ライフサイエンスコーパス: influenza A virus

1 confirmed by analyzing different strains of influenza A virus.

2 the wild-type and V27A mutant M2 channels of influenza A virus.

3 important for the replicative efficiency of influenza A virus.

4 a kind of glycoprotein that is found on the influenza A virus.

5 (MVBs) and the endocytic host cell entry of influenza A virus.

6 e open reading frame in PB1 segments of most influenza A virus.

7 redundant bystander during coinfection with influenza A virus.

8 ted to affect the temperature sensitivity of influenza A viruses.

9 ard ducks, the natural host and reservoir of influenza A viruses.

10 assessment of the pandemic risk of zoonotic influenza A viruses.

11 rapeutic potential of 81.39a against diverse influenza A viruses.

12 with pandemic H1N1 (2009) and seasonal H1N1 influenza A viruses.

13 of 81.39a against both seasonal and emerging influenza A viruses.

14 virucidal for H1 hemagglutinin-bearing human influenza A viruses.

15 f segment 8 (NS) circulate in nonchiropteran influenza A viruses.

16 zing diverse subtypes of group 1 and group 2 influenza A viruses.

17 pacts multiple steps in viral replication of influenza A viruses.

18 basic 2 (PB2) and the nucleoprotein (NP) of influenza A viruses.

19 r insights into the replication mechanism of influenza A viruses.

20 le in the defense of mammalian cells against influenza A viruses.

21 the Aries Flu A/B & RSV assay were 98.1% for influenza A virus, 98.0% for influenza B virus, and 97.7

22 The M2-S31N proton channel of the influenza A virus (A/M2) is one of the validated and mos

23 ion and its downstream effects responding to influenza A virus (A/WSN/33 [H1N1]), tumor necrosis fact

24 e estimated the effective population size of influenza A virus across donor-recipient pairs to be app

25 a new lineage in the human population, avian influenza A viruses (AIV) must overcome the intracellula

26 Subtype H7 avian-origin influenza A viruses (AIVs) have caused at least 500 conf

27 Reassortment among influenza A viruses allows viruses to expand their host

28 In addition to the continuous circulation of influenza A viruses among various host species, cross-sp

29 cted in universal viral transport medium (80 influenza A virus and 16 influenza B virus positive) fro

30 nsitivities of the Alere test were 71.3% for influenza A virus and 93.3% for influenza B virus, with

31 enhances the susceptibility to infection by influenza A virus and West Nile virus.

32 Ab 3I14 binds and neutralizes groups 1 and 2 influenza A viruses and protects mice from lethal challe

33 sisting of globular head domains from exotic influenza A viruses and stalk domains from influenza B v

34 is one of the major surface glycoproteins of influenza A viruses and the target for the influenza dru

35 ral activities against currently circulating influenza A viruses and their genetic barrier to drug re

36 The NS1 protein encoded by influenza A virus antagonizes the interferon response th

37 Although vaccines confer protection against influenza A viruses, antiviral treatment becomes the fir

38 the polymerase complex (PB1, PB2, and PA) of influenza A virus are necessary for viral adaptation to

39 of the influenza virus RNA genome.IMPORTANCE Influenza A viruses are a major global health threat, no

40 These findings indicate that LP avian H7 influenza A viruses are able to infect and cause disease

41 Influenza A viruses are constantly changing.

42 Influenza A viruses are known to primarily replicate in

43 Influenza A viruses are major pathogens for humans, dome

44 Influenza A viruses are major pathogens for humans, dome

45 Human infections with novel influenza A viruses are of global public health concern,

46 Segment reassortment and base mutagenesis of influenza A viruses are the primary routes to the rapid

47 H7 subtype influenza A viruses are widely distributed and have been

48 Low-pathogenic (LP) avian H7 influenza A viruses are widely distributed in the avian

49 on the virion surface, is important in both influenza A virus assembly and entry.

