ライフサイエンスコーパス: inflammatory disease

1 ischemia, pancreatitis, viral infection and inflammatory diseases).

2 (and possibly other gastrointestinal mucosal inflammatory diseases).

3 eads to the development of autoimmune and/or inflammatory disease.

4 improve the quality of life of patients with inflammatory disease.

5 Asthma is a chronic inflammatory disease.

6 th implications for the treatment of chronic inflammatory disease.

7 velopment of strategies to prevent and treat inflammatory disease.

8 harmful pathobionts, and the development of inflammatory disease.

9 and of chlamydial morbidity, such as pelvic inflammatory disease.

10 novel pro-resolution drugs for treatment of inflammatory disease.

11 potential for ES-62 SMA-based DC therapy in inflammatory disease.

12 eting metabolic pathways in the treatment of inflammatory disease.

13 ines or receptors has not been successful in inflammatory disease.

14 therapeutic intervention in autoimmunity and inflammatory disease.

15 esponse that directly contributes to chronic inflammatory disease.

16 Coronary artery disease (CAD) is a chronic inflammatory disease.

17 y disrupt the chemokine network in models of inflammatory disease.

18 ophil lineage) is sufficient to cause severe inflammatory disease.

19 onse, but dysregulation of the system causes inflammatory disease.

20 g inflammasome responses and their impact on inflammatory disease.

21 -healing; however, excessive responses cause inflammatory disease.

22 vel therapeutic approach for T cell-mediated inflammatory disease.

23 ss due to hemihaemato(metro)colpos or pelvic inflammatory disease.

24 by self DNA can also lead to autoimmune and inflammatory disease.

25 dipitously, exhibit therapeutic potential in inflammatory disease.

26 have shown efficacy in preclinical models of inflammatory disease.

27 fection further increased the risk of pelvic inflammatory disease.

28 verriding need to control the primary ocular inflammatory disease.

29 esponse to small microbes that contribute to inflammatory disease.

30 y intense pruritis and is a common childhood inflammatory disease.

31 1)-mediating signaling were required to spur inflammatory disease.

32 A are protective in various animal models of inflammatory disease.

33 f malignant or premalignant, infectious, and inflammatory disease.

34 gakaryocytes to mediate IL-1-driven systemic inflammatory disease.

35 mixtures, suggesting therapeutic efficacy in inflammatory disease.

36 e not been explored in any in vivo models of inflammatory disease.

37 tages over catalytic inhibitors for treating inflammatory diseases.

38 cessful immunotherapy against autoimmune and inflammatory diseases.

39 (CVB) can cause a number of life-threatening inflammatory diseases.

40 overexpressed in cancer cells as well as in inflammatory diseases.

41 tial therapeutic target for the treatment of inflammatory diseases.

42 nals are linked to an increasing spectrum of inflammatory diseases.

43 e system to regulate pain, host defense, and inflammatory diseases.

44 derscored by their newly recognized roles in inflammatory diseases.

45 become pathogenic and promote autoimmune and inflammatory diseases.

46 a potent target in imaging of infectious and inflammatory diseases.

47 l targets for the treatment of metabolic and inflammatory diseases.

48 nd cause or contribute to the development of inflammatory diseases.

49 ons (AJs) is associated with several chronic inflammatory diseases.

50 arget for various forms of tissue injury and inflammatory diseases.

51 l immune alterations predisposing to complex inflammatory diseases.

52 produce approaches to treat chronic pain and inflammatory diseases.

53 ns for the treatment of T-cell-mediated skin inflammatory diseases.

54 l tolerance in the setting of autoimmune and inflammatory diseases.

55 ating inflammation in various infectious and inflammatory diseases.

56 plore its therapeutic potential for treating inflammatory diseases.

57 tant function in the pathogenesis of various inflammatory diseases.

58 tokine secretion and ultimately exacerbating inflammatory diseases.

59 eactive T cells in hyperlipidemia-associated inflammatory diseases.

60 re pharmaceutical mainstays to treat chronic inflammatory diseases.

61 erived oxidants contribute to propagation of inflammatory diseases.

