ライフサイエンスコーパス: influenza virus

1 pment of broad-spectrum therapeutics against influenza virus.

2 al data for young and old mice infected with influenza virus.

3 .9%) had adenovirus (ADV), and 30 (1.3%) had influenza virus.

4 re being vaccinated or infected with another influenza virus.

5 ne with remarkable activity against the H1N1 influenza virus.

6 cule- and peptide-based therapeutics against influenza virus.

7 ein 3 (IFITM3) restricts endocytic fusion of influenza virus.

8 promote antiviral host defenses against the influenza virus.

9 gainst a lethal challenge dose of homologous influenza virus.

10 tection against respiratory reinfection with influenza virus.

11 ly of RNA viruses, which include the various influenza viruses.

12 ant role in the interspecies transmission of influenza viruses.

13 the pandemic potential of circulating avian influenza viruses.

14 r hemagglutinin activation, similar to human influenza viruses.

15 their susceptibility to both avian and human influenza viruses.

16 re surveillance and risk assessment of novel influenza viruses.

17 A changes on drug susceptibility of emerging influenza viruses.

18 s which is characteristic for virulent swine influenza viruses.

19 eparedness efforts directed against emerging influenza viruses.

20 ween genetic and antigenic evolution of H3N2 influenza viruses.

21 herapeutic protection against human or avian influenza viruses.

22 ated membrane scission during the budding of influenza viruses.

23 cacy and provide protection against emerging influenza viruses.

24 and was effective against drug-resistant H1 influenza viruses.

25 revent or treat infection by a wide range of influenza viruses.

26 patient households and surrounding areas for influenza viruses.

27 th 10-100 MLD50 of H1N1, H3N1, H3N2 and H5N1 influenza viruses.

28 ignificant human pathogens such as Ebola and influenza viruses.

29 an disease caused by highly pathogenic avian influenza viruses.

30 dies included, 134 evaluated rapid tests for influenza viruses, 32 for respiratory syncytial virus (R

31 The M2 proton transport channel of the influenza virus A is an important model system because i

32 sitized mice and controls were infected with influenza virus A/X31 H3N2 and either or not treated wit

33 Surveillance data on influenza virus activity permitted inference on influenz

34 We used, as the key indicator of influenza virus activity, the overall proportion of spec

35 uggestive that GFT is not fully specific for influenza virus activity.

36 fruit bats and serological evidence of avian influenza virus (AIV) H9 infection in frugivorous bats r

37 Several subtypes of avian influenza viruses (AIVs) are emerging as novel human pat

38 Our surveillance of avian influenza viruses (AIVs) at Delaware Bay, USA, revealed

39 R is the odds ratio for testing positive for influenza virus among vaccinated versus unvaccinated par

40 orm the design of universal vaccines against influenza virus and can guide pandemic-preparedness effo

41 Hcfc2 mutations compromised survival during influenza virus and herpes simplex virus 1 infections.

42 -viral cytokine which inhibits HIV-1, HIV-2, Influenza virus and herpes simplex virus infection, and

43 ral fusion protein, within the same group as influenza virus and HIV.

44 Data on the relative contribution of influenza virus and other respiratory pathogens to respi

45 xtremely powerful multivalent binders of the Influenza virus and other viruses, comparably little is

46 coprotein genes from Nipah, chikungunya, and influenza viruses and nonstructural genes from Semliki F

47 These data highlight the promiscuity of influenza viruses and the need for diligent surveillance

48 anding of the intricate interactions between influenza viruses and their host cells.

49 nce programs to detect antigenic variants of influenza viruses and to select vaccine strains for use

50 rful in predicting antigenic distances among influenza viruses and vaccines from partially revealed h

51 deaths during 2012-2013 and 2013-2014, when influenza viruses and vaccines were similar.

52 by viruses including human rhinovirus (HRV), influenza virus, and respiratory syncytial virus (RSV).

53 was coated on a microneedle with inactivated influenza virus, and then immunized into BALB/c mouse to

54 g from amino acid substitutions in the major influenza virus antigen hemagglutinin (HA).

