ライフサイエンスコーパス: ingression

1 tion and defects in cytokinesis after furrow ingression.

2 traction that drives apical constriction and ingression.

3 eads to a failure of apical constriction and ingression.

4 which controls cleavage furrow formation and ingression.

5 own RhoGAP domain also contributes to furrow ingression.

6 nhibitor sFlt-1 locally blocked blood vessel ingression.

7 unction in promoting skeletogenic mesenchyme ingression.

8 ne is expressed only after skeletogenic cell ingression.

9 er, which is active in blastula stage, block ingression.

10 F-actin and membrane integrity during furrow ingression.

11 in, a cellular activity that accompanies PMC ingression.

12 focus on its roles regulating EMT during PMC ingression.

13 that Snail is required in micromeres for PMC ingression.

14 ilament dynamics, thereby controlling furrow ingression.

15 rs including invagination, delamination, and ingression.

16 osin ring contraction during cleavage furrow ingression.

17 cates to the equatorial region before furrow ingression.

18 tion, altering the timing and rate of furrow ingression.

19 m exocytosis and membrane demand from furrow ingression.

20 esistive forces that slow the rate of furrow ingression.

21 furrow ingressed but failed to complete the ingression.

22 hromosome segregation and cytokinetic furrow ingression.

23 beled PMCs remain within the local region of ingression.

24 eractions with neighboring cells can prevent ingression.

25 urrow, and that Cdc42 plays a role in furrow ingression.

26 f microvilli unfolds to fuel cleavage furrow ingression.

27 he marginal region of the blastoderm undergo ingression.

28 or midzone MT stabilization following furrow ingression.

29 ngly, pioneer cells delaminate shortly after ingression.

30 strate attachment could be regulating furrow ingression.

31 sively stronger cortical contractions during ingression.

32 negative mutant increases the rate of furrow ingression.

33 specific midbody region called the secondary ingression.

34 ack to form the PS as a zone of massive cell ingression.

35 anisotropic loss of cell contacts during NB ingression.

36 ryo is important in supporting timely furrow ingression.

37 generally considered the initiator of furrow ingression.

38 onverge to ensure successful cleavage furrow ingression.

39 rface curvature allow the furrow to complete ingression.

40 myosin II are sufficient to initiate furrow ingression.

41 r chromatid segregation with cleavage furrow ingression.

42 cule PPMP, causes failure of cleavage furrow ingression.

43 the furrow cortex are not disassembled after ingression.

44 ecome highly stable after furrows have begun ingression [2], indicating that furrow-to-MT communicati

45 Thus, asymmetric furrow ingression, a prevalent but previously unexplored featur

46 Here, we show that Ea/Ep ingression also requires the function of either HMR-1/ca

47 but its role, if any, during cleavage-furrow ingression and abscission is poorly understood.

48 s a lengthy interval between cleavage furrow ingression and abscission, during which the midbody micr

49 a sequential manner to bring about secondary ingression and abscission, respectively.

50 B depletion affects the speed of both furrow ingression and abscission.

51 evation and folding combined with local cell ingression and accretion.

52 late the cortex of the cell to ensure proper ingression and completion of the cleavage furrow.

53 dynacortin and fimbrin similarly slow furrow ingression and contribute to cell mechanics in a myosin-

54 a novel role for ARF6 during cleavage furrow ingression and cytokinesis.

55 Knockdown of FoxN2/3 inhibits normal PMC ingression and foxN2/3 morphant PMCs do not organize in

56 en morphogenesis begins with mesenchyme cell ingression and gastrulation.

57 oreover, our observations reveal that furrow ingression and membrane insertion are not strictly linke

58 there is active coordination between furrow ingression and microtubule dynamics.

59 asma membrane at the site of cleavage furrow ingression and midbody formation, and dominant negative

60 re, we calculate the full dynamics of furrow ingression and predict cytokinesis completion above a we

61 is rapid but regulated for cycles of furrow ingression and regression.

62 uncoupling between a fast ring and membrane ingression and slow septum synthesis, suggesting that cy

63 ry/T transcription factor, reducing mesoderm ingression and slowing down the elongation process.

64 iding of a basement membrane during cellular ingression and tissue formation.