62 and affect the immune response to unrelated inflammatory diseases.

63 fied cyclooxygenase inhibitors in preventing inflammatory diseases.

64 point underlying the pathogenesis of chronic inflammatory diseases.

65 een autophagy, mucosal immunity, and chronic inflammatory diseases.

66 , is associated with the development of many inflammatory diseases.

67 h is involved in the pathogenesis of several inflammatory diseases.

68 function and have been implicated in various inflammatory diseases.

69 T cell-mediated immune responses in numerous inflammatory diseases.

70 al for initiation and progression of infecto-inflammatory diseases.

71 ntributing to cancer, neurodegeneration, and inflammatory diseases.

72 cantly contributes to both acute and chronic inflammatory diseases.

73 kines (IL-17A to IL-17F) is involved in many inflammatory diseases.

74 ficant roles in immunity and pathogenesis of inflammatory diseases.

75 ential target for treatment of metabolic and inflammatory diseases.

76 ets to treat periodontitis and other chronic inflammatory diseases.

77 therapeutic inhibition of CD95's activity in inflammatory diseases.

78 tissue protection but can also contribute to inflammatory diseases.

79 revention or treatment of allergic and other inflammatory diseases.

80 signaling involved in cancer metastasis and inflammatory diseases.

81 senting a key mechanism in acute and chronic inflammatory diseases.

82 pharmacological target implicated in various inflammatory diseases.

83 understanding of the pathobiology of tissue inflammatory diseases.

84 COT is an appropriate therapeutic target for inflammatory diseases.

85 i disease vasculitis and other IL-1 mediated inflammatory diseases.

86 ns and involvement in the control of chronic inflammatory diseases.

87 to have an anti-inflammatory role in several inflammatory diseases.

88 ctive and pathogenic roles in autoimmune and inflammatory diseases.

89 on to both hematologic disorders and chronic inflammatory diseases.

90 ivity contributes to the development of auto-inflammatory diseases.

91 ovel therapeutic agents for the treatment of inflammatory diseases.

92 validate it in its own right as a target in inflammatory diseases.

93 als its potential as a novel therapeutic for inflammatory diseases.

94 ity and tissue homeostasis in infectious and inflammatory diseases.

95 l to inflammation, but also promotes chronic inflammatory diseases.

96 ainly relapsing central nervous system (CNS) inflammatory diseases.

97 human pathologies, including immune-mediated inflammatory diseases.

98 r 17 cell responses linked to autoimmune and inflammatory diseases.

99 eutic intervention of mast cell functions in inflammatory diseases.

100 t could be used for the treatment of chronic inflammatory diseases.

101 regulated, it leads to several major chronic inflammatory diseases.

102 ed in the development of many autoimmune and inflammatory diseases.

103 en Lcn2 and iron, and its effects in various inflammatory diseases.

104 laps in genetic variants with autoimmune and inflammatory diseases.

105 general mechanism to control inflammation in inflammatory diseases.

106 enterovirus that can cause various systemic inflammatory diseases.

107 ound at sites of infection and in a range of inflammatory diseases.

108 tive topical agents for treating respiratory inflammatory diseases.

109 ired for improving the management of chronic inflammatory diseases.

110 pivotal role in the development of multiple inflammatory diseases.

111 to cystitis and urethritis, all of which are inflammatory diseases.

112 TH17 differentiation and TH17 cell-mediated inflammatory diseases.

113 hers, and have application in infectious and inflammatory diseases.

114 Inflammatory disease activity might be captured by the I

115 Ulcerative colitis is a chronic inflammatory disease affecting the colon, and its incide

116 e-wide association studies in autoimmune and inflammatory diseases (AID) have uncovered hundreds of l

117 A link between inflammatory disease and bone loss is now recognized.

118 S-62 exhibits protection in murine models of inflammatory disease and hence a library of drug-like PC

119 icacy in cellular and animal models of human inflammatory disease and in some human clinical conditio

120 bicans and Staphylococcus aureus and chronic inflammatory disease and vasculitis since early childhoo

121 gression, severity, and prognosis of chronic inflammatory diseases and a multitude of cancers.