55 Evolution of influenza virus antigens means that vaccines must be upd

56 Furthermore, our data suggest that influenza virus antigens prepared via systems not relian

57 he costs of building a T4 phage and a single influenza virus are nearly the same.

58 Seasonal influenza viruses are a common cause of acute respirator

59 try to control the disease burden; however, influenza viruses are able to rapidly evolve to escape i

60 for avian influenza viruses.IMPORTANCE Avian influenza viruses are capable of crossing the species ba

61 H9N2 avian influenza viruses are enzootic in poultry across Asia an

62 antigenic drift and viral fitness for avian influenza viruses as well as the challenges of predictin

63 rtant for rapidly evolving pathogens such as influenza virus, as narrow bottlenecks reduce the amount

64 Influenza virus assembles and buds at the plasma membran

65 portant factor in transmission efficiency of influenza viruses between and among host species.

66 owed weak in vitro activity against human H2 influenza viruses, but the in vivo efficacy against H2 v

67 ccines, diagnostics and therapeutics against influenza virus by providing a comprehensive collection

68 s with influenza-like illness and tested for influenza virus by real-time reverse-transcription polym

69 properties in predicting the antigenicity of influenza viruses by a random forest model.

70 red protection against different subtypes of influenza viruses by lessening weight loss and lowering

71 ibodies and an antiviral agent, Oseltamivir, influenza virus can exploit these networks to transfer v

72 bility after only one passage indicates that influenza viruses can continue to evolve in galliform sp

73 Avian H9N2 and 2009 pandemic H1N1 (pH1N1) influenza viruses can infect pigs and humans, raising th

74 Animal influenza viruses can reassort or mutate to infect and s

75 These observations indicate that influenza viruses can spread using these intercellular n

76 Accordingly, an engineered avian H7N7 influenza virus carrying a nucleoprotein with signature

77 merging pandemic threats.IMPORTANCE Seasonal influenza viruses cause considerable morbidity and morta

78 consecutive seasons was 7.2% and 11.6%, and influenza virus caused 18.9% and 34.2% of ILI episodes.

79 Influenza virus causes life-threatening infections in pr

80 resent a serious public health problem, with influenza virus causing a contagious respiratory disease

81 specific antibodies and protect mice against influenza virus challenge.

82 otection against homologous and heterologous influenza virus challenges.

83 ernal influenza immunisation in Nepal, where influenza viruses circulate throughout the year.

84 influenza A virus (IAV), avian-origin canine influenza virus (CIV) H3N2 (CIV-H3N2) and equine-origin

85 A single subtype of canine influenza virus (CIV), A(H3N8), was circulating in the U

86 respiratory disease of dogs caused by canine influenza virus (CIV).

87 ted in dogs in the last 16 years: the canine influenza viruses (CIV) H3N8 and H3N2 of equine and avia

88 Canine influenza viruses (CIVs) are the causative agents of can

89 nza (HPAI) viruses along with other emerging influenza viruses continue to pose pandemic threats.

90 Seasonal human influenza virus continues to cause morbidity and mortali

91 We applied this model into H3N2 seasonal influenza virus data.

92 In summary, inactivated influenza virus delivered through PLGA-NPs reduced the c

93 The frequency of novel influenza virus detection is increasing, and human infec

94 we demonstrate the first instance of intact influenza virus detection using a combination of antibod

95 Most people infected with influenza virus display mild-to-moderate disease phenoty

96 Mice infected with influenza virus displayed high accumulation of extracell

97 of K186 and E186 among H3N8 CIVs and equine influenza viruses (EIVs), the ancestors of H3N8 CIV, and

98 r, sequential infection of ferrets with H1N1 influenza viruses elicited an Igkappa-biased Ab response

99 sing NA from avian (H5N1) or pandemic (H1N1) influenza virus, elicited NA-specific antibody and T cel

100 In 2009, a novel H1N1 influenza virus emerged in humans, causing a global pand

101 Seasonal influenza virus epidemics represent a significant public

102 sures HA protein sequence similarities among influenza viruses (especially on epitopes) and then inte

103 he specific proteases that activate seasonal influenza viruses, especially H3N2 viruses, in the human

104 Circulating influenza viruses evade neutralization in their human ho

105 ue to sequence diversity and the dynamics of influenza virus evolution, rapid and high-throughput seq

106 ghlight the importance of mutational load in influenza virus evolution.

