ライフサイエンスコーパス: infertility

1 sweat glands (heat shock), and vas deferens (infertility).

2 the human population and is associated with infertility.

3 ovarian reserve, leading to subfertility and infertility.

4 e gene, are an important cause of human male infertility.

5 llele in PRL2(-/-) male mice causes complete infertility.

6 ure to PFOS might induce BTB dysfunction and infertility.

7 , loss of the GAS2 homolog, Pigs, results in infertility.

8 ase progression and link SMN to general male infertility.

9 ere differentiation defects, leading to male infertility.

10 in brain defects, respiratory diseases, and infertility.

11 ongly support a direct involvement in hybrid infertility.

12 n receptor gene in PM cells resulted in male infertility.

13 c syndrome, IR, cardiovascular diseases, and infertility.

14 ssive in mice and results in female-specific infertility.

15 perm function in certain cases of human male infertility.

16 ging from a lack of testis formation to male infertility.

17 disease, ectopic pregnancy, or tubal factor infertility.

18 eded to reduce the risk of endometriosis and infertility.

19 t at the pachytene-like stage and results in infertility.

20 found hyperphagia and obesity, diabetes, and infertility.

21 of premature ovarian insufficiency (POI) and infertility.

22 d that deletion of Mkrn2 in mice led to male infertility.

23 linemia, hepatic steatosis, nephropathy, and infertility.

24 ial formation of the BTB at puberty leads to infertility.

25 ain neurons delays the onset of diet-induced infertility.

26 differentiation leading to hypogonadism and infertility.

27 plantation as a treatment for uterine factor infertility.

28 ed by the presence or absence of male factor infertility.

29 tion of KISS1R on the GnRH neuron results in infertility.

30 man diseases such as obesity, narcolepsy and infertility.

31 ve increase among cycles without male factor infertility.

32 important in clinical assessments of female infertility.

33 ly relevant single target for stress-induced infertility.

34 h chronic airway diseases, hydrocephalus and infertility.

35 )) display hypogonadotropic hypogonadism and infertility.

36 echanisms that might be common in cancer and infertility.

37 tions in their development or function cause infertility.

38 estinal obstruction, pelvic pain, and female infertility.

39 , and is particularly associated with female infertility.

40 s loss results in neurodegeneration and male infertility.

41 etion can be enhanced to treat some forms of infertility.

42 ading to severe complications, such as tubal infertility.

43 on leads to ovarian insufficiency and female infertility.

44 CSI and 499,135 (35.8%) reported male factor infertility.

45 otic recombination, leading to profound male infertility.

46 r the diagnosis and management of human male infertility.

47 could be an important therapeutic target for infertility.

48 elevation of transaminase levels, and female infertility.

49 G3 is a strong candidate gene for human male infertility.

50 of early menopause, poor oocyte quality, and infertility.

51 rachomatis lead to serious sequelae, such as infertility.

52 to display male-specific germ cell loss and infertility.

53 ypothesized its putative involvement in male infertility.

54 ng breast cancer, cardiovascular disease and infertility.

55 al biomarker and therapeutic target for male infertility.

56 ts that the AROM+ mouse model reflects human infertility.

57 go- and azoospermia are severe forms of male infertility.

58 ical disease associated with pelvic pain and infertility.

59 o limit family size plays some role, as does infertility.

60 agnosis and treatment of some types of human infertility.

61 lications, including chronic pelvic pain and infertility.

62 testicular macrophages that may lead to male infertility.

63 e ovarian failure is a major cause of female infertility.

64 ssociated with cancer, aging, hepatitis, and infertility.

65 o the maturing spermatozoa resulting in male infertility.

66 ects are major but not sole causes of hybrid infertility.

67 s defects can result in testicular cancer or infertility.

68 ude fallopian tube fibrosis and tubal factor infertility.

69 s on bone and the cardiovascular system, and infertility.

70 ses a number of side effects, including male infertility.

71 nd have been implicated in leptin-associated infertility.

72 ll growth can lead to endometrial cancer and infertility.

73 tion to 9 women with absolute uterine factor infertility.

74 gain insight into the underlying reasons for infertility.

75 causes a severe temperature-sensitive female infertility.

76 he first meiotic division, resulting in male infertility.

77 for the treatment of absolute uterine factor infertility.

78 offer unique perspectives on sex chromosome infertility.

79 a2 develop hypogonadotropic hypogonadism and infertility.

