ライフサイエンスコーパス: infectivity

1 a substantial effect on HIV-1 production and infectivity.

2 V capsid without compromising viral titer or infectivity.

3 clustering of envelope glycoprotein Env for infectivity.

4 in sequences were still required for optimal infectivity.

5 major capsid gene vp1 is essential for SSV1 infectivity.

6 the glomerulus of the human kidney for ZIKV infectivity.

7 ions to envelope protein function and virion infectivity.

8 M gene were shown to mediate enhanced virus infectivity.

9 strated to be prime contributors to enhanced infectivity.

10 on pathways and how they contribute to viral infectivity.

11 Phage-resistant mutants had impaired infectivity.

12 PLF1 knockout virus results in decreased EBV infectivity.

13 which directly contributes to the bacterial infectivity.

14 carbohydrate attachment to further increase infectivity.

15 be efficacious in a cellular model of viral infectivity.

16 on, BB0406 was not found to be essential for infectivity.

17 increase in intercellular transfer of prion infectivity.

18 individuals, with the potential for retained infectivity.

19 ps among knob expression, cytoadherence, and infectivity.

20 bution of bb0318 to B. burgdorferi mammalian infectivity.

21 in this region abolished virus recovery and infectivity.

22 to malaria-naive human volunteers to explore infectivity.

23 se host defense mechanisms and promote their infectivity.

24 2 (SMAD2) signaling in MDLC restores cells' infectivity.

25 ed virion production and a further defect in infectivity.

26 ed into different animal models showing high infectivity.

27 hift efficiencies have significantly reduced infectivity.

28 Vaccination may lower infectivity.

29 intriguing aspects of spirochete biology and infectivity.

30 MA trimer-defective particles, thus rescuing infectivity.

31 s resulting in a greater ability to maintain infectivity.

32 in (GP) mutant A82V, for its effect on viral infectivity.

33 ng cyclic amplification, used as a proxy for infectivity.

34 ly with the HIV-1 capsid and regulates viral infectivity.

35 tingly, capsid stability was correlated with infectivity.

36 longer inoculation time to reach its maximal infectivity.

37 onstrated the essential property of mosquito infectivity.

38 ates with severity of disease, survival, and infectivity.

39 veral that are known to be involved in HIV-1 infectivity.

40 HIV-1 viral particles is essential for viral infectivity.

41 , PrP(res), as well as prion propagation and infectivity.

42 lowered semen-mediated enhancement of HIV-1 infectivity.

43 r understanding the molecular basis of prion infectivity.

44 ted H7N9 and H10N8 reassortants toward human infectivity.

45 associated protein (SRA) necessary for human infectivity.

46 teases is necessary for viral activation and infectivity.

47 resulted in a significant reduction of viral infectivity.

48 s by eliciting antibodies that inhibit virus infectivity.

49 ling required for influenza virus growth and infectivity.

50 n the HSV envelope support similar levels of infectivity.

51 and pharmacological inhibition limited ZIKV infectivity.

52 tion and examined how it supports spirochete infectivity.

53 amino acid substitutions in capsids to HIV-1 infectivity.

54 ir, GS-9669 and GS-9451 rapidly reduce virus infectivity.

55 le for proper folding of gp120 and for viral infectivity.

56 is UL20 palmitoylation is required for HSV-1 infectivity.

57 nd that these cellular factors enhance viral infectivity.

58 of neutralizing antibodies that reduce viral infectivity.

59 ronmental monitoring to make inference about infectivity.

60 ulated into immunodeficient mice to test for infectivity.

61 rions, and therefore is essential for virion infectivity.

62 within-person percentage change in mosquito infectivity 2 days after primaquine treatment in partici

63 o introduced patient-specific differences in infectivity across disease stages, and on the epidemic l

64 efficacious (EC50 </= 100 nM) in attenuating infectivity across multiple serovars of C. trachomatis w

65 ls whose sera had high capture but weak anti-infectivity activity were infected at a higher rate than

66 e animals with low capture and stronger anti-infectivity activity.