122 fundamental biological processes but also in inflammatory diseases and cancer.

123 been proposed as a strategy for treatment of inflammatory diseases and cancer.

124 erosis and potentially other immune-mediated inflammatory diseases and deserves further investigation

125 ponsible for the association between chronic inflammatory diseases and increased tumor incidence.

126 ulation of several processes associated with inflammatory diseases and infection.

127 ifferences of genomic response between human inflammatory diseases and murine models, we developed KE

128 Pain is a main symptom of inflammatory diseases and often persists beyond clinical

129 phasize the safety of dietary cholesterol in inflammatory diseases and point to a previously unrecogn

130 Mosquito-borne viruses can cause severe inflammatory diseases and there are limited therapeutic

131 ssential to protect the host against chronic inflammatory diseases and tissue damage.

132 s of 10ng/mL (for neonatal sepsis and pelvic inflammatory disease) and 30ng/mL (for inflammatory bowe

133 ction (ie urethritis, cervicitis, and pelvic inflammatory disease) and their sex partners.

134 zed regulatory event underlying immunity and inflammatory disease, and a novel target for clinical ap

135 kinase 1 (TBK1) to developmental disorders, inflammatory disease, and cancer.

136 Atherosclerosis is a chronic inflammatory disease, and developing therapies to promot

137 CRP)-a biomarker for neonatal sepsis, pelvic inflammatory disease, and inflammatory bowel diseases-at

138 izing enzyme involved in the pathogenesis of inflammatory disease, and its pharmacological inhibition

139 in men and cervicitis, endometritis, pelvic inflammatory disease, and possibly preterm birth, tubal

140 an aggravate tissue damage during infection, inflammatory diseases, and chemotherapy-induced intestin

141 1 (26%) risk loci across nine autoimmune and inflammatory diseases, and we find that individual genes

142 Many such chronic, inflammatory diseases are accompanied (and may be exacer

143 Chronic inflammatory diseases are associated with a persistent a

144 mphocyte responses observed in NOD-dependent inflammatory diseases are not driven solely by microbial

145 ated in the pathogenesis of several acquired inflammatory diseases as well as cryopyrin-associated pe

146 aining additional insights into allergic and inflammatory diseases, as well as normal physiology.

147 Psoriasis, a chronic inflammatory disease associated with an accelerated risk

148 inophilic esophagitis (EoE) is an esophageal inflammatory disease associated with atopic diseases.

149 d vasculitis, a chronic relapsing autoimmune inflammatory disease associated with extensive cell deat

150 Functional consequences for most inflammatory disease-associated loci are incompletely de

151 Serum samples from 505 patients with CNS inflammatory diseases at the National Cancer Center were

152 arisons of the genomic response of six human inflammatory diseases (burns, trauma, infection, sepsis,

153 Complement plays a major role in inflammatory diseases, but its involvement and mechanism

154 icoid receptor (GR)-are widely used to treat inflammatory diseases, but suffer from significant side

155 sponse to infection, and can also drive auto-inflammatory diseases, but the cell types and signalling

156 These kinases contribute to many inflammatory diseases, but the currently available p38 c

157 ation contributes to pathogenesis of various inflammatory diseases, but the immunometabolic programs

158 ion of helminth-derived molecules on chronic inflammatory diseases, but thus far, clinical trials in

159 he setting and progression of autoimmune and inflammatory diseases by controlling the balance between

160 sibly contribute to the pathology of chronic inflammatory diseases by driving premature endothelial s

161 ammation-associated angiogenesis ameliorates inflammatory diseases by reducing the recruitment of tis

162 satisfactory treatment for the malignant or inflammatory diseases caused by HTLV-1.

