ライフサイエンスコーパス: infectious virus

1 ion, including reactivation to produce newly infectious virus.

2 VP40-driven virus-like particles (VLPs) and infectious virus.

3 has different antigenic properties than the infectious virus.

4 s postinfection (dpi), despite production of infectious virus.

5 d (ATM) protein produced wild-type levels of infectious virus.

6 dd4 facilitate efficient release of VLPs and infectious virus.

7 apsid, sometimes called a procapsid, and the infectious virus.

8 evel of KSHV reactivation and an increase in infectious virus.

9 lytic replication and the production of new infectious virus.

10 s required for KSHV to replicate and produce infectious virus.

11 ation pathway, resulting in the formation of infectious virus.

12 slational machinery to replicate and produce infectious virus.

13 ress immediate early lytic genes and produce infectious virus.

14 expanded and antigenically distinct from the infectious virus.

15 gut, and contained replication-competent and infectious virus.

16 s also replicated and produced low levels of infectious virus.

17 ets directly bind DENV saturably and produce infectious virus.

18 (CEs), have been implicated in production of infectious virus.

19 sue sites and also neutralized reservoirs of infectious virus.

20 kes and nucleocapsid is necessary to produce infectious virus.

21 logy, irregular HIV-1 core formation and non-infectious virus.

22 replication, which assists in production of infectious virus.

23 A hyperphosphorylation and the production of infectious virus.

24 novel accessory factor in the production of infectious virus.

25 is not sufficient to result in production of infectious virus.

26 ed to increased viral load and production of infectious virus.

27 transcription cascade and the production of infectious virus.

28 /-) mice, consistent with similar control of infectious virus.

29 ZV), and the cell culture medium contains no infectious virus.

30 viral Ag for >2 mo after the eradication of infectious virus.

31 on of viral lytic proteins and production of infectious virus.

32 an immunoglobulin gamma 2b that neutralizes infectious virus.

33 ral genome replication and the production of infectious virus.

34 transcripts were detected in the absence of infectious virus.

35 nd remained elevated long after clearance of infectious virus.

36 rion maturation but compromised the yield of infectious virus.

37 establish latency and reactivate to produce infectious virus.

38 ned independently in the wild to generate an infectious virus.

39 that this reduction diminishes the yield of infectious virus.

40 D8 T cell apoptosis, and impaired control of infectious virus.

41 ongly down-regulates levels of extracellular infectious virus.

42 clone, successfully allowing the recovery of infectious virus.

43 es viral gene expression and accumulation of infectious virus.

44 embly complex and thus for the production of infectious virus.

45 stabilization of HCV RNA, and production of infectious virus.

46 spontaneously in hepatoma cells and releases infectious virus.

47 ting in viral DNA replication and release of infectious virus.

48 lum to sites of viral replication to produce infectious virus.

49 ication, resulting in enhanced production of infectious virus.

50 of viral DNA that can be packaged to produce infectious virus.

51 biting a 4-log decrease in the production of infectious virus.

52 s temporal replication without production of infectious virus.

53 s, generating progeny cells that can release infectious virus.

54 ned in yeast into mammalian cells to produce infectious virus.

55 and targeted EDIII or quaternary epitopes on infectious virus.

56 piked with viral RNA, inactivated virus, and infectious virus.

57 ses, and cells from these clones can release infectious virus.

58 (VLPs) that accurately mimic the budding of infectious virus.

59 assembly, but principally the secretion, of infectious virus.

60 s-host interaction crucial for production of infectious virus.

61 imilar trend as plaque assay measurements of infectious viruses.

62 obtain the remaining fraction of individual infectious viruses.

63 uselloviruses, vp3, allows the production of infectious viruses.

64 he AAA ATPase p97/VCP in a similar manner to infectious viruses.

65 It was based on the recovery of infectious virus 28 days or more post infection and has

66 Infection is followed by clearance of infectious virus, a gradual decrease in viral RNA, and t

67 : rapid decline coincident with clearance of infectious virus, a rebound phase with increases up to 1

68 but <1% of proviruses are induced to release infectious virus after maximum in vitro activation.