67 s display a commensurate deficiency in their infectivity, albeit without additional defects in virion

68 play distinct roles in pathogen biology and infectivity although a significance of their interaction

69 01_AE Envs as measured by a dramatic loss in infectivity and ability to mediate cell-to-cell fusion.

70 d that PSTVd severely interferes with TYLCSV infectivity and accumulation, most likely as a consequen

71 rmational integrity and multiple-cycle viral infectivity and bind to several broadly neutralizing ant

72 restored CD4 binding and wild-type levels of infectivity and cell-to-cell fusion.

73 In cultured cells, infectivity and cytokine induction were observed even at

74 N-beta-pretreated cells had reduced specific infectivity and decreased relative fitness, suggesting t

75 could be applied to study mechanisms of ZIKV infectivity and effects on brain development.

76 glycosylation of HA at N-142 modulates virus infectivity and host immune response.

77 tions that eliminate canine parvovirus (CPV) infectivity and identify how those mutations changed the

78 complex, a process linked to enhanced viral infectivity and immune escape.

79 ctopically expressed SERINC5 restricts HIV-1 infectivity and is antagonized by Nef and analyzed both

80 will facilitate long-overdue studies on its infectivity and pathogenic potential in humans.

81 and transgenic rice were used to test RBSDV infectivity and pathogenicity.

82 ental component demonstrated to affect prion infectivity and persistence.

83 antigenaemia in infected hosts promotes ZIKV infectivity and prevalence in mosquitoes, which could ha

84 Infectivity and production of physical particles were qu

85 ether key host and pathogen factors modulate infectivity and progression of infection using a mouse m

86 g a large set of A3H mutants in single-cycle infectivity and replication assays.

87 e glycosylation sites greatly diminish viral infectivity and result in significantly reduced binding

88 gene vp3 could be deleted without a loss in infectivity and results in virions with abnormal morphol

89 Infectivity and RT-qPCR reductions are also presented fo

90 bank parasites have a dramatic reduction in infectivity and the ability to adhere to CD36.

91 Here, we evaluate the roles of viral infectivity and the replication capacity of viruses from

92 surface receptors is a major determinant of infectivity and therefore transmissibility.

93 o test the influences of E. cloacae on HuNoV infectivity and to determine whether HuNoV infects B cel

94 ielding cell-to-cell transmissibility, prion infectivity and toxicity.

95 this interaction is important for mammalian infectivity and transmission of B. burgdorferi.

96 , such as identification of risk factors for infectivity and transmission.

97 Extreme infectivity and virulence of F. tularensis is due to its

98 The relationship between influenza virus infectivity and virus shedding, based on different diagn

99 aminoacylation activity but failed to rescue infectivity and was not packaged.

100 mutations in these regions on fusogenicity, infectivity, and incorporation.

101 half of the SSV1 genes are not essential for infectivity, and the requirement for a particular gene c

102 ys3) localized to the nucleus, rescued HIV-1 infectivity, and was packaged into virions.

103 ompleted the study after optimisation of the infectivity assay, had both a pre-treatment infectivity

104 viral mutants was aberrant, as determined by infectivity assays and pulsed-field gel electrophoresis.

105 Infectivity assays were performed in vitro and in human

106 rticles to focus-forming units determined by infectivity assays.

107 ter than 3.7-log reduction measured by virus infectivity assays.

108 Sequencing and infectivity assessments of related bacterial and phage s

109 ion of the anti-prion eliminated 99% of the infectivity associated to pathogenic prions.

110 antly lower mean within-person reductions in infectivity at day 2-92.6% (95% CI 78.3-100; p=0.0014) f

111 ivatives that inhibit more than 99% of HIV-1 infectivity at low micromolar concentrations.

112 relial protein required for cell fission and infectivity, BB0323, is impaired in BbhtrA mutants grown

113 rimaquine (PQ) reduces Plasmodium falciparum infectivity before it impacts gametocyte density.

114 e activity of Negative factor (Nef) in HIV-1 infectivity, being required to antagonize the inhibitory

115 These proteins are often essential for infectivity but are difficult to locate within the virio

116 erine incorporator 5 (SERINC5) impairs HIV-1 infectivity but is antagonized by the viral Nef protein.

