ライフサイエンスコーパス: infective

1 ting potential additional utility as an anti-infective.

2 e virion with just a single free gD is still infective.

3 NOS interaction have potential as novel anti-infectives.

4 ment of this group of inhibitors as new anti-infectives.

5 ugs, and autonomic drugs, compared with anti-infectives.

6 ioactive compounds for novel B. abortus anti-infectives.

7 immunity thereby negating their use as anti-infectives, abrogation of alkaline signalling has, there

8 Despite their potential anti-infective action, in vitro studies indicate that several

9 as thiazolides (TZD) endowed with broad anti-infective activities.

10 s study provides an explanation for the anti-infective activity of peppertree remedies and yields ins

11 t sepsis intervention, the mean time to anti-infective administration following fulfillment of system

12 founding factors, and infrequently caused by infective aetiology (112/1207 (9.2%)) such as Clostridiu

13 are unit patients, and its relationship with infective aetiology and clinical outcomes.

14 ffector gene avrPphB from its chromosome are infective against previously resistant plant hosts.

15 lection of a bifunctional peptide-based anti-infective agent and its delivery via biodegradable nanop

16 ociated with periodontal disease, whose main infective agent is Porphyromonas gingivalis.

17 ac7, and confirming its potential as an anti-infective agent, also suggesting it may be a vehicle for

18 merging strategy for the development of anti-infective agents against this bacterium.

19 ould be valuable for the development of anti-infective agents against this important pathogen.

20 ive drug targets for the development of anti-infective agents and herbicides.

21 hermore, evidence is growing to suggest that infective agents can cause the release of extracellular

22 exemplifies potentially a new class of anti-infective agents that acts on the host innate response,

23 nd, with further development, potential anti-infective agents.

24 ant leads for the development of potent anti-infective agents.

25 e, hastening the need for selective new anti-infective agents.

26 of medicine's most important classes of anti-infective agents; yet in contrast to many other classes

27 te A/Guangzhou/39715/2014 (H5N6), were fully infective and highly transmissible by direct contact in

28 VHD is expanding rapidly and parallels other infective and inflammatory conditions in which a predomi

29 Immune, infective and ischaemic mechanisms are all potential con

30 in terms of lower respiratory consultations (infective and non-infective), lower respiratory consulta

31 ere used for functional analysis of nematode infective and reproductive parameters.

32 s key questions that concern the use of anti-infectives and both microbe- and host-based immunomodula

33 itiated to investigate the potential of anti-infectives and immunomodulators in asthma.

34 ith applications for the development of anti-infectives and the prevention of biocontrol emasculation

35 and Enterococcus faecalis (Ef) by using anti-infective, antivirulence, and antibiotic assays.

36 ecific microorganisms for diagnostic or anti-infective applications, but that can be formed from simp

37 i-QS signal synthesis as basis of novel anti-infective approach.

38 up to 89% reduction of Lp growth in an anti-infective assay at 30 muM.

39 et in contrast to many other classes of anti-infectives, astonishingly few details concerning the ori

40 quantified human exposure to both bites and infective bites of a major malaria vector in Papua New G

41 the initial site of viral infection after an infective blood meal.

42 Depletion of LC8 from mammalian-infective bloodstream trypanosomes affected cell cycle p

43 ger function and susceptibility to recurrent infective bronchitis that may, in turn, contribute to fu

44 ed polymer (LMIP) designed to act as an anti-infective by blocking the quorum sensing (QS) mechanism

45 which had greatly increased replication and infective capacities.

46 In the absence of an infective cause, the concurrent association of prolonged

47 Our findings suggest non-infective causes of diarrhoea in ICU predominate and pat

48 ene copies represented viable and presumably infective cells, a quantitative microbial risk assessmen

49 e highest expression was detected during the infective cercaria stage.

50 tosomes transform rapidly from free-swimming infective cercariae in freshwater to endoparasitic schis

51 ltimately improve outcomes for patients with infective CF lung disease.

52 , known to have increased airway ATP levels, infective challenge causes exacerbated inflammation.