80 doxins (PRDXs) is associated with human male infertility.

81 al and nuclear genomes contributes to female infertility.

82 and safety of procedures used to treat human infertility.

83 n of the PF reserve leads to subfertility or infertility.

84 disease, ectopic pregnancy, and tubal factor infertility.

85 s attenuate gonadotropin release, leading to infertility.

86 reased motility, resulting in selective male infertility.

87 CCP5 deficiency does cause male infertility.

88 rs of endometrial receptivity, fertility and infertility.

89 amination are essential in diagnosis of male infertility.

90 the gametes, and their loss results in adult infertility.

91 ic defects are directly responsible for male infertility.

92 Mitochondrial dysfunction can cause female infertility.

93 olism and who had not received treatment for infertility.

94 d apply to treatment of disease such as male infertility.

95 n assisted reproduction for the treatment of infertility.

96 t for infertility or to prompt treatment for infertility.

97 y high fidelity to prevent birth defects and infertility.

98 ns of PAWP in the diagnosis and treatment of infertility.-

99 0.6%; ectopic pregnancy, 0.2%; tubal factor infertility, 0.1%).

100 Male infertility accounts for almost half of infertility case

101 the patient's condition in terms of cause of infertility, actual ovarian function, responsiveness to

102 for species survival.SIGNIFICANCE STATEMENT Infertility affects 15%-20% of couples; failure to ovula

103 rian androgen biosynthesis, anovulation, and infertility, affects 5-7% of reproductive-age women.

104 regnancy, AHR 0.42 [0.39-0.44]; tubal factor infertility AHR 0.29 [0.25-0.33]).

105 regnancy, AHR 1.31 [1.25-1.38]; tubal factor infertility, AHR 1.37 [1.24-1.52]) and 60% lower in wome

106 Our data indicate that segregating infertility alleles exist in human populations.

107 inkage-free approach to identify segregating infertility alleles, in which CRISPR/Cas9 genome editing

108 expressed on sperm and testis occur in human infertility and after vasectomy.

109 ether thyroid antibodies are associated with infertility and assisted reproductive technology outcome

110 te defects lie at the heart of some forms of infertility and could potentially be addressed therapeut

111 somal abnormalities that potentially lead to infertility and developmental disorders.

112 was a 27-year-old female who presented with infertility and dysmenorrhea.

113 atory disease (PID) is an important cause of infertility and ectopic pregnancy, and Chlamydia trachom

114 PID) is a leading cause of both tubal factor infertility and ectopic pregnancy.

115 rvicitis, pelvic inflammatory disease (PID), infertility and ectopic pregnancy.

116 of the etiology, diagnosis, and treatment of infertility and gonadal cancers, and in efforts to augme

117 cy of the micronutrient copper (Cu) leads to infertility and grain/seed yield reduction in plants.

118 important broader relevance to human female infertility and mitochondrial replacement therapy.

119 The findings have relevance to overcoming infertility and other trisomic phenotypes.

120 These findings have implications for human infertility and post-coital contraception.

121 de developmental disorders, premature aging, infertility and predisposition to cancer.

122 e and cell proliferation, resulting in pain, infertility and pregnancy loss.

123 , and limited data suggest associations with infertility and preterm birth, yet the attributable risk

124 te to negative reproductive outcomes such as infertility and preterm birth.

125 l delay and autism, and families affected by infertility and reproductive wastage.

126 findings identify Piwi as a factor in human infertility and reveal its role in regulating the histon

127 protein kinase phosphorylation site, caused infertility and revealed a novel function in regulating

128 Menopause timing has a substantial impact on infertility and risk of disease, including breast cancer

129 elationship with fitness, human development, infertility and risk of neuropsychiatric disorders.

130 f BRD7 (BRD7(-/-)) resulted in complete male infertility and spermatogenesis defects, including defor

131 ta demonstrate that BRD7 is involved in male infertility and spermatogenesis in mice, and BRD7 defect

132 34/449 miRNAs exhibited postnatal mortality, infertility and strong respiratory dysfunction caused by

133 encing influences sex differences in meiotic infertility and the profound impact that meiotic silenci

134 ditions such as pelvic inflammatory disease, infertility, and blindness.

135 ssociated with congenital genetic disorders, infertility, and cancers.

136 leading genetic abnormality contributing to infertility, and chromosome segregation errors are commo

137 se, and possibly preterm birth, tubal factor infertility, and ectopic pregnancy in women.