117 population averages of susceptibilities and infectivities, but that their amplitude depends on highe

118 Gastric acid neutralization increases infectivity, but 30%-40% of mice succumb to infection wi

119 interior surface of the capsid reduced viral infectivity by >100-fold and included two cysteine resid

120 bpopulations all were shown to contain prion infectivity by bioassays in ovine PrP transgenic mice.

121 determines the extent of inhibition of viral infectivity by IFITM3.

122 isolates of HIV-1 to the inhibition of viral infectivity by IFITMs.

123 use of quantitative PCR testing and assessed infectivity by means of the inoculation of hamsters and

124 The inhibition of HK2 infectivity by NRTIs appears to take place at either the

125 y factor (Vif), Vif antagonists reduce viral infectivity by rescuing APOBEC3G (A3G) expression and en

126 egulatory effect on the maintenance of viral infectivity by restoring APOBEC3G expression.

127 The support of progeny virion infectivity by RHA is attributable to structure-dependen

128 trate that the restriction of HIV-1 particle infectivity by SERINC5 does not depend on alterations in

129 er system for observing ASFV replication and infectivity can circumvent the time and labor-intensive

130 Peak AECII infectivity coincided with the timing of KGF administrat

131 Importantly, the increase in infectivity comes with the cost of decreased virus stabi

132 n approximately 5-fold reduction in specific infectivity, commensurate with the defect in cell-cell f

133 Twelve vaccinees and 15 infectivity controls subsequently underwent blood-stage

134 at viral replication capacity, but not viral infectivity, correlates with the set point viral load (S

135 could further show that HCV as well as HIV-1 infectivity could be abrogated in syringes and filters.

136 ission tree, the diversification process and infectivity dynamics also add discriminatory power to di

137 bacterial surface determinants important for infectivity (eg, the pilT and galU genes involved in pil

138 cytic machinery is essential for S2-mediated infectivity enhancement, and S2-mediated enhancement is

139 These infectivity enhancements were not observed when GalNAcT3

140 , interfered with HIV-1 production and viral infectivity even in the absence of APOBEC3.

141 absence of the viral accessory protein viral infectivity factor (Vif) by deaminating viral cDNA cytos

142 The virion infectivity factor (Vif) open reading frame is conserved

143 RN-18 based viral infectivity factor (Vif), Vif antagonists reduce viral i

144 Viral integrity is salvaged by HIV-1 virion infectivity factor (Vif), which mediates A3G polyubiquit

145 -1) infectivity, in the absence of the viral infectivity factor Vif, through deoxycytidine deaminatio

146 s the expression of viral protein Vif (viral infectivity factor) at the protein level.

147 ce HIV-1 infectivity in cell culture, virion infectivity follows gp120 density as a sigmoidal depende

148 in tick or BHK-21 cells, suggesting a higher infectivity for tick cell-derived viruses.

149 e tissue Envs mediated a range of macrophage infectivities, from background levels to modest infectio

150 n mutations that result in the loss of virus infectivity, giving a better understanding of the portio

151 ough the contribution of individual TALEs to infectivity has been shown, the specific roles of most T

152 release and intercellular transfer of prion infectivity, highlighting an integral role for exosomes

153 Transmission stage production influences infectivity, host exploitation, and the impact of medica

154 hese drugs will be useful in suppressing HK2 infectivity if these viruses prove to be pathogenic in c

155 he HIV-1 Nef accessory factor enhances viral infectivity, immune evasion, and AIDS progression.

156 into how UL20 palmitoylation regulates HSV-1 infectivity.IMPORTANCE HSV-1 UL20 is a nonglycosylated e

157 exposed pigs could act as a reservoir of CWD infectivity.IMPORTANCE We challenged domestic swine with

158 cidic pH of 5 to 6 partially inactivates HSV infectivity in an irreversible manner.

159 ral polyprotein substantially increased ZIKV infectivity in both human and mouse neural progenitor ce

160 absence of TmeA manifested as a decrease in infectivity in both tissue culture and murine infection

161 tly, the mutant showed significantly reduced infectivity in C3H/HeN mice via needle inoculation.