50 been previously identified to play a role in influenza A virus assembly were found to complement the

51 moprophylaxis of human infections with novel influenza A viruses associated with severe human illness

52 id (BALF) from a non-lethal mouse model with influenza A virus at 0, 6, 10, 14, 21 and 28 days post i

53 Unlike conventional influenza A viruses, bat influenza A-like viruses starte

54 K II cells; however, similar to conventional influenza A viruses, bat influenza A-like viruses were r

55 Influenza A viruses bear an eight-segmented single-stran

56 ons probably need to be acquired by emerging influenza A viruses before they can spread in the human

57 The NS1 protein from all strains of influenza A virus binds TRIM25, although not all virus s

58 The data suggest that influenza A virus budding and genome incorporation can o

59 sistant to highly pathogenic avian H5 and H7 influenza A viruses, but were almost as susceptible to i

60 which exerts antiviral activity against the influenza A virus by inhibiting proton conductance of th

61 Influenza A viruses can also cause sporadic infections o

62 Zoonotic transmission of influenza A viruses can give rise to devastating pandemi

63 Influenza A viruses can replicate in the olfactory mucos

64 Influenza A virus causes pandemics and annual epidemics

65 able of conferring protection in a stringent influenza A virus challenge.

66 both seasons in which the pandemic 2009 H1N1 influenza A virus circulated, ILI peaked earlier in coun

67 o date, transmission models have depended on influenza A virus coinfection, which greatly enhances pn

68 inflammatory immune response to 2 strains of influenza A virus, compared with nonpregnant women, char

69 NPs from all strains of influenza A viruses contain two nuclear localization sig

70 Antibodies capable of neutralizing divergent influenza A viruses could form the basis of a universal

71 ng with the generation of and maintenance of influenza A virus diversity in exhibition swine, present

72 tion of specific peptides from vaccinia- and influenza A virus-encoded proteins.

73 discuss the implications of reassortment for influenza A virus evolution, including its classically r

74 pression, demonstrating that some strains of influenza A virus express truncated forms of the NS1 pro

75 Influenza A viruses express PA-X proteins to suppress gl

76 A panel of influenza A viruses expressing chimeric hemagglutinins (

77 A major factor that determines influenza A virus fitness and therefore transmissibility

78 First, frequent introduction of influenza A viruses from commercial swine populations pr

79 Influenza A virus gene segment 7 encodes two proteins: t

80 o MHC class I Ag presentation, we engineered influenza A virus gene segment 7 to encode the model H-2

81 Influenza A viruses generally mediate binding to cell su

82 acid receptors.IMPORTANCE The interaction of influenza A virus glycoproteins with cell surface recept

83 H15 is the other member of the subgroup of influenza A virus group 2 hemagglutinins (HAs) that also

84 n.Broadly reactive antibodies that recognize influenza A virus HA can be protective, but the mechanis

85 ffinity relationship for interactions of the Influenza A virus HA with bivalent displays of the natur

86 Influenza A virus haemagglutinin conformational change d

87 al replication, the M2 proton channel of the influenza A virus has been the focus of many studies.

88 the RNA polymerase complex of seasonal human influenza A viruses has been shown to localize to the mi

89 aminidase (NA) for the intestinal tropism of influenza A viruses has been unclear.

90 Influenza A viruses have caused a number of global pande

91 Influenza A virus hemagglutinin (HA) initiates viral ent

92 chy to the five major antigenic sites in the influenza A virus hemagglutinin globular domain.

93 n antiviral response, whereas infection with influenza A virus, herpes simplex virus 1, or cytomegalo

94 serve as the principal natural reservoir for influenza A virus; however, the key properties of NA for

95 Influenza A virus (IAV) and influenza B virus (IBV) caus

96 the response to vaccination with inactivated influenza A virus (IAV) and were responsible for protect

97 When hemagglutinin (HA) glycoproteins from influenza A virus (IAV) are expressed in cells, ER stres

98 Influenza A virus (IAV) can adapt to poultry and mammali

99 Influenza A virus (IAV) causes an acute infection in hum

100 Influenza A virus (IAV) causes annual epidemics and occa

101 Influenza A virus (IAV) causes up to half a million deat

102 y CD4 T cell recall following heterosubtypic influenza A virus (IAV) challenge of mice primed previou