107 Influenza virus evolves rapidly to constantly escape fro

108 Thus, influenza virus exploits host PKCs to regulate RNP assem

109 Influenza virus expresses transcripts early in infection

110 A subset of ferrets was infected with influenza viruses expressing the COBRA HA antigens.

111 mically amplified protein-based detection of influenza virus from nasal swab specimens was developed

112 xpression of IFITMs, known to potently block influenza virus fusion with late compartments, was found

113 Sequence information from influenza virus genomes is instrumental in determining m

114 ody responses after infection of humans with influenza virus H1N1 or H3N2 and found markedly broad re

115 rystal structures of Arbidol in complex with influenza virus HA from pandemic 1968 H3N2 and recent 20

116 from which we report antibody titers to the influenza virus HA1 protein using a continuous titer mea

117 serology for respiratory viruses other than influenza virus have not been fully evaluated.

118 Pandemic influenza viruses have consistently higher attack rates

119 Low pathogenic H7N9 influenza viruses have recently evolved to become highly

120 similar to those shown to describe fusion by influenza virus hemagglutinin (a "class I" fusogen) and

121 ligands are potent adjuvants for recombinant influenza virus hemagglutinin antigen induction of humor

122 tic cells (cDC1), and that immunization with influenza virus hemagglutinin fused to hXCL1 or hXCL2 in

123 OI) inserted into the RepRNA (luciferase, or influenza virus hemagglutinin or nucleoprotein) could de

124 We show that SC-Ads generate markedly more influenza virus hemagglutinin protein and require substa

125 icle cryoEM for determining the structure of influenza-virus hemagglutinin (HA):single-chain variable

126 es) caused an antigenic drift event for H3N2 influenza viruses historically.

127 pic studies, the membrane-ordering effect of influenza virus, HIV, and Dengue virus FPs has been cons

128 only considered intermediate hosts for avian influenza viruses.IMPORTANCE Avian influenza viruses are

129 secondary structure model and tested against influenza virus in cell culture.

130 We show that inhalation of aerosolized H5N1 influenza virus in cynomolgus macaques results in fulmin

131 l inoculation of a liquid suspension of H5N1 influenza virus in nonhuman primates likely results in e

132 defined as molecular diagnostic evidence of influenza virus in pharyngeal specimens collected during

133 infection and tropism of human and avian H9 influenza virus in the human respiratory tract using ex

134 ons in humans, as well as detection of avian influenza viruses in birds in the United States.

135 umerous outbreaks of highly pathogenic avian influenza viruses in commercial poultry farms.

136 cessfully to induce broad protection against influenza viruses in humans, and our limited data indica

137 roteolytic activation and spread of seasonal influenza viruses in humans.IMPORTANCE Influenza A virus

138 replication and pathogenicity of these H5N1 influenza viruses in mice.

139 H9N2 viruses are the most widespread influenza viruses in poultry in Asia.

140 he COBRA approach, a set of vaccines against influenza viruses in the H3N2 subtype was tested for the

141 t evidence of human infection with an animal influenza virus, in 1958, 16 different novel, zoonotic i

142 continuous surveillance of emerging zoonotic influenza viruses inclusive of mammalian species, such a

143 FP7 protected mice from influenza virus-induced lethality and reduced both proin

144 Infection with influenza virus induces antibodies to the viral surface

145 allergen-sensitized and challenged mice into influenza virus-infected mice resulted in reduced morbid

146 n reaction (RT-PCR) for laboratory-confirmed influenza virus infection (LCI).

147 of the hospitalized infants were tested for influenza virus infection and 1 tested positive.