53 Additionally, anti-infective chemotherapies may be successfully achieved by

54 cus (likely not related) versus transplanted infective colitis with colonic perforation and Bell Pals

55 -cytarabine plus rituximab and thiotepa, but infective complications were similar in the three groups

56 c hospital, we retrospectively assessed anti-infective cost using pharmacy purchasing data, patient-l

57 iety of America (IDSA) recommended that anti-infective costs be measured by patient-level administrat

58 y available and standardized measure of anti-infective costs over time.

59 ph shown to have a spermatial rather than an infective-dispersal function.

60 different subtypes with a geometric mean 50% infective dose (ID50) between 100 and 800.

61 om 4 x 10(7) to 4 x 10(2) 50% tissue culture infective dose (TCID50)/ml, as well as the no-virus nega

62 f bacteria necessary to colonize a host (50% infective dose [ID50]) was 5-fold higher for the arnT mu

63 g virus was revealed by a 50% tissue culture infective dose assay after the combined treatment under

64 oncentration of 1 x 10(8) 50% tissue culture infective dose per milliliter [TCID50 . ml(-1)]) and mur

65 MVA-BN-Filo (1 x 10(8) median tissue culture infective dose) and boosted with the alternative vaccine

66 mined to be 0.015 50% TCID50 (tissue culture infective dose) of MARV/Ang-MA in SCID mice, and i.p. in

67 ral shedding, based on median tissue culture infective dose, were observed in patients who received p

68 nging from 10(7) to 10(9) 50% tissue culture infective doses (TCID50) consistently infected all the a

69 se (LD50) of 5.3 x 10(-2) 50% tissue culture infective doses (TCID50), was developed.

70 og units and 1.3 x 10(-3) 50% tissue culture infective doses (TCID50)/ml of cultured MERS-CoV per rea

71 om 6 x 10(2) to 2 x 10(5) 50% tissue culture infective doses (TCID50)/ml.

72 asally at a dose of 10(6) 50% tissue culture infective doses in a range of inoculum volumes (0.2, 0.5

73 y ducks, and Embden geese with 10(6) 50% egg infective doses of the A/Anhui/1/2013 virus resulted in

74 ly 10(6) genome copies or 50% tissue culture infective doses/ml).

75 ia, especially in antiproliferative and anti-infective drug classes.

76 spG and IspH, and open up new routes to anti-infective drug design targeting [Fe4 S4 ] clusters in pr

77 tRNA synthetases have been the focus of anti-infective drug development efforts and two aaRS inhibito

78 zyme is an important anti-virulence and anti-infective drug target for resistant strains of Gram-posi

79 isoprenoid biosynthesis are attractive anti-infective drug targets.

80 her investigations in the quest for new anti-infective drugs.

81 n of EBOV and evidence of the persistence of infective EBOV in semen for 179 days or more after the o

82 cattle, bovine milk might exert similar anti-infective effects in human infants.

83 (3.49/1000 patient-years), and 20 (0.7%) had infective endocarditis (3.65/1000 patient-years).

84 by doxorubicin plus cyclophosphamide group), infective endocarditis (docetaxel plus bevacizumab follo

85 atus, and dental procedures in patients with infective endocarditis (IE) according to whether the IE-

86 characteristics, management, and outcomes of infective endocarditis (IE) after transcatheter aortic v

87 to identify patients with increased risk of infective endocarditis (IE) among patients with Enteroco

88 Use of surgery for the treatment of infective endocarditis (IE) as related to surgical indic

89 ography plays a key role in the diagnosis of infective endocarditis (IE) but can be inconclusive in p

90 of Cardiology and American Heart Association infective endocarditis (IE) guideline update, antibiotic

91 population-based epidemiological changes in infective endocarditis (IE) in Europe.

92 The diagnosis of infective endocarditis (IE) in prosthetic valves and int

93 Infective endocarditis (IE) is a rare disease with poor

94 Infective endocarditis (IE) is a serious complication of

95 Early diagnosis of infective endocarditis (IE) is based on the yielding of

96 or and treating the portal of entry (POE) of infective endocarditis (IE) is important, but published

97 Infective endocarditis (IE) mostly occurs after spontane

98 ct of vancomycin MIC on left-sided S. aureus infective endocarditis (IE) treated with cloxacillin.