138 elae, including pelvic inflammatory disease, infertility, and ectopic pregnancy.

139 ave PCD characterized by hydrocephalus, male infertility, and mucus accumulation.

140 s that cause high caloric diet (HCD)-induced infertility are poorly understood but may involve upregu

141 uced obesity, but the effects on HCD-induced infertility are unknown.

142 scription and how this relates to human male infertility are unknown.

143 n of N1ICD in the uterus results in complete infertility as a consequence of multiple developmental a

144 of any offspring conceived, and always view infertility as a possible symptom of a more general or c

145 onsequently, mice lacking miR-34/449 display infertility as well as severe chronic airway disease lea

146 osalpinx is a pathological hallmark of tubal infertility associated with chlamydial infection.

147 strogen receptors on both carcinogenesis and infertility associated with urogenital schistosomiasis a

148 We identified 5,370 men seen for infertility at Frederiksberg Hospital, Denmark, during 1

149 re and Rosa26CreERT2 lines) resulted in male infertility, atrophic testes with vacuolation, azoosperm

150 new insights into the mechanisms that cause infertility attributable to malnourishment.

151 genetic ablation ofCul4ain mice led to male infertility because of aberrant meiotic progression.

152 damage to maternal DNA during meiosis causes infertility, birth defects and abortions.

153 reproductive technologies (ART) can address infertility, but fail to preserve the natural function o

154 romosome, independently contribute to hybrid infertility by causing nonrandom spore death.

155 ic deficiency, AgRP signaling contributes to infertility by inhibiting Kiss1 neurons.

156 further reproductive research and treat male infertility by using natural plant extracts.

157 Nearly one-half of idiopathic infertility cases are thought to have a genetic basis, b

158 Male infertility accounts for almost half of infertility cases worldwide.

159 births, miscarriages, infertility >/=1 year, infertility cause, and breastfeeding.

160 ovided insights into a new mechanism of male infertility caused by the MKRN2 downregulation.

161 or women with untreated male partner-related infertility compared with those with any other cause, bu

162 m cell-specific deletion of Cul4bled to male infertility, despite normal testicular morphology and co

163 uctive outcomes, irrespective of male factor infertility diagnosis.

164 life and plants and have been linked to male infertility disorders in humans.

165 function, and provides a novel mechanism for infertility disorders related to SPAG6.

166 em among Arab women and is the main cause of infertility due to anovulation.

167 aceptive under development) causes permanent infertility due to irreversible blood-testis barrier (BT

168 lation of Raptor in the male germline causes infertility due to meiotic arrest and impaired inactivat

169 of these genomic parasites on evolution and infertility, few meiotic drive loci have been identified

170 disease, ectopic pregnancy, and tubal factor infertility) following chlamydia infection and repeat in

171 8; range, 18-55), and the median duration of infertility for all 257,398 cycles was 4 years (interqua

172 y self-screening test by patients suspecting infertility for warranting further medical attention and

173 oor sperm motility is a common cause of male infertility for which there are no empirical therapies.

174 e at first birth, stillbirths, miscarriages, infertility >/=1 year, infertility cause, and breastfeed

175 ing 1996-2012; for those without male factor infertility, ICSI use increased from 15.4% (4197/27,191)

176 Among cycles with male factor infertility, ICSI use increased from 76.3% (10,876/14,25

177 mutation of Lhfpl2 (LHFPL2(G102E)) leads to infertility in 100% female mice, which have normal ovari

178 We enrolled couples with unexplained infertility in a multicenter, randomized trial.

179 as one of the most important contributors to infertility in both males and females.

180 the dopamine regulatory protein Catsup cause infertility in D. sechellia due to maternal arrest of oo

181 d shRNA completely alleviates stress-induced infertility in female rats, resulting in mating and preg

182 d in apoptosis protects oocytes and prevents infertility in females exposed to radiation.

183 S3 delays the onset of leptin resistance and infertility in HCD-fed female mice, but given continued

184 Obesity is commonly associated with infertility in humans and other animals.

185 induced leptin resistance is associated with infertility in humans and rodents, and treatments for hu

186 n globozoospermia, one of the causes of male infertility in humans.

187 duction in vertebrates, results in long-term infertility in male and female mice.

188 ications include neurotoxicity, memory loss, infertility in males, and development of a neurologic ps

189 ations in the PLCZ1 gene are associated with infertility in men.