103 The genome of influenza A virus (IAV) comprises eight RNA segments (vR

104 Influenza A virus (IAV) consists of eight viral RNA (vRN

105 Influenza A virus (IAV) continues to pose an enormous an

106 One of the major unresolved questions in influenza A virus (IAV) ecology is exemplified by the ap

107 The matrix protein 1 (M1) of influenza A virus (IAV) exists as a three-dimensional ol

108 Influenza A virus (IAV) expresses m(6)A-modified RNAs, b

109 Influenza A virus (IAV) genomes are composed of eight si

110 The emergence of the novel influenza A virus (IAV) H7N9 since 2013 has caused conce

111 th threat of animal to human transmission of influenza A virus (IAV) has stimulated interest in rapid

112 We have shown that glycosylation of influenza A virus (IAV) hemagglutinin (HA), especially a

113 Using a murine model of influenza A virus (IAV) infection and a panel of chromos

114 allergic inflammation was protective against influenza A virus (IAV) infection and disease.

115 Exaggerated inflammatory responses during influenza A virus (IAV) infection are typically associat

116 ility of human alveolar macrophages (AMs) to influenza A virus (IAV) infection in comparison with aut

117 he outcome of infectious diseases, including influenza A virus (IAV) infection, are rarely evaluated.

118 respiratory epithelial cells in response to influenza A virus (IAV) infection, as well as the CHIP-s

119 es in our understanding of the mechanisms of influenza A virus (IAV) infection, the crucial virus-hos

120 empers the intensity of the host response to influenza A virus (IAV) infection.

121 nspecific protection has been observed after influenza A virus (IAV) infection.

122 Influenza A virus (IAV) infections cause major morbidity

123 We then apply our method to a data set of influenza A virus (IAV) infections for which viral deep-

124 The pathogenesis of influenza A virus (IAV) infections is a multifactorial p

125 fections increase morbidity and mortality of influenza A virus (IAV) infections.

126 Influenza A virus (IAV) is a lytic virus in primary cult

127 Influenza A virus (IAV) is an RNA virus that is cytotoxi

128 s of infections, but its role in immunity to influenza A virus (IAV) is not well studied.

129 A unique feature of influenza A virus (IAV) life cycle is replication of the

130 ing it with the well-characterized viroporin influenza A virus (IAV) matrix-2 protein.

131 Influenza A virus (IAV) nonstructural protein 1 (NS1) is

132 Influenza A virus (IAV) of the H3 subtype is an importan

133 human A549 cells from lethal infection with influenza A virus (IAV) or vesicular stomatitis virus (V

134 Asia is considered an important source of influenza A virus (IAV) pandemics, owing to large, diver

135 S and human and mouse genetics, we show that influenza A virus (IAV) ribogenesis and growth are suppr

136 Influenza A virus (IAV) RNA packaging signals serve to d

137 e T cells in children to genetically diverse influenza A virus (IAV) strains to which the children ha

138 he mechanisms that are being utilized by the Influenza A virus (IAV) to induce host shutoff.

139 rcoma-associated herpesvirus (KSHV), against influenza A virus (IAV) were investigated in vitro and i

140 PB1-F2 is a virulence factor of influenza A virus (IAV) whose functions remain misunders

141 Here, we show that that influenza A virus (IAV) with maximised frequencies of th

142 Two subtypes of influenza A virus (IAV), avian-origin canine influenza v

143 SV-1), encephalomyocarditis virus (EMCV) and influenza A virus (IAV), we identified several TRIM prot

144 e, we track the number and phenotype of four influenza A virus (IAV)-specific CTLp populations in nai

145 d virus Epstein-Barr virus (EBV), as well as influenza A virus (IAV).

146 g infection, including RNA and proteins from influenza A virus (IAV).

147 broad protection against distinct strains of influenza A virus (IAV).

148 or detrimental at different stages of lethal influenza A virus (IAV).

149 he emergence of drug resistance mutations in influenza A virus (IAV).

150 control of enveloped RNA viruses, including influenza A virus (IAV).

151 ding protein 1 (ZBP1) as an innate sensor of influenza A virus (IAV).

152 ed mortality after infectious challenge with influenza A virus (IAV).