162 Human immunodeficiency virus type 1 (HIV-1) infectivity in CD4(+) T cells, monocyte-derived macropha

163 xtran, the polycation known to enhance HIV-1 infectivity in cell culture, virion infectivity follows

164 iophysical conformation and attenuate virion infectivity in cell-based assays.

165 ro, the mutant virus had reduced binding and infectivity in cholangiocytes.

166 uronal cells, with distinct consequences for infectivity in different cell types.

167 be an effective treatment by suppressing HK2 infectivity in diseases where these viruses have been im

168 Serum-derived HBV has poor infectivity in HepG2 cells reconstituted with sodium tau

169 e show that NS1 antigenaemia determines ZIKV infectivity in its mosquito vector Aedes aegypti, which

170 aintenance by ELISA and thermal stability of infectivity in live RSV.

171 31 and m129 MCK-2 is essential for full MCMV infectivity in macrophages and for persistent infection

172 This function is critical for parasite infectivity in mammals, and its activation has been cons

173 shell assembly is a prerequisite for virion infectivity in many multi-shelled dsRNA viruses.

174 V-GPC were shown to increase rCl-13/LASV-GPC infectivity in mice.

175 ions that take place in RNA and affect viral infectivity in natural and engineered environments, howe

176 However, detection of infectivity in orally inoculated pigs with a mouse bioas

177 2 of the ICP0 gene profoundly reduced HSV-1 infectivity in permissive human cell culture models and

178 conferring increased infection severity and infectivity in primary chicken embryonic fibroblasts and

179 ormal levels of virions and normal levels of infectivity in the complete absence of O-linked carbohyd

180 , reciprocal Vif variants that rescued viral infectivity in the presence of two Vif-resistant A3H mut

181 cultures, indicating the generation of prion infectivity in vitro.

182 human immunodeficiency virus type 1 (HIV-1) infectivity, in the absence of the viral infectivity fac

183 rast, in the absence of DEAE-dextran, virion infectivity increases monotonically with gp120 density a

184 ore more likely to explain the loss of F-MLV infectivity incurred by mutations in key ISD residues E1

185 Notably, a loss of infectivity incurred by the F-MLV mutant with the E14R a

186 fact, result in a substantial loss of F-MLV infectivity, independently of host immunity, challenging

187 itutions in S61 remained untethered and lost infectivity, indicating phosphorylation of p12 serine 61

188 r of physiological processes including HIV-1 infectivity, inflammation, tumorigenesis, stem cell migr

189 eading to highly potent 1,2,3-triazole based infectivity inhibitors (EC50 </= 20 nM).

190 ling with the possible outcomes of increased infectivity, intrinsic resistance to antibiotics, and su

191 SERINC5-mediated restriction of HIV particle infectivity involves alterations of membrane lipid compo

192 tinal cells restricts virus replication, and infectivity is abrogated by inactivation (e.g., irradiat

193 sm by which SERINC5 restricts HIV-1 particle infectivity is still unclear.

194 pivotal role in host cell invasion, and thus infectivity, is poorly understood, largely because high-

195 UPR) plays a major role in certain microbial infectivity, its role in chlamydial pathogenesis is unkn

196 CPSF6 knockout changed viral infectivity kinetics, decreased proviral formation, and

197 ance of apolipoproteins in HCV secretion and infectivity, leading to the notion that HCV coopts the s

198 y infected oral cells (1 to 4) and low viral infectivity (<1.5 new cells infected/cell).

199 Such increased infectivity may have enhanced the ability of EBOV to tra

200 in better antibody capture but similar anti-infectivity may not improve vaccine efficacy.

201 infectivity assay, had both a pre-treatment infectivity measurement and at least one follow-up infec

202 ivity measurement and at least one follow-up infectivity measurement, and who were given the correct

203 Infectivity models were used to associate the log10 prob

204 b env pseudovirus variants exhibited similar infectivities, neutralization susceptibilities to autolo

205 Si of haploid PV presents cellular infectivity of a single genotype.

206 in (MSHA) type IV pilus operon), had reduced infectivity of A. cytherea.