148 dy, we investigated the role of NLRC5 during influenza virus infection and found a major role for NLR

149 AhR suppresses class switching in vivo after influenza virus infection and immunization with model an

150 y to provide better protection from seasonal influenza virus infection and improve pandemic preparedn

151 nflammation and increased survival following influenza virus infection and improved resistance agains

152 onality extends beyond its classical role in influenza virus infection and that antineuraminidase ant

153 ped mAbs for studying the immune response to influenza virus infection and vaccination in the ferret

154 commonly used animal model for the study of influenza virus infection and vaccination.

155 increase in morbidity or mortality following influenza virus infection because of other compensatory

156 Influenza vaccination reduced influenza virus infection by 73% (95% confidence interva

157 s can mediate more potent protection against influenza virus infection in animal models.

158 Through the systematic study of influenza virus infection in mice, we herein show that I

159 5 virologically confirmed secondary cases of influenza virus infection in the household setting, incl

160 icits robust, cross-reactive protection from influenza virus infection in two animal models.

161 Innate sensing of influenza virus infection induces activation of programm

162 entially positive protective effect of early influenza virus infection later in life continues to be

163 ved dendritic cells (DCs) and in vivo during influenza virus infection of mice.

164 ieve an optimal antiviral response following influenza virus infection or immunization.Broadly reacti

165 expansion of memory CD8(+) T cells following influenza virus infection or vaccination, they failed to

166 IFITM3 palmitoylation and its inhibition of influenza virus infection remained strong in the absence

167 ha/beta, in protection of the lung following influenza virus infection.

168 form as new therapeutic agents against H1N1 influenza virus infection.

169 vaccine adjuvant that could broadly prevent influenza virus infection.

170 of anti-viral RNAi delivery systems against influenza virus infection.

171 sIgM-mediated IgG response regulation during influenza virus infection.

172 echanisms to promote the host defense during influenza virus infection.

173 sponses are essential for protection against influenza virus infection.

174 Influenza virus infections are associated with a wide sp

175 Approximately 25% of all influenza virus infections are caused by type B viruses,

176 Vaccination reduces the number of influenza virus infections but not the overall number of

177 Studies in preclinical models of influenza virus infections have shown that antibodies al

178 ed hundreds of cellular factors required for influenza virus infections in human cells.

179 the pathogenicity and low incidence of avian influenza virus infections in humans, the immune correla

180 persons with asymptomatic or clinically mild influenza virus infections to influenza virus transmissi

181 To successfully treat influenza virus infections, detection of the virus durin

182 this method to an existing data set of human influenza virus infections, showing that transmission is

183 istics of asymptomatic and mild illness with influenza virus infections.

184 eing pursued as a universal strategy against influenza virus infections.

185 nsmission of and approaches to prevent novel influenza virus infections.

186 ted how preexisting antibodies to historical influenza viruses influenced HAI-specific antibodies and

187 Influenza virus is a frequent pathogen in older adults w

188 Influenza virus is a significant cause of morbidity and

189 unology, structural biology, and virology of influenza virus is invaluable for development and design

190 y of the epidemiology and virology of animal influenza viruses is key to understanding pandemic risk

191 The natural reservoir for influenza viruses is waterfowl, and from there they succ

192 Live attenuated influenza virus (LAIV) vaccines have been shown to provi

193 By contrast with influenza viruses, little is known about the contemporan

194 Influenza virus' low replicative fidelity contributes to

195 to identify the universal biomarker for the influenza virus, M1 protein.

