrogen generation is inefficient because of the lack of robust catalysts that

76 , the overall remyelination capacity remains inefficient because precursor cells often fail to genera

77 rechargeable zinc-air batteries lies in the inefficient bifunctional electrocatalysts for the oxygen

78 crotubules from heterogeneous brain seeds is inefficient but can be fully rescued by incorporating as

79 ral) networks are relatively computationally-inefficient but large modular networks are slightly more

80 in planar films, where light out-coupling is inefficient, but observe values as high as 57% in films

81 beta-alanine supplementation protocol is so inefficient, by demonstrating that exogenous beta-alanin

82 mmature excitation-contraction coupling, and inefficient Ca-induced Ca release remain major limitatio

83 erations are limited by low photogeneration, inefficient carrier-separation, and low mobility.

84 These include inefficient cellular uptake and poor in vivo stability,

85 lyze because individual steps are fast, both inefficient chain processes and non-chain processes affo

86 This is likely a consequence of inefficient chaperoning and accumulation of alpha7 subun

87 d creatinine during sample preparation or by inefficient chemical separation of those compounds by so

88 Ras species, decreased random motility, and inefficient chemotaxis toward cAMP and folic acid gradie

89 The inefficient clearance of dying cells can lead to abnorma

90 This study reports that inefficient codon usage in a herpesviral gene is strikin

91 of-life recycling rates are low, a result of inefficient collection, separation, and processing.

92 or IL10 neutralization as monotherapies were inefficient, combination of these two led to improved su

93 ies with a detailed inventory of Diffuse and Inefficient Combustion Emissions in Africa (DICE-Africa)

94 lution in Africa is dominated by diffuse and inefficient combustion sources, as electricity access is

95 such error-prone/efficient and hyperaccurate/inefficient conformations during the splicing cycle to r

96 -drug conjugates (ADCs) rely on mutations or inefficient conjugation chemistries.

97 One factor may be inefficient conversion of gaseous CO2 to bicarbonate, th

98 tion of such systems is limited, however, by inefficient current generation.

99 Inefficient cytosolic delivery and vector toxicity contr

100 ia reduced proline hydroxylation and, hence, inefficient degradation by the proteasome.

101 Unc13A(null) mutants suffered from inefficient, delayed and EGTA-supersensitive release.

102 gy and hyperpermeability that together cause inefficient delivery of chemotherapeutic agents.

103 -nanogram quantities is impractical owing to inefficient delivery of DNA molecules into the confines

104 heir use in biomedicine has been hampered by inefficient delivery to nuclear and cytoplasmic targets.

105 elivery vector and DNA cargo, and subsequent inefficient delivery to target cells.

106 Nucleic acid therapeutics are limited by inefficient delivery to target tissues and cells and by

107 ings in phage-based delivery systems such as inefficient delivery, narrow host range, and potential t

108 sk due to the long incubation period of MAP, inefficient diagnostic tests, and delayed clinical signs

109 early development checkpoints culminating in inefficient differentiation of CD4(+)CD8(+) double posit

110 on of the subglacial drainage system from an inefficient distributed to efficient channelized configu

111 played weaker TCR signalling in DN cells, an inefficient DN-to-DP transition, and reduced contributio

112 veness of HR repair genes to irradiation and inefficient double-strand break repair correlated with s

113 litated by continuous sediment supply and an inefficient drainage system.

114 ons are colloidal instability, hemolysis and inefficient drug loading and release.

115 aired hepatocyte proliferation, expansion of inefficient ductular cells and high lipopolysaccharide (

116 ring a trait by random mutagenesis is highly inefficient due to gene redundancy.

117 nly treated using eye drops, which is highly inefficient due to rapid clearance (low residence time)

118 es, where intradermally administered BCG has inefficient effectiveness against pulmonary tuberculosis

119 understood, and energy loss may occur due to inefficient electron transfer (ET) processes.

120 duced complex I defects but also rescues the inefficient electron transfer between complex I and ubiq

121 ons cause mitochondrial defects that include inefficient electron transport between complex I and ubi

122 In traditional electrophysiology, spatially inefficient electronics and the need for tissue-to-elect

123 n phase-change memory involves fundamentally inefficient energy conversion events; and this translate

124 ticular, low stroke, limited cycle life, and inefficient energy conversion have combined with high co

125 for protein synthesis, enhanced proteolysis, inefficient energy generation and reduced cell growth.