65 inesis became abnormal, generating irregular ingressions and ectopic cleavage sites even when mitosis

66 sociated with abnormal and striking membrane ingressions and protrusions.

67 ch as sister nuclei being kept apart, furrow ingression, and abscission.

68 structures, contractile ring assembly, ring ingression, and completion.

69 es of microtubule bundle formation, cortical ingression, and F-actin and myosin II accumulation.

70 repression of cadherin expression during PMC ingression, and in part through its role in the endocyto

71 ulatory requirements of skeletogenesis after ingression, and may be similarly useful in many other de

72 ing, cell elongation, polar ruffling, furrow ingression, and separation of daughter cells.

73 interest, ring closure and hence the furrow ingression are nonconcentric (asymmetric) within the div

74 to examine the molecular mechanisms of cell ingression at a high temporal and spatial resolution, in

75 nesis phenotype, frequently arresting furrow ingression at the dumbbell shape and/or causing recessio

76 ctin filaments, enabling furrow assembly and ingression before cell division.

77 Ingression begins immediately after the onset of epiboly

78 receptors suggests that intracellular lipid ingression between receptor helices H6 and H7 may be a g

79 s against EB1 or p150glued suppressed furrow ingression but did not prevent elongation of anaphase as

80 c process before actin assembly and membrane ingression but does not affect the velocity or depth of

81 y of a single micromere do not disperse upon ingression, but instead remain in a closely associated c

82 Either system is sufficient for Ea/Ep ingression, but loss of both together leads to a failure

83 which active Rab8 populations direct furrow ingression by guiding the targeted delivery of cytoplasm

84 ral epidermis, consistent with the view that ingression can be regulated by leading-edge cells.

85 ions in apical cross-sectional area and cell ingression characterized by persistent loss of apical ar

86 or expression of skeletogenic genes prior to ingression, complete skeletogenesis also requires the ex

87 mere protein (INCENP) was not found in these ingressions, confirming that INCENP is dispensable for f

88 Ingression constitutes the first invasive cellular activ

89 s microvillar F-actin assembly, while furrow ingression controls microvillar F-actin disassembly.

90 1-GTPase regulator slam and show that furrow ingression controls the rate of microvillar depletion.

91 es while net cortical tension at the site of ingression decreases throughout constriction and suggest

92 Sorbitol also rescues endocytic ingression defects of certain endocytic mutants and of c

93 Ea/Ep ingression depends on correct cell fate specification an

94 nce of morphogenetic behaviors that includes ingression, directed migration, and cell-cell fusion.

95 d microvilli are contiguous, we suggest that ingression drives unfolding of the microvilli and incorp

96 Plasma membrane ingression during cytokinesis involves both actin remode

97 ynamics has allowed us to account for furrow ingression during cytokinesis, a model cell-shape-change

98 cells, resulting in partial cleavage furrow ingression during cytokinesis.

99 , and was further observed to inhibit furrow ingression during cytokinesis.

100 romotes contractile ring assembly and furrow ingression during cytokinesis.

101 h prevent mutant NM II from hampering furrow ingression during cytokinesis.

102 ryo undergoes several cycles of rapid furrow ingression during early development that culminate in th

103 , block or dramatically slow cleavage-furrow ingression during early telophase in dividing spermatocy

104 g cleavage furrow stiffness and slows furrow ingression during late cytokinesis as compared to myoII

105 d for daughter cell symmetry than for furrow ingression dynamics.

106 of PMC development, including specification, ingression/EMT, differentiation and skeletogenesis.

107 of the molecular mechanisms regulating cell ingression, epithelial-mesenchymal transition and migrat

108 compartmental behaviors with cortical furrow ingression events are unclear.

109 Thus, FoxN2/3 is necessary for normal ingression, for expression of several skeletal matrix ge

110 Myosin II function is thought to provide the ingression force for cytokinetic furrows, but the role o

111 nger adhesion to the substrate directed less ingression from the bottom of the cell through a pathway

112 mic trigeminal placode begins prior to their ingression (HH11), as early as HH8, and considerably ear

113 intracellular trafficking pathways in furrow ingression; however, the pathways that link compartmenta

114 the cytoskeletal network that drives furrow ingression in Dictyostelium.