99 biotic prophylaxis (AP) for those at risk of infective endocarditis (IE) undergoing dental procedures

100 g, and the number of episodes complicated by infective endocarditis (IE) varies.

101 c valve abnormalities have increased risk of infective endocarditis (IE), it is unknown whether these

102 ment in surgical mortality for patients with infective endocarditis (IE), presumably because of impro

103 Substantial infective endocarditis (IE)-related morbidity and mortal

104 tal plaque and important agents of bacterial infective endocarditis (IE).

105 taphylococcus aureus left-sided native valve infective endocarditis (LNVIE) has higher complication a

106 Staphylococcus aureus (SA) prosthetic valve infective endocarditis (PVIE) is unresolved.

107 nal Registry included patients with definite infective endocarditis after TAVR from 47 centers from E

108 ssociated with higher risk of progressing to infective endocarditis after TAVR was younger age (78.9

109 acteristics and outcomes of patients who had infective endocarditis after undergoing transcatheter ao

110 ycin and imipenem as rescue therapy for MRSA infective endocarditis and complicated bacteremia.

111 anguinis class Ib RNR in an animal model for infective endocarditis and establishing whether the mang

112 Streptococcus sanguinis is a cause of infective endocarditis and has been shown to require a m

113 Infective endocarditis and in-hospital mortality after i

114 er aortic valve replacement for incidence of infective endocarditis and infective endocarditis for in

115 sent article reviews the challenges posed by infective endocarditis and outlines current and future s

116 ificant for both individuals at high risk of infective endocarditis and those at lower risk.

117 The challenges posed by infective endocarditis are significant.

118 We compared the incidence of infective endocarditis before and after the introduction

119 (95% CI, 10.4%-19.2%) of patients during the infective endocarditis episode.

120 antibiotic prophylaxis for the prevention of infective endocarditis fell substantially after introduc

121 for incidence of infective endocarditis and infective endocarditis for in-hospital mortality.

122 ics for patients with a primary diagnosis of infective endocarditis from Jan 1, 2000, to March 31, 20

123 The epidemiology of infective endocarditis has become more complex with toda

124 procedures in patients at risk of developing infective endocarditis has historically been the focus o

125 ve fallen substantially and the incidence of infective endocarditis has increased significantly in En

126 Prophylaxis and treatment guidelines for infective endocarditis have changed substantially over t

127 eases of the skeletal system in children and infective endocarditis in children and adults.

128 is versus no prophylaxis on the incidence of infective endocarditis in England.

129 of antibiotic prophylaxis for prevention of infective endocarditis in March, 2008.

130 cus is an increasing cause of bacteremia and infective endocarditis in the elderly.

131 fy trends in the incidence and etiologies of infective endocarditis in the United States.

132 rting in March, 2008, the number of cases of infective endocarditis increased significantly above the

133 Infective endocarditis is a complex disease, and patient

134 Infective endocarditis is a potentially lethal disease t

135 mon cause of nosocomial infections, of which infective endocarditis is associated with substantial mo

136 important interaction in the pathogenesis of infective endocarditis is attachment of the organisms to

137 Infective endocarditis is defined by a focus of infectio

138 Infective endocarditis is life-threatening; identificati

139 n of empA also resulted in attenuation in an infective endocarditis model (P = 0.0088).

140 th their respective parental strains, in the infective endocarditis model.

141 athogenesis of Enterococcus faecium in a rat infective endocarditis model.

142 ry genes in vivo was carried out using a rat infective endocarditis model.

143 A total of 250 cases of infective endocarditis occurred in 20006 patients after

144 Infective endocarditis occurs worldwide, and is defined

145 No infective endocarditis or aortic dissection was found.

146 ocarditis has historically been the focus of infective endocarditis prevention.