126 phenotype incurred a significant cost due to inefficient energy production (i.e., aerobic glycolysis)

127 We hypothesized that inefficient Env binding to rhesus CD4 (rhCD4) limits vir

128 s, METTL16 occupancy on hp1 increases due to inefficient enzymatic turnover, which promotes MAT2A spl

129 ygenase (RubisCO) is a critical yet severely inefficient enzyme that catalyses the fixation of virtua

130 isolation, the phosphatase becomes a highly inefficient enzyme, which prevents the system from achie

131 terial carboxysome, enhances the activity of inefficient enzymes by selectively concentrating them wi

132 or a mutation in the SMCHD1 gene results in inefficient epigenetic repression of DUX4 in skeletal mu

133 we demonstrate that the previously reported inefficient ER trapping of Golgi enzymes in a rapamycin-

134 s still infeasible because current tools are inefficient, especially for non-dividing cells, which co

135 Acquired immunity to malaria is inefficient, even after repeated exposure to P. falcipar

136 or defects in Sde2 activation both result in inefficient excision of selected introns from a subset o

137 d lymphocytes to tumor sites, and the cells' inefficient expansion in the immunosuppressive tumor mic

138 Therefore, we hypothesize that the inefficient extension from 8-oxoG:dA serves as a newly d

139 Inefficient fatty acid oxidation in mitochondria and inc

140 BACKGROUND & AIMS: Inefficient fatty acid oxidation in mitochondria and inc

141 Theoretically, the inefficient filtering observed in low-capacity individua

142 f a constant absolute threshold, making them inefficient for data that exhibit scale variability.

143 are either not statistically rigorous or are inefficient for high-dimensional data that include tens

144 f domain predictions and are computationally inefficient for high-resolution Hi-C data.

145 ignificant manual intervention and is highly inefficient for high-throughput electronic structure scr

146 stical nature and can become computationally inefficient for large systems; analytical approaches use

147 However, this approach is challenging and inefficient for multigene expression due to increased la

148 man and NHP species makes human-based probes inefficient for the capture of genomic regions of NHP fo

149 midazolin-2-ylidene, the so-called SIMes, is inefficient for the same transformation.

150 functional, yet not necessarily specialized, inefficient form in genomes undergoing reduction.

151 Indeed, unlike the inefficient genotype 1b NS3, which has been well studied

152 match induces increased anaplerotic flux and inefficient glucose metabolism.

153 entially make direct flight toward that goal inefficient have been limited in spatiotemporal scales a

154 nd burnout among providers and contribute to inefficient health resource utilization.

155 velength of 4.5 micrometres, which indicates inefficient heat redistribution from the dayside to the

156 em15 are respiratory-defective because of an inefficient heme delivery to the mitochondria.

157 nd that downregulation of cyclin D1 leads to inefficient homologous-mediated DNA repair.

158 can be explained by slow viral expansion and inefficient immunologic control.

159 rdiac screening is likely to be particularly inefficient in adults at low risk for coronary heart dis

160 plasmid DNA transfections have so far proven inefficient in clinical trials.

161 interference, and non-interfering repair is inefficient in heterozygous regions.

162 nock-out or precise mutagenesis, but remains inefficient in hPSCs.

163 However, neuronal conversion is relatively inefficient in human cells compared to mouse cells.

164 al macrophages from Gal3-deficient mice were inefficient in killing engulfed H. pylori Furthermore, r

165 ed with highly asymmetric gene-flow that was inefficient in maintaining connectivity between populati

166 Knockout of IFN-gamma rendered TcREG inefficient in preventing actin ring formation in osteoc

167 averse of interstrand crosslinks and is also inefficient in promoting FANCD2 monoubiquitination, a ke

168 s, indicating that wild-type human PHFs were inefficient in seeding tau aggregates made of G272V/P301

169 lasmic accumulation of unspliced M1 mRNA was inefficient in the absence of NS1, both in the context o

170 A change in spin state is inefficient in the product region so that excited-state

171 sual detection limit of 6ng/mL with reagents inefficient in the traditional test strip (which is not

172 cinated with full-length SIV gag pDNA showed inefficient induction (58% response rate) of cellular re

173 n explanation holds that in these organisms, inefficient intercellular nutrient exchange compels the

174 with the missense substitutions ranged from inefficient internal scaffolding protein B binding to fa

175 cells harvested from naive mice resulted in inefficient invasion by the bacteria (<0.1% of the inocu

176 uses and poor "connectivity." One driver of inefficient land uses is construction decisions for high

177 red to produce these activated structures is inefficient, leading to poor step- and atom-economies.

178 er, their efficacy is potentially limited by inefficient linker cleavage, and lysosomal entrapment of

179 reviously, deriving such data depended on an inefficient manual trial-and-error approach to simulatio

180 defects, including impaired beta-oxidation, inefficient matrix protein import, and decreased growth.