153 to humans have enhanced the virulence of the influenza A virus (IAV).

154 Swine influenza A viruses (IAV) are a major cause of respirato

155 Influenza A viruses (IAV) are zoonotic pathogens that po

156 Influenza A viruses (IAV) can cause lung injury and acut

157 between H5 or H9 subtype avian and mammalian influenza A viruses (IAV) can generate a novel virus tha

158 ng to the genetic and antigenic diversity of influenza A viruses (IAV) currently circulating in swine

159 Influenza A Viruses (IAV) in nature must overcome shifti

160 ckaging of the eight genomic RNA segments of influenza A viruses (IAV) into viral particles is coordi

161 Two zoonotic influenza A viruses (IAV) of global concern, H5N1 and H7

162 Avian influenza A viruses (IAV) of the H9N2 subtype have succe

163 ope tag in the C terminus of PB1 resulted in influenza A viruses (IAV) that are safe and effective as

164 interactomes between human host and several influenza A viruses (IAV).

165 ne are one of the main reservoir species for influenza A viruses (IAVs) and play a key role in the tr

166 uenza virus pathogenesis.IMPORTANCE Seasonal influenza A viruses (IAVs) are among the most common cau

167 ion of genetically and antigenically diverse influenza A viruses (IAVs) are circulating among the swi

168 Influenza A viruses (IAVs) are endemic in swine and repr

169 ve vaccine approaches against IAV.IMPORTANCE Influenza A viruses (IAVs) are one of the most common ca

170 key role in the ecology and transmission of influenza A viruses (IAVs) between species.

171 reassortment is segment dependent.IMPORTANCE Influenza A viruses (IAVs) can exchange genes through re

172 sonal influenza viruses in humans.IMPORTANCE Influenza A viruses (IAVs) cause acute infection of the

173 Influenza A viruses (IAVs) cause seasonal epidemics and

174 Influenza A viruses (IAVs) continue to threaten animal a

175 n variability in subjects infected with H3N2 influenza A viruses (IAVs) during the 2010/2011 season w

176 ortment of gene segments between coinfecting influenza A viruses (IAVs) facilitates viral diversifica

177 equenced the genomes of 441 wild-bird origin influenza A viruses (IAVs) from North America and subjec

178 are critical for activating HAs of seasonal influenza A viruses (IAVs) in humans.

179 ) that neutralizes both group I and group II influenza A viruses (IAVs) in vitro.

180 Different influenza A viruses (IAVs) infect the same cell in a hos

181 The risk of emerging pandemic influenza A viruses (IAVs) that approach the devastating

182 sights into the mechanisms of replication of influenza A virus in ducks.

183 The emergence of avian H7N9 influenza A virus in humans with associated high mortali

184 anding the underlying population dynamics of influenza A viruses in commercial and exhibition swine i

185 the disease-causing potential of LP avian H7 influenza A viruses in mammals may be underestimated, an

186 Since the emergence of human H3N2 influenza A viruses in the pandemic of 1968, these virus

187 tiviral efficacy against multidrug-resistant influenza A viruses, in vitro drug resistance barrier, a

188 y against several human clinical isolates of influenza A viruses, including both oseltamivir-sensitiv

189 ne are actively involved in the evolution of influenza A viruses, including zoonotic strains.

190 to pigs resulted in substantial evolution of influenza A viruses infecting swine, contributing to the

191 ding EPS15 at endosomes, thereby influencing influenza A virus infection as well as degradation of EG

192 ceptives, levonorgestrel, impacts sequential influenza A virus infection by modulating antibody respo

193 e to the increased morbidity associated with influenza A virus infection during pregnancy.

194 s and plasmacytoid dendritic cells (pDCs) to influenza A virus infection in 21 pregnant and 21 nonpre

195 Although it is well established that Influenza A virus infection is initiated in the respirat

196 mune-competent children and that a preceding influenza A virus infection may not provide cross-protec

197 Susceptibility to colitis and influenza A virus infection occurring upon commensal bac

198 describe the imprinting by the initial first influenza A virus infection on the antibody response to

199 ed influenza, we identified 13 children with influenza A virus infection who were subsequently infect

200 sponses are important for protection against influenza A virus infection, that these can be most effi

201 uate the microminipig as an animal model for influenza A virus infection, we compared the receptor di

202 ficantly affect adaptive immune responses to influenza A virus infection, with their effect on the ou

203 the microminipig as a novel animal model for influenza A virus infection.