115 ons in fws caused failure of cleavage furrow ingression in dividing spermatocytes and failure of cell

116 and MgcRacGAP have been implicated in furrow ingression in mammalian cells, but the signaling upstrea

117 Although furrows can form and initiate ingression in the absence of anillin, furrows cannot for

118 Arf GAP Asap is required for cleavage furrow ingression in the early embryo.

119 protein A (RalA) is required for fast furrow ingression in the early fly embryo.

120 biphasic manner, first, after 12 h and until ingression in the skeletogenic descendants of the large

121 imarily due to slower formation of secondary ingressions in WDR5 knockdown cells.

122 rrow assembles; anaphase and cleavage furrow ingression initially appear normal.

123 on microscopy and found that cleavage furrow ingression initiates by contraction of an equatorial act

124 pithelial sheet, leading to delamination and ingression into the mesenchyme where they continue to di

125 f the plasma membrane during cleavage furrow ingression involves the exocytic and endocytic pathways,

126 Unipolar ingression is a common form of gastrulation in the phylu

127 furrows is affected, but the rate of furrow ingression is decreased threefold.

128 Based on these results, we propose that ingression is driven by an actomyosin-based contraction

129 t Schizosaccharomyces pombe, cleavage furrow ingression is driven by polymerization of cell wall fibe

130 Ingression is independent of the Snail family of transcr

131 ophila embryos, to show that cleavage furrow ingression is kinetically coupled to the loss of surface

132 A model of unipolar ingression is proposed.

133 0.3-9.5 mum(2)/min), the rate for completing ingression is remarkably constant (0.83 cells/min, r(2)

134 Furthermore, cleavage furrow ingression is sensitive to the balance of contractile fo

135 ics reminiscent of bottle cell formation and ingression, known mechanisms of germ layer internalisati

136 g cell, generates force to help drive furrow ingression late in cytokinesis.

137 Indeed, during much of ingression, many marginal cells are so loosely arranged

138 ntial steps of cytokinesis, including furrow ingression, membrane resolution and cell separation in b

139 P16 is not required for PMC specification, ingression, migration, or fusion, but is essential for s

140 This ingression movement is a classic EMT during which the PM

141 hanges contribute to primary mesenchyme cell ingression movements and to cell rearrangements during a

142 , we present evidence that gastrulation-like ingression movements from the surface continue in the ea

143 is formed as a result of the continuation of ingression movements of gastrulation.

144 In the absence of zygotic transcription, ingression movements proceed normally, but epibolic move

145 n microscopy at the stage and position where ingression occurs suggests that superficial presumptive

146 yosin contractile ring that drives the rapid ingression of a deep cleavage furrow.

147 In H. erythrogramma, the differences include ingression of a much higher number of mesenchyme cells,

148 undamental changes in cell morphology is the ingression of a plasma membrane furrow.

149 ulted in the unexpected phenotype of initial ingression of a polar body ring with twice the diameter

150 at the end of cell division; it proceeds by ingression of an acto-myosin furrow at the equator of th

151 Cell division after mitosis is mediated by ingression of an actomyosin-based contractile ring.

152 ling in the embryonic crosstalk required for ingression of angiogenic vessel sprouts into the develop

153 esenchymal conversion that characterizes the ingression of both primary and secondary mesenchyme cell

154 The ingression of cells in the anterior tailbud only gives r

155 Further, these mutant cells initiate the ingression of cleavage furrows earlier than normal, shor

156 eural gene expression results from continued ingression of CNH-derived cells into the position of the

157 ud, the lateral part derives from continuous ingression of epiblastic material.

158 chick, we show that isolated EMT events and ingression of individual cells start well before gastrul

159 astrulation acted as a likely switch from an ingression of individual cells to the invagination of th

160 Gastrulation in C. elegans embryos involves ingression of individual cells, but is driven by apical

161 the epithelial-to-mesenchymal transition and ingression of mesoderm cells through the primitive strea

162 In addition, alpha-bis-PCBM resists the ingression of moisture and passivates voids or pinholes

163 avoid the presumptive cornea despite dynamic ingression of neural crest cells.