196 Vaccines against H7 avian influenza viruses may be more effective than HI and viru

197 Influenza viruses may cause severe human infections lead

198 Hemagglutinin (HA) of influenza virus must be activated by proteolysis before

199 Influenza viruses mutate rapidly, necessitating annual v

200 The influenza virus mutates faster than we previously though

201 nd fluctuation tests have suggested that the influenza virus mutation rate is 2.7 x 10(-6) - 3.0 x 10

202 Influenza virus NS1 protein is a nonstructural, multifun

203 vice was based on a sandwich immunoassay for influenza virus nucleoprotein; it used an enzyme-labeled

204 were almost as susceptible to infection with influenza viruses of human origin as nontransgenic litte

205 Influenza viruses of the H1N1, H2N2, and H3N2 subtypes h

206 Since 1997, highly pathogenic avian influenza viruses of the H5N1 subtype have been transmit

207 However, wild-type MDA5 did not restrict influenza virus or RSV replication.

208 Most tests detected only influenza viruses or RSV.

209 and M2 proteins in virus assembly.IMPORTANCE Influenza virus particle assembly involves the careful c

210 represent a host-virus adaptation affecting influenza virus pathogenesis.IMPORTANCE Seasonal influen

211 ely and to identify new molecules inhibiting influenza virus polymerase assembly.

212 novel inhibitors targeting the formation of influenza virus polymerase complex but also present a ne

213 er system to facilitate the investigation of influenza virus polymerase complex formation.

214 o quantify both strong and weak PPIs between influenza virus polymerase subunits.

215 Influenza virus positivity was associated with shorter d

216 participants, 1309 (19%) tested positive for influenza virus, predominantly for A(H1N1)pdm09 (11%) an

217 on to seasonal infections, emerging pandemic influenza viruses present a continued threat to global p

218 for prepandemic vaccines.IMPORTANCE H7 avian influenza viruses present a serious risk to human health

219 l nucleoprotein (NP) level and inhibition of influenza virus production in infected cell lines (MDCK

220 Inhibition of influenza virus proliferation was noticed, identifying g

221 For seasonal influenza viruses, protection is correlated with antibod

222 xpression of M1.IMPORTANCE The complement of influenza virus proteins necessary for the budding of pr

223 adly neutralizing antibodies (bnAbs) against influenza virus provide valuable insights into antiviral

224 The distribution of influenza virus receptors in the respiratory tract of th

225 Human and avian influenza viruses recognize different sialic acid-contai

226 ion, rapid and high-throughput sequencing of influenza viruses remains a challenge.

227 dentified a small molecule that can suppress influenza virus replication by disrupting the polymerase

228 ed the impact of the PLK inhibitor BI2536 on influenza virus replication in a human lung tissue cultu

229 udy is the first to assess the role of MT in influenza virus replication in human bronchial airway ep

230 ils promote host cellular immunity to reduce influenza virus replication in lungs, thereby providing

231 ock host gene expression is not required for influenza virus replication in mammals but might be impo

232 y four different compounds, leads to reduced influenza virus replication, and we map the requirement

233 ve AMPylation also abolished HSP70-dependent influenza virus replication.

234 on is crucial for SPL-mediated inhibition of influenza virus replication.

235 was confirmed by its activity in suppressing influenza virus replication.

236 H2 influenza viruses represent a pandemic threat due to con

237 H7 subtype influenza viruses represent a persistent public health t

238 ated to providing bioinformatics support for influenza virus research.

239 C virus, hepatitis B virus, enterovirus 71, influenza virus, respiratory syncytial virus, dengue vir

240 uss a range of pathogenic viruses, including influenza virus, respiratory syncytial virus, human immu

241 uses (RVs), respiratory enteroviruses (EVs), influenza virus, respiratory syncytial viruses (RSVs), a

242 inin (the glycoprotein on the surface of the influenza virus responsible for its binding to host cell

243 h graded doses of Listeria monotcytogenes or influenza virus revealed comparable and significantly re

244 main in transcription and replication of the influenza virus RNA genome.IMPORTANCE Influenza A viruse

245 o, indicating that the PB2 627 domain of the influenza virus RNA polymerase is not involved in core c

246 t is important to gain wider knowledge about influenza virus RNA to create new strategies for drugs t

247 Influenza virus RNA-dependent RNA polymerase consists of

248 ial for the replication and transcription of influenza virus RNA.