69 n the context of both the JFH-1 cell culture infectious virus and a corresponding subgenomic replicon

70 nt for viral DNA synthesis and production of infectious virus and indicate a functional role for this

71 y of UL12 is essential for the production of infectious virus and may be considered a target for deve

72 action that is crucial for the production of infectious virus and reveal that HPV infection remodels

73 itors were rapidly depleted of intracellular infectious virus and RNA-containing hepatitis C virus pa

74 mph nodes four to five times longer than the infectious virus and that the clearance of MeV RNA from

75 VZV is a highly infectious virus and the causative agent of chickenpox a

76 h is required for the secretion of cell-free infectious virus and thus has been identified as an anti

77 e colonies, quickly become infected, produce infectious virus and undergo lysis within 48 h after exp

78 Indeed, differentiation requires infectious virus and viral protein synthesis.

79 Detection of infectious viruses and disease biomarkers is of utmost i

80 iruses (E-, X-, and P-MLVs) exist in mice as infectious viruses and endogenous retroviruses (ERVs) in

81 ilitate the development of sensors to detect infectious viruses and novel disinfection strategies to

82 unction as an adaptive immune system against infectious viruses and plasmids.

83 mune system that defends prokaryotes against infectious viruses and plasmids.

84 is classified as a select agent, an emerging infectious virus, and an agricultural pathogen.

85 mmunogenic, vulnerable to antibody attack on infectious virus, and could be involved in the ontogeny

86 question has been how a cell can assemble an infectious virus, and dismantle a virus entering an unin

87 Pol eta resulted in decreased production of infectious virus, and further, Pol eta was found to bind

88 teinases, is essential for the production of infectious virus, and here we report its structure at 0.

89 Analyses were conducted with replicons, infectious virus, and human hepatoma cells that express

90 cing levels of Rad18 decreased production of infectious virus, and infectious titers of BPLF1 knockou

91 scriptase-quantitative PCR, no production of infectious virus, and maintenance of the viral DNA genom

92 gree to which clonally expanded cells harbor infectious viruses, and thus the extent to which they co

93 lication, when only low numbers of cells and infectious virus are involved.

94 protein interactions that govern budding of infectious virus are not known.

95 ous human immunodeficiency virus, but highly infectious viruses are able to establish infection regar

96 ocesses that govern epitope accessibility on infectious viruses are reversible.

97 rescence microscopy experiments performed on infectious virus as well as in a virus-like particle (VL

98 eplication with the production of high-titer infectious virus as well as Japanese fulminant hepatitis

99 source of replication-competent HIV-1 and of infectious virus, as compared to any other (CXCR5(-)PD-1

100 s in the increased production and release of infectious virus, as well as increased susceptibility to

101 dramatic reduction in the amount of progeny infectious viruses, as also described in the accompanyin

102 roteins with both overexpressed proteins and infectious virus but also provides novel data that can b

103 t induce antibodies that bind to and capture infectious virus but do not inhibit virus infectivity wi

104 -induced antibody that binds to and captures infectious virus but does not inhibit its infectivity ma

105 5RO(+) CD4(+) T cells were main producers of infectious virus but largely refractory to TCR-CD3 downm

106 in the process of assembly and production of infectious virus, but the molecular mechanism of RSV ass

107 w preneutralized HIV-1 can be transferred as infectious virus by DCs, we followed the processing of 2

108 these bunyavirid-like sequences belong to an infectious virus by passaging KIGV in mosquito cell cult

109 e infected intravenously with HAdV-C6, live, infectious virus can be isolated from the lung and the k

110 HSPG-nonbinding strain Griggs and recovered infectious virus capable of binding to immobilized hepar

111 extracellular virions, and the production of infectious virus capable of infecting naive fibroblasts.

112 144 vaccinees synergized for neutralization, infectious virus capture, and ADCC.

113 Infectious virus cores can move from one cell to another

114 Infectious virus cores can move from one cell to another

115 re is due to a drug effect of generating non-infectious virus could be a basis for future response gu

116 ble IE expression by immunofluorescence, and infectious virus could be produced upon differentiation

117 In the presence of T-705, titers of infectious virus decreased significantly (P < 0.0001) du

118 We show that infectious virus detection by direct homogenization of e

119 y reduced in the CNS, resulting in increased infectious virus during persistence.

120 es virus (MeV) involves rapid elimination of infectious virus during the rash followed by slow elimin

121 o the assembly complex and for production of infectious virus during VZV pathogenesis in skin.

122 fected Kasumi-3 cells initiate production of infectious virus following TPA treatment, which requires

123 an Escherichia coli host, and reconstituted infectious virus following transfection into mammalian c

124 lion, could be stress reactivated to produce infectious virus, following explant cocultivation and th

125 Postmortem examination identified infectious virus for up to 185 dpi and viral genomes for

126 hood method to estimate the fraction of true infectious viruses for a given host in viral tagging exp

127 ive Bayes for separating infectious from non-infectious viruses for nine bacterial host genera with a

128 A19 synthesis and infectious virus formation were dependent on inducer.

129 NL10" and "HL18NL11." All efforts to isolate infectious virus from bats or to generate these viruses

130 reater cell death and the reduced release of infectious virus from infected pig epithelial cells.