204 ipig could serve as a novel model animal for influenza A virus infection.

205 ntribute to pulmonary inflammation following influenza A virus infection.

206 mponents and TLR3 as crucial for immunity to influenza A virus infection.

207 S2 plays an important and unexpected role in influenza A virus infection.

208 ecognition by the immune system during human influenza A virus infection.

209 es the ThCTL that develop in the lung during influenza A virus infection.

210 ominipigs represent a novel animal model for influenza A virus infection.

211 ed to an elevated cellular susceptibility to influenza A virus infection.

212 etween younger and aging mice in response to influenza A virus infection.IMPORTANCE Influenza virus i

213 Furthermore, we demonstrate that herpes and influenza A virus infections are enhanced when host circ

214 Emerging evidence from vaccinia and influenza A virus infections indicates that subsets of c

215 ugs used for the prevention and treatment of influenza A virus infections.

216 fluenza B virus infections than for treating influenza A virus infections.

217 Together with the influenza A virus, influenza B virus causes seasonal flu

218 positive and negative percent agreement for influenza A virus, influenza B virus, and RSV were 79.2%

219 influenza epidemics that can be severe, and influenza A viruses intermittently cause pandemics.

220 e identified 10 independent introductions of influenza A virus into Ohio and/or Indiana exhibition sw

221 Influenza A virus is a human pathogen whose genome is co

222 Influenza A virus is a human pathogen with a genome comp

223 y to promote their nuclear export.IMPORTANCE Influenza A virus is a major pathogen of a wide variety

224 Influenza A virus is a threat for humans due to seasonal

225 ergetic barrier to pore expansion.IMPORTANCE Influenza A virus is an airborne pathogen causing season

226 The M2 proton channel of influenza A virus is an integral membrane protein involv

227 Influenza A virus is characterized by high genetic diver

228 ain-specific neutralizing antibodies against influenza A virus is known to confer potent protection a

229 sm underlying the genetic diversification of influenza A virus is reassortment of intact gene segment

230 Reassortment of influenza A viruses is an important driver of virus evol

231 Reassortment of influenza A viruses is readily observed during coinfecti

232 The RNA genome of influenza A viruses is transcribed and replicated by the

233 ain, implicated in host range restriction of influenza A viruses, is still poorly understood.

234 Similarly, challenge with influenza A virus led to increased infiltration of the v

235 role for cellular chaperone Hsp40/DnaJB1 in influenza A virus life cycle by assisting nuclear traffi

236 The influenza A virus M1 and M2 proteins play important role

237 ell epitope from the extracellular domain of influenza A virus M2 protein (M2e).

238 identified a mutation at position 76 of the influenza A virus M2 protein that drastically reduces in

239 results suggest that PB1-F2 from H7N9 avian influenza A virus may be a major contributory factor to

240 Influenza A virus mRNAs are transcribed by the viral RNA

241 e pandemic threat posed by emerging zoonotic influenza A viruses necessitates development of antivira

242 In contrast, the influenza A virus NS1 protein interacts with RIG-I and T

243 The influenza A virus nucleoprotein (NP) is an essential mul

244 we identify several acetylation sites of the influenza A virus nucleoprotein (NP), including the lysi

245 host species, cross-species transmission of influenza A viruses occurs occasionally.

246 ns in 2012 and the widespread circulation of influenza A viruses of the same genotype in exhibition s

247 Attachment of the Influenza A virus onto host cells involves multivalent i

248 The threat of an influenza A virus pandemic stems from continual virus sp

249 reactive oxygen species production abrogates influenza A virus pathogenicity.

250 Avian influenza A virus polymerases typically do not function

251 then coinfected them with mouse-adapted H1N1 influenza A virus (PR/8/34).