181 ge local expert knowledge, it also may be an inefficient means of achieving large-scale objectives if

182 on and biological activity may be limited by inefficient membrane permeability and/or endosomal escap

183 Thus, a consequence of inefficient metabolism of this phytochemical may be comp

184 acetyl-CoA carboxylase pathway, and promoted inefficient metabolism, as shown by the increase in prot

185 However, a high monzodioritic proportion and inefficient metamorphism in the Breaksea Orthogneiss res

186 of simulations, but this remains a slow and inefficient method for all but simple problems, especial

187 Thus, the user defaults to using inefficient methods for transfer across the commercial i

188 iferation and differentiation, and, in fact, inefficient MHCII deletion on B cells led to strong sele

189 electivity (1 < kappaobs < kA/kB), caused by inefficient microscopic mixing of a reagent X with two c

190 In contrast, the inefficient (minutes to hours) PAE-based RCL cleavage, w

191 iaturized assays is often challenging due to inefficient mixing, aggregation, and the advanced instru

192 s have been developed for mRNA delivery, the inefficient mRNA expression inside cells remains a major

193 Mechanistically, the inefficient muscle cell fusion correlates well with the

194 in damage following injury or disease due to inefficient myelin debris clearance.

195 urrounding spinal motor axons, causing pain, inefficient nerve conduction, and the ectopic migration

196 ell-connected efficient and poorly connected inefficient network structures.

197 However, inefficient networks are superior when individuals follo

198 We show that efficient networks outperform inefficient networks when individuals rely on conformity

199 nnel, is associated with impaired cognition, inefficient neural processing and schizophrenia.

200 equired to initiate photorelease using these inefficient non-linear optical methods, limiting their i

201 These results suggest that,in vivo, an inefficient operation of the shuttle in the aralar hemiz

202 merous pharmaceutical residues are currently inefficient or expensive.

203 tochondrial processing protease and a second inefficient or regulated cleavage by mitochondrial inter

204 ivated sludge process, which suffers from an inefficient overall energy balance.

205 n is slowly reduced by H2S and catalyzes its inefficient oxidative conversion to thiosulfate.

206 Loss of these activities results in inefficient p53-dependent cell-cycle checkpoint and exit

207 ophenylenes when poor molecular cohesion and inefficient packing is required.

208 nd experimental measurement we find that the inefficient packing of the two-dimensional (2D) chains o

209 R directly promoted DNA damage accumulation, inefficient PAR removal, and persistent PARP-1 residency

210 (LRD) and a greater shoot biomass than the P-inefficient parent Tapidor under both treatments and gro

211 ucing these substrates remains laborious and inefficient, particularly when using the traditional thr

212 However, S. cerevisiae uses a chemically inefficient pathway for isoprenoid biosynthesis, resulti

213 M is limited by severe systemic toxicity and inefficient penetration of brain tumor tissue even when

214 ns to methodological challenges for studying inefficient phage-host interactions.

215 This could eliminate inefficient phosphor conversion and enable color-tunable

216 D-induced transposon up-regulation is due to inefficient piRNA biogenesis.

217 d stem cell transplantation and may underlie inefficient platelet production by megakaryocytes derive

218 Difficulties include inefficient polarization in water, relatively short-live

219 nucleic acids to selected tissues remains an inefficient process mired by low transfection efficacy,

220 Reprogramming is a slow and inefficient process, suggesting the presence of safeguar

221 Sexual transmission of HIV-1 is an inefficient process, with only one or few variants of th

222 They make metastasis a highly inefficient process.

223 Accumulation of oxidized DNA bases and their inefficient processing by base excision repair (BER) are

224 erials use for energy applications and their inefficient processing is the main motivation for explor

225 HCV activity, an observation attributable to inefficient prodrug metabolism which was found to be CYP

226 ted expression of mLTGF-beta and resulted in inefficient production of active TGF-beta.

227 In contrast, CPPase is an inefficient promiscuous enzyme, which synthesizes the "i

228 To circumvent the use of expensive and inefficient Pt catalysts, multicopper oxidases (MCOs) ha

229 ellular component that acts as alternate but inefficient receptor for HSV-1 on dermal fibroblasts.

230 rugs in particles increases uptake by cells, inefficient release of drugs from these particles into t

231 similar experiments highlighted a relatively inefficient religation activity of RepC.

232 Taken together, we argue that inefficient removal of the internalizing amnioserosa tis

233 here immune-driven demyelination occurs with inefficient remyelination, but therapies are limited, es

234 Inefficient repair of these ICL can lead to leukemia and

235 However, inefficient replication in several mucosa-derived cell l

236 lls and memory B cells (MBCs), is remarkably inefficient, requiring years of malaria exposure.

237 health system ("unnecessary, excessive, and inefficient resource utilization").

238 cisions are often based primarily on age, is inefficient, resulting in underuse of screening for some

239 system, but all available tools suffer from inefficient retrograde transport or limited clinical pot

240 Inefficient reverse transcription in these cells leads t

241 ytic step of splicing, whereas hyperaccurate/inefficient RH alleles exhibit synthetic sickness.