131 hese same inhibitors block the production of infectious virus from lytically infected cells, each at

132 coinfected, which indicates that exposure to infectious virus from multiple sources is common during

133 employed to assess the early reactivation of infectious virus from reservoirs in HIV-1-infected indiv

134 unique tool to assess early reactivation of infectious virus from reservoirs in HIV-infected individ

135 envelopment in the cytoplasm and release of infectious virus from the cell) are severely restricted

136 is in adult C57BL/6 mice during clearance of infectious virus from the CNS, and the virus-specific im

137 ion following inoculation with no detectable infectious virus from the sensory neurons.

138 5) LD50 of MERS-CoV, we were able to recover infectious virus from these mice only infrequently, alth

139 e hepatitis C virus genotype 1a cell culture-infectious virus H77S.3.

140 fect monocytes and reprogram them to deliver infectious virus, HCMV must overcome biological obstacle

141 HCV pseudoparticle (HCVpp) and cell culture-infectious virus (HCVcc) infection albeit with different

142 important for the production of cell culture-infectious virus (HCVcc).

143 To generate infectious viruses, HIV-1 must package viral RNA genome

144 y, suggesting they promote the production of infectious virus in a small subset of latently infected

145 ons with Ab to NGF resulted in production of infectious virus in about 25% of the latently infected c

146 against apoptosis and allows high yields of infectious virus in BHK-21 cells.

147 ations caused defects in the accumulation of infectious virus in both the cellular and supernatant fr

148 ability to interfere with the replication of infectious virus in cell culture and their potential as

149 205432 retains similar potency against fully infectious virus in cultured human neuronal cells.

150 While unable to produce infectious virus in DCs, this mutant virus expresses ear

151 sal virus challenge can involve clearance of infectious virus in distal tissues.

152 tive, large-scale screening and titration of infectious virus in experimental and clinical samples, i

153 ower or in some cases undetectable levels of infectious virus in faeces and tissues.

154 This lethality results from a pool of infectious virus in glial cells and is regulated by the

155 h viral protein expression, but detection of infectious virus in medium samples from explanted cultur

156 dy, which demonstrated a slower loss rate of infectious virus in relapsers than in participants who a

157 Thus, methods for rapid detection of this infectious virus in the environment are urgently needed

158 ng lpr and gld mutations, the persistence of infectious virus in the trigeminal ganglia was the same

159 ing the full lytic cascade and production of infectious virus in vivo.

160 ion technologies and novel sensors to detect infectious viruses in drinking water.

161 out this mutation, and the same was true for infectious virus, including in competition assays.

162 Antibody capacity to recognize infectious virus is a prerequisite of many antiviral fun

163 n events occur in women when semen harboring infectious virus is deposited onto the mucosal barriers

164 romoter behaves similarly, and production of infectious virus is enhanced by the presence of vIRF4.

165 urons, viral gene expression is minimal, and infectious virus is not released.

166 a major site of the virus lytic cycle, where infectious virus is propagated and transmitted via saliv

167 h is required for the secretion of cell-free infectious virus, is not required for cell-to-cell sprea

168 Infectious virus levels, however, were different: in rib

169 Self-propagating, infectious, virus-like vesicles (VLVs) are generated whe

170 U/cell) have been reached, with loss of most infectious virus (<5 PFU/cell) by 20 to 24 h p.i.

171 stablishment of subgenomic replicons and the infectious virus model (HCVcc).

172 d entry of 68.5% of total virus and 56.6% of infectious virus (n = 2).

173 or blocked 64.5% of total virus and 66.5% of infectious virus (n = 3).

174 or blocked 99.8% of total virus and 99.6% of infectious virus (n = 3).

175 d entry of 94.5% of total virus and 94.8% of infectious virus (n = 3).

176 regulates its genome packaging and generate infectious viruses necessary for transmission to new hos

177 wed a significant reduction in the amount of infectious virus on day 2 but not on day 4 postinfection

178 ifferent conformations in the context of the infectious virus particle.

179 associated manner in vitro and in vivo, with infectious virus particles being released only from feat

180 To this end, individual, infectious virus particles bound by fluorescently labele

181 even mutations that prevented generation of infectious virus particles did not abolish acylation of

182 ture system (HCVcc), it is known that highly infectious virus particles have low to very low buoyant

183 hances intracellular HCV RNA and accumulates infectious virus particles in cells.