207 subtype in vitro, but only KLK5 promoted the infectivity of A/Puerto Rico/8/34 (H1N1) and A/Scotland/

208 thylation activity of atALKBH9B affected the infectivity of AMV but not of CMV, correlating with the

209 We observed that the infectivity of B virus isolates with a single amino acid

210 1 overexpression in human cells impaired the infectivity of both the F-MLV double mutant and the wild

211 le HDMBOA-Glc and MBOA reduce the growth and infectivity of both the nematodes and the bacteria, MBOA

212 Our results demonstrate that the infectivity of different HIV-1 primary isolates, includi

213 rotective equipment according to the assumed infectivity of each patient with MERS may be appropriate

214 the hypothesis that the heightened intrinsic infectivity of GP-A82V contributed to disease severity d

215 The infectivity of H. avenae was significantly reduced when

216 d peptidase 5) is efficient in promoting the infectivity of H3N2 IAV in vitro and in vivo Furthermore

217 has been shown to preserve the stability and infectivity of HAdVs.

218 onverging toward an increase in the level of infectivity of HCV virions.

219 Accordingly, infectivity of high-risk HPV types 16, 18 and 31 as well

220 ction factor SERINC5 potently suppresses the infectivity of HIV, type 1 (HIV-1) particles, and is cou

221 hermore, microwave irradiation reduced viral infectivity of HIV-1 and of HCV/HIV-1 suspensions indica

222 s glycoprotein-pseudotyped lentiviral vector infectivity of HSPCs, the lysine residues on the N-termi

223 lls and provide evidence that the known poor infectivity of HTLV-1 particles may correlate with HTLV-

224 This variant showed increased infectivity of Huh7.5 cells, compared with DBN3a, and wa

225 Vectofusin-1 enhances the infectivity of lentiviral and gamma-retroviral vectors p

226 ll parasites were infective in vivo However, infectivity of NF54 was dramatically reduced.

227 This study indicates that METH increases HIV infectivity of NPCs, through the NFkappaB/SP1-dependent

228 Infectivity of paramyxovirus particles depends on matrix

229 Here, we analyse ZIKV infectivity of peripheral blood mononuclear cells (PBMCs

230 ssion through degradation of Vif to regulate infectivity of progeny virions.

231 o determine whether opossum A1 restricts the infectivity of retroviruses including human immunodefici

232 ate that the T3D mu1-mediated enhancement in infectivity of T1L is dependent on the function of sigma

233 Unexpectedly, the enhancement in infectivity of T1L/T3DM2 is due to its capacity to attac

234 cytes in vivo These results suggest that the infectivity of the decidua is not the result of an enhan

235 onitoring allows for inference regarding the infectivity of the pathogen and thus improves our abilit

236 nsity per virion is then correlated with the infectivity of the virions measured in cell culture.

237 levels of mCAT1 in the producer cell and the infectivity of the virions produced.

238 tween capsid core stability and the relative infectivity of the virus.

239 against HIV-1 clade B and C and also reduced infectivity of the virus.

240 re supernatants significantly suppressed the infectivity of various influenza viruses.

241 ue in question and that this could boost the infectivity of virions beyond the levels seen in the abs

242 urthermore, these compounds potently blocked infectivity of viruses harboring mutant PR that are resi

243 Interestingly, the infectivity of wild-type or P90A virus could be rescued

244 cise quantitative dependence of HIV-1 virion infectivity on Env density has remained unknown.

245 ive activity were shown to affect retrovirus infectivity only if the host cell that produced the retr

246 thout disrupting respiratory syncytial virus infectivity or filament formation and allowing for inter

247 affected by variable infectious periods and infectivity over time.

248 The specific infectivities (PFU per viral genome) of HSV(chol) and HS

249 polyproline motif somewhat attenuates virus infectivity, presumably blocking host-cell attachment.

250 rectly links individual particle behavior to infectivity, providing unprecedented insights into the b

251 differences in viral infectivity rates, with infectivity rates of dengue serotypes 2 and 3 exceeding

252 t for serotype-specific differences in viral infectivity rates, with infectivity rates of dengue sero

253 fed or fasted before exposure showed similar infectivity rates.

254 y neutral pH caused an irreversible >2.5 log infectivity reduction.