242 epsilon-mediated phosphorylation, leading to inefficient RIG-I and Toll-like receptor 3 (TLR3) respon

243 ss multiple individuals has been hampered by inefficient sample processing and technical batch effect

244 e inhibitor therapy creates a functional but inefficient secondary slippery site.

245 he time and expense of design efforts due to inefficient secondary structure choices.

246 psis pex6 and pex26 mutants by screening for inefficient seedling beta-oxidation phenotypes.

247 the correlations among SNPs and by adopting inefficient selection techniques.

248 Annual screening from age 50 to 74 years was inefficient (similar benefits, but more harms than other

249 nimal peak intensity threshold is biased and inefficient since lipid species and classes vary in thei

250 that elevated COUP-TFII activity resulted in inefficient skeletal muscle development.

251 Here, we first established an inefficient solution to a foraging task in five captive

252 or Psi44 relative to wild type, resulting in inefficient spliceosome assembly.

253 es assembled at the alternative exon lead to inefficient splicing and intron retention.

254 plicing and those that promote hyperaccurate/inefficient splicing.

255 Inefficient starch solubilization and the inability to s

256 ron process that constitutes the most energy-inefficient step in water electrolysis.

257 of material and sensitivity due to multiple inefficient steps, while simplifying the workflow to enh

258 Why is such an inefficient strategy among colonies maintained by natura

259 cterial spatial distribution, which leads to inefficient substrate transport.

260 plication in the humanized animals were very inefficient, suggesting either the lack of cellular gene

261 affinity TBP-DNA interaction is surprisingly inefficient, suggesting how other transcription factors

262 tion and cyclization of SFTI-1, however, was inefficient, suggesting that specific seed conditions or

263 ready restored but vesicular storage remains inefficient, suggesting that vesicular storage is a more

264 rning of syllable vocabulary, at the cost of inefficient syntax learning.

265 rogenase activity by SI-derived MLN DCs, and inefficient T cell localization to the SI.

266 ed ubiquitylation potential, suggesting that inefficient targeting by Ltn1 favors the Rqc2-mediated r

267 tion in Bacteria has been limited because of inefficient targeting or repair; and its application to

268 la residue caused phenotypes consistent with inefficient termination in human cells: impaired Xrn2 ch

269 a promising alternative approach to current inefficient therapies for heart failure (HF).

270 lls previously thought to be therapeutically inefficient to be considered for ATT.

271 In conclusion, NTCP appeared inefficient to mediate infection by serum-derived HBV.

272 icular variants and/or individuals extremely inefficient, to the point where compression is often rel

273 ts' has previously been accomplished through inefficient 'top-down' methods.

274 and leads to SMAD2 cytoplasmic retention and inefficient transcription of TGF-beta targets genes.

275 imply that this may occur because generally inefficient transcytosis across intact mucosal surfaces

276 has yet to materialise in large part due to inefficient transgene expression.

277 vaccines (RepRNA) are RNase-sensitivity and inefficient translation in dendritic cells (DCs).

278 osomes normally block Rho access to an mRNA, inefficient translation of an open reading frame in the

279 Inefficient translational processes for technology-orien

280 t because of prolonged incubation periods or inefficient transmission.

281 nels, but it is, unfortunately, an extremely inefficient transport mechanism for microscale particles

282 vity of nano zerovalent iron (nZVI) leads to inefficient treatment due to competition with various na

283 an interfere with mitophagy, suggesting that inefficient turnover of damaged mitochondria may represe

284 elf is nonselective and in some cases rather inefficient under cell-free conditions.

285 with the summary methods but they are due to inefficient use of information in the data by summary me

286 owth, is thought to grow slowly in vivo, the inefficient use of mucin glycoproteins may be relevant t

287 agnitude more features than analytes, and an inefficient use of resources during data analysis.

288 ng large safety factors in design and, thus, inefficient use of resources.

289 The inefficient vascularization of tumor tissue also limits

290 on during exercise, leading to excessive and inefficient ventilation.

291 nst the incomplete DNA products generated by inefficient viral reverse transcription in these cells.

292 ften exhibit crouch gait, a debilitating and inefficient walking pattern marked by excessive knee fle

293 use binary 'bind-elute' separations and are inefficient when applied to the isolation of multiple lo

294 CNV breakpoint junction, but this method is inefficient when challenged by structural complexity suc

295 and transmissibility in pig, but were still inefficient when compared to pH1N1.

296 rmanence of learning may be inappropriate or inefficient when facing environments that are liable to

297 rtly compensated by manual work that becomes inefficient when the solution space is large due to comb

298 ccur and (ii) the virus spread is apparently inefficient, which is consistent with the interpretation

299 filling mechanism that outweighs the cost of inefficient wiring.

300 ome editing using standard protocols remains inefficient, yielding desired targeted alleles at a rate