184 transmission is dependent on the release of infectious virus particles into the virological synapse.

185 produce, for the first time in any metazoan, infectious virus particles through self-assembly from tr

186 plets but appeared to decrease production of infectious virus particles, suggesting a block in virion

187 events are mediated by exosomes rather than infectious virus particles.

188 xhibited postponed and reduced production of infectious virus particles.

189 n approximately 1 to 2% of BM cells produced infectious virus particles.

190 , although this often remains incomplete for infectious virus particles.

191 h in turn has an effect on the production of infectious virus particles.

192 han E(2), with a lower detection limit of 10 infectious virus particles.

193 viral and host factors to optimally produce infectious virus particles.

194 shedding patterns and measure the amount of infectious virus present in exhaled respirable aerosols.

195 he lack of an understanding of the levels of infectious virus present in respirable aerosols exhaled

196 owever, qRT-PCR does not confirm presence of infectious virus, presenting limitations in patient and

197 reactivation and the corresponding amount of infectious virus produced in the ganglia per reactivatio

198 specific infectivity of the virus (amount of infectious virus produced per vRNA copy).

199 ion at residue 76 (Y76A), were essential for infectious virus production and filament formation while

200 A virus M2 protein that drastically reduces infectious virus production and filament formation with

201 order to map the determinants necessary for infectious virus production and gain further insight int

202 ion of miR-H2 but showed wild-type levels of infectious virus production and no increase in ICP0 expr

203 the M-null virus and assessing the impact on infectious virus production and viral protein traffickin

204 EWSR1 expression impairs HCV replication and infectious virus production but not translation.

205 p caused an approximately 1-log reduction in infectious virus production compared to that of the wild

206 its binding partner, ORF38, are required for infectious virus production due to their important role

207 These M1 suppressor mutations restored infectious virus production in the presence of M2Y76A an

208 y different from wild-type virus in terms of infectious virus production in the trigeminal ganglia du

209 required for intracellular and extracellular infectious virus production late in the infection, sugge

210 M2 and MCM could at least partially restore infectious virus production to M2-deficient influenza A

211 sed a gain-of-function phenotype, increasing infectious virus production up to 1 log more than in the

212 Finally, the contribution of Rad18 levels to infectious virus production was examined with small inte

213 istant PABP variant, viral RNA synthesis and infectious virus production were both reduced.

214 ects in cytoplasmic envelopment, egress, and infectious virus production, followed by the double dele

215 erstand the role of this cytoplasmic tail in infectious virus production, we used reverse genetics to

216 s glutamine led to a substantial decrease in infectious virus production, whereas starving infected c

217 ll plaque formation and drastic reduction in infectious virus production, while mutation of C82 and C

218 , which is essential for EBV replication and infectious virus production.

219 is a key step in the process of assembly and infectious virus production.

220 ry syncytial virus, Nipah virus) to suppress infectious virus production.

221 using small molecule inhibitors also reduces infectious virus production.

222 lation of cytoplasmic virion envelopment and infectious virus production.

223 site (Thr205) in M that is critical for RSV infectious virus production.

224 polyprotein synthesis, virion assembly, and infectious virus production.

225 hyperphosphorylation-dependent regulation of infectious virus production.

226 se involved in NS5A hyperphosphorylation and infectious virus production.

227 Ebola, exploit AAK1 and GAK during entry and infectious virus production.

228 lation of cytoplasmic virion envelopment and infectious virus production.

229 acilitate formation of the VAC for efficient infectious virus production.

230 opology and efficient virion envelopment and infectious virus production.

231 ally examine the role of the F protein CT in infectious virus production.

232 ut two blocks had various levels of impaired infectious virus production.

233 ugmentation of IRES-mediated translation and infectious virus production.

234 cytoplasmic domains play important roles in infectious virus production.

235 te gene expression, viral DNA packaging, and infectious virus production.

236 us genetic information in the absence of any infectious virus production.

237 t the EBV SM protein, which is essential for infectious virus production.

238 acilitate cytoplasmic virion envelopment and infectious virus production.

239 required by the nonpermissive cell to ensure infectious virus production.

240 ir ability to inhibit virion envelopment and infectious virus production.

241 in and that treatment with XX-650-23 reduced infectious-virus production and limited lesion formation

242 n expression levels and ultimately promoting infectious-virus production.