252 VX-787 is an inhibitor of the influenza A virus pre-mRNA cap-binding protein PB2.

253 sible reassortment of human and other animal influenza A viruses presents an ongoing risk to public h

254 Specifically, we inoculated 2D2 mice with influenza A virus (Puerto Rico/8/34; PR8) and then monit

255 To understand how the Influenza A virus RdRp coordinates these processes, we a

256 To understand how the influenza A virus RdRp coordinates these processes, we a

257 The Influenza A virus RdRp in contrast, uses a capped RNA ol

258 The influenza A virus RdRp, in contrast, uses a capped RNA o

259 nsider the constraints and drivers acting on influenza A virus reassortment, including the likelihood

260 PB1, PB2, and PA is necessary for efficient influenza A virus replication in new host species.

261 Exogenous SPL expression inhibited influenza A virus replication, which correlated with an

262 role for TRIM25 in specifically restricting influenza A virus replication.

263 An interaction between the influenza A virus RNA polymerase and the C-terminal doma

264 all, this work advances our understanding of influenza A virus RNA synthesis and identifies the initi

265 all, this work advances our understanding of Influenza A virus RNA synthesis and identifies the initi

266 G repeats, which has some resemblance to the influenza A virus shift site, triggers the +1 frameshift

267 ng CD4 effector population, and they mediate influenza A virus-specific cytotoxic activity.

268 Here, we examine the influenza A virus spike protein hemagglutinin (HA), whic

269 Like all influenza A virus strains, A(H5N1) viruses evolve rapidl

270 the N-truncated NS1 proteins encoded by two influenza A virus strains, Udorn/72/H3N2 (Ud) and Puerto

271 alization of PB2 of human from that of avian influenza A virus strains.

272 virus, in 1958, 16 different novel, zoonotic influenza A virus subtype groups in 29 countries, Taiwan

273 le anilines were identified as inhibitors of influenza A virus subtype H1N1, and extensive chemical s

274 Two influenza A virus subtypes has been reported in dogs in

275 r cases of human infection by emerging avian influenza A virus subtypes, including H7N9 and H10N8 vir

276 Influenza A virus suppresses the translation of host mRN

277 Through active influenza A virus surveillance in US exhibition swine an

278 ists in more than 95% of current circulating influenza A viruses, targeting the AM2-S31N proton chann

279 .39a effectively neutralized the majority of influenza A viruses tested, representing 16 HA subtypes.

280 -S31N inhibitors were active against several influenza A viruses that are resistant to one or both cl

281 New influenza A viruses that emerge frequently elicit compos

282 Avian H7N9 influenza viruses are group 2 influenza A viruses that have been identified as the eti

283 ) is a sialidase expressed on the surface of influenza A viruses that releases progeny viruses from t

284 Influenza A viruses that successfully established stable

285 ssion of influenza A(H7N2), an avian-lineage influenza A virus, that occurred during an outbreak amon

286 vessel for the generation of novel pandemic influenza A viruses through reassortment because of thei

287 proteins encoded by the current circulating influenza A viruses; thus, it represents a high-profile

288 NA plays an important role in the ability of influenza A virus to replicate in duck intestine.

289 ary for introduction and adaptation of avian influenza A viruses to mammalian hosts is important for

290 The role of exhibition swine in influenza A virus transmission was recently demonstrated

291 In this paper, the prospect of detecting influenza A virus using digital ELISA has been studied.

292 The only licensed live attenuated influenza A virus vaccines (LAIVs) in the United States

293 nsitivity of the Alere test for detection of influenza A virus was likely due to a study set that inc

294 und that the sensitivity of microminipigs to influenza A viruses was the same as that of larger minia

295 pig, and the sensitivity of microminipigs to influenza A viruses was the same as that of miniature pi

296 Coinfection with influenza A virus, which also expresses a neuraminidase,

297 whole genome sequencing (HT-WGS) method for influenza A viruses, which utilized an enzymatic cleavag

298 ong distances indicate that novel strains of influenza A virus will continue to emerge and spread wit

299 Most influenza A viruses with known subtype were A(H3N2) (570

300 can wild birds are an important reservoir of influenza A viruses, yet the potential of viruses in thi