163 disease included marked thrombocytopenia and inflammatory disease characteristic of the condition in

164 -specific deletion of LKB1 developed a fatal inflammatory disease characterized by excessive TH2-type

165 Autoimmune hypophysitis (AH) is a chronic inflammatory disease characterized by infiltration of T

166 founding factors may relate to stringency of inflammatory disease diagnosis and the effect of therape

167 tes, obesity, and asthma, as well as classic inflammatory diseases (e.g., arthritis and periodontal d

168 lae of chlamydial infection in women: pelvic inflammatory disease, ectopic pregnancy, and tubal facto

169 a novel therapeutic target for chronic lung inflammatory diseases, especially when CD1d-mediated pre

170 l myocarditis remains a prominent infectious-inflammatory disease for patients throughout the lifespa

171 Combined analysis of inflammatory disease GWAS and primary immunodeficiencies

172 s; 50 genes associated with very-early-onset inflammatory disease have been identified.

173 Studies on chronic inflammatory diseases, heart diseases, Alzheimer's disea

174 icrobial stimuli and is essential to prevent inflammatory disease; however, the molecular basis for I

175 tic cells (DCs) are functionally involved in inflammatory diseases; however, the mechanisms remained

176 epletion can either ameliorate or exacerbate inflammatory diseases; however, these cells remain poorl

177 ective tissue disorder in 4.9%, and systemic inflammatory disease in 11.9%.

178 ate lymphoid cells, which are key drivers of inflammatory disease in barrier tissues.

179 rbovirus, causes a crippling musculoskeletal inflammatory disease in humans characterized by fever, p

180 nfluence of these factors can lead to severe inflammatory disease in premature infants; however, inve

181 has been associated with the development of inflammatory disease in situations where an additional d

182 NLRC4 inflammasome activation mediates auto-inflammatory disease in vivo.

183 e to Leishmania braziliensis infection is an inflammatory disease in which skin ulcer development is

184 The mechanisms leading to autoimmune and inflammatory diseases in the CNS have not been elucidate

185 Paradoxically, IgGs are used to treat inflammatory diseases in the form of high-dose intraveno

186 mbryonic development' in MF CD34+ cells, in 'inflammatory disease' in MF mononuclear cells, and in 'i

187 ne family, overexpressed in numerous chronic inflammatory diseases, in which biological activity rema

188 ammatory lipid mediators involved in chronic inflammatory diseases including cancer.

189 implicated in the therapy of several chronic inflammatory diseases including inflammatory bowel disea

190 a variety of autoimmune and immune-mediated inflammatory diseases including primary sclerosing chola

191 d macrophages play an important role in many inflammatory diseases including septic shock and atheros

192 linical intestinal alterations that occur in inflammatory diseases including uveitis, as well as prev

193 ten considered potential triggers of chronic inflammatory disease, including autoimmunity; however, d

194 ped nearly 450 genetic risk loci in 22 major inflammatory diseases, including a core of common genes

195 e responses are also associated with chronic inflammatory diseases, including asthma and atopic derma

196 increased awareness of MDSC in non-malignant inflammatory diseases, including asthma, inflammatory bo

197 P3) inflammasome is involved in many chronic inflammatory diseases, including cardiovascular and Alzh

198 eukin-27 (IL-27) is an important cytokine in inflammatory diseases, including coronary artery disease

199 axis in the regulation of acute and chronic inflammatory diseases, including ischemia/reperfusion in

200 NF-kappaB is a key player in inflammatory diseases, including multiple sclerosis (MS)

201 LP3 is abnormally elevated in numerous human inflammatory diseases, including pulmonary diseases.

202 mmunotherapies for an ever-widening range of inflammatory diseases, including, for example, obesity,

203 Periodontitis is a chronic inflammatory disease induced by a biofilm that forms on

204 ogical disorders, including strokes, trauma, inflammatory diseases, infectious diseases, and neurodeg

205 lt in debilitating conditions such as pelvic inflammatory disease, infertility, and blindness.

206 Allergic asthma is a chronic airway inflammatory disease involving the complementary actions

207 ecific myeloperoxidase inhibitors for use in inflammatory diseases involving neutrophil infiltration.

208 ow recognized as triggers for multiple human inflammatory diseases involving T cells.