249 Seasonal influenza virus routinely causes epidemic infections thr

250 mic preparedness.IMPORTANCE Avian origin H10 influenza viruses sporadically infect humans and other m

251 Influenza viruses steadily evolve to escape detection by

252 ubset of highly pathogenic avian (HPAI) H5N1 influenza virus strains could productively replicate in

253 Different influenza virus strains have caused a number of recent o

254 Typing of influenza virus strains is an important aspect of global

255 sequenced and analyzed 441 wild-bird origin influenza virus strains isolated from wild birds inhabit

256 n, 93/244) that are not found in circulating influenza virus strains or have not been previously iden

257 responses that recognize a broader number of influenza virus strains to prevent infection and transmi

258 ted anamnestic recall of antibody to earlier influenza virus strains.

259 RBS naturally varies across avian and human influenza virus subtypes and is also evolvable.

260 t cellular cytotoxicity (ADCC) against avian influenza virus subtypes, including H7N9 and H5N1, have

261 These results show how pandemic influenza viruses subvert the immune response.

262 otic and pandemic emergence.IMPORTANCE Avian influenza viruses, such as H9N2, cause disease in poultr

263 ues important for NS1 functions and in human influenza virus surveillance to assess mutations affecti

264 Swine influenza virus (SwIV) is one of the important zoonotic

265 Most humoral immune responses to influenza virus target the hemagglutinin (HA) glycoprote

266 tions for assessing the potential of variant influenza viruses that can cause a rising prevalence in

267 spread of these mutations in circulating H1 influenza viruses that the previously subdominant, conse

268 imized or eliminated by targeting the intact influenza virus, thereby reducing assay complexity and l

269 ntribution of respiratory viruses other than influenza virus to CAP.

270 originated from the transfer of H3N8 equine influenza virus to dogs; and the H3N2 CIV, which is an a

271 sgenic mouse (2D2) and a mouse-adapted human influenza virus to test the hypothesis that upper-respir

272 We used influenza virus to test whether the technology has appli

273 We analyzed the adaptation of avian influenza viruses to a mammalian host by passaging an H9

274 n antigenic drift and the potential of avian influenza viruses to infect humans.

275 in the long-term adaptation of avian-origin influenza viruses to mammals.

276 linically mild influenza virus infections to influenza virus transmission in household, institutional

277 Beyond advancing our understanding of influenza virus transmission, we hope that this work wil

278 segment 5 (+)RNA is mostly conserved between influenza virus type A strains.

279 viruses, which offer discrimination between influenza virus types and subtypes.

280 Influenza virus uses a unique mechanism to initiate vira

281 We generated libraries of mutant influenza viruses using reverse genetics (RG) and select

282 A, including PIV5-NA, could improve seasonal influenza virus vaccine efficacy and provide protection

283 of the contribution of neuraminidase (NA) to influenza virus vaccine efficacy.

284 tion, thus setting the stage for a universal influenza virus vaccine.

285 Current influenza virus vaccines are an effective prophylaxis ag

286 a B virus infection.IMPORTANCE While current influenza virus vaccines are effective, they are affecte

287 Currently licensed influenza virus vaccines rely on the antigenic match of

288 n' concept refers to the impact of the first influenza virus variant encounter on lifelong immunity.

289 For protection against influenza virus via heat-killed DK128 pretreatment, B ce

290 Influenza virus was identified in 53% of individuals in

291 Positivity for viruses other than influenza virus was not correlated with significantly di

292 panel of 28 distinct human, avian, and swine influenza viruses, we found that only a small subset can

293 In the detection of influenza viruses, we show that DRELFA can discriminate

294 Substantial disease burden associated with influenza viruses were estimated in Hong Kong particular

295 ding long-term cross-protection against H3N2 influenza virus when compared to other vaccination group

296 Physicians respond to results of testing for influenza virus when managing hospitalized adult patient

297 espiratory syncytial virus and promising for influenza virus, whereas additional effort is needed in

298 Furthermore, such sera neutralized influenza virus, whereas this effect was not detected up

299 tly available antibody-based LFA systems for influenza viruses, which offer discrimination between in

300 ined high-coverage transposon mutagenesis of influenza virus with a rapid high-throughput screening f