147 antibiotic prophylaxis and the incidence of infective endocarditis since the introduction of these g

148 comes in patients with Enterococcus faecalis infective endocarditis treated in the years before and a

149 Median time from TAVR to infective endocarditis was 5.3 months (interquartile ran

150 Health care-associated infective endocarditis was present in 52.8% (95% CI, 46.

151 This increase in the incidence of infective endocarditis was significant for both individu

152 State, the overall standardized incidence of infective endocarditis was stable from 1998 through 2013

153 Streptococcus sanguinisis a leading cause of infective endocarditis, a life-threatening infection of

154 ponses to vancomycin therapy in experimental infective endocarditis, a prototypical biofilm model.

155 ensis, an opportunistic pathogen that causes infective endocarditis, encodes an Isd system.

156 The clinical variability and complexity in infective endocarditis, however, dictate that these reco

157 development of large caseous lesions, and in infective endocarditis, increases the size of pathognomo

158 nagement-based approach for the treatment of infective endocarditis, leading to a strong reduction of

159 ults in serious secondary infections such as infective endocarditis, osteomyelitis, and septic arthri

160 n vivo during infections in rabbit models of infective endocarditis, sepsis, and pneumonia.

161 auses life-threatening infections, including infective endocarditis, sepsis, and pneumonia.

162 icantly associated with an increased risk of infective endocarditis.

163 ary tract infections (UTIs), bacteremia, and infective endocarditis.

164 with Streptococcus mutans and virulence for infective endocarditis.

165 sociated permease A [BepA]), as important in infective endocarditis.

166 attack, recurrent acute rheumatic fever, and infective endocarditis.

167 of the many bacterial species implicated in infective endocarditis.

168 h to advance the understanding of left-sided infective endocarditis.

169 ith C. burnetii can cause a life-threatening infective endocarditis.

170 foci of infection, and no clinical signs of infective endocarditis.

171 colonizes teeth and is an important cause of infective endocarditis.

172 r ~5.7 x enhancement in imaging of S. aureus infective endocarditis.

173 eptococcus sanguinis is a causative agent of infective endocarditis.

174 iction of the embolism risk in patients with infective endocarditis.

175 tor of embolic events (EEs) in patients with infective endocarditis.

176 igens enhanced disease severity as tested by infective endocarditis.

177 ignificant negative impact on the outcome of infective endocarditis.

178 Infective endocarditis.

179 re complications of Streptococcus agalactiae infective endocarditis.

180 coccus oralis is a leading cause of subacute infective endocarditis.

181 endocarditis and in-hospital mortality after infective endocarditis.

182 lorhexidine 0.05% or 0.1% for prophylaxis of infective endophthalmitis was undertaken.

183 ion in vivo in health and in vitro in milder infective events, but not in severe sepsis, supporting t

184 tic fibrosis bronchiectasis and at least two infective exacerbations in the preceding year.

185 rease-related mortality eliminates 30-40% of infective flea vectors, ureD mutation early in the evolu

186 caused that strain to be 40- to 80-fold more infective for amoebae, unequivocally demonstrating that

187 nd safety of nitazoxanide, a thiazolide anti-infective, for treatment of acute uncomplicated influenz

188 sodA cultures were strongly depleted in this infective form and more susceptible to reactive oxygen s

189 al for the viability of both replicative and infective forms of T. cruzi.

190 ontaining the MASP SP in EVs secreted by the infective forms of the parasite.

191 chanisms required for the differentiation of infective forms.

192 as restored in Pla2g1b(-/-) mice by treating infective H. polygyrus L3 larvae with PLA2g1B, which red

193 stant infections, and several MNP-based anti-infectives have already entered phase 1, 2, and 3 clinic

194 eatures that indicate their role in the anti-infective host defense.

195 early life antibiotic prescription with anti-infective immunity and genetic variants on asthma suscep

196 ment C3, influences blood clearance and anti-infective immunity.

197 ific translational development of novel anti-infectives, immunomodulators, and vaccines.

198 All parasites were infective in vivo However, infectivity of NF54 was drama

199 rgy & Clinical Immunology Task Force on Anti-infectives in Asthma was initiated to investigate the po

200 Anti-infectives, including antibiotics, are essentially diffe

201 pathogenesis of a range of both sterile and infective inflammatory conditions.

202 licylic acid (PAS) was one of the first anti-infectives introduced into clinical practice on the basi

203 t number of approaches to develop novel anti-infectives is currently pursued.