209 The clinical relevance of RAGE in inflammatory disease is being demonstrated in emerging c

210 This chronic inflammatory disease is the result of a shift of the ora

211 Irreversible tissue recession in chronic inflammatory diseases is associated with dysregulated im

212 Chronic pancreatitis (CP) is a fibro-inflammatory disease leading to pain, maldigestion, and

213 rant degranulation of neutrophils in several inflammatory diseases leads to redistribution of MPO to

214 ominant producers of interleukin-6 (IL-6) in inflammatory diseases like rheumatoid arthritis.

215 characterize morbid genes at infectious and inflammatory disease loci.

216 otypical neutrophilic dermatosis, a class of inflammatory diseases marked by elevated levels of tumor

217 Obesity is a chronic inflammatory disease mediated in large part by the activ

218 eloid cells and diminished production of pro-inflammatory disease mediators including cytokines, chem

219 In a complex inflammatory disease model, Plcbeta2-, Plcbeta3-, or Rac

220 ance of TREM2 in neurodegenerative and other inflammatory disease models including chronic obstructiv

221 Next, the authors describe human chronic inflammatory disease models that can help elucidate the

222 ve stimulation (VNS) is effective in various inflammatory disease models, such as rheumatoid arthriti

223 lters the response of mice to three distinct inflammatory disease models.

224 ociation studies and pathogenicity in murine inflammatory disease models.

225 In the chronic inflammatory disease multiple sclerosis (MS), reports on

226 ommon features of neonatal-onset multisystem inflammatory disease (NOMID), a disorder caused by NLRP3

227 AR1 leads to a severe neurodevelopmental and inflammatory disease of children, Aicardi-Goutieres synd

228 Allergic asthma is a prevalent inflammatory disease of the airways caused by dysregulat

229 Multiple sclerosis is a degenerative inflammatory disease of the CNS characterised by immune-

230 tiple sclerosis is the most frequent chronic inflammatory disease of the CNS.

231 ll population in this model of virus-induced inflammatory disease of the developing brain.IMPORTANCE

232 nflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract of un

233 Crohn's disease is a chronic inflammatory disease of the gastrointestinal tract, with

234 yocarditis (EM) is an acute life-threatening inflammatory disease of the heart.

235 Studies of Crohn disease (CD), a chronic inflammatory disease of the intestinal tract, report ter

236 Chronic pancreatitis (CP) is a progressive inflammatory disease of the pancreas, leading to its fib

237 Chronic rhinosinusitis (CRS) is an inflammatory disease of the upper airways that affects 1

238 is of TNF-mediated enteropathies and chronic inflammatory diseases of the intestine.

239 tivate later in life, leading to shingles or inflammatory diseases of the nervous system and eye with

240 ses (P = .0412) but not for the detection of inflammatory diseases (P > .99) or noninflammatory and n

241 Schizophrenia might share intrinsic inflammatory disease pathways with type 2 diabetes.

242 gingival tissue of patients with the chronic inflammatory disease periodontitis (PD).

243 is often disrupted, resulting in the common inflammatory disease periodontitis.

244 investigating the association between pelvic inflammatory disease (PID) and ovarian cancer risk are f

245 Pelvic inflammatory disease (PID) is an important cause of infe

246 xample, cervicitis, endometritis, and pelvic inflammatory disease (PID), including an association wit

247 as a cause of urethritis, cervicitis, pelvic inflammatory disease (PID), infertility and ectopic preg

248 Ischaemic acute kidney injury (AKI), an inflammatory disease process, often progresses to chroni

249 orm-specific roles in macrophage biology and inflammatory disease regulation, by controlling inflamma

250 The etiology of sporadic human chronic inflammatory diseases remains mostly unknown.

251 trophils) in vivo exhibits a severe systemic inflammatory disease, reminiscent of human patients that

252 Oxidative stress-dependent inflammatory diseases represent a major concern for the

253 Psoriasis is a chronic inflammatory disease resulting from dysregulated immune

254 ological impacts on diseases such as cancer, inflammatory diseases (rheumatoid arthritis and inflamma

255 re the implications of sleep disturbance for inflammatory disease risk, and provide a map to guide th

256 associated with improvements in a marker of inflammatory disease risk.