255 ts with the viral capsid and modulates HIV-1 infectivity remains unclear.

256 es leads to a mild reduction or no effect on infectivity, respectively.

257 P2(Min) displayed a vastly reduced specific infectivity (si) (WT, 1 PFU/118 particles vs. P2(Min), 1

258 In this report, previous volunteer infectivity studies have been extended to examine the as

259 Mouse infectivity studies revealed that the Deltaarg lesion re

260 hVLPs showed greater infectivity than standard pseudovirions but largely simi

261 vation may lead to a persistent reservoir of infectivity that contributes to the environmental mainte

262 spite its critical role in bolstering virion infectivity, the molecular basis for the incorporation o

263 With moderate influenza infectivity, the number of cases averaged 1,117,285 for

264 perceived that more Env gives rise to higher infectivity, the precise quantitative dependence of HIV-

265 oreover, although essential for assembly and infectivity, the trafficking of mature virions is seemin

266 However, infectivity titres were decreased in viruses possessing

267 that this mutation is associated with higher infectivity to human cells, representing the clearest ex

268 ined in relation to time since treatment and infectivity to mosquitoes.

269 to determine which immune cells transfer MeV infectivity to the human airway epithelium.

270 phage to the bacteria and enhances the phage infectivity to V. parahaemolyticus, indicating that pola

271 Meanwhile, the inactivation and infectivity (to amoebae) of the released L. pneumophila

272 lored this possibility by characterizing the infectivity, tropism, and neutralization susceptibility

273 tein species, but the mechanism for acquired infectivity upon maturation is unclear.

274 treatment of human cells with D-Wt-O reduces infectivity upon subsequent challenge with C. pneumoniae

275 de 6 was discovered as an inhibitor of HIV-1 infectivity using a phenotypic screen and derivatives of

276 t site stem-loop, frameshift efficiency, and infectivity, using pseudotyped HIV-1 and HEK293T cells.

277 ulent, the H7N8 HPAI virus exhibited greater infectivity, virulence, and lethality.

278 ted biofilms was 1-2 times higher and amoeba infectivity was 2-29 times lower than that from untreate

279 Viral infectivity was analyzed by means of microscopy, immunof

280 Virus infectivity was assessed by detection of virus antigen b

281 Infectivity was assessed through membrane-feeding assays

282 ZIKV infectivity was confirmed in all 3 cell types by means o

283 Prion infectivity was confirmed within the uterus, amniotic fl

284 ZIKV infectivity was enhanced by this amino acid substitution

285 alactosaminyltransferase 1 (GalNAcT1), viral infectivity was increased 2.5-fold compared to that of v

286 f virus produced in wild-type HEK293T cells; infectivity was increased 8-fold when the Thr499Ser muta

287 The increased infectivity was restricted to cells that have primate-sp

288 ted, while a more pronounced dose-restricted infectivity was seen in ex vivo cultures of porcine corn

289 ectious hematopoietic necrosis virus (IHNV), infectivity was significantly inhibited in vitro (using

290 ressed in target cells and also impair HIV-1 infectivity when expressed in virus producer cells.

291 Indeed, the F-MLV mutant retained infectivity when it was produced by human cells, which n

292 that the loss of SUN1 had no effect on HIV-1 infectivity, whereas the loss of SUN2 had a modest suppr

293 ected, only Ser5-001 strongly inhibits HIV-1 infectivity, whereas the other Ser5 isoforms and mutants

294 cascade necessary for HIV-1 replication and infectivity-which in turn detrimentally affects proviral

295 per virion that is required for the optimal infectivity will depend on the inclusion of facilitating

296 re infectious virus but do not inhibit virus infectivity will not be effective in preventing infectio

297 th reduced viral fusion, linking the loss in infectivity with a perturbation of the viral envelope.

298 This is the first report of prion infectivity within the cervid pregnancy microenvironment

299 The presence of pregnancy-related prion infectivity within the uterus, amniotic fluid, and the p

300 2-pyridones which attenuated C. trachomatis infectivity without affecting host cell or commensal bac

301 clin F as negatively influencing HIV-1 viral infectivity without any significant impact on virus prod