204 Secretions released by infective juvenile nematodes are thought to be crucial f

205 nematodes and the bacteria, MBOA-Glc repels infective juvenile nematodes.

206 epoxidase gene was dispensable in a nematode-infective juvenile recovery assay, indicating the oxidiz

207 with the gut and parenchymal tissues of the infective juvenile stage of Fasciola hepatica, a helmint

208 Free-living infective juveniles (IJs) of EPNs employ host-seeking be

209 egulation of neuropeptides in the dauer-like infective juveniles of diverse parasitic nematodes, sugg

210 n the body periphery and digestive system of infective larvae (L3), as demonstrated by immunofluoresc

211 oats were inoculated with 5,000 H. contortus infective larvae and followed for 50 days.

212 respiratory consultations (infective and non-infective), lower respiratory consultations with a cours

213 on recommendations of nonpharmacologic anti-infective measures and infectious complications were ava

214 Although nonpharmacologic anti-infective measures are widely used in children treated f

215 y unappreciated mechanism of action for anti-infective medicinal plants.

216 sease and other inflammatory, granulomatous, infective, metabolic, and genetic causes that can mimic

217 rom non-infective procyclic promastigotes to infective metacyclic promastigotes.

218 During differentiation to infective metacyclics, d-arabinopyranose (d-Arap) caps t

219 lly contributed to the observed reduction of infective MS2.

220 en delivered to the lungs of mice, this anti-infective nanomaterial exhibits improved safety profiles

221 r to improve antibacterial delivery, an anti-infective nanomaterial is developed that utilizes two st

222 velopment of AEF in patients presenting with infective, neurological, gastrointestinal, or cardiac sy

223 to develop a biocompatible hydrogel as anti-infective ointment.

224 We showed that MHV and varphi6 remained infective on the time scale of days.

225 candidate for further development as an anti-infective or antitumor lead.

226 nal ultrasound found no evidence of systemic infective or cystic disease.

227 An acute infective organism (15%) or abnormal cerebrospinal fluid

228 These appearances suggested chronic infective osteomyelitis of the xiphoid process of the st

229 recently gained much interest as novel anti-infectives owing to their ability to kill bacteria and s

230 ched for its subcellular localization in the infective parasite stages (intracellular amastigotes and

231 The human-infective parasite Trichomonas vaginalis causes the most

232 wing an excellent correlation with the human infective parasite Trypanosoma brucei rhodesiense, the m

233 ll that protects the dormant but potentially infective parasites from harsh environmental conditions

234 - a differential timing only seen in mammal-infective parasites.

235 Trypanosoma brucei brucei, but not the human-infective pathogens T. brucei rhodesiense and T. brucei

236 igate the comorbidity association of these 2 infective pathologies with other 7 diseases (heart failu

237 These studies show novel anti-infective pathways that could drive development of new s

238 anemia, transient tachypnea of the newborn, infective pneumonia, asphyxia, intracerebral hemorrhage,

239 ets should result in reconsideration of anti-infective policies.

240 these patients to decide on appropriate anti-infective preventive measures.

241 riggered by infection, termed sepsis, or non-infective processes, termed non-infective systemic infla

242 s that occur as L. major transforms from non-infective procyclic promastigotes to infective metacycli

243 er, the molecules responsible for these anti-infective properties and their potential mechanisms of a

244 finding that might be important for the anti-infective properties of B. subtilis and its relatives.

245 uses on the nutritional, functional and anti-infective properties of pomegranate (Punica granatum L.)

246 in (SP)-B proprotein, and SP-A are lung anti-infective proteins.

247 Infective PSTVd circles are replicated via an asymmetric

248 The most common adverse events were infective pulmonary exacerbations, cough, increased sput

249 d crescentic GN, acute tubular necrosis, and infective pyelonephritis or sepsis.