257 Inflammatory diseases such as arthritis are chronic cond

258 Upper respiratory tract inflammatory diseases such as asthma and chronic obstruc

259 ognized to play an important role in chronic inflammatory diseases such as cystic fibrosis (CF), and

260 t of novel therapeutics to alleviate chronic inflammatory diseases such as inflammatory bowel disease

261 innate immunity is a feature of certain skin inflammatory diseases such as psoriasis and atopic derma

262 aberrant activities are also associated with inflammatory diseases such as rheumatoid arthritis and C

263 fer a viable alternative for better treating inflammatory diseases such as SS.

264 xes (ICs) are a prominent feature of chronic inflammatory disease, such as atherosclerosis, type-2 di

265 shown to protect against the development of inflammatory diseases, such as allergy, asthma, and infl

266 is the underlying cause of prevalent chronic inflammatory diseases, such as arthritis, asthma, cancer

267 nses are well-established drivers of chronic inflammatory diseases, such as asthma, and represent a l

268 sinophil- and mast cell-related allergic and inflammatory diseases, such as asthma.

269 s involved in acute systemic sepsis, chronic inflammatory diseases, such as atherosclerosis and diabe

270 ential strategy for the treatment of chronic inflammatory diseases, such as atherosclerosis, in the f

271 Chronic airway inflammatory diseases, such as chronic rhinosinusitis wi

272 We propose that chronic inflammatory diseases, such as colitis and pancreatitis,

273 In case of a BAA associated with chronic inflammatory diseases, such as COPD, in patients with he

274 lammatory chemokine, but its role in chronic inflammatory diseases, such as coronary atherosclerosis,

275 tion in the symptoms and severity of chronic inflammatory diseases, such as rheumatoid arthritis.

276 inosinusitis (CRS) is a troublesome, chronic inflammatory disease that affects over 10% of the adult

277 Polymyalgia rheumatica is an inflammatory disease that affects the shoulder, the pelv

278 es have discovered that dry eye is a chronic inflammatory disease that can be initiated by numerous e

279 Atopic dermatitis (AD) is a chronic pruritic inflammatory disease that commonly presents in the pedia

280 osis (RPF), reviewed herein, is a rare fibro-inflammatory disease that develops around the abdominal

281 Periodontitis is a chronic inflammatory disease that occurs due to the interaction

282 NF-kappaB is a major player in inflammatory diseases that acts by regulating inflammati

283 Despite its contribution to inflammatory diseases, the role of EBI2 in pulmonary eos

284 uences endothelial inflammation and vascular inflammatory diseases.The molecular mechanisms underlyin

285 ndyloarthritis encompasses a group of common inflammatory diseases thought to be driven by IL-17A-sec

286 cular pattern molecule, which promotes fibro-inflammatory disease through the activation of toll-like

287 d in patients with psoriasis, another common inflammatory disease, to assess the efficacy of topical

288 nt unselected cohort of mainly relapsing CNS inflammatory diseases, we confirmed that NMOSD phenotype

289 wn about the role of T-bet(+) Treg1 cells in inflammatory diseases, we studied the function of these

290 Twenty-two of 505 (4.4%) patients with CNS inflammatory diseases were positive for MOG-IgG.

291 Established rodent models of ocular inflammatory diseases were used to determine therapeutic

292 a T cells may open a novel strategy to treat inflammatory diseases where gammadelta T cells play a pa

293 se (NE) is a serine protease of relevance in inflammatory diseases whose activity can lead to patholo

294 Periodontitis is a common dysbiotic inflammatory disease with an estimated heritability of 5

295 ccal enterotoxin B precipitated a lupus-like inflammatory disease with characteristic lympho-monocyti

296 enterocolitis is a neonatal gastrointestinal inflammatory disease with high mortality and severe morb

297 tions ranging from simple fever to fulminant inflammatory diseases with high mortality rates.

298 proteomic signatures to distinguish between inflammatory diseases with similar epidermal disruption

299 Periodontitis is one of the most common inflammatory diseases, with a prevalence of 11% worldwid

300 reating the prostanoid-mediated component of inflammatory diseases would produce a therapeutic effect