243 Furthermore, it reduced infectious virus release by 80-90% without affecting vir

244 alphaviruses has strong negative effects on infectious virus release.

245 Attempts to isolate infectious virus rely on in vivo or basic cell culture a

246 However, the efficiency of infectious virus replication was still dependent on the

247 a molecular mechanistic understanding of how infectious viruses reproduce in their living host cells.

248 ontaining inducible replication-competent or infectious virus, respectively.

249 inate expression of disease-causing genes or infectious viruses, resulting in the preclinical and cli

250 s isolation study has been done to elucidate infectious virus secretion or serotype variability.

251 on of neutralization of more than 50% of the infectious virus seed dose on plaque-reduction neutraliz

252 least two virus variants in the RhCMV 180.92 infectious virus stock.

253 ed-flow kinetics, quench-flow reactions, and infectious virus studies were used to characterize 15 en

254 By studying the entry properties of infectious virus subpopulations differing in their buoya

255 t only VPA induced significant production of infectious virus, suggesting that HDAC regulation after

256 39, U90, and U100, without the production of infectious virus, suggesting that the tested stimuli wer

257 g genotype 2a JFH-1 subgenomic replicons and infectious virus systems.

258 5-fold more viral DNA, and 7- to 9-fold more infectious virus than did 293 cell lines latently infect

259 C2A mRNA produced approximately 10-fold less infectious virus than the controls.

260 The highly expanded clone produced infectious virus that was detected as persistent plasma

261 l lung was assessed by the quantification of infectious virus titers and HCMV genome copies and the d

262 Infectious virus titers were present in the blood and mo

263 TIAR downregulation decreases extracellular infectious virus titers with little effect on intracellu

264 These mutations increased infectious virus titers, demonstrated a strong positive

265 utated, yielded at least a 1 log decrease in infectious virus titers.

266 by catalyzing the transition from the mature infectious virus to the A-particle uncoating intermediat

267 Dormant HIV genomes readily produce infectious virus upon cellular activation because host t

268 HIV genomes, which are capable of producing infectious virus upon T cell activation.

269 man SOCS3 enhances budding of Ebola VLPs and infectious virus via a mechanism linked to the host ubiq

270 Quantitation of infectious virus, via the fluorescent forming unit assay

271 l-dependent, antibody-independent control of infectious virus was associated with a similar recruitme

272 Infectious virus was detected in 15 of 26 (58%) specimen

273 In wild-type mice, infectious virus was detected in the femur, tibia, patel

274 ly initiated infection; however, no released infectious virus was detected.

275 Infectious virus was isolated from the urine of a patien

276 In contrast, infectious virus was no longer detectable by days 30 to

277 le threshold value 23.7) than plasma (31.3); infectious virus was only recovered from CSF.

278 R amplification were severely reduced and no infectious virus was recovered after RNA transfection in

279 Recombinant infectious virus was recovered for all mutants, and tran

280 Infectious virus was recovered from each library and was

281 l and intraperitoneal mouse models, and less infectious virus was recovered from organs.

282 After intranasal inoculation, infectious virus was recovered only from nasal epitheliu

283 of ZIKV in a novel linear vector from which infectious virus was recovered.

284 The yield of infectious virus was reduced 4- to 5-fold by repression,

285 o-plasmid infectious clone system from which infectious virus was rescued that replicates in human an

286 S5A- or protease-inhibitors can generate non-infectious virus, we incorporated this effect into a mat

287 nine bacterial host genera with at least 45 infectious viruses, we show that random forest together

288 High titers of infectious virus were detected in nasal turbinates and n

289 The HTNV genomic RNA (vRNA) copy number and infectious virus were measured in lungs of untreated and

290 The virus genome and infectious virus were observed soon after immunization,

291 e NS6-7 junction, leads to the production of infectious virus when the MNV NS6 protease, but not the

292 es substantially decreases the production of infectious virus, which can be rescued through medium su

293 anced late gene expression and production of infectious virus, while ectopic Pin1 showed inhibitory e

294 greater number of aerosol particles and more infectious virus within respirable aerosols than ferrets

295 We demonstrate that ISG15 suppressed infectious virus yield in human cardiac myocytes and the

296 to the suppression of viral replication and infectious virus yield in the heart; in the absence of s

297 re, specific virus infectivity (the ratio of infectious virus yield to viral RNA copy number) was red

298 cholesterol and concomitantly increased the infectious virus yield.

299 de resistance, RNA replication capacity, and infectious virus yields in a cell culture model of infec

300 antly impaired viral replication and reduced infectious virus yields without substantially affecting