164 urogenesis integrating cell dynamics whereby ingression of pioneer cells instructs neuronal specifica

165 This induction triggers expression of Pax3, ingression of placode cells and their differentiation in

166 Ingression of primary mesenchyme cells is accompanied by

167 This process begins by ingression of prospective primary mesenchyme cells into

168 Brain neurogenesis proceeds by the ingression of single cells from the anterior ectoderm to

169 um of pregastrula stage embryos demonstrates ingression of surface cells into both paraxial and axial

170 s involves formation of a blastocoel and the ingression of surface cells into the blastocoel.

171 tin role during the organization and initial ingression of the cellularization furrow even in the abs

172 Cell-cell contacts also direct ingression of the cleavage furrow in coordination with F

173 allows coordination of AMR contraction with ingression of the cleavage furrow.

174 ntinued translation is required for complete ingression of the cleavage furrow.

175 bly of the contractile ring and triggers the ingression of the cleavage furrow.

176 erence (RNAi) failed cytokinesis without any ingression of the cleavage furrow.

177 he assembly of the contractile ring, and the ingression of the cleavage furrow.

178 ein may not have a role in the formation and ingression of the contractile ring in the cortex.

179 but does not affect the velocity or depth of ingression of the endocytic pit in wild-type cells.

180 We show that ingression of the endodermal precursor cells is regulate

181 Furrow specification occurred normally, but ingression of the furrow was inhibited.

182 lanogaster but do not appear during mesoderm ingression of the midge Chironomus riparius.

183 xocytic events that may be involved in prior ingression of the plasma membrane.

184 mental processes in C. elegans including the ingression of vulval cells as well as germline prolifera

185 on of CED-10/Rac1 and ARX-2/Arp2 facilitates ingression of weak cleavage furrows.

186 overcome turgor, is largely dispensable for ingression; once septation has started, cleavage can con

187 3T3 fibroblasts exhibited irregular cortical ingression only when cells started to increase attachmen

188 From ingression onward, however, a dedicated distal module ut

189 hibited SS formation but not cleavage-furrow ingression or the concomitant actomyosin ring constricti

190 ll reservoir is depleted in sync with furrow ingression over 60-70 min.

191 tube resulted in supernumerary blood vessel ingression points and disrupted vessel patterning.

192 1 did not produce supernumerary blood vessel ingression points, although the vessels that entered the

193 This is in addition to previously observed ingression processes associated with zipping and apoptos

194 During ingression proper, cells leave a single-layered epitheli

195 At ingression, quantitative adhesion assays demonstrated pr

196 We propose that this constant ingression rate contributes to the spatiotemporal regula

197 which correlated with slower cleavage furrow ingression rates.

198 bryos correlates with faster cleavage furrow ingression rates.

199 Finally, ingression relies on the epithelialisation timing contro

200 Asymmetric ingression requires Anillin and the septins, which promo

201 tailbud undergo subduction, a novel form of ingression resulting in the restriction of this tailbud

202 Ring constriction coupled to plasma-membrane ingression separates the two daughter cells.

203 Interestingly, although most ingression takes place supramarginally, much occurs clos

204 s initially at the blastoderm margin undergo ingression there, but most recede from the margin and in

205 mporarily inactivated during cleavage-furrow ingression; this inactivation requires the protein Cyk3,

206 s a combination of invagination and unipolar ingression through epithelial to mesenchymal transitions

207 ile simultaneously promoting cleavage-furrow ingression through primary septum formation.

208 the migration of mesoderm cells after their ingression through the primitive streak.

209 d following their movement as they underwent ingression through the primitive streak.

210 , the epiblast, gives rise to new tissues by ingression through the primitive streak.

211 on of axial mesoderm and the continuation of ingression throughout zebrafish tail development suggest

212 n cytoskeleton, resulting in extended furrow ingression times and asymmetrical cell division.

213 We provide evidence that ingression times are determined by genes that control ce

214 indle midpoint are required for initial ring ingression to occur close to the membrane-proximal spind

215 a multilayered cell mass; we refer to it as ingression-type cell migration.

216 , we have found that, during cleavage furrow ingression, vesicles are internalized from the polar reg

217 endothelial cells to stimulate blood vessel ingression, vessel patterning, and acquisition of mature

218 onmuscle myosin at their apical surfaces and ingression was slowed.

219 that the CPC is integral for coupling furrow ingression with midzone microtubule stabilization.

220 eny and the exhibition of different forms of ingression within specific tailbud domains.