190 nd loss of libido, erectile dysfunction, and infertility in men; they are generally treated with the

191 in intracellular Ca(2+) can overcome genetic infertility in mice and suggest this approach may prove

192 homatis serovar D (strain UW-3/Cx) to induce infertility in mice whose major histocompatibility compl

193 efective sperm chromatin compaction and male infertility in mice, mirroring the observation of low CH

194 s leads to hypogonadotropic hypogonadism and infertility in mice.

195 deletion of Shp2 in Sertoli cells results in infertility in mice.

196 ion of either of those channels confers male infertility in mice.

197 NAs and inactivation of Alkbh5 leads to male infertility in mice.

198 proliferation, and subsequently led to male infertility in mice.

199 gn tumors that can cause pain, bleeding, and infertility in some women.

200 highlights the conditional manifestation of infertility in specific genotypic combinations.

201 The general infertility in the interspecies crossings suggests that

202 chromosome segregation, and leading to male infertility in the patient.

203 lls in the BT-IgSF-KO mice, we conclude that infertility in these mice is most likely caused by a fun

204 menorrhea, loss of libido, galactorrhea, and infertility in women and loss of libido, erectile dysfun

205 cted is consistent with an increased risk of infertility in women from everyday exposures to our chem

206 rosalpinx, a pathological hallmark for tubal infertility in women infected with C. trachomatis.

207 In combination with clinical data regarding infertility in women with X chromosome aneuploidies, res

208 se implantation defects are a major cause of infertility in women, identifying these signaling pathwa

209 se, preterm birth, spontaneous abortion, and infertility in women, yet treatment has proven challengi

210 is is the leading cause of infection-induced infertility in women.

211 trate ART procedures independent of existing infertility induce epigenetic perturbations in the embry

212 ifying these signaling pathways will improve infertility interventions.

213 Infertility is a prevalent health issue, affecting appro

214 Infertility is a widespread problem and a male contribut

215 Infertility is also observed in ~70% mutant males, which

216 Here we show that leptin resistant infertility is caused in part by the leptin signaling mo

217 standard therapy for women with unexplained infertility is gonadotropin or clomiphene citrate.

218 vitamin D in human fertility or treatment of infertility is less clear.

219 syndrome (PCOS), the leading cause of female infertility, is associated with an increase in luteinizi

220 se of sexually transmitted infection-induced infertility, is frequently detected in the gastrointesti

221 can lead to oocyte activation deficiency and infertility, it is currently unknown whether the express

222 pect to male factor infertility, unexplained infertility, maternal age 38 years or older, low oocyte

223 omised oocyte quality associated with female infertility may make embryos more susceptible to the ind

224 RI therapy due to sexual side effects (e.g., infertility, menstrual disturbances, and impotence).

225 Other mutations seem to be associated with infertility, miscarriage and prematurity.

226 Among cycles without male factor infertility (n = 317,996), ICSI use was associated with

227 ghts on some of the potential causes of male infertility, new underlining molecular mechanisms still

228 linism with ovarian hyperandrogenism and the infertility of obesity.

229 ead, it is phenotypically reminiscent of the infertility of olt mice.

230 These results suggest that the infertility of SR-BI KO females is caused, at least in p

231 sm might underlie some cases of human female infertility of unknown etiology.

232 ame infertile after 4 months of HCD feeding, infertility onset in knock-out females was delayed by 4

233 Failure to properly regulate SSCs leads to infertility or germ cell hyperplasia.

234 t high risk for neurodegenerative disorders, infertility or having children with a disability as a re

235 festyle intervention preceding treatment for infertility or to prompt treatment for infertility.

236 In women with unexplained infertility, ovarian stimulation with letrozole resulted

237 cific stimulation, could participate in male infertility pathogenesis via inflammatory cytokine induc

238 ol mechanism that is aberrantly regulated in infertility patients.

239 f RHOX genes in sperm from a large cohort of infertility patients.

240 a vinclozolin-induced transgenerational male infertility phenotype.

241 The infertility phenotypes of females with a Zp3-Cre-driven

242 Analysis of SR-BI KO female infertility raises the possibility that abnormalities in

243 th Lrrc8a(-/-) mice that include curly hair, infertility, reduced longevity, and kidney abnormalities

244 ans, ALOX15 inhibitors might counteract male infertility related to GPX4 deficiency.

245 opmental abnormalities were found, including infertility, relatively hypoplastic uteri, abnormal ovar

246 Although in most men the origin of infertility remains unexplained, genetic causes are incr

247 ther Piwi is an actual disease gene in human infertility remains unknown.