250 paper, we study a variant of the susceptible-infective-recovered model of epidemic spread, which comb

251 Infective rhinitis can be caused by viruses, and less co

252 iopsy (9%), HBsAg+ (6%), neoplastic (6%), or infective risk (5%).Most recipient and donor features we

253 We compared responses of infective second stage juveniles (J2s) to root volatiles

254 Anti-infective shortages are a pervasive problem in the Unite

255 nd 1.52 (IQR: 1.15-1.92) fold higher for non-infective SIRS and sepsis respectively (p < 0.0001), hen

256 mong critically ill patients, sepsis and non-infective SIRS are associated with substantial, differen

257 ifferentially affected during sepsis and non-infective SIRS.

258 ; severe (n = 23) or non-severe (n = 21) non-infective SIRS; or no SIRS (n = 16) were studied.

259 tionship of these species to the other human-infective species has been contested.

260 lack of genetic information for three human-infective species: P. malariae and two P. ovale species

261 te, thereby identifying the likely source of infective spores.

262 Plasmodium falciparum antigen upregulated in infective sporozoites 3 (PfUIS3) as a vaccine candidate.

263 obust oocyst and sporocyst walls protect the infective sporozoites from deleterious external attacks

264 tility, and immune evasion properties of the infective sporozoites.

265 humans by immunization with sporozoites, the infective stage injected by bite of the mosquito vector,

266 in activation and flight towards a host when infective stage larvae (L3) were present (p < 0.001).

267 gen species (ROS) control promastigotes, the infective stage of the parasite, but not the amastigote

268 nce dispersal from the environmental pool of infective stages (i.e. the regional species pool).

269 tosynthetic genes is decreased in the dodder infective stages compared with normal stem.

270 were differentially expressed in the dodder infective stages compared with stems and seedlings.

271 limate warming increases the availability of infective stages of both helminth species and the propor

272 lation (6-fold change) of TcP5CDH during the infective stages of the parasite.

273 ematode parasite (production of the cercaria infective stages) and the parasite's snail intermediate

274 tic dispersal from the environmental pool of infective stages, can affect the community composition.

275 at could guide the development of novel anti-infective strategies.

276 t required for microbial survival, this anti-infective strategy has the potential to treat multidrug-

277 psis, or non-infective processes, termed non-infective systemic inflammatory response syndrome (SIRS)

278 me lytic factors (TLFs), against which human-infective T. brucei gambiense and T. brucei rhodesiense

279 Folate biosynthesis is an established anti-infective target, and the antifolate para-aminosalicylic

280 ved from HIV-1 infected DCs were 4 fold more infective than either cell free HIV-1 or exosomes derive

281 oduction, confirming their potential as anti-infectives that do not function by traditional bacterioc

282 Antimicrobial peptides (AMPs) are anti-infectives that may represent a novel and untapped class

283 for measuring the amount of circulating anti-infective therapeutic antibodies.

284 ns is expected to help in the design of anti-infective therapeutic interventions.

285 Peptide anti-infective therapeutics with combined antimicrobial and i

286 Recently, the ability of H. aspersa to shed infective third-stage larvae (L3s) of A. abstrusus and T

287 nerated without drug resistance markers were infective to human hepatocytes in vitro and to humanized

288 x-CcP overexpressers were significantly more infective to macrophages and cardiomyocytes, as well as

289 ly sexual parasites, called gametocytes, are infective to the mosquito vector.

290 re of the illness raised the suspicion of an infective, toxic, or metabolic insult, which was exclude

291 here the whole-genome sequences of the human-infective Trichuris trichiura and the mouse laboratory m

292 OL1 variants for their ability to kill human infective trypanosomes in vivo to identify the molecular

293 c profiling of the insect (epimastigote) and infective (trypomastigote) forms by two-dimensional gel

294 revealed that aerosolized viruses can remain infective under meteorological conditions prevailing dur

295 Despite their broad anti-infective utility, the biosynthesis of the paradigm carb

296 hree patients met the criteria for either an infective ventilator-associated complication or pneumoni

297 cally significant gastrointestinal bleeding, infective ventilator-associated complication or pneumoni

298 fe cycle are genome encapsidation to form an infective virion and genome exit to infect the next host

299 entiate into ASC soon after contact with the infective virus.

300 concerned with the development of novel anti-infectives with dual antibacterial and antiretroviral ac