248 disease with randomized body laterality and infertility, resulting from cilia and sperm dysmotility.

249 The infertility results from defects in spermatogenesis.

250 30-year-old primigravid (G1P000) female with infertility secondary to her partner's oligospermia and

251 Treatments for human infertility show a decreased success rate with increasin

252 humans and rodents, and treatments for human infertility show a decreased success rate with increasin

253 se included small numbers of women attending infertility specialist services and subsequently screene

254 in patients with hypothalamic amenorrhea, an infertility syndrome in females.

255 mined whether the proportion of tubal factor infertility (TFI) that is attributable to Chlamydia trac

256 in the male germline, which may explain the infertility that has been associated with such inhibitor

257 as been used as a surrogate marker for tubal infertility, the medical relevance of nontubal pathologi

258 n multiparous (p = 0.0167), had a history of infertility therapies (p = 0.0004), and had pre-eclampsi

259 n and could serve as a novel target for male infertility therapies.

260 might be the optimal target for an effective infertility therapy, possibly decreasing the need for in

261 l gene expression, in human reproduction and infertility, thereby increasing understanding of these c

262 s responsible for cancers, birth defects and infertility, this new insight into centrosome behavior h

263 me estrogen-like molecules may contribute to infertility through hormonal imbalances.

264 -intervention program preceding 18 months of infertility treatment (intervention group) and 287 were

265 5841 children, including 1830 conceived with infertility treatment and 2074 twins.

266 ion is critical for new developments in both infertility treatment and contraception.

267 (conducted 2008-2014) that sampled based on infertility treatment and plurality.

268 ntion group) and 287 were assigned to prompt infertility treatment for 24 months (control group).

269 atios (aORs) and 95% CIs for use and type of infertility treatment in relation to failing a developme

270 Clomiphene is the current first-line infertility treatment in women with the polycystic ovary

271 cytoplasm may offer a source of oocytes for infertility treatment or mitochondrial replacement thera

272 ough age 3 years was similar irrespective of infertility treatment or specific type.

273 Maternal self-report of any infertility treatment was further categorized into ART a

274 Infertility treatment was not associated with risk of th

275 le women, a lifestyle intervention preceding infertility treatment, as compared with prompt infertili

276 fertility treatment, as compared with prompt infertility treatment, did not result in higher rates of

277 ric diagnosis, cancer, venous thrombosis, or infertility treatment.

278 sted reproductive technology (ART) and other infertility treatment.

279 n [SD], age, 34.1 [5.2] years) who underwent infertility treatment.

280 and birth size, scarce data exist regarding infertility treatments and children's development in the

281 By contrast with female infertility treatments-especially hormonal manipulations

282 during 1996-2012 with respect to male factor infertility, unexplained infertility, maternal age 38 ye

283 age at menarche, parity, age at first birth, infertility, use of diethylstilbestrol by participant's

284 The potential role of RHOX in human infertility was addressed by sequencing all RHOX exons i

285 During 2008-2012, male factor infertility was reported for 35.7% (176,911/494,907) of

286 Risk of infertility was similarly elevated (pooled OR, 2.43 [95%

287 HOX cluster methylation associates with male infertility, we evaluated the methylation status of RHOX

288 lting accumulation of GlcCer results in male infertility, whereas mutations in the GBA1 gene and loss

289 substantial reduction in sperm motility and infertility, whereas those carrying missense changes wer

290 ce were protected from tubal pathologies and infertility, whereas WT (IL-10(+/+)) mice were not.

291 rst available treatment for absolute uterine infertility, which is caused by absence of the uterus or

292 intolerable pelvic pain and subfertility or infertility, which profoundly affect the quality of life

293 81) aged 30 to 44 years without a history of infertility who had been trying to conceive for 3 months

294 men aged 30 to 44 years without a history of infertility who had been trying to conceive for 3 months

295 imary hepatocytes, and it resulted in female infertility with abnormal ovaries lacking corpora lutea

296 Studies have associated infertility with celiac disease.

297 Oocyte Kat8 deletion resulted in female infertility, with follicle development failure in the se

298 Genetic deletion of mir-7a2 causes infertility, with low levels of gonadotropic and sex ste

299 Patients experience chronic pelvic pain and infertility, with the most likely origin of the tissue d

300 used in patients without severe male factor infertility without clear evidence of a benefit over con